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Search Results for " p70 "

Targets Recommended: Others

22

抑制剂 & 化合物

1

化合物库

22

重组蛋白

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Cat. No.	Product Name
L1300	PI3K/Akt/mTOR 化合物库		420 compounds
	420 种与PI3K/Akt/mTOR 相关的生物活性小分子化合物的特有集合，用于PI3K/Akt/mTOR 相关研究以及高通量、高内涵筛选；

化合物库

PI3K/Akt/mTOR 化合物库

Cat.No: L1300

Compounds: 420

Cat. No.	Product Name	Target	Signaling Pathways
TP1616L	Hsp70-derived octapeptide acetate Hsp70-derived octapeptide acetate(736171-62-3 free base)	Others	Others
	Hsp70-derived octapeptide acetate (Hsp70-derived octapeptide acetate)(736171-62-3 free base) 是一组含有四肽重复 (TPR) 的蛋白质，已显示与 70 kDa 热休克同源蛋白 (hsc70) 的 C 末端结构域相互作用。在本研究中，含 TPR 的蛋白质，包括 hsc70 相互作用蛋白 (CHIP)、TPR1 和人富含谷氨酰胺的 TPR 含蛋白 (hSGT) 的 C 端，对 DnaJ 和 hsc70 对荧光素酶重折叠的影响进行了调查。
T3487	HSP70-IN-1	Others; HSP	Cytoskeletal Signaling; Metabolism; Others
	HSP70-IN-1是一种热休克蛋白 (HSP) 抑制剂，可抑制 Kasumi-1 细胞的生长，IC50值为2.3 μM。
TP1616	Hsp70-derived octapeptide
	A group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognate protein (hsc70). In the present study, the effect of the TPR-containing proteins, including the C-terminus
T82167	HSP70/SIRT2-IN-2	HSP	Cytoskeletal Signaling; Metabolism
	HSP70/SIRT2-IN-2（Compounds 1a）为针对SIRT2与HSP70的双重抑制剂，其IC50值为45.1±5.0 μM，展现了抗肿瘤活性。
T74278	HSP70-IN-3
	HSP70-IN-3 是一种有效的热休克蛋白 (HSP70) 抑制剂 (ASZ001 和 C3H10T1/2 的 IC50分别为1.1和1.9 μM)。HSP70-IN-3 具有抗 Hedgehog 信号转导通路活性和抗增殖活性，并降低致癌转录因子 GLI1 的表达。
T82168	HSP70/SIRT2-IN-1	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HSP70/SIRT2-IN-1 (Compounds 2a)作为SIRT2与HSP70的双重抑制剂，展示了抗肿瘤活性，其IC50值为17.3±2.0 μM。
T71199	CGP7040
	CGP7040 is a rifamycin analogue, is a protein 50S ribosomal subunit inhibitor that was being developed by Novartis.
T2002	PF-4708671 PF4708671	S6 Kinase; Autophagy	Autophagy; MAPK; PI3K/Akt/mTOR signaling
	PF-4708671 是一种可渗透细胞的 p70 核糖体 S6 激酶抑制剂，对 S6K1的Ki 为 20 nM，IC50为 160 nM。
T6159	LY-2584702 free base	S6 Kinase; mTOR	MAPK; PI3K/Akt/mTOR signaling
	LY-2584702 free base 是一种选择性的 ATP 竞争性 p70S6K 抑制剂，IC50为 4 nM，对S6K1的IC50为 2 nM，用于研究癌症治疗的试验。
T1746	LY-2584702 tosylate salt LY2584702 tosylate	S6 Kinase	MAPK; PI3K/Akt/mTOR signaling
	LY-2584702 tosylate salt 是一种选择性的 ATP 竞争性 p70S6K 抑制剂，IC50为 4 nM，对S6K1的IC50为 2 nM，用于研究癌症治疗的试验。
TP1978	11R-VIVIT NFAT inhibitor, Cell Permeable
	NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse
T6303L	CCT128930 hydrochloride CCT128930 hydrochloride(885499-61-6 Free base)	Apoptosis; Akt; PKA; mTOR; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	CCT128930 hydrochloride (CCT128930 hydrochloride) 是一种选择性 AKT 抑制剂，具有抗肿瘤活性。它通过靶向 AKT 的 Met282 (PKA-AKT 嵌合体的 Met173)，对 PKA 激酶具有 28 倍的选择性，对 p70S6K 具有 20 倍的选择性。
T11928	M2698 MSC2363318A	Akt; mTOR	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	M2698 (MSC2363318A) 是 p70S6K、Akt1 和 Akt3 的抑制剂，IC50 为 1 nM。 M2698 显示出抗癌活性。
TP1978L1	11R-VIVIT TFA (592517-80-1 Free base)
	11R-VIVIT TFA (592517-80-1 Free base) 是一种 NFAT 抑制剂。 11R-VIVIT TFA 抑制 LPS 或 LPS 加 IFN-γ 诱导的骨髓源性巨噬细胞 (BMDM) 分泌 IL-12 p40、IL-12 p70、IL-23 和 TNF。 11R-VIVIT TFA 减弱 LPS 刺激的 BMDM 中 NO 的产生和 Nos2 mRNA 的表达。 11R-VIVIT TFA 改善结肠炎小鼠模型的症状。 11R-VIVIT TFA 表现出免疫抑制作用并提高小鼠移植物的存活率。 11R-VIVIT TFA 具有细胞渗透性。
T2482	AT13148	ROCK; SGK; Akt; PKA; S6 Kinase	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	AT13148 是一种 ATP 竞争性 AGC 激酶口服抑制剂，能够抑制 Akt1/Akt2/Akt3、p70S6K、PKA 和 ROCKI/ROCKII 的活性，IC50值分别为 38/402/50、8、3 和 6 nM/4 nM。
T6304	AT7867	Akt; PKA; S6 Kinase	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	AT7867 是 ATP 竞争性的Akt1/Akt2/Akt3和p70S6K/PKA 抑制剂，IC50分别为 32、17、47 和 85、20 nM。
T1920	Capivasertib AZD5363	Akt; PKA; mTOR; Autophagy	Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Capivasertib (AZD5363) 是一种广谱的 AKT 抑制剂，对 Akt1、Akt2 和 Akt3 均有抑制活性 (IC50=3/7/7 nM)，具有口服活性。Capivasertib 具有抗肿瘤活性，可以用于治疗乳腺癌。
T11900	LY-2584702 hydrochloride	S6 Kinase	MAPK; PI3K/Akt/mTOR signaling
	Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.
T39733	Hu7691 free base	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Hu7691 free base 是一种具有口服活性、高效性和选择性的 Akt 抑制剂，对多种神经母细胞瘤细胞系的抗增殖和神经发生作用。Hu7691 free base 抑制 Akt1、Akt2 和 Akt3 ，诱导神经母细胞瘤细胞分化。
T10275	AKT-IN-3	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3). AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1
T10274	AKT-IN-2	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT-IN-2 is a selective, and orally bioavailable AKT inhibitor (IC50: 5 nM for AKT1).
T39899	Hu7691	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Hu7691 是一种具有口服活性、选择性和高效性的 Akt 抑制剂，抑制 Akt1、Akt2 和 Akt3，抑制神经母细胞瘤细胞增殖，诱导神经母细胞瘤细胞的分化。

化合物

Hsp70-derived octapeptide acetate

Cat.No: TP1616L

Synonym: Hsp70-derived octapeptide acetate(736171-62-3 free base)

Target: Others

Cat.No: T3487

Target: Others, HSP

Hsp70-derived octapeptide

Cat.No: TP1616

HSP70/SIRT2-IN-2

Cat.No: T82167

Target: HSP

Cat.No: T74278

HSP70/SIRT2-IN-1

Cat.No: T82168

Target: Sirtuin

Cat.No: T71199

Cat.No: T2002

Synonym: PF4708671

Target: S6 Kinase, Autophagy

LY-2584702 free base

Cat.No: T6159

Target: S6 Kinase, mTOR

LY-2584702 tosylate salt

Cat.No: T1746

Synonym: LY2584702 tosylate

Target: S6 Kinase

Cat.No: TP1978

Synonym: NFAT inhibitor, Cell Permeable

CCT128930 hydrochloride

Cat.No: T6303L

Synonym: CCT128930 hydrochloride(885499-61-6 Free base)

Target: Apoptosis, Akt, PKA, mTOR, Autophagy

Cat.No: T11928

Synonym: MSC2363318A

Target: Akt, mTOR

11R-VIVIT TFA (592517-80-1 Free base)

Cat.No: TP1978L1

Cat.No: T2482

Target: ROCK, SGK, Akt, PKA, S6 Kinase

Cat.No: T6304

Target: Akt, PKA, S6 Kinase

Cat.No: T1920

Synonym: AZD5363

Target: Akt, PKA, mTOR, Autophagy

LY-2584702 hydrochloride

Cat.No: T11900

Target: S6 Kinase

Hu7691 free base

Cat.No: T39733

Target: Akt

Cat.No: T10275

Target: Akt

Cat.No: T10274

Target: Akt

Cat.No: T39899

Target: Akt

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05680	CD122/IL2RB Protein, Human, Recombinant (mFc) CD122,IL15RB,IL-15RB,interleukin 2 receptor, beta,interleuki...	Human	HEK293 Cells
	CD122/IL2RB Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 51 kDa and the accession number is P14784.
TMPY-05216	CD122/IL2RB Protein, Human, Recombinant (His) IL-15RB,interleukin 2 receptor, β,P70-75,IL15RB,int...	Human	Baculovirus Insect Cells
	CD122/IL2RB Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P14784.
TMPY-00860	CD122/IL2RB Protein, Human, Recombinant interleukin 2 receptor, β,interleukin 2 receptor, beta,CD122...	Human	HEK293 Cells
	CD122/IL2RB Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.2 kDa and the accession number is P14784.
TMPY-05784	CD122/IL2RB Protein, Mouse, Recombinant (hFc) IL-15Rβ,Il-2/15Rbeta,Il-2Rβ,interleukin 2 receptor, β,IL-15R...	Mouse	HEK293 Cells
	CD122/IL2RB Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.76 kDa and the accession number is P16297.
TMPY-04031	CD122/IL2RB Protein, Mouse, Recombinant (His) IL-15Rβ,Il-2/15Rbeta,interleukin 2 receptor, β,IL15Rbeta,	Mouse	HEK293 Cells
	CD122/IL2RB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is P16297.
TMPY-04540	S6K1/RPS6KB1 Protein, Human, Recombinant (GST) p70(S6K)-alpha,PS6K,p70-alpha,p70...	Human	Baculovirus Insect Cells
	PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase (S6K). S6K can be activated by mitogenic stimuli such as growth factors, insulin and cytokines. It phosphorylates the ribosomal protein S6. PS6K also phosphorylates other proteins such as elF4B, eEF2K and SKAR. It is a crucial effector of mTOR(rapamycin) signaling. PS6K is disso...
TMPY-04863	IL-12 Protein, Human, Recombinant IMD29,CLMF,IL12,NFSK,白细胞介素,IL-12A,interleukin 12A,NKSF1,IL12...	Human	HEK293 Cells
	IL-12 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 57.2 kDa and the accession number is P29459-1&NP_002178.2.
TMPY-06515	CD122/IL2RB Protein, Human, Recombinant (His & Avi), Biotinylated P70-75,IL15RB,interleukin 2 receptor, beta,CD122,IL...	Human	HEK293 Cells
	CD122/IL2RB Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 28.73 kDa and the accession number is NP_000869.1.
TMPY-00859	CD122/IL2RB Protein, Human, Recombinant (hFc) IL-15RB,interleukin 2 receptor, beta,interleukin 2 receptor,...	Human	HEK293 Cells
	CD122/IL2RB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.3 kDa and the accession number is P14784.
TMPY-03440	Sts1 Protein, Human, Recombinant (His) STS-1,ubiquitin associated and SH3 domain containing B,p...	Human	E. coli
	UBASH3B contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. UBASH3B was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. UBASH3B interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. It promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on...
TMPY-02109	IL-12 Protein, Human, Recombinant (His) IL12,NKSF1,IMD28,CLMF2,白细胞介素,NKSF2,NKSF,CLMF,IMD29,IL-12B,IL...	Human	HEK293 Cells
	IL-12 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.13 kDa and the accession number is P29459-1&NP_002178.2.
TMPY-05458	IL-12 Protein, Human, Recombinant (His), Biotinylated NKSF,IL-12A,白细胞介素,白介素,interleukin 12A,IMD29,NFSK,NKSF2,CLMF2...	Human	HEK293 Cells
	IL-12 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.13 kDa and the accession number is P29459.2&NP_002178.2.
TMPK-00320	IL-2 R beta/CD122 Protein, Human, Recombinant (His & Avi) IL-2 R β/CD122,IL-15 R beta,RP5-1170K4.6,IL-2R subunit beta,...	Human	HEK293 Cells
	IL-2 R beta/CD122 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27.5 kDa and the accession number is P14784.
TMPK-00321	IL-2 R beta/CD122 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated IL-2 R beta,IL-2R subunit beta,IL-2 R β,IL-2R subunit β,IL-1...	Cynomolgus	HEK293 Cells
	IL-2 R beta/CD122 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 25.6 kDa and the accession number is Q38J85.
TMPY-02443	HSP70 Protein, Human, Recombinant (His) heat shock 70kDa protein 1A,HSP70-1,HSP70I...	Human	Baculovirus Insect Cells
	HSP70 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 72.2 kDa and the accession number is A8K5I0.
TMPH-00371	HSP70 Protein, Chicken, Recombinant (His)	Chicken	E. coli
	HSP70 Protein, Chicken, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 48.6 kDa and the accession number is P08106.
TMPH-00765	HSP70 Protein, Gallus gallus, Recombinant (His & Myc)	Chicken	Baculovirus Insect Cells
	HSP70 Protein, Gallus gallus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 46.5 kDa and the accession number is P08106.
TMPH-02280	SNRNP70 Protein, Human, Recombinant (His)	Human	E. coli
	Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA.; Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.; Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. SNRNP70 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.7 kDa and the accession n...
TMPH-03636	HSP70 Protein, Toxoplasma gondii, Recombinant (His)	Toxoplasma gondii	E. coli
	N/A. HSP70 Protein, Toxoplasma gondii, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 78.9 kDa and the accession number is A0A125YXI9.
TMPY-06092	HSP70 Protein, Rat, Recombinant (His) heat shock 70kDa protein 1A	Rat	HEK293 Cells
	HSP70 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.6 kDa and the accession number is A6KTP2.
TMPY-06091	HSP70 Protein, Mouse, Recombinant (His) Hsp70-3,Hsp72,hsp68,hsp70A1,heat shock 70k...	Mouse	HEK293 Cells
	HSP70 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.5 kDa and the accession number is Q3TU85.
TMPH-00064	MRJP1 Protein, Apis mellifera, Recombinant (His)	Apis mellifera	P. pastoris (Yeast)
	Induces the differentiation of honeybee larvae into queens through an Egfr-mediated signaling pathway. Promotes body size increase by activating p70 S6 kinase, stimulates ovary development by augmenting the titer of vitellogenin (Vg) and juvenile hormone, and reduces developmental time by increasing the activity of mitogen-activated protein kinase and inducing the 20-hydroxyecdysone protein (20E). Most abundant protein found in the royal jelly which is the food of the queen honey bee larva. The ...

重组蛋白

CD122/IL2RB Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05680

Species: Human

Expression System: HEK293 Cells

CD122/IL2RB Protein, Human, Recombinant (His)

Cat.No: TMPY-05216

Species: Human

Expression System: Baculovirus Insect Cells

CD122/IL2RB Protein, Human, Recombinant

Cat.No: TMPY-00860

Species: Human

Expression System: HEK293 Cells

CD122/IL2RB Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-05784

Species: Mouse

Expression System: HEK293 Cells

CD122/IL2RB Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04031

Species: Mouse

Expression System: HEK293 Cells

S6K1/RPS6KB1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04540

Species: Human

Expression System: Baculovirus Insect Cells

IL-12 Protein, Human, Recombinant

Cat.No: TMPY-04863

Species: Human

Expression System: HEK293 Cells

CD122/IL2RB Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06515

Species: Human

Expression System: HEK293 Cells

CD122/IL2RB Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00859

Species: Human

Expression System: HEK293 Cells

Sts1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03440

Species: Human

Expression System: E. coli

IL-12 Protein, Human, Recombinant (His)

Cat.No: TMPY-02109

Species: Human

Expression System: HEK293 Cells

IL-12 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05458

Species: Human

Expression System: HEK293 Cells

IL-2 R beta/CD122 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00320

Species: Human

Expression System: HEK293 Cells

IL-2 R beta/CD122 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated

Cat.No: TMPK-00321

Species: Cynomolgus

Expression System: HEK293 Cells

HSP70 Protein, Human, Recombinant (His)

Cat.No: TMPY-02443

Species: Human

Expression System: Baculovirus Insect Cells

HSP70 Protein, Chicken, Recombinant (His)

Cat.No: TMPH-00371

Species: Chicken

Expression System: E. coli

HSP70 Protein, Gallus gallus, Recombinant (His & Myc)

Cat.No: TMPH-00765

Species: Chicken

Expression System: Baculovirus Insect Cells

SNRNP70 Protein, Human, Recombinant (His)

Cat.No: TMPH-02280

Species: Human

Expression System: E. coli

HSP70 Protein, Toxoplasma gondii, Recombinant (His)

Cat.No: TMPH-03636

Species: Toxoplasma gondii

Expression System: E. coli

HSP70 Protein, Rat, Recombinant (His)

Cat.No: TMPY-06092

Species: Rat

Expression System: HEK293 Cells

HSP70 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06091

Species: Mouse

Expression System: HEK293 Cells

MRJP1 Protein, Apis mellifera, Recombinant (His)

Cat.No: TMPH-00064

Species: Apis mellifera

Expression System: P. pastoris (Yeast)

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