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20

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4297	Flibanserin BIMT-17BS,氟立班丝氨,Girosa,BIMT-17	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Flibanserin (Girosa) 一种具有口服活性的 5-HT1A 受体激动剂和 5-HT2A 受体拮抗剂，Ki 值分别为 1 和 49 nM。它与多巴胺 D4 受体结合，Ki 值在 4 到 24 nM 之间。它是一种血清素能抗抑郁药，用于治疗性欲减退症。
T4595	YHO-13177 YHO 13177,YHO13177	BCRP	Membrane transporter/Ion channel
	YHO-13177 是高活性乳腺癌耐药蛋白多药转运通道（BCRP）抑制剂，可增强SN-38活性。
T62899	Tau-aggregation and neuroinflammation-IN-1	Microtubule Associated; NO Synthase	Cytoskeletal Signaling; Immunology/Inflammation
	Tau-aggregation and neuroinflammation-IN-1 是一种有效的 Tau 蛋白聚集体抑制剂，对 AcPHF6 和全长 tau 蛋白聚集体显示出显著的抑制活性。Tau-aggregation and neuroinflammation-IN-1具有抗炎活性且可减少 NO 释放。Tau-aggregation and neuroinflammation-IN-1 对 LSP 刺激的 BV2 细胞具有低细胞毒性。Tau-aggregation and neuroinflammation-IN-1 可逆转冈田酸诱导的大鼠记忆障碍。
T4306	CCG-203971 CCG203971	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	CCG-203971 是一种Rho/MRTF/SRF 通路抑制剂，具有潜在的抗转移作用。它有效靶向 RhoA/C 激活的 SRE 荧光素酶，IC50为 6.4 μM。它抑制 PC-3 细胞迁移，IC50为 4.2 μM。
T27642	I-XW-053 sodium I-XW-053 Na,I XW 053 sodium,IXW053 sodium,I XW 053 Na,IXW053 Na
	I-XW-053 sodium inhibits the replication of a diverse panel of primary HIV-1 isolates in Peripheral blood mononuclear cell with no appreciable cytotoxicity.
T22462	1,2,3,4,5,6-Hexabromocyclohexane	Others	Others
	The compound effectively and directly inhibits JAK2 tyrosine kinase autophosphorylation and specifically inhibits ligand-dependent JAK2 activation. It has no cytotoxicity at 100 μM. A 16-hour treatment with compound (1 μM) decreases JAK2 tyrosine autophos
T61555	Aldose reductase-IN-6
	Aldose reductase-IN-6 (Compound 3) is a competitive inhibitor of aldose reductase (AR), possessing an IC50 of 3.164 μM and a Ki of 0.018 μM. Notably, Aldose reductase-IN-6 demonstrates no cytotoxicity toward normal cells [1].
T26413	A 30312 A-30312,A30312
	A 30312 is a fused indole, which overcomes multidrug resistance in P388/Adr cells in vitro. It potentiates the cytotoxicity of the antitumor drugs Adriamycin, vincristine and vinblastine in multidrug-resistant cells with no effect on drug-sensitive parent P388 cells.
T62086	Tuberculosis inhibitor 5
	Tuberculosis inhibitor 5 (Compound 11i) 是一种有效的抗结核剂，无明显细胞毒性。Tuberculosis inhibitor 5 是一种抗分枝杆菌 (antimycobacterial) 联苯类似物。
T36109	L Moses dihydrochloride
	High affinity and selective cell-permeable p300/CBP-associated factor (PCAF) inhibitor (Ki = 47 nM). Exhibits no significant activity against a panel of 48 other bromodomains except GCN5 (Kd = 600 nM). Exhibits >4500-fold selectivity for PCAF over BRD4. Also exhibits metabolic stability in mouse and human liver microsomes and no observable cytotoxicity in peripheral blood mononuclear cells (PBMC). Moustakim et al (2017) Discovery of a PCAF bromodomain chemical probe. Angew.Chem.Int.Ed. 56 827 P...
T70223	UA8967
	UA8967 is a membrane-active anti-tumor agent. Cytotoxicity studies in six pancreatic cancer cell lines, one normal human pancreatic ductal epithelial line and two colon cancer cells showed the IC50s UA8967 ranged from 12–61 μM for exposure times of 72 h. There was also no selective inhibition of DNA, RNA or protein synthesis after exposure to UA8967. UA8967 is observed to affect the plasma membrane.
T63491	MtTMPK-IN-8
	MtTMPK-IN-8 是具有中等效力的分支杆菌胸苷酸激酶 (MtbTMPK)抑制剂，没有显著的细胞毒性，对抗分枝杆菌表现出亚微摩尔活性 (MICs = 0.78~9.4 μM)，能够用于研究结核病。
T32050	HCV-371 HCV 371
	HCV-371 is a potent selective HCV NS5B polymerase inhibitor that shows broad inhibitory activity against NS5B RDRP and no inhibitory activity against a set of human polymerases (including mitochondrial DNA polymerase γ and other unrelated viral polymerase
T36318	28-Acetylbetulin
	28-Acetylbetulin is a lupane triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found inM. chiapensisand has anti-inflammatory and anticancer activities.1,2It inhibits LPS-induced nitric oxide (NO) and prostaglandin E2production by 55.9 and 69.5%, respectively, in RAW 264.7 cells (IC50s = 4.7 and 1.7 μM, respectively).128-Acetylbetulin induces cytotoxicity in a variety of cancer cells, including A549, HT-29, and MCF-7 cells (IC50s = 14.37, 10.96, and 11.3...
T68485	Apilimod HCl
	Apilimod dimesylate is a potent and selective PIKfyve inhibitor. It exhibits no significant activity at other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K. Apilimod dimesylate inhibits cellular entry by SARS-CoV-2, MERS-CoV and MHV S pseudovirions. It reduces the number of SARS-CoV-2-infected hiPSC-derived pneumocyte-like cells by 85% and inhibits SARS-CoV-2 replication in donor lung tissue. It also exhibits selective cytotoxicity in B-cell non-Hodgkin lymphoma ...
T83044	Antimalarial agent 33	Parasite	Microbiology/Virology
	Antimalarial agent 33 (compound 5g) 显示针对红细胞期和肝期疟原虫的抗活性，特别是对 K1 恶性疟原虫株，其EC50为1.1 μM。Antimalarial agent 33 还展示出提升的微粒体稳定性（T1/2=29分钟），并且对原代肝细胞未表现出明显的细胞毒效应。
T27038	CL385319 HCl CL-385319,CL385319 hydrochloride,CL 385319,CL385319
	CL385319 is a potent inhibitor of H5N1 avian influenza A virus infection by blocking viral entry. CL-385319 is effective in inhibiting infection of highly pathogenic H5N1 influenza A virus in Madin-Darby Canine Kidney (MDCK) cells with an IC50 of 27.03±2.
T74762	Influenza A virus-IN-8
	Influenza A virus-IN-8 (S5) 为一种大环肽，无细胞毒性，并作为甲型流感病毒 (IAV) 的有效抑制剂，显示出较好的蛋白酶稳定性。其对 H1 和 H5 变体的IC50值分别低至 6.7 nM 和 6.6 nM。此外，Influenza A virus-IN-8 能够与 HA 茎的一个保守区域结合，特别是对 H1 变体展现出 1.0 nM 的高亲和性Kd 值。
T74461	Chalcones A-N-5
	ChalconesA-N-5, 一种三羟基查耳酮衍生物化合物，浓度低于100 µM (IC50> 1 mM) 时无细胞毒性，能显着促进细胞增殖。此外，ChalconesA-N-5 能促进受损脑组织中神经元的生长，抑制RSL或erastin诱导的铁死亡，并降低Aβ1-42蛋白聚集引发的脂质过氧化水平。因此，ChalconesA-N-5 作为分子骨架的候选物，对于开发用以研究AD的体内试验先导化合物具有重要潜力。
T35893	rac-1,2-bis-Palmitoyl-3-chloropropanediol
	rac-1,2-bis-Palmitoyl-3-chloropropanediol is a 3-monochloropropane-1,2-diol (3-MCPD) ester.1It has been found as a contaminant in edible olive oils, with the lowest and highest concentrations in extra virgin and olive pomace oils, respectively.rac-1,2-bis-Palmitoyl-3-chloropropanediol has also been found in cottonseed and palm oils, as well as in shortening.2It induces renal tubular necrosis and a decrease in spermatids, but no gross pathological changes, in mice.3 1.Hung, W.-C., Peng, G.-J., Ts...

化合物

Cat.No: T4297

Synonym: BIMT-17BS,氟立班丝氨,Girosa,BIMT-17

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T4595

Synonym: YHO 13177,YHO13177

Target: BCRP

Tau-aggregation and neuroinflammation-IN-1

Cat.No: T62899

Target: Microtubule Associated, NO Synthase

Cat.No: T4306

Synonym: CCG203971

Target: Rho, Ras

I-XW-053 sodium

Cat.No: T27642

Synonym: I-XW-053 Na,I XW 053 sodium,IXW053 sodium,I XW 053 Na,IXW053 Na

1,2,3,4,5,6-Hexabromocyclohexane

Cat.No: T22462

Target: Others

Aldose reductase-IN-6

Cat.No: T61555

Cat.No: T26413

Synonym: A-30312,A30312

Tuberculosis inhibitor 5

Cat.No: T62086

L Moses dihydrochloride

Cat.No: T36109

Cat.No: T70223

Cat.No: T63491

Cat.No: T32050

Synonym: HCV 371

28-Acetylbetulin

Cat.No: T36318

Cat.No: T68485

Antimalarial agent 33

Cat.No: T83044

Target: Parasite

Cat.No: T27038

Synonym: CL-385319,CL385319 hydrochloride,CL 385319,CL385319

Influenza A virus-IN-8

Cat.No: T74762

Chalcones A-N-5

Cat.No: T74461

rac-1,2-bis-Palmitoyl-3-chloropropanediol

Cat.No: T35893

Cat. No.	Product Name	Target	Signaling Pathways
T3826	Polygalasaponin F 异牡荆苷,瓜子金皂苷己	NF-κB; TLR; Akt; PI3K	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。
TN5146	Thunalbene	Others	Others
	Thunalbene shows weak inhibitory activities without cytotoxicity on the production of nitric oxide (NO) which is an important inflammatory mediator.
T81602	Ophiopogonin R
	Ophiopogonin R (compound 3)，一种甾体皂苷，源自麦冬的分离纯化。该化合物对包括HepG2、HLE、BEL7402、BEL7403和Hela在内的五种人类肿瘤细胞系均未显示细胞毒性。
T33492	Methyl pyropheophorbide-a MPPa (Methyl pyropheophorbide-a),NSC267052,Pyropheophorbidea,MPPa,NSC-267052,NSC 267052
	Pyropheophorbide-a methyl ester (MPPa) is a PDT photosensitizer, and is also a semisynthetic natural product derived from chlorophyll a. The absorption peak of MPPa in organic solvent and in cells was at 667 and 674 nm, respectively. 3-(4,5-Dimethylthiazo
T75461	Harzianum A
	Harzianum A 是一种单端孢霉烯化合物，可从 Trichoderma harzianum 中分离得到。Harzianum A 对小仓鼠肾细胞没有细胞毒性，对革兰氏阴性和革兰氏阳性细菌没有活性，但在 100 μg/mL 时具有适度的抗真菌活性。
TN5011	Shizukaol B	ERK; IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; HIV Protease; DNA/RNA Synthesis; Prostaglandin Receptor; JNK	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimul

天然产物

Polygalasaponin F

Cat.No: T3826

Synonym: 异牡荆苷,瓜子金皂苷己

Target: NF-κB, TLR, Akt, PI3K

Cat.No: TN5146

Target: Others

Cat.No: T81602

Methyl pyropheophorbide-a

Cat.No: T33492

Synonym: MPPa (Methyl pyropheophorbide-a),NSC267052,Pyropheophorbidea,MPPa,NSC-267052,NSC 267052

Cat.No: T75461

Cat.No: TN5011

Target: ERK, IL Receptor, p38 MAPK, TNF, NOS, NF-κB, COX, HIV Protease, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

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