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57

抑制剂 & 化合物

25

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22774L	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]（TFA)	Others	Others
	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) 是延伸因子 1 亚基。真核翻译延伸因子 1 alpha 1 (EEF1A1) 编码延伸因子 alpha 亚基的同种型- 1 复合物，负责将氨酰 tRNA 酶促递送至核糖体。这种亚型（α 1）在脑、胎盘、肺、肝、肾和胰腺中表达，另一种亚型（α 2）在脑、心脏和骨骼肌中表达。这种亚型在 66% 的 Felty 综合征患者中被鉴定为自身抗原。已发现该基因在许多染色体上具有多个拷贝，其中一些（如果不是全部）代表不同的假基因。
T60682	Elongation factor P-IN-2
	Elongation factor P-IN-2可影响大肠杆菌的增殖率。Elongation factor P-IN-2 是 β-赖氨酸衍生化合物，是延伸因子 P (EFP)的有效抑制剂。
T60491	Elongation factor P-IN-1
	Elongation factor P-IN-1 是 β-赖氨酸衍生化合物，是延伸因子 P (EFP) 的有效抑制剂，可影响大肠杆菌的增殖率。
T22774	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]	Others	Others
	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed
T16710	Mericitabine R-7128,RG 7128,PSI 6130 diisobutyrate	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Mericitabine (R-7128) 是一种核苷HCV NS5B 聚合酶抑制剂。它充当 RNA 链终止子并防止 RNA 转录物在复制过程中延伸。
TQ0137	A-484954 A 484954	CaMK; Parasite; Autophagy	Autophagy; Microbiology/Virology; Neuroscience
	A-484954 (A 484954) 是一种高度特异性的真核延伸因子-2 抑制剂，其 IC50值为 280 nM。
T21152	Ac-Phe-NH2 Ac-Phe NH2,Ac Phe NH2,乙酰基苯甲酰胺,Ac Phe-NH2	Others	Others
	Ac-Phe-NH2 是一种非竞争性多聚泛素链延长抑制剂，Ki 值为 8 ± 1.2 mM。
T13974	ZL0580	Epigenetic Reader Domain; HIV Protease	Chromatin/Epigenetic; Microbiology/Virology; Proteases/Proteasome
	ZL0580 通过抑制 Tat 反式激活和转录延伸以及通过在 HIV 启动子处诱导抑制性染色质结构来诱导 HIV 抑制。
T60219	ELOVL1-IN-3	Others	Others
	ELOVL1-IN-3 是一种有效且具有口服活性的超长链脂肪酸 1 (ELOVL1) 酶延长抑制剂。ELOVL1-IN-3 是研究肾上腺脑白质营养不良 (ALD) 的有用工具。
T8886	NITD-2	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NITD-2 是一种登革病毒 (DENV) 聚合酶抑制剂，可抑制 DENV RdRp 介导的 RNA 延伸。
T72076	H2-Gamendazole	HSP	Cytoskeletal Signaling; Metabolism
	H2-Gamendazole 是一种抑制精子发生和癌症治疗的新型化合物，可作为热休克蛋白和/或延伸因子1 α的抑制剂，是 Hsp90调节剂。
T60619	CDK9-IN-15	CDK	Cell Cycle/Checkpoint
	CDK9-IN-15 是一种有效的小分子CDK9抑制剂，可通过降解、抑制 CDK9 来阻断正性转录延长因子 P-TEFb (positive transcription elongation factor b) 对 RNA Poly-II C末端区域的磷酸化，抑制转录，迅速降低细胞内 mRNA 水平，从而引起肿瘤细胞凋亡。
T23840	BUR1 BMP upregulator-1,1-{1-苯基-1H-吡唑并[3,4-D]嘧啶-4-基}哌啶,BMP upregulator 1,BUR 1,BUR-1	CDK	Cell Cycle/Checkpoint
	BUR1 是一种酿酒酵母细胞周期蛋白依赖性激酶 (CDK)，与在转录延伸中起作用的哺乳动物 Cdk9 同源。
T12006	Metarrestin ML246	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Metarrestin (ML246) 是一种口服有效的选择性核仁周区室 (PNC) 抑制剂，可有效抑制转移。Metarrestin 破坏核仁结构并抑制 RNA 聚合酶 (Pol) I 转录，部分是通过与翻译延伸因子 eEF1A2 的相互作用。
T16868	SEC inhibitor KL-2 KL-2	Others	Others
	SEC inhibitor KL-2 (KL-2) (KL-2) 是一种拟肽先导化合物，有效的选择性 SEC 抑制剂，通过破坏 SEC 支架蛋白 AFF4 和 P-TEFb 之间的相互作用，导致 Pol II 从启动子近端暂停位点的释放受损并且进行性转录延伸的平均速率降低。SEC inhibitor KL-2 剂量依赖性地抑制 AFF4-CCNT1 相互作用，Ki 值为 1.50 μM。
T60627	ELOVL1-IN-2	Others	Others
	ELOVL1-IN-2 是一种被称为极长链脂肪酸 1 (ELOVL1) 酶延长抑制剂的化合物，对 ELOVL1 表现出微弱的抑制作用（IC50 为 21 μM），并在原代细胞中表现出中等效力。对 HEK293 C26 细胞进行测定（IC50 为 6.7 μM）[1]。
T16867	SEC inhibitor KL-1 KL-1	Others	Others
	SEC inhibitor KL-1 (KL-1) 是一种拟肽先导化合物，是一种有效的选择性SEC 抑制剂，能够剂量依赖性地抑制 AFF4-CCNT1 相互作用。它能够破坏 SEC 支架蛋白 AFF4 和 P-TEFb 之间的相互作用，导致 Pol II 从启动子近端暂停位点的释放受损，并且进行性转录延伸的平均速率降低。
T29260	(R)-ß-lysine R ß lysine,MG1655,R-ß-lysine,(R) ß lysine,MG-1655
	(R) - ß - lysine is a functional modifier of elongation factor P (EF-P).
T26001	Pulvomycin Antibiotic 1063Z
	Pulvomycin is a protein biosynthesis inhibitor preventing ternary complex formation between elongation factor Tu, GTP, and aminoacyl-tRNA.
T35356	Gibberellins A4/A7 Gibberellin A4&A7,Gibberellins A4/A7	Others	Others
	Gibberellins A4/A7 (Gibberellin A4 and A7) is the Gibberellin A4 Mixture With Gibberellin A7. Gibberellins A4/A7 promotes internode elongation & breaks certain dormancies in seeds. Gibberellins A4/A7 is an endogenous plant growth regulator, promotes the growth and elongation of cells.
T71263	CBL0100
	CBL0100 is an inhibitor of viral transcriptional elongation, blocking both HIV-1 replication and reactivation.
T27822	LFF 571 LFF571,LFF-571
	LFF 571 is an inhibitor of protein-synthesizing GTPase (Elongation Factor).
T40880	(±)-Jasmonic acid
	(±)-Jasmonic acid, a plant growth regulator and derivative of α-linolenic acid, exhibits chlorophyll-lowering effects in green and etiolated barley leaf segments, while also inhibiting the elongation of rice seedlings.
T10436L	AZD4573 HCl (2057509-72-3 free base) AZD4573 hydrochloride,AZD4573,AZD4573 HCl,AZD-4573,AZD 4573
	AZD-4573 is a selective and short-acting inhibitor of the serine/threonine cyclin-dependent kinase 9, the catalytic subunit of the RNA polymerase II elongation factor positive transcription elongation factor b. It also has a potential antineoplastic activ
T70918	GE-2270 A
	GE-2270 A inhibits bacterial protein synthesis in vitro via the GTP-bound form of elongation factor Tu.
T78637	ddTTP trisodium	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	ddTTP trisodium是一种ddNTPs，用于抑制DNA聚合酶链延长，应用于DNA测序。
T74108	ddTTP
	ddTTP 是一类双脱氧核糖核苷酸 (ddNTPs)，可作为 DNA 聚合酶链延长抑制剂用于 DNA 测序。
T24272	KT5926 KT 5926,KT-5926
	KT5926 is an effective and selective inhibitor of myosin light chain kinase. KT5926 is an analogue of K-252a, which blocks all responses to NGF. KT5926 selectively inhibits nerve growth factor-dependent neurite elongation.
T26973	Cefatrizine Cephatriazine,BL-S-640,BLS640,S 640P,BL S 640
	Cefatrizine is an inhibitor of eukaryotic elongation factor-2 kinase, a unique calcium/calmodulin-dependent protein kinase, is well known to regulate apoptosis, autophagy and ER stress in many types of human cancers.
T38353	Pyrenocine A
	Pyrenocine A is a fungal metabolite that has been found inP. terrestrisand has diverse biological activities.1It inhibits the asexual spore germination of the plant pathogenic fungiF. oxysporum,F. solani,M. hiemalis, andR. stolonifer(EC50s = 14, 20, 20, and 25 μg/ml, respectively). Pyrenocine A is active againstB. subtilis,S. aureus, andE. coli(IC50s = 30, 45, and 200 μg/ml, respectively). It inhibits onion seedling elongation (EC50= 4 μg/ml). Pyrenocine A is also a phytotoxin that inhibits lett...
T24330	L 681217 L-681,217,L-681217,L681,217,L 681,217,L681217
	L 681217 is a glycolipid-type antibiotic related to the efrotomycin class. L-681217 inhibits bacterial protein synthesis at the elongation stage. L 681217 shows broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria.
T71815	TX-1918
	TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K). TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells.
T74115	Decanoyl coenzyme A
	Decanoyl coenzyme A (Decanoyl CoA) 是 Mycobacterium smegmat 中脂肪酸延伸系统的引物。
T27128	DCB-3503 NSC716802,NSC 716802,NSC-716802,DCB3503,DCB 3503
	Tylophorine analog DCB-3503 is a potential anticancer and immunosuppressive agent. DCB-3503 suppresses the translation of cellular regulatory proteins, including cyclin D1, at the elongation step. DCB-3503 allosterically regulates the ATPase and chaperone activities of HSC70 by promoting ATP hydrolysis in the presence of specific RNA binding motifs (AUUUA) of cyclin D1 mRNA.
T36600	Cefsulodin (sodium salt hydrate)
	Cefsulodin is a β-lactam antibiotic that lyses actively-growingE. coliby binding specifically to the intermembrane proteins, penicillin-binding proteins 1a and b, whose transglycosylase and transpeptidase activities are involved in cell elongation and septation.1Cefsulodin has been used in combination with other β-lactam antibiotics, such as cefazolin as a strategy to circumvent drug resistance.2
T83836	3'-O-Methylguanosine-5'-O-triphosphate sodium 3'-O-methyl GTP
	3'-O-Methylguanosine-5'-O-triphosphate（3'-O-methyl GTP）是GTP的甲基化衍生物，用作早期RNA聚合酶II延伸中间体制备中的链终止试剂。
T11534L	Haemanthamine hydrochloride (466-75-1 free base) Haemanthamine hydrochloride	Others	Others
	Haemanthamine hydrochloride is an alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. It inhibits protein biosynthesis during the elongation stage of translation. It has antimalarial, pro-apoptotic, antiviral, antioxidant, an
T37677	3-hydroxy Docosanoic Acid
	3-hydroxy Docosanoic acid is a hydroxylated form of the 22-carbon saturated docosanoic acid . It is found in lipopolysaccharides from C. trachomatis and C. psittaci and in S. synnaedendra. 3-hydroxy Docosanoic acid, in the form of an acyl-CoA metabolite, is an intermediate in fatty acid chain elongation from arachidic acid to docosanoic acid (C22:0).
T36214	16,16-dimethyl Prostaglandin E1 16,16-dimethyl Prostaglandin E1
	16,16-dimethyl Prostaglandin E1 是 PGE1 (T1626) 类似物，可诱导支气管收缩和血管平滑肌收缩，并抑制吲哚美辛诱导的细胞伸长。
TP2247	eukaryotic translation initiation factor 3	Others	Others
	Eukaryotic initiation factors (eIF) are proteins involved in the initiation phase of eukaryotic translation. Eukaryotic translation initiation factor 3 binds to the ribosome subunit-mRNA complex. It has been implicated in preventing the large ribosomal subunit from binding the small subunit before it is ready to commence elongation.
T60709	Acyclovir monophosphate
	Acyclovir monophosphate 是抗单纯疱疹病毒 (HSV)剂，并且具有抗肿瘤活性。Acyclovir monophosphate 通过抑制病毒 DNA 聚合酶从而阻断 DNA 合成，同时能终止病毒 DNA 的链延伸。
T28266	Org-6906 Org6906,Org 6906,Org-6906 free
	Tylophorine analog Org-6906 is a potential anticancer and immunosuppressive agent. Org-6906 suppresses the translation of cellular regulatory proteins, including cyclin D1, at the elongation step. Org-6906 allosterically regulates the ATPase and chaperone activities of HSC70 by promoting ATP hydrolysis in the presence of specific RNA binding motifs (AUUUA) of cyclin D1 mRNA.
T36045	1a,1b-dihomo Prostaglandin E2 1a,1b-dihomo Prostaglandin E2
	1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid . 1a,1b-dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid . This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.
T12135	Mycophenolic acid-d3 Mycophenolate-d3,Mycophenolate D3	Others; Antibacterial	Microbiology/Virology; Others
	Mycophenolic acid-d3 (Mycophenolate-d3) 是 Mycophenolic acid 的衍生物。Mycophenolic acid 是一种降低GTP 水平和损害RNA 聚合酶II (RNAP II)转录延伸的化合物，促进了近端位点的使用，能够逆转虫草素对选择性聚腺苷化的作用。
T37678	3-hydroxy Lignoceric Acid
	3-hydroxy Lignoceric acid is a hydroxylated form of the 24-carbon saturated lignoceric acid . 3-hydroxy Lignoceric acid is found in minor amounts in Methyloligella, a novel Gram-negative bacteria. 3-hydroxy Lignoceric acid, in the form of an acyl-CoA metabolite, is an intermediate in fatty acid chain elongation from docosanoic acid to lignoceric acid (C24:0).
T75419	alpha-2,8-Sialyltransferase (CstII)
	alpha-2,8-Sialyltransferase (CstII) (ST8Sia VI)，属于alpha2,8-sialyltransferase (ST8Sia) 家族，广泛应用于生化研究中。该酶负责催化Sia残基通过α2,8键连接形成的寡聚/聚唾液酸链的延伸。
T62417	MELK-8a
	MELK-8a (NVS-MELK8a) 是一种高效的、选择性的母体胚胎亮氨酸拉链激酶 (MELK) 抑制剂 (IC50: 2 nM)。MELK-8a 也能够抑制 Flt3 (ITD) (IC50: 0.18 μM)、Haspin (IC50: 0.19 μM)、PDGFRα (IC50: 0.42 μM)。其中 MELK 在调节癌细胞的细胞有丝分裂中具有重要作用。
T38151	Germicidin A
	Germicidin A is a pyranone originally derived from S. viridochromogenes that acts as a reversible, autoregulative inhibitor of spore germination and hyphal elongation in the genus Streptomyces at concentrations as low as 200 pM. During germination, spores of Streptomyces excrete germicidin A along with other germicidin homologs, which inhibit germination of its own arthrospores. At higher concentrations, germicidin A can inhibit the porcine Na+/K+-activated ATPase (ID50 = 100 μM) and prevent the...
T79579	ddUTP 2′,3′-Dideoxyuridine-5′-triphosphate	Reverse Transcriptase	Microbiology/Virology
	ddUTP (2′,3′-Dideoxyuridine-5′-triphosphate) 作为HIV与AMV逆转录酶的选择性抑制剂，其Ki为0.05 µM及1 µM。ddUTP在dTTP位点掺入生长中的DNA链，从而抑制其进一步的链延伸。
T78138	SIC5-6	Others	Others
	SIC5-6为一强效Separase抑制剂，此酶为大型半胱氨酸蛋白酶，关键参与有丝分裂与减数分裂中染色体分离，DNA损伤修复，中心体分离与复制，以及纺锤体稳定与伸长。Separase在众多实体瘤高表达，成为潜在的化疗靶标。

化合物

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]（TFA)

Cat.No: T22774L

Target: Others

Elongation factor P-IN-2

Cat.No: T60682

Elongation factor P-IN-1

Cat.No: T60491

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]

Cat.No: T22774

Target: Others

Cat.No: T16710

Synonym: R-7128,RG 7128,PSI 6130 diisobutyrate

Target: HCV Protease

Cat.No: TQ0137

Synonym: A 484954

Target: CaMK, Parasite, Autophagy

Cat.No: T21152

Synonym: Ac-Phe NH2,Ac Phe NH2,乙酰基苯甲酰胺,Ac Phe-NH2

Target: Others

Cat.No: T13974

Target: Epigenetic Reader Domain, HIV Protease

Cat.No: T60219

Target: Others

Cat.No: T8886

Target: DNA/RNA Synthesis

Cat.No: T72076

Target: HSP

Cat.No: T60619

Target: CDK

Cat.No: T23840

Synonym: BMP upregulator-1,1-{1-苯基-1H-吡唑并[3,4-D]嘧啶-4-基}哌啶,BMP upregulator 1,BUR 1,BUR-1

Target: CDK

Cat.No: T12006

Synonym: ML246

Target: DNA/RNA Synthesis

SEC inhibitor KL-2

Cat.No: T16868

Synonym: KL-2

Target: Others

Cat.No: T60627

Target: Others

SEC inhibitor KL-1

Cat.No: T16867

Synonym: KL-1

Target: Others

Cat.No: T29260

Synonym: R ß lysine,MG1655,R-ß-lysine,(R) ß lysine,MG-1655

Cat.No: T26001

Synonym: Antibiotic 1063Z

Gibberellins A4/A7

Cat.No: T35356

Synonym: Gibberellin A4&A7,Gibberellins A4/A7

Target: Others

Cat.No: T71263

Cat.No: T27822

Synonym: LFF571,LFF-571

(±)-Jasmonic acid

Cat.No: T40880

AZD4573 HCl (2057509-72-3 free base)

Cat.No: T10436L

Synonym: AZD4573 hydrochloride,AZD4573,AZD4573 HCl,AZD-4573,AZD 4573

Cat.No: T70918

ddTTP trisodium

Cat.No: T78637

Target: DNA/RNA Synthesis

Cat.No: T74108

Cat.No: T24272

Synonym: KT 5926,KT-5926

Cat.No: T26973

Synonym: Cephatriazine,BL-S-640,BLS640,S 640P,BL S 640

Cat.No: T38353

Cat.No: T24330

Synonym: L-681,217,L-681217,L681,217,L 681,217,L681217

Cat.No: T71815

Decanoyl coenzyme A

Cat.No: T74115

Cat.No: T27128

Synonym: NSC716802,NSC 716802,NSC-716802,DCB3503,DCB 3503

Cefsulodin (sodium salt hydrate)

Cat.No: T36600

3'-O-Methylguanosine-5'-O-triphosphate sodium

Cat.No: T83836

Synonym: 3'-O-methyl GTP

Haemanthamine hydrochloride (466-75-1 free base)

Cat.No: T11534L

Synonym: Haemanthamine hydrochloride

Target: Others

3-hydroxy Docosanoic Acid

Cat.No: T37677

16,16-dimethyl Prostaglandin E1

Cat.No: T36214

Synonym: 16,16-dimethyl Prostaglandin E1

eukaryotic translation initiation factor 3

Cat.No: TP2247

Target: Others

Acyclovir monophosphate

Cat.No: T60709

Cat.No: T28266

Synonym: Org6906,Org 6906,Org-6906 free

1a,1b-dihomo Prostaglandin E2

Cat.No: T36045

Synonym: 1a,1b-dihomo Prostaglandin E2

Mycophenolic acid-d3

Cat.No: T12135

Synonym: Mycophenolate-d3,Mycophenolate D3

Target: Others, Antibacterial

3-hydroxy Lignoceric Acid

Cat.No: T37678

alpha-2,8-Sialyltransferase (CstII)

Cat.No: T75419

Cat.No: T62417

Cat.No: T38151

Cat.No: T79579

Synonym: 2′,3′-Dideoxyuridine-5′-triphosphate

Target: Reverse Transcriptase

Cat.No: T78138

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1160	Fusidic acid Fusidine,夫西地酸	Others; CAT; Antibacterial; Antibiotic	Microbiology/Virology; Others; oxidation-reduction
	Fusidic acid (Fusidine) 是一种从 Fusidium coccineum 发酵液中分离出来的甾体类抗生素。它通过阻止核糖体释放翻译延长因子 G 来抑制细菌的生长。
T1289	Fusidic acid sodium salt Sodium fusidate,夫西地酸钠,Fusidate Sodium,Fucidin,SQ-16360	Others; CAT; Antibacterial; Antibiotic	Microbiology/Virology; Others; oxidation-reduction
	Fusidic acid sodium salt (SQ-16360) 是一种Fusidium coccineum 属甾体类抑菌抗生素。它阻止核糖体释放翻译延长因子G 来抑制细菌生长。
T3151	Brassinolide Brassin lactone,24-Epibrassinolide,芸苔素内酯	Apoptosis; Others	Apoptosis; Others
	Brassinolide (Brassin lactone) 是一种植物生长调节剂，可调节植物细胞伸长。
T21430	Oxytetracycline Hydrochloride Biosolvomycin,盐酸土霉素,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin	Antiviral; Endogenous Metabolite; Antibacterial; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology
	Oxytetracycline Hydrochloride (Dalimycin) 是由 Streptomyces rimosus 生产的，一种具有抗菌活性的四环素衍生物。它干扰氨酰-tRNA 与 mRNA-核糖体复合物的结合，从而阻止肽延伸并抑制蛋白质合成。
T7132	(Rac)-Brassinazole BRASSINAZOLE,3-(4-氯苯基)-1-甲基-1-苯基-2-(1,2,4-三唑-1-基)-1-丙醇,(Rac)-芸苔素唑	P450	Metabolism
	(Rac)-Brassinazole 是三唑型化合物，是油菜素甾醇 (BR) 生物合成抑制剂。它能够增强 CYP90B 在 BR 生物合成中的抑制作用。
T6512	G-418 disulfate Geneticin,G418 Sulfate,Antibiotic G-418 sulfate,遗传霉素,Geneticin sulfate	Antibacterial; Antibiotic	Microbiology/Virology
	G-418 disulfate (Geneticin sulfate) 属于氨基糖苷类抗生素，是一种蛋白质合成的抑制剂，具有真核细胞选择性。G-418 disulfate 通过抑制肽链的延伸来阻断多肽合成。
T9715	Aplidine	SARS-CoV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Aplidine 是有效的eEF1A2(KD=80 nM) 靶向的抗癌药物。Aplidine 具有抗病毒活性，抑制SARS-CoV-2的 IC90为 0.88 nM。Aplidine 在多发性骨髓瘤，晚期癌症及 COVID-19 领域有研究的价值。
T3380	Homoharringtonine Myelostat,Ceflatonin,高三尖杉酯碱,HHT,Omacetaxine mepesuccinate	STAT	JAK/STAT signaling; Stem Cells
	Homoharringtonine (HHT) 属于生物碱类天然产物，可以抑制蛋白质的翻译，具有细胞毒性。Homoharringtonine 作用于肿瘤细胞的核糖体，抑制蛋白质翻译的延伸步骤，从而抑制蛋白质合成，具有抗肿瘤活性。
T20945	2,4-D Hedonal,Macondray,2,4-D acid,Chloroxone,2,4-二氯苯氧乙酸	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	2,4-Dichlorophenoxyacetic acid (Hedonal) 是一种合成生长素，用作植物生长调节剂，也用作植物细胞培养基中的补充剂。它是除草剂中的一种活性成分，用于破坏肌动蛋白细胞骨架，以控制根系伸长和细胞生成。
T5088	3-Indoleacetic acid sodium Indole-3-Acetic Acid sodium salt,Sodium 2-(1H-indol-3-yl)acetate,IAA sodium salt,吲哚乙酸钠,Heteroauxin sodium salt	Others; Endogenous Metabolite	Metabolism; Others
	3-Indoleacetic acid sodium (Heteroauxin sodium salt) 是一种天然存在的植物生长素类激素。能刺激细胞伸长和分裂，促进植物生长发育。然而，高浓度时，它表现出生长抑制作用，包括生长和阻止茎和根的生长。后一种效应形成了合成生长素被开发为农业除草剂和生物调节剂的基础。
TN3861	Dihydropinosylvin 山药	Anti-infection	Microbiology/Virology
	Dihydropinosylvin 是一种植物抗毒素，对枝孢枝孢菌、Botryodiplodia theobromae、黑曲霉和石化青霉具有抗真菌活性，对蜡状芽孢杆菌、金黄色葡萄球菌、铜绿假单胞菌和大肠杆菌也有很强的抗菌活性。双色高粱幼苗的种子和根伸长。
TMM2618	Gibberllin A7 Gibberellin A7,Gibberllin 7,赤霉素GA7	Others	Others
	Gibberllin A7 (Gibberllin 7) 是重要的植物生长激素，可促进植物细胞生长和伸长。它可促进茎和根的快速生长，诱导有丝分裂并启动（打破休眠）并提高种子发芽率。它还参与诸如作为向地力、张力和花卉展示。Gibberellin A3(G1025, G7645) 和 A4 (G7276) 可用作植物生长培养基如 Murashige 和 Skoog 培养基的补充剂。 A3 和 A4 或 Gebberellins 组合的具体作用应在具体的植物应用中确定。
TN4509	Medicarpin 3-O-glucoside	Others	Others
	Medicarpin-3-O-glucoside, a phytoalexin, inhibits the germination of G. intraradices spores and hyphal elongation.
T82629	Cytochalasin K
	Cytochalasin K (化合物7) 是一种IC50为22.58 μM的细胞松弛素，能抑制小麦根系伸长。
T11534	Haemanthamine	Others	Others
	Haemanthamine is an alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. It inhibits protein biosynthesis during the elongation stage of translation. It has antimalarial, pro-apoptotic, antiviral, antioxidant, and anticonvulsa
TN4570	Minumicrolin	Others	Others
	Minumicrolin is a plant growth inhibitor against the 2nd leaf sheath elongation of rice seedlings. Murrangatin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100, it might be valuable anti-tumor-promoting agents. Minumicrolin shows mild butyrylcholinesterase inhibition activity.
T38275	Kirromycin
	Kirromycin is an antibiotic originally isolated from Streptomyces and an inhibitor of protein biosynthesis. It inhibits isoleucine incorporation, polyphenylalanine synthesis, and growth of B. brevis. Kirromycin inhibits elongation factor Tu-dependent peptidyl transfer activity in E. coli.
T15703	Lactimidomycin	Others	Others
	Lactimidomycin, isolated from Streptomyces, is an inhibitor of eukaryotic translation elongation. It is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Lactimidomycin has an antiproliferative effect on tumor cell lines. It i
TN4623	Nagilactone C	Antifection	Microbiology/Virology
	Nagilactone C and phyllanthoside are novel protein synthesis inhibitors, they are specific for the eukaryotic translation apparatus, function in vivo and in vitro, and interfere with translation elongation. Nagilactone C shows high insecticidal activity against second-instar nymphs of Eocanthecona furcellata. Nagilactone C possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 microg/ml, respectivel...
T83466	10-Phenyl-[12]-cytochalasins Z16
	10-Phenyl-[12]-cytochalasins Z16 (Compounds 5)为一种细胞松弛素，对小麦根系伸长具有抑制作用，其IC50值为17.35 μM。
T80346	Tur1A
	Tur1A，宽吻海豚源抗菌肽，通过结合核糖体并阻断蛋白质合成从起始阶段至延伸阶段的转变，抑制细菌蛋白质合成。
T15039	Cytochalasin E	Others	Others
	Cytochalasin E is a potent actin depolymerization agent and an epoxide containing Aspergillus-derived fungal metabolite. Cytochalasin E also inhibits angiogenesis and tumor growth. It binds and caps the barbed end of actin filaments to prevent actin elong
T73813	Haemanthamine hydrochloride
	Haemanthamine hydrochloride 是从Amaryllidaceae 植物中分离出来的一种蛇毒碱样生物碱，具有强大的抗癌活性。Haemanthamine hydrochloride 靶向核糖体以在翻译的延长阶段抑制蛋白质的生物合成。Haemanthamine hydrochloride 具有促凋亡，抗氧化剂，抗病毒，抗疟疾和抗惊厥活性。
T36992	Monocerin
	Monocerin is a fungal metabolite that has been found inF. larvarumand has diverse biological activities.1,2,3It is active against the bacteriaE. coliandB. megaterium, the phytopathogenic fungusM. violaceum, and the algaC. fuscain an agar diffusion assay when used at a concentration of 50 μg/disc.1Monocerin (17.5 μg/ml) induces mortality in adultC. erythrocephala.2It reduces root elongation in pre-germinatedS. halepenseseeds when used at a concentration of 33 ppm.3 1.Zhang, W., Krohn, K., Draeger...
T83693	Magainin 2 TFA MG2
	Magainin 2是一种从非洲爪蟾（X. laevis）皮肤中分离出的阳离子肽，具有宿主防御和抗菌活性。该化合物对细菌E. coli、K. pneumoniae、S. epidermidis、S. aureus及真菌C. albicans表现出活性（MICs分别为5、10、10、50和80 µg/ml）。Magainin 2（20 µM）能降低猕猴桃花粉的萌发率和平均管长。在被单纯疱疹病毒1型（HSV-1）或2型（HSV-2）感染的Vero细胞中，它可减少病毒复制（EC50s分别为22.16和19.8 µM），同时不影响细胞活性，其50%细胞毒性浓度值（CC50）大于100 µM。

天然产物

Cat.No: T1160

Synonym: Fusidine,夫西地酸

Target: Others, CAT, Antibacterial, Antibiotic

Fusidic acid sodium salt

Cat.No: T1289

Synonym: Sodium fusidate,夫西地酸钠,Fusidate Sodium,Fucidin,SQ-16360

Target: Others, CAT, Antibacterial, Antibiotic

Cat.No: T3151

Synonym: Brassin lactone,24-Epibrassinolide,芸苔素内酯

Target: Apoptosis, Others

Oxytetracycline Hydrochloride

Cat.No: T21430

Synonym: Biosolvomycin,盐酸土霉素,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin

Target: Antiviral, Endogenous Metabolite, Antibacterial, HSV

(Rac)-Brassinazole

Cat.No: T7132

Synonym: BRASSINAZOLE,3-(4-氯苯基)-1-甲基-1-苯基-2-(1,2,4-三唑-1-基)-1-丙醇,(Rac)-芸苔素唑

Target: P450

G-418 disulfate

Cat.No: T6512

Synonym: Geneticin,G418 Sulfate,Antibiotic G-418 sulfate,遗传霉素,Geneticin sulfate

Target: Antibacterial, Antibiotic

Cat.No: T9715

Target: SARS-CoV, DNA/RNA Synthesis

Homoharringtonine

Cat.No: T3380

Synonym: Myelostat,Ceflatonin,高三尖杉酯碱,HHT,Omacetaxine mepesuccinate

Target: STAT

Cat.No: T20945

Synonym: Hedonal,Macondray,2,4-D acid,Chloroxone,2,4-二氯苯氧乙酸

Target: DNA/RNA Synthesis

3-Indoleacetic acid sodium

Cat.No: T5088

Synonym: Indole-3-Acetic Acid sodium salt,Sodium 2-(1H-indol-3-yl)acetate,IAA sodium salt,吲哚乙酸钠,Heteroauxin sodium salt

Target: Others, Endogenous Metabolite

Dihydropinosylvin

Cat.No: TN3861

Synonym: 山药

Target: Anti-infection

Cat.No: TMM2618

Synonym: Gibberellin A7,Gibberllin 7,赤霉素GA7

Target: Others

Medicarpin 3-O-glucoside

Cat.No: TN4509

Target: Others

Cat.No: T82629

Cat.No: T11534

Target: Others

Cat.No: TN4570

Target: Others

Cat.No: T38275

Cat.No: T15703

Target: Others

Cat.No: TN4623

Target: Antifection

10-Phenyl-[12]-cytochalasins Z16

Cat.No: T83466

Cat.No: T80346

Cat.No: T15039

Target: Others

Haemanthamine hydrochloride

Cat.No: T73813

Cat.No: T36992

Cat.No: T83693

Synonym: MG2

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