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35

抑制剂 & 化合物

20

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13667L1	Dusquetide aceate Dusquetide aceate (931395-42-5 Free base)	Antibacterial	Microbiology/Virology
	Dusquetide aceate 是一种针对损伤相关分子模式和病原体相关分子模式的先天免疫防御调节剂。 Dusquetide aceate 具有抗炎和抗菌活性。
T27064	CP-312 CP312,Cardioprotectant 312	Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	CP-312 (Cardioprotectant 312)是一种抗氧化防御反应激活剂，它通过诱导血红素加氧酶-1发挥作用，通过诱导 HMOX1 表达来靶向抗氧化反应网络，从而保护 hiPSC-CM 的活力。CP-312 保护人 iPSC 衍生的心肌细胞免受氧化应激。
T124384	Jasmonic acid (-)-Jasmonic acid
	Jasmonic acid (JA) 是一种植物激素，也是植物生长调节剂，参与植物迫防御和生长发育。Jasmonic acid 在信号传导过程中起着很重要的作用，诱导 MAP 激酶级联通路和钙通道发挥作用。
T1435	Praziquantel 吡喹酮,Pyquiton,Droncit,Biltricide	Calcium Channel; Antibiotic; Parasite	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Praziquantel (Droncit) 是一种外消旋混合物，由 (R)-Praziquantel 和 (S)-Praziquantel 组成。它可研究血吸虫病。
T60522	Letosteine Viscotiol	Others	Others
	Letosteine (Viscotiol) 是具有口服活性、有效且安全的祛痰剂，可用于研究急性或慢性呼吸道疾病，如支气管肺炎。Letosteine 能够溶解支气管粘液并减轻呼吸道炎症症状，从而实现恢复肺部气体交换和自然防御机制。
T1562	Rebamipide Proamipide,OPC12759,瑞巴派特	Free radical scavengers; COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience; oxidation-reduction
	Rebamipide (OPC12759) 是一种粘膜保护剂，可诱导COX-2表达，增加PGE2水平，并以 COX-2 依赖性方式增强胃粘膜防御。
T0920	Ambroxol 氨溴索,氨溴索碱,Ambroxolum,NA-872	P450; Autophagy	Autophagy; Metabolism
	Ambroxol (NA-872) 是前药溴己辛的活性代谢产物，是一种分泌溶解剂，具有强效祛痰作用，用于治疗与粘液或过多粘液相关的呼吸道疾病。它可诱导肺组织细胞自噬，有用于帕金森氏病和神经性戈谢病的研究潜力。它是一种葡糖脑苷脂酶伴侣，可增加葡糖脑苷脂酶的活性。
T40466	Penta-N-acetylchitopentaose
	Penta-N-acetylchitopentaose, a chemical compound, elicits the activation of plant defense systems. This compound also functions as a substrate for the Rhizobium leguminosarum nodulation protein NodL.
T19801	Acibenzolar-S-methyl Bion, BTH,Bendicar,Acibenzolar S methyl,Acibenzolar S-methyl,Actigard
	Acibenzolar-S-methyl is a fungicide. Acibenzolar-S-methyl works by activating a plant's own defense system by increasing the transcription of W-box controlled genes such as CAD1, NPR1, and PR2.
T13667L	Dusquetide SGX942	Others	Others
	Dusquetide is a first-in-class innate defense regulator. Dusquetide displays activity in both reducing inflammation and increasing the clearance of bacterial infection.
T40936	Quinclorac
	Quinclorac, a commonly used agricultural herbicide, elicits oxidative stress by triggering the production of free radicals and altering the antioxidant defense system.
T82025	Isotianil
	Isotianil 是植物防御诱导剂，无直接抗菌效果，主要通过激活植物的典型防御反应来发挥作用。该化合物用于作为植物保护剂，防治稻瘟病。
T40327	Tetra-N-acetylchitotetraose
	Tetra-N-acetylchitotetraose, a component of the hpo-chitoo gosacchaπdes (LCOs) secreted from Rhizobia, stimulates plant defense systems. Moreover, it serves as a substrate for the CO deacetylase nodulation protein NodB in Rhizobium leguminosarum.
T13652	Dicarbine	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Double carbene can be used for the study of schizophrenia and alcoholism. It can block dopamine receptors in various parts of the brain and prevent the reduction of conditioned defense reflexes caused by the stimulation of the mid-brain part of the networ
T25050	Alloferon 3
	Alloferon 3 is a natural peptide that mediates signaling by the NF-kappa B pathway to enhance the recognition of viral and tumor antigens. It is known to induce the production of endogenic interferons that promote a cascade of defense responses and also e
T76181	Human milk lysozyme
	Human milk lysozyme，一种在人乳中发现的溶菌酶，被认为是保护新生儿胃肠道免受细菌感染的关键防御因子。
T80398	Brevinin-1PMa
	Brevinin-1PMa为宿主防御肽，对金黄色葡萄球菌（Staphylococcus aureus）和大肠杆菌（Escherichia coli）展现出抗菌活性，并具溶血活性。
T80473	Citrullinated LL-37 3cit	Influenza Virus	Microbiology/Virology
	Citrullinated LL-37 3cit，一种宿主防御肽(HDP)，展现出广泛的免疫调节和抗菌活性，且能有效抑制人鼻病毒(HRV)。
T76064L	Beta-defensin 103 isoform X1, pig TFA
	Beta-defensin 103 isoform X1, pig TFA 是一种抗菌肽、在多种生物体内被发现，参与了先天性免疫防线。
T76064	Beta-defensin 103 isoform X1, pig
	Beta-defensin 103 isoform X1, pig 是一种抗菌肽、在多种生物体内被发现，参与了先天性免疫防线。
T13667	Dusquetide TFA (931395-42-5 free base) SGX942 TFA,Dusquetide TFA	Others	Others
	Dusquetide TFA is a kind of innate defense regulator (IDR).Dusquetide TFA has been shown to be active in reducing inflammation and increasing clearance of bacterial infections.Dusquetide TFA regulates innate immune responses to PAMPs and DAMPs in combinat
T38352	Ebelactone A
	Ebelactone A is a β-lactone enzyme inhibitor that was first isolated from a cultured strain of soil actinomycetes. It can inhibit esterases, lipases, and N-formylmethionine aminopeptidases (IC50s = 0.056, 0.003, and 0.08 μg/ml, respectively) found on cell surfaces, which has been shown to stimulate host defense in immune cells. Ebelactone A is also reported to inhibit cutinases produced by fungal pathogens, thus demonstrating a plant-protective function.
TP1707	LL-37, acetylated,amidated
	This LL-37 peptide is acetylated on the N-terminus and amidated on the C-terminus.It plays a key role in the first line of defense against local infection and systemic invasion of pathogens at sites of inflammation and wounds.
T80394	Des(8-14)brevinin-1PMa
	Des(8-14)brevinin-1PMa是一种具有抗金黄色葡萄球菌和大肠杆菌活性的宿主防御肽，同时也表现出溶血性。
T78616	Glutathione ethyl ester	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Glutathione ethyl ester 为细胞渗透性的GSH供体，能为卵母细胞提供高效率的谷胱甘肽供给。该化合物通过提升抗氧化防御，对胚胎体外生产具有促进效应。
T76040	Dusquetide TFA
	Dusquetide (SGX942) TFA 是一类天然防御调节因子(IDR)。Dusquetide TFA 通过与 p62 结合调节 PAMPs 和 DAMPs 的天然免疫应答。Dusquetide TFA 在减轻炎症和增加细菌感染清除方面都显示出活性。
TP2190	vitamin D binding protein precrusor (208-218) [Homo sapiens]/[Oryctolagus cuniculus]	Others	Others
	Vitamin D-binding protein is a multifunctional, highly expressed, polymorphic serum protein. These range from the transport of vitamin D metabolites to possible roles in the immune system and host defense. The molecular weight range, the time course of ap
T82793	Caerin 1.1 TFA	Apoptosis	Apoptosis
	Caerin 1.1 TFA 是澳大利亚树蛙Litoria腺体分泌物中分离出的宿主防御肽，具有抑制 HeLa 细胞增殖及介导细胞凋亡 (apoptosis) 的能力，并可能促进适应性 T 细胞免疫反应。
T36542	Prostaglandin A2 Medullin
	PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity.[1] At a 25 uM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase .[2] It has also been shown to act as a vasodilator with natriuretic properties.[3]
T83942	IDR 1002
	IDR 1002是一种先天性防御调节肽。在小鼠的鼻窦炎感染和细菌性急性肺部感染模型中减少细菌负荷和炎症反应。它抑制LPS诱导的NF-κB和COX-2，促进p38、ERK1/2、MSK1和CREB的磷酸化/激活。
T80258	WRW4-OH
	WRW4-OH 是一种抑制 WKYMVm（一种 FPRL1 激动剂）与其受体结合的生物活性肽。FPRL1，作为典型的趋化受体，在外周血液和大脑的吞噬细胞中有表达，其激活过程与宿主的防御机制及神经退行性疾病相关炎症反应紧密相连。
T81491	Pheromonotropin (pseudaletia separata) Pss-PT
	Pheromonotropin (Pseudaletia separata) (Pss-PT)，是粘虫信息素，含有C端五肽FXPRL-酰胺。该化合物隶属于PK/PBAN家族，能够促进飞蛾性信息素的生物合成，并介导其摄食行为（肠道肌肉收缩）、发育过程（胚胎滞育、蛹滞育及蛹化）以及抵御天敌昆虫。
T38124	Piloty's Acid
	Nitric Oxide (NO) is a free radical gas that is involved in a variety of biological processes including regulation vascular tone, neuronal signaling, and host defense. Nitroxyl (HNO) is the one electron reduced form of nitric oxide. Piloty's acid is one of the best known and most widely used HNO donors. Under basic conditions Piloty's acid decomposes to HNO and benzenesulfinate anion. The rate of HNO release at pH 7 is very slow (t = 5,500 minutes) making its use most effective above pH 8.0. Th...
T83679	Parasin I (catfish) TFA
	Parasin I是来自鲶鱼(P. asotus)组蛋白H2A N端区域的一种抗微生物肽片段，参与宿主防御。它通过在受伤P. asotus的皮肤黏膜中的cathepsin D从组蛋白H2A形成。Parasin I对多种革兰氏阳性和阴性细菌以及真菌具有活性（MICs分别为1-2, 1-4, 和1-2 µg/ml）。
T80242	TNO211	MMP	Proteases/Proteasome
	TNO211为具备生物活性的肽，主要研究对象是基质金属蛋白酶（MMP），一类能够降解多种细胞外基质蛋白并调控诸多生物活性分子的肽链内切酶家族。MMP在细胞表面受体裂解、凋亡配体释放及趋化因子/细胞因子失活等过程中起作用，同时与细胞增殖、迁移（粘附/分散）、分化、血管生成、细胞凋亡及宿主防御等生物行为密切相关。TNO211可靶向MMP-2、8、12、13和14，包含MMP特定可裂解的Gly-Leu键，并具有EDANS/DABCYL荧光标记，其荧光检测在监测内皮细胞培养基和患者滑液中的MMP活性方面表现出高灵敏度。吸光度/电磁场测量参数为340/490 nm。

化合物

Dusquetide aceate

Cat.No: T13667L1

Synonym: Dusquetide aceate (931395-42-5 Free base)

Target: Antibacterial

Cat.No: T27064

Synonym: CP312,Cardioprotectant 312

Target: Reactive Oxygen Species, Autophagy

Cat.No: T124384

Synonym: (-)-Jasmonic acid

Cat.No: T1435

Synonym: 吡喹酮,Pyquiton,Droncit,Biltricide

Target: Calcium Channel, Antibiotic, Parasite

Cat.No: T60522

Synonym: Viscotiol

Target: Others

Cat.No: T1562

Synonym: Proamipide,OPC12759,瑞巴派特

Target: Free radical scavengers, COX, Prostaglandin Receptor

Cat.No: T0920

Synonym: 氨溴索,氨溴索碱,Ambroxolum,NA-872

Target: P450, Autophagy

Penta-N-acetylchitopentaose

Cat.No: T40466

Acibenzolar-S-methyl

Cat.No: T19801

Synonym: Bion, BTH,Bendicar,Acibenzolar S methyl,Acibenzolar S-methyl,Actigard

Cat.No: T13667L

Synonym: SGX942

Target: Others

Cat.No: T40936

Cat.No: T82025

Tetra-N-acetylchitotetraose

Cat.No: T40327

Cat.No: T13652

Target: Dopamine Receptor

Cat.No: T25050

Human milk lysozyme

Cat.No: T76181

Cat.No: T80398

Citrullinated LL-37 3cit

Cat.No: T80473

Target: Influenza Virus

Beta-defensin 103 isoform X1, pig TFA

Cat.No: T76064L

Beta-defensin 103 isoform X1, pig

Cat.No: T76064

Dusquetide TFA (931395-42-5 free base)

Cat.No: T13667

Synonym: SGX942 TFA,Dusquetide TFA

Target: Others

Cat.No: T38352

LL-37, acetylated,amidated

Cat.No: TP1707

Des(8-14)brevinin-1PMa

Cat.No: T80394

Glutathione ethyl ester

Cat.No: T78616

Target: Reactive Oxygen Species

Cat.No: T76040

vitamin D binding protein precrusor (208-218) [Homo sapiens]/[Oryctolagus cuniculus]

Cat.No: TP2190

Target: Others

Cat.No: T82793

Target: Apoptosis

Prostaglandin A2

Cat.No: T36542

Synonym: Medullin

Cat.No: T83942

Cat.No: T80258

Pheromonotropin (pseudaletia separata)

Cat.No: T81491

Synonym: Pss-PT

Cat.No: T38124

Parasin I (catfish) TFA

Cat.No: T83679

Cat.No: T80242

Target: MMP

Cat. No.	Product Name	Target	Signaling Pathways
TQ0211	Brusatol (+)-Brusatol,鸦胆子苦醇,NSC 172924	Others; Ferroptosis; Nrf2	Apoptosis; Immunology/Inflammation; Others
	Brusatol (NSC-172924) 是一种从鸦胆子植物中分离出来的天然产物，抑制Nrf2通路，可使多种癌细胞对 Cisplatin 和其他化疗药物敏感。它可开发为辅助化疗化合物，可增加细胞凋亡。
TN2216	Alpha-Solamarine Solamarine,奥洲边茄碱,澳洲茄边碱
	Alpha-Solamarine (Solamarine) 是从 Solanum nigrum 中分离得到的一种糖苷生物碱。Alpha-Solamarine 对 Globodera pallid 具有抑制作用，可能用于植物防御。
TN7040	Taxifolin 7-O-β-D-glucoside 花旗松素7-O-葡萄糖苷,Taxifolin 7-Glucoside	Others	Others
	Taxifolin 7-O-β-D-glucoside 是一种 Scutellaria baicalensis 种子萌发阶段的主要代谢产物。它是一种主要存在于胚乳中的类黄酮，能够防御病原体和紫外线损伤。
T34295	Resiniferatoxin RTX,[3H]resiniferatoxin,树脂毒素	IL Receptor	Immunology/Inflammation
	Resiniferatoxin ([3H]resiniferatoxin) 抑制 Th1 细胞因子的产生，有助于防御 T.spiralis 感染，并可用于免疫反应调节剂的研究。
T8076	cis-Jasmone 茉莉酮,Jasmone,顺式茉莉酮	Others	Others
	cis-Jasmone 是一种来源于植物中的天然产物。它由许多花组成型释放，有时通过叶子作为传粉者的引诱剂或作为昆虫花食草动物宿主定位的化学提示。它处理作物可以诱导对食草动物的直接防御，并能够释放吸收天敌的挥发性化合物来诱导间接防御。
T2S2264	Linalool Linalol,(±)-Linalool,Phantol,沉香醇	Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物，是竞争性NMDA 受体拮抗剂，具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤，具有镇痛、抗菌和抗炎的特性。
T5076	L-Allothreonine L-别苏氨酸,L-allo-Threonine	Others; Endogenous Metabolite	Metabolism; Others
	L-Allothreonine (L-allo-Threonine) 是内源性代谢产物的一种。
T6S0525	Farrerol	ERK; p38 MAPK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Farrerol 是一种杜鹃花的生物活性成分，具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。
T6S1572	Sauchinone	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS，TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。
T39179	β-Tomatine
	β-Tomatine, a derivative of α-tomatine, is a fungitoxic compound that efficiently inhibits plant defense responses.
T31102	Cryptopine NSC32984,Kryptocavin,Cryptocavine,Kryptopine,Cryptopin
	Cryptopine in vivo disturbs the cellular defense system, so that it tips in the direction of autoxidative lipid peroxidation, producing cytotoxicity.
T76129	Hemocyanin
	Hemocyanin是一种含铜的大分子呼吸蛋白，扮演着重要的非特异性先天免疫防御分子角色，具备酚氧化酶、抗病毒、抗菌、溶血及抗肿瘤活性。
T36560	(±)9-HpODE
	(±)9-HpODE is a racemic mixture of the fatty acid hydroperoxide product (9(S)-HpODE) formed from lipoxygenase action on linoleic acid. It shows antimicrobial activity against various fungal and bacterial pathogens and thus may play a role in plant defense. In mammalian species, monocyte-induced oxidization of LDL generates significant amounts of esterified 9-HpODE, which is rapidly reduced to 9-HODE.
T83319	4-epi-Withaferin A
	4-epi-Withaferin A（化合物28）是Withaferin A的一个类似物，它增强了细胞毒性及细胞保护性热休克诱导活性（HSA）。此外，4-epi-Withaferin A还展现了通过激活细胞防御机制来研究蛋白质聚集相关疾病的潜力。
T75632	Ganoderic acid T1
	Ganoderic acid T1是Ganoderic acid T的去乙酰化衍生物，具有促进癌细胞凋亡(apoptosis)的功能。它通过降低线粒体膜电位以及激活caspase-9和caspase-3来引发细胞凋亡，并增加细胞内ROS的产生，从而表现出促氧化活性和细胞性毒作用，同时减弱抗氧化防御系统。
TN5942	Dammarenediol II 达玛烯二醇II,Dammar-24-ene-3,20-diol
	Dammarenediol II may have the ability to prevent diabetic microvascular complications, including diabetic retinopathy, it can inhibit vascular endothelial growth factor (VEGF)-induced intracellular reactive oxygen species generation and stress fiber forma
T32326	Juvabione
	Juvabione is the methyl ester of todomatuic acid, both of which are sesquiterpenes (C15) found in the wood of true firs of the genus Abies. They exist as part of a mixture of sesquiterpenes based on the bisabolane scaffold. Sesquiterpenes of this family,
T83693	Magainin 2 TFA MG2
	Magainin 2是一种从非洲爪蟾（X. laevis）皮肤中分离出的阳离子肽，具有宿主防御和抗菌活性。该化合物对细菌E. coli、K. pneumoniae、S. epidermidis、S. aureus及真菌C. albicans表现出活性（MICs分别为5、10、10、50和80 µg/ml）。Magainin 2（20 µM）能降低猕猴桃花粉的萌发率和平均管长。在被单纯疱疹病毒1型（HSV-1）或2型（HSV-2）感染的Vero细胞中，它可减少病毒复制（EC50s分别为22.16和19.8 µM），同时不影响细胞活性，其50%细胞毒性浓度值（CC50）大于100 µM。
T38036	Lumisterol
	Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol. Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities[1]. [1]. Anyamanee Chaiprasongsuk, et al. Protective Effects of Novel Derivatives of Vitamin D 3 and Lumisterol Against UVB-induced Damage in Human Keratinocytes Involve Activation of Nrf2 and p53 Defense Mechanisms. Redox Biol. 2019 Jun;24:101206.
T36563	(E)-Guggulsterone
	Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy...

天然产物

Cat.No: TQ0211

Synonym: (+)-Brusatol,鸦胆子苦醇,NSC 172924

Target: Others, Ferroptosis, Nrf2

Alpha-Solamarine

Cat.No: TN2216

Synonym: Solamarine,奥洲边茄碱,澳洲茄边碱

Taxifolin 7-O-β-D-glucoside

Cat.No: TN7040

Synonym: 花旗松素7-O-葡萄糖苷,Taxifolin 7-Glucoside

Target: Others

Resiniferatoxin

Cat.No: T34295

Synonym: RTX,[3H]resiniferatoxin,树脂毒素

Target: IL Receptor

Cat.No: T8076

Synonym: 茉莉酮,Jasmone,顺式茉莉酮

Target: Others

Cat.No: T2S2264

Synonym: Linalol,(±)-Linalool,Phantol,沉香醇

Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR

L-Allothreonine

Cat.No: T5076

Synonym: L-别苏氨酸,L-allo-Threonine

Target: Others, Endogenous Metabolite

Cat.No: T6S0525

Target: ERK, p38 MAPK, Akt

Cat.No: T6S1572

Target: ERK, p38 MAPK, NF-κB

Cat.No: T39179

Cat.No: T31102

Synonym: NSC32984,Kryptocavin,Cryptocavine,Kryptopine,Cryptopin

Cat.No: T76129

Cat.No: T36560

4-epi-Withaferin A

Cat.No: T83319

Ganoderic acid T1

Cat.No: T75632

Dammarenediol II

Cat.No: TN5942

Synonym: 达玛烯二醇II,Dammar-24-ene-3,20-diol

Cat.No: T32326

Cat.No: T83693

Synonym: MG2

Cat.No: T38036

(E)-Guggulsterone

Cat.No: T36563

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