91
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13858 |
RA190
|
Proteasome | Proteases/Proteasome; Ubiquitination |
RA190 能够与泛素受体 RPN13 的半胱氨酸 88 共价结合,并抑制蛋白酶体功能。 | |||
T18889 |
5-Aminofluorescein
5-氨基荧光素,5-AF |
Others | Others |
5-Aminofluorescein (5-AF) (5-AF) is a covalently-bound fluorescence marker conjugated with human serum albumin. It exhibits an excitation wavelength of 490 nm and an emission wavelength of 515 nm. | |||
T19947 |
EDC hydrochloride
EDC-HCl Crosslinker,1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride |
Others | Others |
EDC hydrochloride (EDC-HCl Crosslinker) 是一种零长度交联剂。 EDC hydrochloride 非常适合将蛋白质或肽共价结合到含羧基的珠子、树脂或其他纳米颗粒上。 | |||
T16732 |
Reproxalap
NS-2,ADX-102 |
Others | Others |
Reproxalap (NS-2) 是一种活性醛类隔离剂,可用于干眼症的研究。它能够与醛 (包括丙二醛和 4-羟基壬醛) 共价结合。 | |||
T7541 |
PTP inhibitor 1
PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮 |
Phosphatase | Metabolism |
PTP inhibitor 1 是蛋白酪氨酸磷酸酶 (PTP) 抑制剂,具有抗血管生成作用。 | |||
T13586L |
BPK-29 hydrochloride
|
Others | Others |
BPK-29 hydrochloride 是特殊配体,能够共价修饰 C274 ,破坏非典型孤核受体NR0B1与RBM45、SNW1蛋白质的相互作用。它能够损害KEAP1突变癌细胞的锚定独立生长。 | |||
T38960 |
QL-X-138
|
Virus Protease; MNK; BTK | Angiogenesis; MAPK; Microbiology/Virology; Tyrosine Kinase/Adaptors |
QL-X-138 是一种强效的选择性 BTK和 MNK 双激酶抑制剂,与 BTK 具有共价结合,与 MNK 具有非共价结合。QL-X-138 对 BTK、MNK1 和 MNK2 激酶的 IC 50 s 分别为 9.4 nM、107.4 nM 和 26 nM。QL-X-138 对登革病毒 2 具有抑制作用,其 IC 50 为 3.5 μM。QL-X-138 可用于 B 细胞恶性肿瘤的研究。 | |||
T10460 |
Batabulin
巴他布林,T138067 |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Batabulin (T138067) 是一种抗肿瘤剂,可与 β-微管蛋白同种型的子集共价且选择性地结合,从而破坏微管聚合。它影响细胞形态并导致细胞周期停滞,最终诱导细胞凋亡。 | |||
T77762 |
ROS-generating agent 1
|
Apoptosis; Ferroptosis; ROS Kinase | Apoptosis; Tyrosine Kinase/Adaptors |
ROS-generating agent 1 具有抗癌活性,通过共价修饰 TrxR 的 Sec-498 残基以生成 ROS。ROS-generating agent 1 降低细胞内 TrxR 蛋白水平,促进 NCI-H460 细胞中 ROS 依赖的性细胞凋亡 (apoptosis) 和铁死亡 (ferroptosis)。 | |||
T5674 |
H-151
|
STING | Immunology/Inflammation |
H-151 是一种 STING 拮抗剂,具有高效性和选择性。H-151 与 STING 的 Cys91 共价结合,抑制 Cys91 的棕榈酰化,从而抑制 STING 的活性。H-151 可用于体内外自身炎症性疾病的研究。 | |||
T3215 |
JNJ-42165279
JNJ42165279 |
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
JNJ-42165279 是一种 FAAH 抑制剂,抑制 hFAAH 和 rFAAH,IC50分别为70 ± 8 nM 和 313 ± 28 nM。它对其他酶、离子通道、转运蛋白和受体具有高度选择性。 | |||
T7084 |
2-Bromo-4'-hydroxyacetophenone
SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮 |
Phosphatase | Metabolism |
2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) 是一种PTP1B 的有效抑制剂,其Ki=42 μM。 | |||
TQ0236 |
Tirabrutinib
ONO-4059,GS-4059,Velexbru |
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
Tirabrutinib (GS-4059) (ONO-4059) 是一种口服有效的高选择性 Bruton’s Tyrosine Kinase (BTK) 抑制剂 (能透过血脑屏障),其 IC50 值为 6.8 nM。Tirabrutinib 不可逆共价结合 BTK 并抑制异常 B 细胞受体信号传导。Tirabrutinib 可用于自身免疫性疾病和血液学恶性肿瘤的研究。 | |||
T6446 |
Clevudine
L-FMAU,克拉夫定,Levovir |
HBV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Clevudine (Levovir) 是一种非自然 L-构型的核苷类似物,是一种与聚合酶结合的非竞争性抑制剂,具有较强的抗 HBV 活性,半衰期长,毒性低的特点。 | |||
T0668 |
1-Aminohydantoin hydrochloride
|
Others | Others |
1-Aminohydantoin hydrochloride 是一种呋喃妥因在动物组织中的主要代谢物。它与组织蛋白共价结合,在微酸性条件下从组织中释放出来,与 2-硝基苯甲醛衍生形成 AHD 的硝基苯基衍生物可被检测。它可作为测定肉、奶等兽药残留的测定指标。 | |||
T21320 |
Methoxyamine HCl
甲氧基胺盐酸盐,TRC102,TRC 102,Methoxyamine,TRC-102 |
Others | Others |
Methoxyamine HCl (Methoxyamine) 与脱嘌呤/脱嘧啶 (AP) DNA 损伤位点共价结合并抑制碱基切除修复 (BER),这可能导致 DNA 链断裂和细胞凋亡增加。 Methoxyamine 是一种具有潜在佐剂活性的口服生物可利用的小分子抑制剂。该药剂可增强烷化剂的抗肿瘤活性。 | |||
T36256 |
LC-2
LC 2,PROTAC KRASG12C Degrader-LC-2,LC2 |
PROTACs | PROTAC |
LC-2 (PROTAC KRASG12C Degrader-LC-2) 是一种新型基于von Hippel-Lindau的内源性 KRAS G12C 的 PROTAC 降解剂,DC50 在 0.25 和 0.76 μM 之间。LC-2 是一种与 MRTX849 共价结合 KRAS G12C 并招募 E3 连接酶 VH的 PROTAC,诱导 KRAS G12C 快速持续降解。LC-2 对纯合和杂合子 KRAS G12C 细胞系 MAPK 信号有抑制作用。 | |||
T21687 |
Conoidin A
|
Parasite | Microbiology/Virology |
Conoidin A 是刚地弓形虫过氧化物酶 II 的细胞通透性抑制剂,有杀线虫特性。它共价结合 TgPrxII 的过氧化物催化位点 Cys47,不可逆地抑制其过氧化物活性,IC50为 23 µM。它也抑制哺乳动物 PrxI 和 PrxII 的氧化。它具有抗氧化、神经保护作用,可研究缺血性心脏病。 | |||
T11191 |
EN6
|
Proton pump; Autophagy | Autophagy; Membrane transporter/Ion channel |
EN6 是一种小分子体内自噬激活剂,其共价靶向溶酶体v-ATP 酶的 ATP6V1A 亚基中的半胱氨酸 277。它以溶酶体依赖性方式清除 TDP-43 聚集体,这是额颞叶痴呆的病原体。它介导的 ATP6V1A 修饰使 v-ATP 酶与 Rags 分离,从而抑制 mTORC1 信号传导、增加溶酶体酸化和激活自噬。 | |||
T38960L |
QL-X-138 HCl
QL-X-138 HCl(1469988-63-3 Free base) |
MNK; BTK | Angiogenesis; MAPK; Tyrosine Kinase/Adaptors |
QL-X-138 HCl 是一种新型具有选择性和高效性的 BTK/MNK 双激酶抑制剂,具有抗癌活性,可与 BTK 共价结合,与 MNK 非共价结合。QL-X-138 HCl 对 BTK、MNK1 和 MNK2 激酶有抑制作用。QL-X-138 HCl 具有抗登革热病毒 2 活性,在急性髓系白血病细胞中显示抗增殖活性。QL-X-138 HCl 可用于研究淋巴瘤和白血病。 | |||
T3024 |
Avitinib
AC0010,艾维替尼 |
EGFR; JAK; BTK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Avitinib (AC0010) 是一种不可逆的、突变体选择性的EGFR 抑制剂,可有效抑制非小细胞肺癌中EGFR T790M 耐药突变。阿比替尼也是一种新型BTK 抑制剂。 | |||
T27391 |
FSBA
|
||
FSBA inhibits covalently anthrax edema factor. | |||
T35061 |
Vinthionine
L-Vinthionine,S-Ethenyl-L-homocysteine |
||
Vinthionine binds covalently to rat liver DNA, RNA, and protein in vivo, but not in vitro. | |||
T29596 |
Acetylaminofluorene-dG
dG-8-AAF,8-AAF dG,8 AAF-dG,8-AAF-dG |
||
Acetylaminofluorene-dG is a carcinogenic adduct which covalently binds DNA bases and promotes mutagenesis near the adduct site. | |||
T15626 |
JPM-OEt
|
Others | Others |
JPM-OEt is a broad spectrum cysteine cathepsin inhibitor with antitumor activity. JPM-OEt binds covalently in the active site and irreversibly inhibits the cysteine cathepsin family. | |||
T27766 |
Hymeglusin
L659,699,L 659,699,L-659,699 |
||
L-659,699, also known as hymeglusin, is a fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme. | |||
T28389 |
PF-6422899
PF6422899,PF 6422899 |
||
PF-6422899 irreversibly inhibits EGFR kinase activity by binding covalently to active-site cysteine residues in the ATP binding pocket of EGFR. | |||
T11956L |
MBC-11
|
Others | Others |
MBC-11 is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). It also has the potential to treat tumor-induced bone disease (TIBD). | |||
TP2303 |
ZIP, Biotinylated
|
Others | Others |
ZIP with a biotin moiety covalently attached | |||
T13586 |
BPK-29
|
Others | Others |
BPK-29 is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein interactions by covalently modifying C274. It impairs the anchorage-independent growth of KEAP1-mutant cancer cells. | |||
T17060 |
Tetramethylrhodamine-5-iodoacetamide
5-TMRIA |
Others | Others |
Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) is a thiol-selective reactive dye that is used to non-specifically label proteins via the cysteine residues and covalently label DNA fragments[1]. | |||
T33957 |
PF-Alkyne
PF Alkyne |
||
PF-Alkyne is a fluorophosphonate-based probe which specifically and covalently reacts with the tyrosine-111 residue of the Schistosoma japonicum GST (sjGST) tag. PF-Alkyne rapidly and site-selectively immobilizes sjGST fusion proteins. | |||
T21318 |
Efaproxiral
RSR13,Efaproxyn,RSR 13,RSR-13 |
||
Efaproxiral is a synthetic small molecule with radiosensitizing activity. Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity, increasing tumor | |||
T41056 |
Phalloidin-TRITC
|
||
Phalloidin-TRITC is a TRITC labeled, red fluorescence probe for F-actin . Phalloidin, bound to actin filaments, reacts covalently with amino acids Glu-llT, Met-ll9, and Met355, which are very close to the nucleotide binding site. | |||
T30461 |
BI-RJ 70
BI RJ 70,BIRJ70,BI-RJ-70 |
||
BI-RJ 70 is a tritiated photoaffinity azide analog of nevirapine, which can be used to study the binding of nevirapine to HIV-1 transcriptase through covalently labeled enzymes and amino acid residues. | |||
T73006 |
cis-ccc_R08
|
||
cis-ccc_R08(化合物1)为黄酮衍生物,适用于乙型肝炎病毒(HBV)感染研究,作为cccDNA(共价封闭环状DNA)的抑制剂。 | |||
T27200 |
DOX−NOP1 HCl
doxorubicin-NOP1 conjugate,doxorubicin-NOP1 HCl,DOX−NOP1 Hydrochloride |
||
DOX−NOP1 is a molecular hybrid covalently joining doxorubicin (DOX) and NOP1. DOX−NOP1 showed similar increased toxicity toward resistant cancer cells and, in addition, lower cardiotoxicity than DOX. | |||
T16568 |
PR-924
|
Proteasome | Proteases/Proteasome; Ubiquitination |
PR-924 is a selective inhibitor of tripeptide epoxyketone immunoproteasome subunit LMP-7 (IC50: 22 nM). PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities. PR-924 covalently modifies proteasomal N-terminal threonine active sites. | |||
T16327 |
Nitracrine
|
Others | Others |
Nitracrine is a 1-nitroacridine derivative and is an effective hypoxia-selective agent in vitro and antitumor drugs. Nitracrine suppresses RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine h | |||
T11956 |
MBC-11 triethylamine
|
Others | Others |
MBC-11 triethylamine has potential to treat tumor-induced bone disease (TIBD), is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). | |||
T11957 | MBC-11 trisodium | Others | Others |
MBC-11 trisodium has potential to treat tumor-induced bone disease (TIBD).It is a first-in-class conjugate of the bone-targeting bisphosphonate HEDP covalently linked to the antimetabolite Ara-C. | |||
T70403 |
VUF14480
|
||
VUF14480 is a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H₄ receptor. VUF14480 was shown to be a partial agonist of hH4 receptor-mediated G protein signalling and β-arrestin2 recruitment. VUF14480 bound covalently to the hH₄ receptor with submicromolar affinity. Serine substitution of C98(3.36) prevented this covalent interaction. | |||
T75139 | TMX1 | ||
TMX1 是一种 BRD4共价分子胶降解剂。TMX1 选择性地将 DCAF16 招募到 BRD4BD2 上,导致 BRD4的降解。 | |||
T62534 | POP-IN-2 | ||
POP-IN-2 (Compound 7k) 是一种有效的、共价结合的 prolyl oligopeptidase (POP) 抑制剂 (Ki: 6 nM)。POP-IN-2 能够用于神经退行性疾病和癌症的研究。 | |||
T73282 | HBV-IN-31 | ||
HBV-IN-31 是一种有效的共价闭合环状 DNA (cccDNA) 抑制剂。HBV-IN-31 具有抗HBV 活性,对 HBsAg 的 IC50值为 0.13 µM。HBV-IN-31 抑制细胞生长。 | |||
T63704 |
FGFR4-IN-11
|
||
FGFR4-IN-11 是选择性的、有效的、共价结合的 FGFR4 抑制剂 (IC50: 2.1 nM)。FGFR4-IN-11 能够明显抑制 FGF19/FGFR4 信号通路,表现出抗癌效果。 | |||
TP1837 |
Acyl Carrier Protein (ACP) (65-74)
Acyl Carrier Protein (ACP) 65-74 |
||
Acyl Carrier Protein (ACP) (65-74) is an active acyl carrier protein (ACP) fragment.Acyl Carrier Protein (ACP) is a component of plastid-located plant fatty acid synthetase. It binds acyl groups covalently via the prosthetic group, 4-phosphopantetheine, d | |||
T72328 | Cyclopropenone probe 1 | ||
Cyclopropenone probe 1 可以通过在催化活性位点共价结合,特异且有效地修饰三阴性乳腺癌驱动因子 GSTP1。 | |||
T74026 |
AUTAC2
|
||
AUTAC2 是一种 FKBP12靶向自噬介导降解体 (AUTAC)。AUTAC2 包含一个 FBnG 和 SLF 部分,其中 SLF 与 FKBP12 非共价结合。 | |||
T63340 |
CCG-273220
|
||
CCG-273220 是 G 蛋白偶联受体 (GPCR) 激酶 5 (GRK5) 共价抑制剂 (IC50: 220 nM)。CCG-273220 可以共价结合GRK5亚家族特异性残基 Cys474 ,而对GRK5的选择性比 GRK2 高。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6830 |
Epoxomicin
BU-4061T,BU-4061T,Aids010837,环氧酶素 |
Apoptosis; Proteasome | Apoptosis; Proteases/Proteasome; Ubiquitination |
Epoxomicin (BU-4061T,Aids010837) 是一种含环氧酮的天然产物,可穿越血脑屏障,并具有很强的抗肿瘤和抗炎活性。它是一种选择性不可逆的蛋白酶体抑制剂,抑制类胰凝乳蛋白酶的活性。 | |||
T3949 |
Myristic acid
肉豆蔻酸,Crodacid,Tetradecanoic acid,n-Tetradecanoic acid |
Others; Endogenous Metabolite | Metabolism; Others |
Myristic acid (Crodacid) 是饱和的 14 碳脂肪酸,存在于大多数动物、植物的脂肪中,特别是乳脂,椰子油,棕榈油和肉豆蔻油。 | |||
T40810 |
Rachelmycin
拉奇霉素,NSC298223,CC-1065 |
||
Rachelmycin (CC-1065; NSC 298223) is a potent naturally antibiotic isolated from Streptomyces zelensis . Rachelmycin binds non-covalently and covalently (N-3 adenine adduct) in the minor groove of B-form DNA. Rachelmycin has exceptionally potent antitumor activity. | |||
T38673 | Sibiromycin | ||
Sibiromycin, a glycosylated pyrrolobenzodiazepines (PBDs) compound, is a naturally occurring and potent antitumor antibiotic. It exerts its activity by covalently binding to DNA in the minor groove at the NH2 of guanine. |