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42

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9353	OXOMEMAZINE	AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Oxomemazine 是毒菌碱 M1 受体的选择性拮抗剂，具有明显的抗毒蕈碱活性。它是基于吩噻嗪的组胺 H1 受体阻滞剂，是抗组胺和抗胆碱能试剂，可用于咳嗽相关研究。
T9519	Eliapixant BAY 1817080	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	Eliapixant (BAY 1817080) 是一种选择性的P2X3受体拮抗剂，IC50值为 8 nM，可用于难治性慢性咳嗽的研究。
T5099	Gefapixant RO 4926219,AF219,MK-7264	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	Gefapixant (AF219) 是一个 P2X3 受体拮抗剂，其对人同源重组 hP2X3 和 hP2X2/3 的 IC50值分别是约 30 和 100-250 nM。
T0828	Bromhexine hydrochloride Bromhexine HCl,Auxit,盐酸溴己新,Bisolvon	SARS-CoV; HIV Protease; Autophagy	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Bromhexine hydrochloride (Bisolvon) 是TMPRSS2蛋白酶的一种特异性有效抑制剂，IC50为 0.75 μM。它可预防和控制SARS-CoV-2感染。它是一种粘液溶解剂，用于治疗与粘稠或过多粘液相关的呼吸系统疾病。
T8333	Aurintricarboxylic acid ATA,NSC-4056,NSC4056,金精三羧酸,NSC 4056	Apoptosis; P2X Receptor; Influenza Virus; Topoisomerase	Apoptosis; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Aurintricarboxylic acid (NSC-4056) 是高效的αβ-亚甲基-ATP 敏感选择性P2X1Rs 和P2X3Rs 变构拮抗剂。它是核糖核酸酶和拓扑异构酶 II 的有效抑制剂，可阻止核酸与酶结合。
T5007	Benproperine phosphate 磷酸苯丙哌林,Blascorid,Pirexyl phosphate	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	Benproperine phosphate (Pirexyl phosphate) 是一种具有口服活性的，肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。它通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。它可抑制癌细胞迁移和肿瘤转移，有用于治疗止咳的潜力。
T3267	Potassium guaiacolsulfonate hemihydrate 愈创木酚磺酸钾水合物,Potassium guaiacolsulfonate,Potassium 4-guaiacolsulfonate hemihydrate,愈创木酚磺酸钾	Antibacterial; Antibiotic	Microbiology/Virology
	Potassium guaiacolsulfonate hemihydrate (Potassium guaiacolsulfonate) 是一种芳香族磺酸，在医药中用作祛痰剂，可治疗急性呼吸道感染。它可松弛粘液，与其他药物合用，可治疗普通感冒、感染或过敏引起的咳嗽。
T0768	Oxolamine citrate 柠檬酸奥索拉明,AF-438 citrate,SKF-9976 citrate	Others	Others
	Oxolamine citrate (AF-438 citrate) 是一种止咳剂，也表现出抗炎作用，可用于呼吸道疾病的研究。
T28728	SCH-486757
	SCH-486757, a nociceptin receptor (NOP) agonist, is used potentially for the treatment of cough.
T0464	Carbetapentane citrate 托可拉斯,Pentoxyverine citrate,咳必清	AChR	Neuroscience
	Carbetapentane citrate (Pentoxyverine citrate) 能够选择性抑制咳嗽中枢，具有轻度的阿托品样作用和局麻作用。
T0576	Diethylaminoethoxyethanol	Others	Others
	Diethylaminoethoxyethanol 用于生产止咳药Toclase 等。
T0452	Dropropizine (±)-Dropropizine,UCB-196,羟丙哌嗪,UCB-1967	Others	Others
	Dropropizine (UCB-1967) 是外周镇咳剂，能够作用于外周受体及其传入导体，发挥抑制咳嗽反射的作用。
T0056	Oxeladin citrate	Others	Others
	Oxeladin citrate 是止咳剂，能够对各种病因引发咳嗽进行有效研究。
T0284	Sulfogaiacol guaiacolsulfonate,愈创木酚磺酸钾	Others; Antibacterial	Microbiology/Virology; Others
	Sulfogaiacol (guaiacolsulfonate) 是一种镇咳剂，可研究急性呼吸道感染。
T12489L	Pimethixene maleate Pimetixene maleate	Dopamine Receptor; 5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Pimethixene maleate (Pimetixene maleate) 是一种高效的 5-HT2B 受体拮抗剂，具有镇静和镇咳活性。Pimethixene maleate 抑制 5-HT1A，5-HT2A，5-HT2B，5-HT2C，组胺 H1，多巴胺 D2 和 D4.4 以及毒蕈碱 M1 和 M2，可用于研究儿童干咳和刺激性咳嗽。
T0217L	(+)-Dropropizine (+)-Dropropizine,左羟丙哌嗪	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	(+)-Dropropizine 可以抑制组胺受体，抗过敏，并通过调节参与咳嗽反射的神经肽和干扰感觉神经末梢的刺激激活来减少咳嗽。
T6660	SB-705498	TRP/TRPV Channel	Membrane transporter/Ion channel
	SB705498 是一种口服有效的 TRPV1选择性拮抗剂，pIC50值为 7.1。
T64394	GW 833972A	Cannabinoid Receptor	GPCR/G Protein
	GW 833972A 是一种选择性的 CB2 受体激动剂。GW 833972A 对诱导神经去极化具有抑制作用，且在动物模型中对柠檬酸引起的咳嗽具有抑制作用。
T1229	Erdosteine 厄多司坦,RV 144,KW-9144	NF-κB; Antibacterial; Adenosine deaminase	Metabolism; Microbiology/Virology; NF-κB
	Erdosteine (RV 144) 抑制脂多糖诱导的NF-κB 激活，具有粘液调节、抗菌、抗炎、抗氧化和自由基清除作用。
T19644	Benzonatate	Sodium Channel	Membrane transporter/Ion channel
	Benzonatate 是外周口服镇咳药，对咳嗽延伸受体 (cough stretch receptors) 的活性具有抑制作用。它是丁卡因样代谢物，能够阻断呼吸延伸受体的钠通道并产生局部麻醉作用。
T67885	Camlipixant BLU-5937	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	Camlipixant (BLU-5937) 是一种具有口服活性的嘌呤P2X3受体拮抗剂，具有有效性、选择性和竞争性。Camlipixant 对 hP2X3 同型三聚体的 IC50 为 25 nM。Camlipixant 可用于治疗呼吸系统疾病和免疫系统疾病，研究难治性慢性咳嗽和特应性皮炎。Camlipixant 具有较强的止咳效果。
T34672	Sodium dibunate L1633,Dibunato di sodio,L 1633,Becantex,L-1633
	Sodium dibunate is a type of cough suppressant.
T20056	Oxolamine BRN 0527181,Bredon,AF-438,Ossolamina,AF 438
	Oxolamine is an agent of a cough suppressant.
T0768L	Oxolamine hydrochloride Oxolamine HCl,683 M hydrochloride,AF 438 hydrochloride
	Oxolamine hydrochloride is a cough suppressant which may be useful in the treatment of pediatric asthma.
T34068	Pipazethate Pipazetatum,Lenopect,pipazethate monohydrochloride,Theratuss,Pipazetate
	Pipipyrazine is a nonnarcotic oral cough suppressant, cough suppressant.
T21372	Chlophedianol Hydrochloride clofedanol hydrochloride,clofedanol,chlophedianol
	Chlophedianol hydrochloride, a centrally acting cough suppressant, is used in the treatment of dry cough. It has antihistamine and local anesthetic properties, and may have anticholinergic effects at high doses.
T29880	Alloclamide hydrochloride Alloclamide HCl,Hexacol
	Alloclamide hydrochloride is a cough suppressant.
T32739	Libexin Lomapect,Toparten,HK 256,HK-256,Prenoxdiazine hydrochloride,HK256
	Libexin is a cough suppressant.
T26924	Butamirate
	Butamirate is a cough suppressant, it works by acting centrally through the receptors in the brainstem.
T81457	Piperidione
	Piperidione是一种止咳药物。
T68723	FPL-59257
	FPL-59257 is a leukotriene antagonist that has been shown to abolish cough response & partly inhibit bronchoconstriction produced by leukotrienes C & D.
T3609	Dioxopromethazine Prothanon,Dioxoprothazine,盐酸二氧丙嗪	Others	Others
	Dioxopromethazine (Dioxoprothazine) 是一种口服具有活性的抗组胺药，能够抑制哮喘症状。
T25189	Butopiprine Butopiprinum
	Butopiprine 是一种镇咳药，具有解痉、局部麻醉和镇咳活性。
T16406	Orvepitant maleate GW823296 maleate	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Orvepitant maleate is an effective, selective, and well-tolerated neurokinin-1 receptor (NK-1) antagonist (pKi: 10.2 for human neurokinin-1 receptor). Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatmen
T60393	Clobutinol
	Clobutinol 具有止咳作用。Clobutinol 影响心率和血压，可用于咳嗽的相关研究。
T25543	Isoaminile citrate
	Isoaminile citrate 是一种安全有效的中枢镇咳药。在动物实验中，它与 codeine 一样有效，但没有任何呼吸抑制作用。
T78523	Clobutinol hydrochloride	Potassium Channel	Membrane transporter/Ion channel
	Clobutinol hydrochloride是一种具有止咳作用的化合物，能够影响心率和血压，通常用于咳嗽相关的研究。
T60473	Nepinalone
	Nepinalone 是 β-tetralone 的alchilaminate 衍生物。Nepinalone 是一种口服活性止咳药，具有非阿片类止咳活性。
T63846	Gefapixant citrate
	Gefapixant citrate 是口服具有活力的 P2X3 受体 (P2X3R) 拮抗剂，能够作用于人同源重组 hP2X3 (IC50: ~30 nM)和 hP2X2/3 (IC50: 100-200 nM)。Gefapixant citrate 能够用于研究慢性咳嗽与膝骨关节炎。
T62422	Nav1.8-IN-2
	Nav1.8-IN-2 (compound 35A) 是一种 Nav1.8 的有效抑制剂 (IC50: 0.4 nM)。Nav1.8-IN-2 能够用于疼痛障碍、咳嗽、急性和慢性瘙痒症的研究。
T68904	GW-833972A free base
	GW833972 is a CB2 Agonist. GW 833972A inhibited capsaicin-induced depolarization of the human and guinea-pig and prostaglandin E(2) (PGE(2)) and hypertonic saline-induced depolarization of the guinea-pig isolated vagus nerve in vitro. GW 833972A also inhibited citric acid-induced cough but not plasma extravasation in the guinea-pig and this effect was blocked by a CB(2) receptor antagonist.
T71141	Fenspiride-d5
	Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from ...

化合物

Cat.No: T9353

Target: AChR, Histamine Receptor

Cat.No: T9519

Synonym: BAY 1817080

Target: P2X Receptor

Cat.No: T5099

Synonym: RO 4926219,AF219,MK-7264

Target: P2X Receptor

Bromhexine hydrochloride

Cat.No: T0828

Synonym: Bromhexine HCl,Auxit,盐酸溴己新,Bisolvon

Target: SARS-CoV, HIV Protease, Autophagy

Aurintricarboxylic acid

Cat.No: T8333

Synonym: ATA,NSC-4056,NSC4056,金精三羧酸,NSC 4056

Target: Apoptosis, P2X Receptor, Influenza Virus, Topoisomerase

Benproperine phosphate

Cat.No: T5007

Synonym: 磷酸苯丙哌林,Blascorid,Pirexyl phosphate

Target: Others, Microtubule Associated

Potassium guaiacolsulfonate hemihydrate

Cat.No: T3267

Synonym: 愈创木酚磺酸钾水合物,Potassium guaiacolsulfonate,Potassium 4-guaiacolsulfonate hemihydrate,愈创木酚磺酸钾

Target: Antibacterial, Antibiotic

Oxolamine citrate

Cat.No: T0768

Synonym: 柠檬酸奥索拉明,AF-438 citrate,SKF-9976 citrate

Target: Others

Cat.No: T28728

Carbetapentane citrate

Cat.No: T0464

Synonym: 托可拉斯,Pentoxyverine citrate,咳必清

Target: AChR

Diethylaminoethoxyethanol

Cat.No: T0576

Target: Others

Cat.No: T0452

Synonym: (±)-Dropropizine,UCB-196,羟丙哌嗪,UCB-1967

Target: Others

Oxeladin citrate

Cat.No: T0056

Target: Others

Cat.No: T0284

Synonym: guaiacolsulfonate,愈创木酚磺酸钾

Target: Others, Antibacterial

Pimethixene maleate

Cat.No: T12489L

Synonym: Pimetixene maleate

Target: Dopamine Receptor, 5-HT Receptor, AChR, Histamine Receptor

(+)-Dropropizine

Cat.No: T0217L

Synonym: (+)-Dropropizine,左羟丙哌嗪

Target: Histamine Receptor

Cat.No: T6660

Target: TRP/TRPV Channel

Cat.No: T64394

Target: Cannabinoid Receptor

Cat.No: T1229

Synonym: 厄多司坦,RV 144,KW-9144

Target: NF-κB, Antibacterial, Adenosine deaminase

Cat.No: T19644

Target: Sodium Channel

Cat.No: T67885

Synonym: BLU-5937

Target: P2X Receptor

Sodium dibunate

Cat.No: T34672

Synonym: L1633,Dibunato di sodio,L 1633,Becantex,L-1633

Cat.No: T20056

Synonym: BRN 0527181,Bredon,AF-438,Ossolamina,AF 438

Oxolamine hydrochloride

Cat.No: T0768L

Synonym: Oxolamine HCl,683 M hydrochloride,AF 438 hydrochloride

Cat.No: T34068

Synonym: Pipazetatum,Lenopect,pipazethate monohydrochloride,Theratuss,Pipazetate

Chlophedianol Hydrochloride

Cat.No: T21372

Synonym: clofedanol hydrochloride,clofedanol,chlophedianol

Alloclamide hydrochloride

Cat.No: T29880

Synonym: Alloclamide HCl,Hexacol

Cat.No: T32739

Synonym: Lomapect,Toparten,HK 256,HK-256,Prenoxdiazine hydrochloride,HK256

Cat.No: T26924

Cat.No: T81457

Cat.No: T68723

Dioxopromethazine

Cat.No: T3609

Synonym: Prothanon,Dioxoprothazine,盐酸二氧丙嗪

Target: Others

Cat.No: T25189

Synonym: Butopiprinum

Orvepitant maleate

Cat.No: T16406

Synonym: GW823296 maleate

Target: Neurokinin receptor

Cat.No: T60393

Isoaminile citrate

Cat.No: T25543

Clobutinol hydrochloride

Cat.No: T78523

Target: Potassium Channel

Cat.No: T60473

Gefapixant citrate

Cat.No: T63846

Cat.No: T62422

GW-833972A free base

Cat.No: T68904

Cat.No: T71141

Cat. No.	Product Name	Target	Signaling Pathways
T5S0691	Shionone 紫菀酮,Shionon	Others	Others
	Shionone (Shionon) 是一种从Aster tataricus 中分离得到的三萜类化合物，具有独特的六元四环骨架和 3-氧代-4-单甲基结构。它具有镇咳、抗炎作用。
T0739	Guaifenesin Glycerol guaiacolate,Guaiacol glyceryl ether,愈创甘油醚,Guaiphenesin	Others	Others
	Guaifenesin (Guaiphenesin) 是一种祛痰剂，来自于 Guajacum officinale Linné 木材中。它可以增加痰液体积和降低其粘度，缓解咳嗽不适，促进有效的咳嗽。
T5S0106	Peimisine 贝母辛,Ebeiensine	RAAS; AChR	Endocrinology/Hormones; Neuroscience
	Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体，抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放，促进一氧化氮释放，可舒张气管平滑肌，有平喘作用。
T3370	Hederacoside C 常春藤苷C,Kalopanaxsaponin B,Hederasaponin C	Others; Antibacterial	Microbiology/Virology; Others
	Hederacoside C (Hederasaponin C) 是常春藤的叶子组分中的主要成分，具有祛痰、抗菌、支气管扩张等作用，可研究呼吸系统疾病。
T6S2238	Eupalinolide B	Others	Others
	Eupalinolide B 是一种胚芽倍半萜，分离自Eupatorium lindleyanum 中。它对BGC-823、A-549 和 HL-60 等肿瘤细胞具有细胞毒性。
TN4540	Methyl demethoxycarbonylchanofruticosinate	Others	Others
	Methyl demethoxycarbonylchanofruticosinate exhibits significant antitussive activity in a citric acid induced guinea pig cough model.
T81584	Oxyresveratrol 4-O-β-D-glucopyranoside
	Oxyresveratrol 4-O-β-D-glucopyranoside (化合物 3)，一种从Morus atropurpurea根皮分离的天然产物，具有研究治疗糖尿病、关节炎、风湿、咳嗽及头痛的潜力。
T4S0083	Protostemonine	Others	Others
	Protostemonine 是一种主要从 Stemona sesslifolia 根中分离得到的生物碱，对哮喘及革兰氏阴性菌所致急性肺损伤有抗炎作用。

天然产物

Cat.No: T5S0691

Synonym: 紫菀酮,Shionon

Target: Others

Cat.No: T0739

Synonym: Glycerol guaiacolate,Guaiacol glyceryl ether,愈创甘油醚,Guaiphenesin

Target: Others

Cat.No: T5S0106

Synonym: 贝母辛,Ebeiensine

Target: RAAS, AChR

Cat.No: T3370

Synonym: 常春藤苷C,Kalopanaxsaponin B,Hederasaponin C

Target: Others, Antibacterial

Cat.No: T6S2238

Target: Others

Methyl demethoxycarbonylchanofruticosinate

Cat.No: TN4540

Target: Others

Oxyresveratrol 4-O-β-D-glucopyranoside

Cat.No: T81584

Cat.No: T4S0083

Target: Others

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