59
16
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38976 |
MUC1, mucin core
MUC1, mucin core |
||
MUC1, mucin core is a type I transmembrane glycoprotein that is characterized by its overexpression and abnormal glycosylation in carcinoma cells. It specifically binds to domain 1 of ICAM-1. | |||
TP1520 |
Hepatitis B Virus Core (128-140)
Hepatitis B Virus Core 128-140 |
||
The hepatitis B virus (HBV) core protein has been found in the nucleus, the cytoplasm, or both of HBV-infected hepatocytes. nuclear localization of the HBV core protein is negatively regulated by phosphorylation during the cell cycle. | |||
T76522 |
HCV Core Protein (59-68)
|
||
HCVCore Protein (59-68) 是一种含有 HCV 核心蛋白 59-68 残基的肽。 | |||
T76523 |
HCV Core Protein (107-114)
|
||
HCVCore Protein (107-114) 是主要线性 HCV 核心区域中免疫原性极低的残基。HCVCore Protein (107-114) 被鉴定为 101-118 区域内的结合位点,其包含基因型 Ⅰ/Ⅱ 和基因型 Ⅲ/Ⅵ 之间不同的两个残基。HCVCore Protein (107-114) 可能是传播 HCV 血清型的潜在位点。 | |||
T26674 |
AT-130
AT 130 |
HBV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
AT-130 是一种苯基丙烯酰胺衍生物,是乙型肝炎病毒复制的非核苷抑制剂。它抑制病毒 DNA 的合成,EC50为 0.13 μM。 | |||
T4687 |
Ro5-3335
CBFβ-Runx1 inhibitor II,Ro 5-3335 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Ro5-3335 (CBFβ-Runx1 inhibitor II) 是苯二氮化合物,是RUNX1-CBFβ 相互作用抑制剂,可抑制 RUNX1/CBFB 依赖性反式激活,能作为核心结合因子 (CBF) 白血病抑制剂。 | |||
T66946 |
(-)-Corey lactone benzoate
|
||
(-)-Corey lactone benzoate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66946,CAS号为 39746-00-4。 | |||
T126048 |
Coreanoside F1
|
||
Coreanoside F1 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T126048,CAS号为 132282-69-0。 | |||
T64221 |
Linvencorvir
RG7907 |
HBV; Antibiotic | Microbiology/Virology |
Linvencorvir 是一种乙型肝炎病毒(HBV)核心蛋白变构调节剂,用于治疗慢性HBV 感染。 | |||
T9225 |
Vebicorvir
ABI-H0731 |
HBV | Microbiology/Virology |
Vebicorvir (ABI-H0731) 是一种乙型肝炎病毒核心蛋白的抑制剂,有抗病毒活性。 | |||
T23146 |
PHA 568487 free base
PHA 568487 |
AChR | Neuroscience |
PHA 568487 free base 是一种选择性的 α7 烟碱乙酰胆碱受体激动剂,可用于减缓神经炎症。 | |||
T11451 |
GPI-1046
1-(1,2-二氧代-3,3-二甲基戊基)-L脯氨酸-(3-吡啶基)-丙酯 |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
GPI-1046 是一种无抗生素作用的亲免素配体,部分通过上调 PFC 和 NAc 核心中的谷氨酸转运蛋白 1 来减少乙醇摄入。 | |||
T63971 |
Canocapavir
ZM-H1505R |
HBV | Microbiology/Virology |
Canocapavir (ZM-H1505R)是一种新型可口服的 HBV 衣壳蛋白调节剂,具有抗病毒活性,可诱导 HBV 核心蛋白连接子区域的构象变化,可用于治疗乙型肝炎病毒。 | |||
T9853 |
STING activator Compound 53
|
STING | Immunology/Inflammation |
基于 oxindole 核心结构的 STING activator Compound 53 在永生化细胞和原代细胞中表现出强大的 STING(人 EC50 185 nM)的靶向功能激活以及与 STING 激活一致的细胞因子诱导指纹。 | |||
T21505 |
Suberoyl bis-hydroxamic acid
SBHA,软木肟酸,Suberohydroxamic acid |
Apoptosis; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Suberoyl bis-hydroxamic acid (SBHA) 是一种竞争性且可透过细胞的HDAC1和HDAC3抑制剂,ID50值分别为 0.25 μM 和 0.30 μM。它使肿瘤细胞易于凋亡并促进线粒体凋亡途径,可研究甲状腺髓样癌。 | |||
Fr14395 |
2,2'-Bipyridine
|
||
2,2'-Bipyridine 是一种独特的生物活性天然产物分子支架,常用于许多螯合配体的核心结构。2,2'-Bipyridine 在催化中心的排列中起到桥梁的作用。2,2'-Bipyridine 具有良好的氧化还原稳定性和升糖活性。 | |||
T0609 |
Azobenzene
偶氮苯,Diazene,Diphenyldiazene |
Others | Others |
Azobenzene (Diazene) 是一种光触发器,可用于设计和合成各种光响应系统。 | |||
T3685 |
SR9009
Stenabolic,REV-ERB Agonist II |
Autophagy | Autophagy |
SR9009 (Stenabolic) 是一种REV-ERBα/β激动剂,可增加由 REV-ERBα/ERBβ 调节的基因的组成性抑制,IC50分别为 670 nM 和 800 nM。 | |||
T17026 |
Tecovirimat
ST-246,特考韦瑞 |
Cysteine Protease | Proteases/Proteasome |
Tecovirimat 是一种核心蛋白半胱氨酸蛋白酶抑制剂,可能用于治疗天花感染。Tecovirimat 是一种新型抗病毒药物,对多种正痘病毒具有有效和选择性的活性(EC50:约 10 nM)。通过靶向病毒 p37 蛋白直系同源物来抑制正痘病毒的排出。迄今为止,Tecovirimat 已在所有小动物和非人类灵长类动物预防和治疗痘病毒引起的疾病模型中显示出功效。 | |||
T12388 |
PDD00031705
|
Others | Others |
PDD00031705 is a benzimidazolone core cell-inactive Poly (ADP-ribose) glycohydrolase (PARG) inhibitor. | |||
T12915 |
Silvestrol aglycone (enantiomer)
|
Others | Others |
Silvestrol aglycone (enantiomer) is a cyclopenta benzofuran core phenol. | |||
T19730 |
12-Crown-4
12 C 4,12-Crown-4 ether,12C4,12-C-4 |
||
12-Crown-4 disrupts Aβ40 fibrils. 12-Crown-4 can enter into the hydrophobic core region and form competitive, hydrophobic interactions with key hydrophobic residues. | |||
T37011 |
Boc-LRR-AMC
|
||
Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core. Upon enzymatic cleavage by the 26S proteasome or 20S proteolytic core, amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify 26S proteasome or 20S proteolytic core trypsin-like activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. | |||
T40360 |
OVA (329-337)
|
||
OVA (329-337) is a 9-aa core epitope (329–337) located in the C-terminal end of the OVA peptide. | |||
T69606 |
ARN23746
|
||
ARN23746 is a NKCC1 Inhibitor for the Treatment of Core Symptoms in Down Syndrome. | |||
T10446 |
BA-53038B
|
Others | Others |
BA-53038B is an HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly in a distinct manner (EC50: 3.32 μM). | |||
T76532 |
HBV Seq1 aa:93-100
|
||
HBVSeq1 aa:93-100 是乙型肝炎病毒 (HBV) 核心抗原 93-100 肽片段。 | |||
T74291 |
18:0 DAP
|
||
18:0 DAP 可用于制备脂质纳米粒 (LNPs),mRNA 被包裹在其核心。 | |||
T60730 |
BA38017
|
||
BA38017 是HBV 核心蛋白有效的组装调节剂,可抑制HBV 的复制,EC50值为 0.20 μM。 | |||
TP1536 |
Histone H4 (2-21)
|
||
Histone H4 (2-21) is a pivotal core histone involved in the process of chromatinization specific to the genomes of herpes simplex virus 1 (HSV-1). | |||
T39744 |
Firzacorvir
|
||
Firzacorvir is a cyclic sulfamide compound that acts as an HBV core protein modulator and exhibits potent anti-HBV activity, with an EC50 value of < 1 μΜ. | |||
T76316 |
PQDVKFP
|
||
PQDVKFP 是一个合成肽,可识别丙型肝炎病毒 (HCV) 核心蛋白的抗原域。 | |||
T76534 |
HBV Seq1 aa:18-27
|
||
HBVSeq1 aa:18-27 是乙型肝炎病毒 (HBV) 核心抗原 18-27 肽片段。 | |||
TP2231 |
HBcAg [Hepatitis B virus] (18-27)
|
Others | Others |
HBcAg (core antigen) is a hepatitis B viral protein. It is an indicator of active viral replication; this means the person infected with Hepatitis B can likely transmit the virus on to another person. | |||
T73492 |
AB-836
|
||
AB-836 是一种口服活性HBV 衣壳抑制剂。AB-836 通过与HBV 核心蛋白相互作用抑制病毒复制。 | |||
T1862 |
PR-619
PR 619,2,6-Diamino-3,5-dithiocyanopyridine |
Apoptosis; DUB; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) 是一种 DUB 抑制剂,可诱导内质网应激和内质网应激相关的凋亡,对 USP4、USP8、USP7、USP2和 USP5的 EC50分别为 3.93、4.9、6.86、7.2 和 8.61 μM。 | |||
T73500 | AB-506 | ||
AB-506 是一种具有口服活性的,靶向病毒核心蛋白 HBV 复制的抑制剂。AB-506 可以与 HBV 核心蛋白结合,加速衣壳组装并抑制 HBV pgRNA 包壳。AB-506 可用于慢性乙型肝炎 (CHB)研究。 | |||
T37418 |
Z-LLL-AMC
|
||
Z-LLL-AMC is a fluorogenic substrate for the chymotrypsin-like activity of the 26S proteasome or 20S proteolytic core. Chymotrypsin-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLL-AMC is typically used in cell lysates after experimental treatment. | |||
T78429 |
QTZ
|
||
QTZ为腔肠素类似的生物发光剂,在活体成像中应用,其发射光具红移特性,且能确保较低的成像背景。 | |||
T64260 | HBV-IN-20 | ||
HBV-IN-20 是一种有效的、口服具有活力的 HBV 抑制剂 (EC50: 0.46 μM)。HBV-IN-20 是一种典型的 II 型 CpAM (核心蛋白组装调节剂)。 | |||
TP2184 |
matrix protein (3-15) [Zaire ebolavirus]
|
Others | Others |
matrix protein (3-15) [Zaire ebolavirus] is a peptide of the structural proteins linking the viral envelope with the zaire ebolavirus core. Ebola virus (EBOV) is a member of the family Filoviridae in the order Mononegavirales. It is the causative agent of | |||
T9126 | PIP-199 | ||
PIP-199 是一种 RecQ 介导的基因组不稳定蛋白 RMI 核心复合物/MM2 相互作用 (RMI core complex/MM2 interaction) 的选择性抑制剂,其 IC50值为 36 μM。PIP-199 可用于研究 DNA 交联修复的潜在机制,并可用作增敏化疗耐药肿瘤。 | |||
T5326L |
Sugammadex
Org-25969,Org25969,Org 25969,361LPM2T56 |
||
Sugammadex is an agent for reversal of neuromuscular blockade by the agent rocuronium in general anaesthesia. It is the first selective relaxant binding agent (SRBA). Sugammadex is a modified γ-cyclodextrin, with a lipophilic core and a hydrophilic periph | |||
T76519 |
HCV Peptide (35-44)
|
||
HCVPeptide (35-44)为HCV核心蛋白的35至44位段,具有HLA-A2限制性CTL表位功能。该肽段通过KIR2DL2/3直接抑制NK细胞活性,以及协同CD94:NKG2A受体抑制NK细胞活性。 | |||
T60711 | Avibactam sodium hydrate | ||
Avibactam sodium hydrate (NXL-104 hydrate) 是 β-内酰胺酶的共价可逆抑制剂,不含β-内酰胺核心 。Avibactam sodium hydrate 抑制 β-内酰胺酶CTX-M-15和TEM-1,IC50分别为5 nM 和 8 nM。 | |||
T80118 |
α-Synuclein (61-95) (human)
|
||
α-Synuclein(61-95) (human) 是 α-Synuclein 的疏水核心区段,具有诱导神经元死亡的能力。该肽段在神经退行性疾病的研究中有应用,涉及阿尔茨海默病 (AD) 与帕金森病 (PD)。 | |||
T37417 |
Z-LLE-AMC
|
||
Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment. | |||
T37417L |
Z-LLE-AMC acetate(348086-66-8 Free base)
|
||
Z-LLE-AMC acetate(348086-66-8 Free base) 是 26S 蛋白酶体或 20S 蛋白水解核心的半胱天冬酶样谷氨酸后肽水解酶的荧光底物。 Z-LLE-AMC acetate 通常用于实验处理后的细胞裂解液中。 | |||
T80700 |
β Amyloid(17-28) human
|
||
β Amyloid(17-28) human 为β-淀粉样肽(Abeta)的一段核心片段,其结构受脂质诱导。本化合物能够促进β Amyloid40全长肽段的聚集,导致阿尔茨海默病(AD)中具毒性的聚集体形成。 | |||
T74887 | GSK3735967 | ||
GSK3735967为选择性、可逆的非核苷类DNMT1抑制剂,具备平面二氰基吡啶核心,专一性嵌入DNMT1所结合的半甲基化CpG双核苷酸中。该化合物包含三个结合位点,其中之一可与组蛋白H4K20me3相结合。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN7094 |
Coreoside B
|
Antibacterial | Microbiology/Virology |
Coreoside B 是从coreoside 中分离出来的,对金黄色葡萄球菌和炭疽杆菌显示出较弱的抗菌活性。 | |||
TN7090 |
Coretinphencone
|
Others | Others |
Coretinphencone 是一种从金鸡菊花蕾中分离出来的天然产物。 | |||
T8085 |
(-)-Corey lactone diol
科立内脂二醇,Corey Lactone Diol |
Others | Others |
(-)-Corey lactone diol 是 corey aldehyde 的还原形式,也是化学合成中的砌块。 | |||
TN7079 |
coreopsin
Butein-4-O-β-D-glucopyranoside,金鸡菊苷 |
Others | Others |
Coreopsin(Butein-4-O-β-D-glucopyranoside) 是金鸡菊的主要成分之一。在中国传统上被用于治疗高血压和糖尿病以及降低体重和血脂。 | |||
T2S1727 |
Lycorenine
|
Antifection | Microbiology/Virology |
Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. The development of tachyph | |||
T82038 |
Isocoreopsin
Flavanocorepsin |
||
Isocoreopsin (Flavanocorepsin)为源自Butea monosperma花的抗癌化合物。 | |||
T67447 |
2-Methylanisole
|
Others | Others |
2-Methylanisole 是一种单甲氧基苯,是一种食品添加剂,可作为合成有甲基对苯二酚为核心的化合物的中间体 。 | |||
T2S0961 |
Chalcone
benzylideneacetophenone,phenyl styryl ketone,Cinnamophenone,benzalacetophenone,β-phenylacrylophenone,查耳酮 |
EGFR; Antibacterial | Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Chalcone (Cinnamophenone) 是从甘草中分离得到的一种芳香酮,可合成查耳酮衍生物。它具有多种生物和药理的活性,如抗炎、抗菌、抗癌、抗氧化、抗寄生虫等活性。 | |||
T3322 |
trans-Chalcone
Chalcone,反-查耳酮,查尔酮,Cinnamophenone,Chalkone |
Apoptosis; Others; Antifungal; Fatty Acid Synthase | Apoptosis; Metabolism; Microbiology/Virology; Others |
trans-Chalcone (Chalkone) 是从 Aronia melanocarpa 果皮中分离出来的一种天然产物,是类黄酮前体的双酚核心结构。它是脂肪酸合酶和 α-淀粉酶的抑制剂,具有抗真菌和抗癌活性。 | |||
T6270 |
Trichostatin A
曲古柳菌素A,曲古抑菌素A,TSA |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Trichostatin A (TSA) 属于二烯异羟肟酸类的天然衍生物。Trichostatin A 是一种组蛋白去乙酰化酶抑制剂 (IC50=1.8 nM),具有可逆性和特异性。Trichostatin A 导致核心组蛋白过度乙酰化,从而调节染色质结构。 | |||
T16340 |
Nosiheptide
RP 9671,Multhiomycin,那西肽 |
Antibacterial; Antibiotic | Microbiology/Virology |
Nosiheptide (Multhiomycin) 是一种由 Streptomyces actuosus 生产的硫肽类抗生素,已被广泛用作动物生长的饲料添加剂。它抑制细菌蛋白质合成,并在特征性大环核心上带有独特的吲哚侧环系统和区域特异性羟基。 | |||
T11855 |
Lipopolysaccharides
脂多糖,LPS |
Others | Others |
Lipopolysaccharides (LPS) 是革兰氏阴性细菌细胞壁的一种特有成分,由脂质A、寡糖核心和 O -特异性多糖 (O-antigen) 3个区域组成。Lipopolysaccharides 有利于维持细胞外膜的完整性,保护细菌免受胆汁盐和脂类抗生素的破坏。Lipopolysaccharides 是一种高免疫原性抗原,可以增强免疫反应,可以用于炎症模型构建。 | |||
T41078 |
Lipopolysaccharides, Escherichiacoli
Lipopolysaccharide, E. coli O111:B4 |
Others | Others |
Lipopolysaccharides, Escherichiacoli (E. coli O111:B4) 是革兰氏阴性细菌细胞壁的一种特有成分,由脂质A、寡糖核心和 O -特异性多糖 (O-antigen) 3个区域组成。Lipopolysaccharides, Escherichiacoli 有利于维持细胞外膜的完整性,保护细菌免受胆汁盐和脂类抗生素的破坏。Lipopolysaccharides, Escherichiacoli 是一种高免疫原性抗原,可以增强免疫反应,可以用于炎症模型构建。 | |||
TN4404 |
Ladanein
|
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Ladanein is a phytochemicals inhibitor that is known to disrupt the interactions of core and other hepatitis C virus (HCV) proteins.Ladanein possesses free radicals DPPH and ABTS +.scavenging activity, it also displays moderate (20-40 microM) activities against K562, K562R (imatinib-resistant), and 697 human leukemia cell lines. | |||
T81957 |
Lacto-N-triose II
|
||
Lacto-N-triose II 作为人乳低聚糖(HMOs)的核心结构单位,具备用于合成复杂HMOs的营养潜力。 | |||
T75638 | Himastatin | ||
Himastatin 是一种具有抗肿瘤活性的抗生素,由S. hygroscopicus sp 菌株产生。Himastatin 是一种二聚环六肽,含有哌嗪酸和一个独特的芳香族中心。 |