Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nosiheptide (Multhiomycin) 是一种由 Streptomyces actuosus 生产的硫肽类抗生素,已被广泛用作动物生长的饲料添加剂。它抑制细菌蛋白质合成,并在特征性大环核心上带有独特的吲哚侧环系统和区域特异性羟基。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 549 | 现货 | ||
2 mg | ¥ 939 | 现货 | ||
5 mg | ¥ 1,950 | 现货 | ||
10 mg | ¥ 3,370 | 现货 | ||
25 mg | ¥ 5,330 | 现货 | ||
50 mg | ¥ 7,290 | 现货 | ||
100 mg | ¥ 9,850 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,530 | 现货 |
产品描述 | Nosiheptide (Multhiomycin), a thiopeptide antibiotic synthesized by Streptomyces actuosus, serves as a potent feed additive to promote animal growth. It functions by hindering bacterial protein synthesis and is distinguished by an indole side ring system and regiospecific hydroxyl groups on its macrocyclic core. |
体外活性 | Nosiheptide is found to be non-cytotoxic against mammalian cells at >> 100X MIC, and its anti-Staphylococcus aureus activity is not inhibited by 20% human serum. Nosiheptide is also highly active against Enterococcus spp and the contemporary hypervirulent BI strain of Clostridium difficile but is inactive against most Gram-negative strains tested. Nosiheptide shows extremely effective activity against all contemporary Staphylococcus aureus strains tested including multiple drug-resistant clinical isolates (MIC values ≤ 0.25 mg/L). Nosiheptide shows an obviously prolonged post-antibiotic effect against both healthcare- and community-associated Staphylococcus aureus compared to vancomycin. Time-kill analysis reveals Nosiheptide to be rapidly bactericidal against Staphylococcus aureus in a concentration- and time-dependent manner, with a nearly 2-log kill, noted at 6 hours at 10X MIC [1]. |
体内活性 | Nosiheptide (20 mg/kg; intraperitoneal injection; injected at 1 and 8 h post-infection; female CD1 mice) offers obviously protection against mortality. Ten out of 10 of the Nosiheptide-treated mice remain alive on day 3, while 6/10 of the controls died on day 1[1]. |
别名 | RP 9671, Multhiomycin, 那西肽 |
分子量 | 1222.36 |
分子式 | C51H43N13O12S6 |
CAS No. | 56377-79-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (102.26 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.8181 mL | 4.0904 mL | 8.1809 mL | 20.4522 mL |
5 mM | 0.1636 mL | 0.8181 mL | 1.6362 mL | 4.0904 mL | |
10 mM | 0.0818 mL | 0.409 mL | 0.8181 mL | 2.0452 mL | |
20 mM | 0.0409 mL | 0.2045 mL | 0.409 mL | 1.0226 mL | |
50 mM | 0.0164 mL | 0.0818 mL | 0.1636 mL | 0.409 mL | |
100 mM | 0.0082 mL | 0.0409 mL | 0.0818 mL | 0.2045 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Nosiheptide 56377-79-8 Microbiology/Virology Antibacterial Antibiotic RP9671 inhibit RP 9671 RP-9671 Multhiomycin 那西肽 Bacterial Inhibitor inhibitor