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8
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2234 |
coagulation factor II (thrombin) B chain fragment [Homo sapiens]
|
Others | Others |
Thrombin is a "trypsin-like" serine protease that is encoded by the F2 gene in humans. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). Thrombin in turn acts as a serine protease that converts soluble | |||
T81655 |
Nonacog alfa
BAX326,Coagulation Factor IX [Recombinant] |
||
Nonacog alfa (BAX326)为重组人凝血因子IX,主要用于血友病B临床研究。 | |||
T4502 |
BISMUTH SUBGALLATE
次没食子酸铋,Dermatol Puder,Bismuth Gallate |
Others | Others |
Bismuth subgallate (Dermatol Puder) 是一种止血剂,可作用于凝血因子 XII ,促使凝血级联的激活,改善纤维蛋白凝块的早期形成。 | |||
T67853 |
Rivaroxaban Impurity
Rivaroxaban-10 |
Factor Xa | Metabolism |
Rivaroxaban Impurity (Rivaroxaban-10) 是一种强效凝血因子Xa 抑制剂,IC50=66 nM。 | |||
T27920 |
LY 517717
LY-517717,LY517717 |
Factor Xa | Metabolism |
LY 517717 是一种具有口服活性的凝血因子 Xa 抑制剂,具有抗血栓活性,可用于研究静脉血栓栓塞(VTE)。 | |||
T0372 |
Gabexate mesylate
甲磺酸加贝酯,FOY |
Factor Xa; Serine Protease; Proteasome | Metabolism; Proteases/Proteasome; Ubiquitination |
Gabexate mesylate (FOY) 是一种非抗原的类胰蛋白酶丝氨酸蛋白酶抑制剂。 | |||
T3469 |
PCI-27483
PCI27483 |
Others | Others |
PCI-27483 是一种FVIIa/tissue factor 抑制剂,具有抗肿瘤的作用。 | |||
T7674 |
Thrombin Receptor Activator for Peptide
|
Protease-activated Receptor | GPCR/G Protein |
Thrombin Receptor Activator for Peptide 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5),用于研究冠心病 (CHD)。 | |||
T83969 |
Casein
|
Hydroxylase | Metabolism |
Casein 是一种具有多种作用的牛奶蛋白,参与新型药物递送系统,通过其胃内凝血特性以不同的方式影响餐后氨基酸递送。 | |||
T1736 |
Apixaban
阿哌沙班,BMS-562247-01 |
Factor Xa | Metabolism |
Apixaban (BMS-562247-01) 是一种高度选择性,可逆的、口服具有活力的凝血因子 Xa (Factor Xa) 抑制剂,抑制人和兔凝血因子 Xa 的 Ki 分别为 0.08 nM 和 0.17 nM。它可以用于研究各种血栓栓塞疾病。 | |||
T66256 |
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
|
Factor Xa | Metabolism |
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 对凝血因子Xa具有抑制作用,可用于研究血栓性静脉炎、动脉粥样硬化、脑栓塞、中风、肺栓塞。 | |||
T11994 |
Melagatran
|
Thrombin | Proteases/Proteasome |
Melagatran 是一种直接作用且可口服的凝血酶抑制剂。Melagatran 专一性抑制凝血酶,但不影响凝血级联中的其他酶或纤溶酶。Melagatran不依赖内源性辅因子发挥其抗凝血酶效果,可缓解内毒素血症的有害影响。因此,Melagatran作为预防动脉闭塞的策略显示出前景。 | |||
T78362 |
Transglutaminase
TG |
||
Transglutaminase (TG) 是一种硫醇酶,促使蛋白质分子间交联,通过催化谷氨酰胺残基的γ-羧酰胺基团与其他化合物的一级ε-胺基团形成异肽键。该酶在包括凝血、抗菌免疫反应和光合作用在内的多种生理过程中发挥作用。 | |||
T1184 |
Rivaroxaban
BAY 59-7939,利伐沙班 |
Factor Xa; Thrombin | Metabolism; Proteases/Proteasome |
Rivaroxaban (BAY 59-7939) 是高效选择性的凝血因子 Xa (FXa) 直接抑制剂,IC50=0.7 nM,Ki 为 0.4 nM。 | |||
T20762 |
Sivelestat sodium tetrahydrate
ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046 |
Serine Protease | Proteases/Proteasome |
Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) 是竞争性的人类中性粒细胞弹性蛋白酶的抑制剂,其 IC50 值为 44 nM, Ki 值为 200 nM。Sivelestat (EI546) sodium tetrahydrate 有潜力用于 COVID-19的急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的研究。 | |||
T39463 |
Asundexian
BAY 2433334,Asundexian,BAY2433334,BAY-2433334 |
Factor Xa | Metabolism |
Asundexian (BAY-2433334) 是一种高效且具有口服活性凝血因子 FXIa 抑制剂,可直接且可逆地与FXIa 的活性位点结合,从而抑制其活性。Asundexian 对缓冲液中的人 FXIa 的 IC50 为 1 nM。Asundexian 具有抗肿瘤活性,可用于研究急性缺血性卒中、短暂性脑缺血发作和缺血性卒中。 | |||
T0815L |
Warfarin sodium
|
||
Warfarin sodium 是一种抗凝血剂,通过抑制维生素 K 依赖性凝血因子的合成起作用。华法林适用于预防和/或治疗静脉血栓形成及其延伸、肺栓塞和房颤栓塞。它还用作预防心肌梗塞后全身性栓塞的辅助剂。华法林也用作杀鼠剂。 | |||
T26240 |
Surfen dihydrochloride
Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl |
FGFR; Antiviral; Antibiotic | Angiogenesis; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Surfen dihydrochloride (Aminoquinuride dihydrochloride) 是一种有效的硫酸肝素小分子拮抗剂,具有抗菌和抗病毒活性,抑制炭疽致死因子、凝血因子 X 和致死因子。Surfen dihydrochloride 可抑制普通肝素和低分子量肝素的抗凝活性,抑制肝素的硫酸化和肝素裂解酶的降解。Surfen dihydrochloridn 抑制阻断硫酸乙酰肝素介导的 FGF2 结合和信号转导。Surfen 抑制 SEVI 和精液介导的 HIV 1 型感染增强。 | |||
T22323 |
Enoxaparin sodium
|
Thrombin | Proteases/Proteasome |
Enoxaparin sodium 是一种低分子量肝素 (LMWH),已获得美国 FDA 批准,可用于医疗管理的 ST 段心肌梗死 (STEMI) 或 STEMI 及随后的经皮冠状动脉介入治疗 (PCI) 患者。它与抗凝血酶结合并增强其作用,并抑制凝血因子 XIa、IXa、Xa 和 IIa(凝血酶),从而防止血栓形成。 | |||
T31370 |
Delparantag
PMX60056,PMX-60056,PMX 60056 |
||
Delparantag( PMX-60056) is a heparins antidote designed to restore coagulation. | |||
T25927 |
Pegnivacogin
RB-006,RB 006,RB006 |
||
Pegnivacogin is a coagulation factor IXa RNA aptamer inhibitor. | |||
T28921 |
Tanogitran
BIBT 986,BIBT986,BIBT-986 |
||
Tanogitran, a coagulation factor Xa inhibitor, is used potentially for the treatment of septic shock. | |||
T20616 |
Coumachlor
G-23133,Ratilan,G23133,Tomorin,G 23133 |
||
Coumachlor, a first-generation anticoagulant rodenticide, blocks the formation of prothrombin and inhibits blood coagulation causing internal haemorrhage. | |||
T69353 |
Darexaban maleate
|
||
Darexaban maleate is a derivative used in the preparation of inhibitors of activated blood coagulation factor X. | |||
T22676 |
Prothrombin (474-477) [Mus musculus]
|
Others | Others |
Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothrombin is proteolytically cleaved to | |||
T77109 | Omfiloctocog alfa | ||
Omfiloctocog alfa (SCT-800) 是一种重组的 factor VIII(FVIII)。FVIII 是一种必需的凝血蛋白,是液相凝血系统的关键组成部分。Omfiloctocog alfa 可用于血友病 A 的研究。 | |||
T80095 |
D-Pro-Phe-Arg-Chloromethylketone
|
Factor Xa | Metabolism |
D-Pro-Phe-Arg-Chloromethylketone是一种抑制剂,它针对凝血因子XII (coagulation factor XII) 和血浆激肽释放酶 (kallikrein),在血栓形成和炎症过程中具有关键作用。 | |||
T29190 |
YM-75466
YM 466,YM-466,YM75466,YM 75466,YM-75466 Free |
||
YM-75466 is a factor Xa inhibitor. YM-75466 did not prolong coagulation time even at the dose which exerted significant antithrombotic effects, while it decreased TAT level in plasma in a dose-dependent manner. | |||
T64298 |
Turoctocog alfa
|
||
Turoctocog alfa 是一种来源于中国仓鼠卵巢 (CHO) 细胞的重组凝血因子 VIII (FVIII)。Turoctocog alfa 能够用于研究 A 型血友病。 | |||
T81234 |
S-(1,2-Dicarboxyethyl)glutathione
|
||
S-(1,2-Dicarboxyethyl)glutathione为多肽类化合物,具有抑制血液凝固与血小板聚集的功能。 | |||
TP1580 |
Activated Protein C (390-404), human TFA
|
||
The peptide region containing residues 390-404 in Activated Protein C (APC) is essential for anticoagulant activity and is available for interaction with antibodies or with other proteins, such as the macromolecular substrates Factors Va or VIIIa. APC reg | |||
T82499 |
Efmoroctocog alfa
|
||
Efmoroctocog alfa,一种重组人凝血因子 VIII-Fc 融合蛋白(rFVIIIFc),主要应用于血友病 A 研究。 | |||
TP1129 |
Boc-Ile-Glu-Gly-Arg-AMC
IEGR-AMC |
||
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC), a specific, highly fluorogenic substrate for clotting enzyme factor Xa (coagulation factor Xa). Boc-IEGR-AMC is also hydrolyzed by acrosin from the ascidian Halocynthia roretzi. | |||
T76619 |
Methoxycarbonyl-D-Nle-Gly-Arg-pNA
|
||
Methoxycarbonyl-D-Nle-Gly-Arg-pNA,这是一种底物,主要用于FIXa (Factors IXa) 和 FXa (Factors Xa)的合成蛋白酶。 | |||
T7496 |
Thrombin Receptor Activator for Peptide 5 (TRAP-5)
Thrombin Receptor Activator for Peptide |
Protease-activated Receptor | GPCR/G Protein |
Thrombin Receptor Activator for Peptide 5 (TRAP-5) 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5),用于研究冠心病 (CHD)。 | |||
T82585 |
Denecimig
Mim8 |
Factor Xa | Metabolism |
Denecimig (Mim8) 是活化凝血因子VIII双特异性抗体,包含抗FIXa和抗FX臂,促进FX活化,实现体外及体内止血。 | |||
T70170 |
Milvexian TFA
|
||
Milvexian, also known as BMS-986177 and JNJ-70033093, is a blood coagulation factor XIa inhibitor. Milvexian demonstrated good selectivity over plasma kallikreinKi = 44 nM (400-fold selective), and chymotrypsinKi = 35 nM (318-fold selective). At a dose of 1.5 mg/kg, Milvexian exhibited an overall exposure of 1215 nM/h, low clearance of 10.3 mL/min/kg, and oral bioavailability of 32%. | |||
T79847 |
Frunexian
EP-7041 |
Factor Xa | Metabolism |
Frunexian (EP-7041) 为针对 Factor XIa 的选择性有效凝血因子 XI/活化因子 XI 抑制剂,展现抗血栓活性,且在大鼠肠系膜动脉穿刺模型中显示出无出血倾向。此化合物亦可应用于体外膜氧合(ECMO)的研究领域。 | |||
T82526 |
Drotrecogin alfa (activated)
|
||
Drotrecogin alfa activated (DrotAA)为重组人活化蛋白C(APC)。该化合物能够抑制由烟雾引起的大鼠肺微血管通透性上升及促炎细胞因子IL-1β水平增加,具有抗凝血与抗炎作用,并促进纤溶过程。Drotrecogin alfa activated主要用于重症脓毒症的实验研究。 | |||
T74647 |
BT5528
|
||
BT5528 是一种双环肽毒素结合物,一种EphA2激活剂。BT5528 由双环肽和AuristatinE 组成,是 BCY6099 的衍生物。BT5528 在大鼠模型中显示出强大的抗肿瘤活性,不导致出血或引起凝血毒性。 | |||
T30192 |
Atecegatran metoxil
Atecegatran fexenetil,AZD-0837,AZD 0837,AZD0837 |
||
Atecegatran Metoxil (Atecegatran Fexenetil ,AZD0837) is an oral direct thrombin inhibitor,which currently in clinical development for the prevention of stroke and systemic embolic events in patients with atrial fibrillation. AZD0837 is a selective and re | |||
T80240 |
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
|
||
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2是一类具有生物活性的肽,作为蛋白酶激活受体1 (PAR-1) 的选择性激动剂,其特异性优于PAR-2。该肽通过HEK293细胞进行的基于细胞的钙信号传导测定确认了其对PAR-1的高特异性,并可用于研究PAR-1在体内的激活。PAR-1除了介导凝血酶的多种细胞作用外,还与PAR-4协作,参与调控凝血酶诱导的被分类为“凝血型”的肝细胞癌。 | |||
T11864 |
Iptacopan
LNP023 |
Others | Others |
Iptacopan (LNP023) 是一种与factor B 亲和力较高的抑制剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19603 |
Vitamin K
Kephton,维生素K,Vitamin K1(20) |
Endogenous Metabolite | Metabolism |
Vitamin K (Kephton) 具有凝血作用,对凝血因子、基质-Gla 蛋白和骨钙素很重要。 | |||
T4S1658 |
Benzoyloxypaeoniflorin
苯甲酰氧化芍药苷,Benzoyloxypeoniflorin,苯甲酰氧芍药苷 |
NF-κB; Tyrosinase | NF-κB; Proteases/Proteasome |
Benzoyloxypaeoniflorin (Benzoyloxypeoniflorin) 是一种酪氨酸酶抑制剂,分离于Paeonia suffruticosa 的根,对mushroom tyrosinase 的 IC50为 0.453 mM。它是一种NF-κB 抑制剂,它通过对血小板聚集和凝血的抑制作用,有助于改善血液循环。 | |||
T11012 |
Dextran
Dextran 40,葡聚糖 |
Platelet aggregation | Others |
Dextran 对血小板聚集和凝血因子有抑制作用,用作增加血浆容量的药剂。 | |||
T2570 |
Vitamin K4
维生素K4,维生素 K4,Kapilin,Menadiol Diacetate,acetomenaphthone |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Vitamin K4 (Menadiol Diacetate) 是一种维生素药物,用于治疗因缺乏 VK4 引起的凝血障碍。 | |||
T13693 |
Fibrin
|
Others | Others |
Fibrin 是血凝块的主要成分,为一种不溶性蛋白质,对凝血过程至关重要。这种蛋白质从牛血中分离出来,特别是在出血时合成。 | |||
T5968 |
DL-Homocysteine thiolactone hydrochloride
DL-Homocysteinethiolactone hydrochloride,DL-高半胱氨酸硫内酯盐酸盐 |
Endogenous Metabolite | Metabolism |
DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) 是具有根生长抑制特性的环状氨基酸衍生物。 | |||
TL0001 |
dencichine
L-Dencichin,ODAP,Dencichin,三七素 |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Dencichine (ODAP) 是抑制从三七中分到的非蛋白氨基酸,可抑制 HIF-prolyl hydroxylase-2 的活性。 | |||
T3229 |
Cytochalasin D
|
ATPase; p38 MAPK; Calcium Channel; Akt; PI3K | Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit |