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Search Results for " anti-tuberculosis "

69

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38359	Dup-721	Antibacterial	Microbiology/Virology
	DuP-721 是广谱的口服有效的抗菌剂，可以抑制多种临床敏感和耐药细菌，特别是结核杆菌M. tuberculosis。
T8694	ML406	Antibacterial; Antibiotic	Microbiology/Virology
	ML406 是一种小分子探针，通过抑制M.tuberculosisBioA(DAPA 合酶) 显示出抗结核活性，IC50为 30 nM。
T22365	Methyl α-D-mannopyranoside 甲基-D-丙噻,Methyl α-D-mannopyranoside	Antibacterial	Microbiology/Virology
	Methyl α-D-mannopyranoside (Methyl α-D-mannopyranoside) 是一种化学合成的中间体，在抗结核吸入治疗中靶向巨噬细胞。
T3642	TBA-354 TBA 354	Antibacterial; Antibiotic	Microbiology/Virology
	TBA-354 有抗结核作用，对结核分枝杆菌 H37Rv 菌株具有活性。
T5400	Q203 IAP6,Telacebec	Antibacterial; Antibiotic	Microbiology/Virology
	Q203 (Telacebec)是一种中氮杂吡啶酰胺。在培养基中抑制结核分枝杆菌H37Rv 活性的MIC50值为2.7 nM。
T11497	Ganfeborole HCl GSK3036656 HCl,GSK656 HCl	Antibacterial	Microbiology/Virology
	Ganfeborole HCl (GSK3036656 HCl) 是一种具有抗结核活性的小分子化合物，是结核分枝杆菌（Mtb）亮氨酰-tRNA 合成酶（LeuRS；IC50：0.2 μM）的抑制剂。
T4531	GSK2200150A	Antibacterial	Microbiology/Virology
	GSK2200150A 是一种通过高通量筛选活动确定的抗结核剂，对 H37Rv 的 MIC 是 0.38 μM。
T10329	anti-TB agent 1	Antibiotic	Microbiology/Virology
	anti-TB agent 1是一种有效的口服活性抗结核化合物，对结核分枝杆菌H37Rv、rRMP 和rINH 的MICs＜2nM。
T2585	Bedaquiline R207910,TMC207,贝达喹啉	Antibacterial; Antibiotic	Microbiology/Virology
	Bedaquiline (R207910) 是一种二芳基喹啉药物，能同时靶向 c-亚基和 ε-亚基，抑制结核分枝杆菌 (Mtb) F1FO-ATP 合酶。它具有解偶联活性和有用于耐多药结核病的潜力。
T5997	TBAJ-587	Antibacterial; Antibiotic	Microbiology/Virology
	TBAJ-587 是一种抗结核药物，在 MABA 和 LORA 试验中抑制 M.tb 菌株 H37Rv 的生长，MIC90 分别为 0.006 和 <0.02 µg/mL。它对 M. tuberculosis 具有更有效的活性，并且在 TB 动物模型中具有更好的功效。
T6096	Pretomanid (S)-PA 824,PA-824	Antibacterial; Antibiotic	Microbiology/Virology
	Pretomanid ((S)-PA 824) 是一种抗生素，可研究肺部多重耐药性结核病。它对结核病(MTB) 具有亚微摩尔作用活性。它对 MTB 泛敏感和抗 Rifampin 的临床分离株的 MIC 值为 0.015 至 0.25 μg/mL。
T12231	NITD-349	Others; Antibacterial	Microbiology/Virology; Others
	NITD-349 是MmpL3的抑制剂，它对毒性结核分枝杆菌 H37Rv 显示出高效的抗分枝杆菌活性，MIC50 为 23 nM。
T38345	SQ609
	SQ609是从一个双哌啶衍生物库中选取的抗结核潜在药物。SQ609在体外小鼠巨噬细胞中具有显著的抗结核活性。
T4202	Delamanid 迪拉马尼,德拉马尼,OPC-67683	Anti-infection; Antibacterial; Antibiotic	Microbiology/Virology
	Delamanid (OPC-67683) 是一种新的分枝杆菌细胞壁合成抑制剂，可用于耐多药结核病。
T9085	JFD01307SC [(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO]	Antibacterial	Microbiology/Virology
	JFD01307SC ([(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO]) 是一种谷氨酰胺合成酶抑制剂。它是抗结核剂，可作为 L-谷氨酸盐的模拟物，靶向参与谷氨酰胺生物合成的酶。
T11449L	Golotimod Gamma-D-glutamyl-L-tryptophan,SCV 07	Antibiotic	Microbiology/Virology
	Golotimod (SCV 07) 是一种具有抗菌活性的二肽，具有免疫调节活性，能显著提高抗结核治疗的疗效，诱导胸腺和脾脏细胞增殖，调节巨噬细胞功能，抑制 STAT3 信号传导。Golotimod 可用于研究复发性生殖器单纯疱疹病毒 2 （HSV-2）感染和口腔黏膜炎。
T11259	FadD32 Inhibitor-1	Others	Others
	FadD32 inhibitor -1 has anti-tuberculosis activity and is an effective FadD32 inhibitor.
T33683	NITD-304 NITD304
	NITD-304 is an anti-tuberculosis drug candidate for the treatment of multidrug-resistant tuberculosis (MDR-TB), showing effective activity against both MTB drug-sensitive and multidrug-resistant clinical isolates.
T27477	GSK366A
	GSK366A is an anti-TB agent against Mycobacterium bovis BCG and Mycobacterium tuberculosis, targeting MmpL3 and inhibiting EchA6.
T23621	Aconiazide Aconiazida
	Aconiazide is a prodrug of anti-tuberculosis.
T62086	Tuberculosis inhibitor 5
	Tuberculosis inhibitor 5 (Compound 11i) 是一种有效的抗结核剂，无明显细胞毒性。Tuberculosis inhibitor 5 是一种抗分枝杆菌 (antimycobacterial) 联苯类似物。
T28120	MTC420 MTC-420,MTC 420
	MTC420 is a anti-tuberculosis agent with acceptable anti-tuberculosis activity (Mtb IC50 =525 nM, Mtb Wayne IC50 = 76 nM and MDR Mtb patient isolates IC50 = 140 nM).
T27978	Maritinone
	Maritinone is a novel anti-tuberculosis (anti-TB) agent.
T10563	BM635	Others	Others
	BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T10171	5-Hydroxypyrazine-2-Carboxylic Acid	Others	Others
	5-Hydroxypyrazine-2-Carboxylic Acid is a metabolite of anti-tuberculosis drug pyrazinamide.
T30604	BTZ-N3 BTZ N3
	BTZ-N3 is an effective and selective anti-tuberculosis drug candidate.
T39091	Spectinamide 1599
	Spectinamide-1599 is a combination partner for anti-tuberculosis therapy.
T110951	Compound F0447-0245
	Antitubercular agent-33 是一种 2-氨基噻唑衍生物，对于结核分枝杆菌 (Mycobacterium tuberculosis,Mtb)显示出有效的抗结核活性。
T63755	Antitubercular agent-22
	Antitubercular agent-22 (Compound 2) 是有效的抗念珠菌和抗结核剂，能够作用于 Candida albicansMTCC 3017 (MIC: 2.34 μg/ml) 和 M. tuberculosis(H37Rv) (MIC: 2 μg/ml)。
T16419	Oxyphenbutazone	COX	Immunology/Inflammation; Neuroscience
	Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is a phenylbutazone derivative. It has an anti-inflammatory effect. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis.
T61303	MmpL3-IN-1
	MmpL3-IN-1, also known as compound 32, is a highly effective inhibitor of Mycobacterial membrane protein large 3 (MmpL3). With an anti-tuberculosis activity exhibiting a minimum inhibitory concentration (MIC) of less than 0.016 μg/mL in M. tuberculosis, MmpL3-IN-1 is a valuable compound for research on drug-resistant tuberculosis [1].
T63525	Antitubercular agent-23
	Antitubercular agent-23 是有效的抗念珠菌及抗结核剂，能够作用于 Candida albicansMTCC 3017 (MIC: 1.1 μg/ml) 和 M. tuberculosis(H37Rv) (MIC: 1 μg/ml)。
T40520	Thiophene-2 Thiophene-2,TP2
	Thiophene-2 (TP2) is a targeted inhibitor of polyketide synthase 13 (Pks13), specifically designed to disrupt mycolic acid biosynthesis. By doing so, it effectively induces rapid cell death in mycobacteria. Thiophene-2 demonstrates notable anti-tuberculosis activity and exhibits a minimum inhibitory concentration (MIC) value of 1 μM against Mycobacterium tuberculosis.
T61676	4-Piperidinecarboxamide
	4-Piperidinecarboxamide is a mycobacterial aspartyl-tRNA synthetase (AspS) inhibitor and a potential anti-tuberculosis (TB) agent [1].
T61520	Antitubercular agent-24
	Antitubercular agent-24 (Compound 1) exhibits anti-tubercular properties against M. tuberculosis H37Rv. It demonstrates an extracellular IC50 of 0.83 μM and an intracellular IC50 of 0.17 μM [1].
T38298	Tuberculosis inhibitor 3
	Tuberculosis inhibitor 3 (compound 2i) displays potent anti-TB activity (MIC < 0.016 μg/mL) against drug-sensitive/resistant MTB strains. Tuberculosis inhibitor 3 (compound 2i) shows acceptable PK profiles with oral bioavailability[1].
T73329	MMV676584
	MMV676584 具有抗结核活性。MMV676584是一种新的真霉菌瘤候选药物。
T10887	CRS400393	Antibacterial	Microbiology/Virology
	CRS400393 is an effective anti-mycobacterial drug , with MIC of 0.03, 2, and ≤ 0.12 µg/mL against M. abs., M. avium, M. intracellulare, and M. tuberculosis, respectively.
T10513	Benzothiohydrazide	Antibacterial	Microbiology/Virology
	Benzothiohydrazide 是异烟肼的类似物，具有抗结核活性，可用于分离真菌和细菌。
T61149	Antibacterial agent 121
	Antibacterial agent 121 (Compound 10) demonstrates antibacterial properties and exhibits efficacy against mycobacterial strains while also possessing anti-inflammatory activity. This compound finds potential applications in Tuberculosis (TB) research [1].
T63786	WX-081
	WX-081 是抗结核剂 (anti-tuberculosis)，对 M. tuberculosisH37Rv 表现出明显的抗分枝杆菌效果，并能够作用于药物敏感结核病 (DS-TB) 杆菌 (MIC: 0.083 μg/ml) 和耐多药结核病 (MDR-TB) 菌株 (MIC: 0.11 μg/ml)，对 hERG 通道表现出抑制作用 (IC50: 1.89 μM)。
T72177	Oxyphenbutazone monohydrate 羟布宗一水合物
	Oxyphenbutazone monohydrate 是一种保泰松 (Phenylbutazone) 代谢物，具有抗炎作用。Oxyphenbutazone monohydrate 是一种具有口服活性的非选择性 COX 抑制剂。Oxyphenbutazone monohydrate 能选择性地杀死不复制的结核分枝杆菌 (Mycobaterium tuberculosis)。
T10563L2	BM635 mesylate (1493762-74-5 free base) BM635 mesylate	Others	Others
	BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T10563L	BM635 hydrochloride (1493762-74-5 free base) BM635 hydrochloride	Others	Others
	BM635 hydrochloride is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T62910	Antibacterial agent 62
	Antibacterial agent 62 是一种新型氧化还原循环抗结核化合物，对生长和营养缺乏的表型耐药非生长细菌表现出显著的杀菌作用。
T38073	Thiocarlide Isoxyl
	Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis in the range of 1-10 &#181g/ml. [1] [2] At concentrations of 10 &#181M, isoxyl inhibits the synthesis of M. bovis during six hours of exposure which is similar to isoniazid (INH) and ethionamide (ETH), two other predominant anti-tuberculosis drug...
T61772	PknB-IN-1
	PknB-IN-1 (Compound 2) is an inhibitor of protein kinase B (PknB) with a concentration causing 50% inhibition (IC50) of 14.4 μM. This compound demonstrates anti-mycobacterial activity by effectively suppressing the growth of M. tuberculosis H37Rv strain, with a minimum inhibitory concentration (MIC) of 6.2 μg/mL [1].
T78602	Chaetoglobosin C
	Chaetoglobosin C (Compound 4)，源自真菌Chaetomium globosum KMITL-N0802，为一种蒽醌-色酮类化合物，具备抗结核分枝杆菌的活性。
T73271	MMV688845 (R)-GSK1729177A
	MMV688845 是一种作用于非结核分枝杆菌的 RNA 聚合酶抑制剂，可有效杀灭脓肿分枝杆菌，并展现出对结核病的治疗潜力。
T73441	TBI-166
	TBI-166，一种利米吩嗪类似物，是一种具有口服活性的抗结核药物，不良反应比 riminophenazine 化合物 Clofazimine 小。

化合物

Cat.No: T38359

Target: Antibacterial

Cat.No: T8694

Target: Antibacterial, Antibiotic

Methyl α-D-mannopyranoside

Cat.No: T22365

Synonym: 甲基-D-丙噻,Methyl α-D-mannopyranoside

Target: Antibacterial

Cat.No: T3642

Synonym: TBA 354

Target: Antibacterial, Antibiotic

Cat.No: T5400

Synonym: IAP6,Telacebec

Target: Antibacterial, Antibiotic

Ganfeborole HCl

Cat.No: T11497

Synonym: GSK3036656 HCl,GSK656 HCl

Target: Antibacterial

Cat.No: T4531

Target: Antibacterial

anti-TB agent 1

Cat.No: T10329

Target: Antibiotic

Cat.No: T2585

Synonym: R207910,TMC207,贝达喹啉

Target: Antibacterial, Antibiotic

Cat.No: T5997

Target: Antibacterial, Antibiotic

Cat.No: T6096

Synonym: (S)-PA 824,PA-824

Target: Antibacterial, Antibiotic

Cat.No: T12231

Target: Others, Antibacterial

Cat.No: T38345

Cat.No: T4202

Synonym: 迪拉马尼,德拉马尼,OPC-67683

Target: Anti-infection, Antibacterial, Antibiotic

Cat.No: T9085

Synonym: [(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO]

Target: Antibacterial

Cat.No: T11449L

Synonym: Gamma-D-glutamyl-L-tryptophan,SCV 07

Target: Antibiotic

FadD32 Inhibitor-1

Cat.No: T11259

Target: Others

Cat.No: T33683

Synonym: NITD304

Cat.No: T27477

Cat.No: T23621

Synonym: Aconiazida

Tuberculosis inhibitor 5

Cat.No: T62086

Cat.No: T28120

Synonym: MTC-420,MTC 420

Cat.No: T27978

Cat.No: T10563

Target: Others

5-Hydroxypyrazine-2-Carboxylic Acid

Cat.No: T10171

Target: Others

Cat.No: T30604

Synonym: BTZ N3

Spectinamide 1599

Cat.No: T39091

Compound F0447-0245

Cat.No: T110951

Antitubercular agent-22

Cat.No: T63755

Oxyphenbutazone

Cat.No: T16419

Target: COX

Cat.No: T61303

Antitubercular agent-23

Cat.No: T63525

Cat.No: T40520

Synonym: Thiophene-2,TP2

4-Piperidinecarboxamide

Cat.No: T61676

Antitubercular agent-24

Cat.No: T61520

Tuberculosis inhibitor 3

Cat.No: T38298

Cat.No: T73329

Cat.No: T10887

Target: Antibacterial

Benzothiohydrazide

Cat.No: T10513

Target: Antibacterial

Antibacterial agent 121

Cat.No: T61149

Cat.No: T63786

Oxyphenbutazone monohydrate

Cat.No: T72177

Synonym: 羟布宗一水合物

BM635 mesylate (1493762-74-5 free base)

Cat.No: T10563L2

Synonym: BM635 mesylate

Target: Others

BM635 hydrochloride (1493762-74-5 free base)

Cat.No: T10563L

Synonym: BM635 hydrochloride

Target: Others

Antibacterial agent 62

Cat.No: T62910

Cat.No: T38073

Synonym: Isoxyl

Cat.No: T61772

Chaetoglobosin C

Cat.No: T78602

Cat.No: T73271

Synonym: (R)-GSK1729177A

Cat.No: T73441

Cat. No.	Product Name	Target	Signaling Pathways
T3332	Isosteviol 异甜菊醇,(-)-Isosteviol	IL Receptor; Potassium Channel; TNF; NF-κB; Reactive Oxygen Species; COX; Topoisomerase	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	Isosteviol ((-)-Isosteviol) 是一种常见的天然甜味剂，属于四环二萜糖苷，是甜菊糖苷通过酸催化水解产生的。它抑制 DNA 聚合酶和 DNA 拓扑异构酶，具有抗菌、抗癌和抗结核作用。
T8298	Vasicine hydrochloride 鸭嘴花碱盐酸盐,Peganine hydrochloride	Antibacterial; Antibiotic	Microbiology/Virology
	Vasicine hydrochloride (Peganine hydrochloride) 是从Justicia adhatoda 中分离得到的一种喹唑啉类生物碱，有抗结核活性。
T67136	1-Hydroxy-2-butanone	Endogenous Metabolite; Antibiotic	Metabolism; Microbiology/Virology
	1-Hydroxy-2-butanone 是可从竹子汁和番茄叶中提取得到的天然产物，具有抗结核活性。
TN1622	Ermanin 堪非醇3,4'-二-O-甲醚	NOS; Influenza Virus; COX; HIV Protease; Antibacterial; Antibiotic	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ermanin 是一种从 Tanacetum microphyllum 中分离出来的类黄酮。Ermanin抑制血小板聚集，具有抗结核和抗病毒/细菌特性。Ermanin 可抑制 iNOS 和 COX-2 的表达，从而具有抗炎活性。Ermanin 可能具有抗 HIV-1 活性。Ermanin 在较低浓度下可有效地抑制 Dione juno 幼虫。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
TN5614	Dehydrobruceantin
	Dehydrobruceantin has anti-tuberculosis activity.
TN3674	Clauszoline M	Antifection	Microbiology/Virology
	Clauszoline M shows a significant anti-tuberculosis activity.
TN5648	Porson
	Porson exhibited anti-tubercular activity against Mycobacterium tuberculosis H37Rv in vitro and MICs values of 40.0 μg/mL.
TN1378	α-Viniferin ALPHA-VINIFERIN,Alpha-葡萄素	P450; NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	α-Viniferin 也称为2-芳基苯并呋喃类黄酮，是前列腺素H2合成酶抑制剂。具有抗阿尔茨海默病、抗结核、抗肿瘤、抗炎、抗糖尿病等多种药理活性
T72742	(-)-Pinocembrin (-)-乔松素
	(-)-Pinocembrin 对 H37Ra 结核分枝杆菌展示了抗菌活性，无论是休眠还是活跃期，其 IC50 值分别为1.11 mg/mL 和 1.21 mg/mL。作为一种抗增殖剂，(-)-Pinocembrin 对于 THP-1、A549、Panc-1、HeLa 和 MCF7 细胞系，IC50 值范围为 1.88 至 11.00 mg/mL。
T38330	Collinin
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...

天然产物

Cat.No: T3332

Synonym: 异甜菊醇,(-)-Isosteviol

Target: IL Receptor, Potassium Channel, TNF, NF-κB, Reactive Oxygen Species, COX, Topoisomerase

Vasicine hydrochloride

Cat.No: T8298

Synonym: 鸭嘴花碱盐酸盐,Peganine hydrochloride

Target: Antibacterial, Antibiotic

1-Hydroxy-2-butanone

Cat.No: T67136

Target: Endogenous Metabolite, Antibiotic

Cat.No: TN1622

Synonym: 堪非醇3,4'-二-O-甲醚

Target: NOS, Influenza Virus, COX, HIV Protease, Antibacterial, Antibiotic

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Dehydrobruceantin

Cat.No: TN5614

Cat.No: TN3674

Target: Antifection

Cat.No: TN5648

Cat.No: TN1378

Synonym: ALPHA-VINIFERIN,Alpha-葡萄素

Target: P450, NO Synthase, Prostaglandin Receptor

(-)-Pinocembrin

Cat.No: T72742

Synonym: (-)-乔松素

Cat.No: T38330

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