Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 2,970 | 6-8周 | ||
25 mg | ¥ 10,500 | 6-8周 | ||
50 mg | ¥ 13,700 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv). |
靶点活性 | M. tuberculosis (strain H37Rv):(MIC50) 0.12 μM |
体内活性 | BM635 has potent MIC (0.12 μM), Tox50:MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity (ED99: 49 mg/Kg; IC95%: 43–54 mg/Kg) [1]. The half-life in vivo of BM635 is 1h, allowing a reasonable maximum concentration (Cmax: 1.62 μM) and a moderate bioavailability (46%) [2]. |
分子量 | 392.51 |
分子式 | C25H29FN2O |
CAS No. | 1493762-74-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31 mg/mL (78.98 mM), Sonication and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5477 mL | 12.7385 mL | 25.4771 mL | 63.6926 mL |
5 mM | 0.5095 mL | 2.5477 mL | 5.0954 mL | 12.7385 mL | |
10 mM | 0.2548 mL | 1.2739 mL | 2.5477 mL | 6.3693 mL | |
20 mM | 0.1274 mL | 0.6369 mL | 1.2739 mL | 3.1846 mL | |
50 mM | 0.051 mL | 0.2548 mL | 0.5095 mL | 1.2739 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
BM635 1493762-74-5 Others BM 635 BM-635 Inhibitor inhibitor inhibit