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20
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6335 |
Tie2 kinase inhibitor 1
Tie2 kinase inhibitor |
Tie-2 | Tyrosine Kinase/Adaptors |
Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor) 是Tie2激酶选择性抑制剂9IC50:250 nM),具有抗癌作用。 | |||
T36718 |
Tie2 Inhibitor 7
|
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Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization. | |||
T22259 |
AMG-Tie2-1
AMG-Tie2,4-甲基-3-[[3-[2-(甲基氨基)-4-嘧啶基]-2-吡啶基]氧基]-N-[3-(三氟甲基)苯基]苯甲酰胺 |
Others | Others |
AMG-Tie2-1 is a dual inhibitor of VEGF receptor 2 (VEGFR2) and tunica interna endothelial cell kinase 2 (Tie2). | |||
T40581 |
TIE-2/VEGFR-2 kinase-IN-2
|
||
TIE-2/VEGFR-2 kinase-IN-2 is a powerful inhibitor of both VEGFR2 and Tie-2 kinases, displaying noteworthy pIC 50 values of 8.61 and 8.56, respectively. This compound acts as an anti-angiogenic agent, making it highly relevant for cancer research. | |||
T8817 |
TIE-2/VEGFR-2 kinase-IN-1
|
||
TIE-2/VEGFR-2 kinase-IN-1 用于合成TIE-2或者VEGFR-2抑制剂,可用于研究不适当的血管生成的相关疾病。 | |||
T14921 |
CE-245677
|
Tie-2; Trk receptor | Tyrosine Kinase/Adaptors |
CE-245677 是可逆的Tie2和TrkA/B 抑制剂,在细胞体系下的IC50值分别为 4.7 和 1 nM。 | |||
T16724 |
Razuprotafib
AKB-9778 |
Phosphatase; Others | Metabolism; Others |
Razuprotafib (AKB-9778) 是一种 VE-PTP (HPTPß)催化活性的有效选择性抑制剂,抑制结构相关磷酸酶 PTP1B。除 HPTPη 和 HPTPγ 外,它对 VE-PTP 具有良好的选择性。它能够促进 TIE2 活化,增强 ANG1 诱导的 TIE2 活化,并刺激 TIE2 通路中信号分子的磷酸化。 | |||
T6154 |
SU11274
Met Kinase Inhibitor,PKI-SU11274 |
Apoptosis; VEGFR; FGFR; c-Met/HGFR; CDK; Autophagy | Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors |
SU11274 (Met Kinase Inhibitor) 是一种选择性的 Met 抑制剂,IC50值为 10 nM。它对 PGDFRβ,EGFR 或 Tie2 没有抑制作用。 | |||
T6479 |
Dovitinib lactate hydrate
Dovitinib (TKI258) Lactate,多韦替尼,Dovitinib Lactate,TKI258 |
VEGFR; FGFR; FLT; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
Dovitinib lactate hydrate (TKI258) 是一种多靶点的酪氨酸激酶抑制剂,抑制 FLT3,c-Kit,FGFR1/3,VEGFR1/2/3和 PDGFRα/β的 IC50值分别为 1,2,8/9,10/13/8,27/210 nM。 | |||
T2640 |
Rebastinib
DCC2036,DCC 2036,DCC-2036 |
Apoptosis; FLT; Bcr-Abl; Src | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Rebastinib (DCC-2036) 是一种口服有效的,非 ATP 竞争性的 Bcr-Abl 抑制剂,作用于 Abl1WT 和 Abl1T315I,IC50分别为 0.8 nM 和 4 nM,还抑制 LYN、SRC、HCK、FGR、FLT3、KDR 和 Tie-2,对 c-Kit 的活性低。Rebastinib 对 Angiopoietin2-Tie2通路具有抑制作用。 | |||
T6289 |
Dovitinib
TKI258,多韦替尼,CHIR-258,度维替尼 |
VEGFR; FGFR; FLT; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
Dovitinib (CHIR-258) 是一种口服有效的、多靶点的酪氨酸激酶 (RTK) 抑制剂,具有抗肿瘤作用。 | |||
T6380 |
AMG 900
AMG900,AMG-900,莪术醇.姜黄醇 |
p38 MAPK; Tyrosine Kinases; Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic; MAPK; Tyrosine Kinase/Adaptors |
AMG 900 是一种有效且高度选择性的泛极光激酶抑制剂,对Aurora A、B 和C 的IC50分别为 5 nM、4 nM 和 1 nM。 | |||
T2054 |
Altiratinib
DCC-2701 |
VEGFR; Tie-2; FLT; Trk receptor; c-Met/HGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Altiratinib (DCC-2701) 是一种多靶点激酶抑制剂,能够抑制 MET (IC50:2.7 nM),TIE2 (IC50:8 nM),VEGFR2 (IC50:9.2 nM),FLT3 (IC50:9.3 nM),Trk1 (IC50:0.85 nM),Trk2 (IC50:4.6 nM) 和 Trk3 (IC50:0.83 nM)。 | |||
T79860 |
TIE-2/VEGFR-2 kinase-IN-5
|
VEGFR; Tie-2 | Angiogenesis; Tyrosine Kinase/Adaptors |
TIE-2/VEGFR-2 kinase-IN-5 是一种高效的 TIE-2 和 VEGFR-2 酪氨酸激酶受体抑制剂,具有的抗血管生成活性,常用于血管生成相关的生物医学研究领域。 | |||
T38930 |
BAY-826
|
Tie-2 | Tyrosine Kinase/Adaptors |
BAY-826 是一种新型、高效且具有选择性的 TIE-2 抑制剂,抑制 TIE-2 磷酸化,可用于研究肿瘤。 | |||
T16853 |
SB-633825
|
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
SB-633825 can inhibit cancer cell growth and angiogenesis. SB-633825 is an effective and ATP-competitive inhibitor of TIE2, LOK, and BRK (IC50s: 3.5 nM, 66 nM, 150 nM, respectively). | |||
T6934 |
Pexmetinib
ARRY-614 |
Tie-2; p38 MAPK; Autophagy | Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Pexmetinib (ARRY-614) 是一种口服生物可利用的双重 p38 MAPK/Tie-2 抑制剂,可研究急性骨髓性白血病。在 HEK-293 细胞系中的 IC50 为 4 nM/18 nM。 | |||
T68286 |
CE-245677 mesylate
|
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CE-245677 is a selective, orally active Tie2 kinase inhibitor identified by Pfizer previously in development for the treatment of certain cancers. CE-245,677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, resp., displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases (e.g. KDR, PDGFR, FGFR) and gene family panels, and demonstrates good oral absorption in in vivo rat PK studies (F=80%). | |||
T4318 |
EOC317
ACTB-1003,ACTB1003,ACTB 1003 |
VEGFR; FGFR; Tie-2 | Angiogenesis; Tyrosine Kinase/Adaptors |
EOC317 (ACTB-1003) 是一种口服可用的激酶抑制剂,能够抑制 FGFR1 (IC50:6 nM),VEGFR2 (IC50:2 nM) 和 Tie-2 (IC50:4 nM)。 | |||
T68539 |
CEP-11981
BOL 303213X,ESK981 ; BOL 303213X,ESK981 |
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CEP-11981 (ESK981 ; BOL 303213X) 是一种具有口服活性的酪氨酸激酶抑制剂(TKI),可以靶向 TIE2,VEGFR1-3和FGFR1,具有潜在的抗肿瘤和抗血管生成效果。 | |||
T78248 |
Nesvacumab
|
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Nesvacumab为全人源IgG1型单克隆抗体,具有高亲和力,可特异性结合并灭活Tie2受体配体Angiopoietin-2(Ang2),与Ang1无结合作用。 | |||
T6193 |
Dovitinib Dilactic Acid
Dovitinib (TKI-258) Dilactic Acid,TKI258 Dilactic acid |
VEGFR; FGFR; FLT; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
Dovitinib Dilactic Acid (Dovitinib(TKI-258) Dilactic Acid) 是 Dovitinib 的双乳酸,是一种多靶点 RTK 抑制剂,主要用于 III 类 (FLT3/c-Kit),IC50 为 1 nM/2 nM,对 IV 类 (FGFR1/ 3) 和 V 类 (VEGFR1-4) RTK,IC50 为 8-13 nM,对 InsR、EGFR、c-Met、EphA2、Tie2、IGFR1 和 HER2 的效力较低。 | |||
T3113 |
Foretinib
GSK089,EXEL-2880,GSK1363089,XL880 |
VEGFR; Tie-2; c-Met/HGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Foretinib (GSK1363089) 是多靶点酪氨酸激酶抑制剂,能够抑制 Met (IC50:0.4 nM) 和 KDR (IC50:0.9 nM)。 | |||
T79858 |
TIE-2/VEGFR-2 kinase-IN-3
|
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TIE-2/VEGFR-2 kinase-IN-3,为苯并咪唑衍生物,具备高效的抑制作用于TIE-2与VEGFR-2受体酪氨酸激酶,其IC50值分别达到6.9 nM和3.5 nM。本化合物主要用于血管生成相关研究。 | |||
T79859 |
TIE-2/VEGFR-2 kinase-IN-4
|
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TIE-2/VEGFR-2 kinase-IN-4,一种苯并咪唑衍生物,作为有效的TIE-2和VEGFR-2酪氨酸激酶受体抑制剂,其IC50值分别为5.2 nM和5.1 nM,适用于血管生成相关研究。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01064 |
TIE2 Protein, Human, Recombinant (His)
TIE2,VMCM,CD202B,TEK tyr... |
Human | HEK293 Cells |
TIE2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1. | |||
TMPY-00930 |
TIE2 Protein, Human, Recombinant (His & hFc)
VMCM1,TIE2,CD202B,TEK ty... |
Human | HEK293 Cells |
TIE2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 108.5 kDa and the accession number is AAA61139.1. | |||
TMPY-04545 |
TIE2 Protein, Human, Recombinant (His & GST)
VMCM,CD202B,TIE-2,VMCM1,... |
Human | Baculovirus Insect Cells |
TIE2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.3 kDa and the accession number is Q02763-1. | |||
TMPJ-00642 |
TIE2 Protein, Human, Recombinant (hFc)
TEK tyrosine kinase, endothelial,EC 2.7.10,Tie<... |
Human | HEK293 Cells |
TIE2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-150 KDa and the accession number is Q02763-1. | |||
TMPY-01954 |
TIE2 Protein, Mouse, Recombinant (hFc)
Tie-2,STK1,Tie2,Hyk,Cd |
Mouse | HEK293 Cells |
TIE2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107.7 kDa and the accession number is B1AWS8. | |||
TMPY-05244 |
TIE2 Protein, Human, Recombinant (His), Biotinylated
TIE2,TEK tyrosine kinase, endothelial,CD |
Human | HEK293 Cells |
TIE2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1. | |||
TMPY-06974 |
TIE2 Protein, Mouse, Recombinant (His), Biotinylated
AA517024,Tie2,STK1,Hyk,Tie |
Mouse | HEK293 Cells |
TIE2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.03 kDa and the accession number is Q02858. | |||
TMPJ-00643 |
TIE2 Protein, Human, Recombinant (aa 23-745, His)
VMCM1,TEK,Tie2,hTIE2,p14... |
Human | HEK293 Cells |
TIE2 Protein, Human, Recombinant (aa 23-745, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-120 KDa and the accession number is Q02763-1. | |||
TMPY-04575 |
TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST)
Cd202b,AA517024,STK1,Tie... |
Mouse | Baculovirus Insect Cells |
TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.2kDa and the accession number is Q02858. | |||
TMPY-03563 |
TIE2 Protein, Cynomolgus, Recombinant (hFc)
TEK tyrosine kinase, endothelial |
Cynomolgus | HEK293 Cells |
TIE2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107.6 kDa and the accession number is G7PS68. | |||
TMPY-02508 |
TIE2 Protein, Rat, Recombinant (hFc)
TEK tyrosine kinase, endothelial |
Rat | HEK293 Cells |
TIE2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 108 kDa and the accession number is A6JRG8. | |||
TMPY-05049 |
TIE2 Protein, Rhesus, Recombinant (His)
TEK tyrosine kinase, endothelial |
Rhesus | HEK293 Cells |
TIE2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.2 kDa and the accession number is G7NFP9. | |||
TMPK-00303 |
ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (His & Avi)
angiopoietin 2,angiopoietin-2a,angiopoitin... |
Human | HEK293 Cells |
Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Mature Ang-2 is 478 amino acids in length.Ang2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel Palade bodies.. | |||
TMPJ-01435 |
ANG2 Protein, Rhesus macaque, Recombinant (hFc)
ANG-2,Angiopoietin-2,AGPT2,angiop... |
Rhesus | HEK293 Cells |
ANG2 Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is XM_001097949. | |||
TMPJ-00303 |
ANG2 Protein, Mouse, Recombinant (hFc)
angiopoietin 2,Angiopoietin-2,ANG2 |
Mouse | HEK293 Cells |
ANG2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is O35608. | |||
TMPH-03241 |
Angiopoietin-2 Protein, Rat, Recombinant (E. coli, His)
Angpt2,Angiopoietin-2,ANG-2 |
Rat | E. coli |
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Angiopoietin-2 Protein,... | |||
TMPH-03240 |
Angiopoietin-2 Protein, Rat, Recombinant (His)
Angiopoietin-2,Angpt2,ANG-2 |
Rat | Baculovirus Insect Cells |
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Angiopoietin-2 Protein,... | |||
TMPH-00479 |
Angiopoietin-1 Protein, Canine, Recombinant (His)
ANG-1,ANGPT1,Angiopoietin-1 |
Canine | Baculovirus Insect Cells |
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Canine, Recombinant (His) is expressed in Baculovirus insect cells with C-6... | |||
TMPH-03239 |
Angiopoietin-1 Protein, Rat, Recombinant (His)
ANG-1,ANGPT1,Angiopoietin-1 |
Rat | HEK293 Cells |
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis ... | |||
TMPH-00343 |
Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His)
Angiopoietin-1,ANG-1,ANGPT1 |
Canine | HEK293 Cells |
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His) is expressed in HEK293 mammalian cells wi... |