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Cat. No. | Product Name | Target | Signaling Pathways |
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T60433 | NF-κB-IN-6 | ||
NF-κB-IN-6 (Compound 3d) 是通过抑制NF-κB 信号通路减少 iNOS 和 COX-2 蛋白的表达的抗炎剂。NF-κB-IN-6 抑制脂多糖诱导的 RAW264.7 细胞中 NO 的生成,IC50值为 23.1 μM。 | |||
T11139 |
(E/Z)-BCI
NSC 150117 |
Apoptosis; Phosphatase | Apoptosis; Metabolism |
(E/Z)-BCI (NSC-150117) 是一种DUSP6抑制剂,可通过激活 Nrf2 信号和抑制 NF-κB 通路,减弱 LPS 诱导的巨噬细胞炎症和 ROS 生成,具有抗炎活性。 | |||
T8477 |
IQ-3
|
JNK | MAPK |
IQ3 是c-JNK 家族选择性抑制剂,对JNK3 的选择性更好。它对JNK1、JNK2 和 JNK3 的Kd 值分别为0.24 μM、0.29 μM 和 0.066 μM。 | |||
T15017 |
CU-T12-9
|
TLR | Immunology/Inflammation |
CU-T12-9 是特异性 TLR1/2激动剂,可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体,可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号,引起下游 TNF-α、IL-10 和 iNOS 增加。 | |||
T40553 | ACAT-IN-6 | ||
ACAT-IN-6, an acyl-Coenzyme A: cholesterol acyltransferase (ACAT) inhibitor, displays potent inhibition of NF-κB mediated transcription. | |||
T10809 |
CHPG
|
Others | Others |
CHPG is a selective agonist of mGluR5. In BV2 microglial cells, it attenuates SO2-induced oxidative stress and inflammation through the TSG-6/NF-κB pathway. | |||
T37449 |
SR 12460
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SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1It inhibits TNF-α-induced NF-κB activation in a reporter assay when used at concentrations ranging from 25 to 150 μM. It reduces LPS-induced production of IL-6 in RAW 264.7 cells. SR 12460 (30 mg/kg) improves grip strength in themdxmouse model of Duchenne muscular dystrophy. 1.Zhao, J., Zhang... | |||
TP2035 |
FSL-1
FSL 1 |
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TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells. | |||
T35701 |
FSL-1 TFA
|
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FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection[1]. FSL-1 TFA induces MMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells[2]. FSL-1 significantly reduces HSV-2 replication in human vaginal epithelial cells (EC)[1].FSL-1 induces significant resistance to experimental genital HSV-2 infection through elaboration of a specific cytokine response profile[1].FSL-1 (50 ng/mL, 24 hours) induce... | |||
T83670 |
F1 TFA
Tat-IKIP (46-60),Tat-Inhibitor of NF-κB Kinase-interacting Peptide |
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F1是一种抗炎肽,由HIV-1 Tat蛋白质转导域与对应于抑制因子NF-κB激酶-相互作用肽(IKIP)46-60残基的15氨基酸肽链接而成。在5 µM浓度下,F1抑制了小鼠腹腔巨噬细胞中LPS诱导的IκB激酶α(IKKα)和IKKβ的磷酸化以及NF-κB(p65)的核内转移。在体内,F1(5 mg/kg)降低了LPS诱导的脓毒症小鼠模型中IL-6、TNF-α和IL-1β的血清水平,并增加了生存率。 | |||
T36198 |
Avenanthramide-C methyl ester
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Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM). Through this mechanism, avenanthramide-C methyl ester dose dependently inhibits the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells. | |||
T80697 |
β5i-IN-1
|
Proteasome | Proteases/Proteasome; Ubiquitination |
β5i-IN-1 是 β5i 选择性抑制剂,具有 8.463 nM 的 IC50 值。该化合物能够诱导 TNF-α 和 IL-6 的释放,同时影响 NF-κB 的转录活性,适用于特发性肺纤维化研究。 | |||
T78056 |
HMGB1-IN-1
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HMGB1-IN-1(化合物6)在RAW264.7细胞中具有显著的NO抑制活性,其IC50为15.9 ± 0.6 μM。该化合物能够抑制HMGB1/NF-κB/NLRP3信号通路,并且在肾损伤模型中展现出优异的抗炎及抗脓毒症效果。 | |||
T72102 | Glucocorticoid receptor modulator 1 | ||
Glucocorticoid receptor modulator1 是一种高效且具有口服活性的 NF-κB 和 AP-1抑制剂,IC50分别为 9 nM 和 130 nM。Glucocorticoid receptor modulator1 可有效降低炎症因子 IL-6、IL-1β、TNF-α 的表达,可缓解小鼠皮炎。 | |||
T78829 |
JNK2-IN-1
|
JNK | MAPK |
JNK2-IN-1(Compound J27)是一款具有抗炎活性的JNK2抑制剂,其解离常数为79.2 μM。该化合物能通过阻断NF-κB/MAPK信号通路来降低肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)的释放,从而减轻脂多糖(LPS)引起的急性肺损伤(ALI)及脓毒症症状。 | |||
T74910 | ODN 24888 | ||
ODN 24888 是一种鸟嘌呤修饰的抑制性寡核苷酸 (INH-ODN),对TLR7/TLR9介导的信号通路表现出强烈的抑制作用。ODN 24888 损害 IFN-α 水平和NF-κB 激活,抑制IL-6的释放。ODN 24888 参与免疫和炎症应答,可作为疫苗佐剂使用。 | |||
T79619 | Anti-inflammatory agent 54 | ||
Anti-inflammatory agent 54 (compound 9c),作为薏苡醇 (Coixol) 的衍生物,显示出显著的抗炎效果。它通过抑制NF-κB通路,降低iNOS、TNF-α、IL-6和IL-1β的表达,进而在LPS诱导的RAW264.7巨噬细胞中降低一氧化氮 (NO) 生成(IC50: 2.4 μM)。此外,该化合物在小鼠耳廓水肿模型中表现出了体内抗炎活性。 | |||
T62111 | Antioxidant agent-5 | ||
Antioxidant agent-5 (compound D-6) 是一种有效的抗氧化剂。Antioxidant agent-5 能够抑制 oxLDL 诱导的 ROS 水平升高和 NF-κB 核转位。Antioxidant agent-5 对 oxLDL (氧化型低密度脂蛋白)诱导的 VECs 细胞凋亡 (apoptosis) 及 ICAM-1 和 VCAM-1 的表达表现出抑制作用。Antioxidant agent-5 可以激活 Nrf2/HO-1 抗氧化通路,对 oxLDL 诱导的内皮损伤表现出保护活性。 | |||
T79620 | Anti-inflammatory agent 55 | ||
Anti-inflammatory agent 55 (compound 9j) 作为薏苡醇 (Coixol) 的衍生物,展现出显著的抗炎活性。该化合物通过抑制NF-κB途径,有效下调iNOS、TNF-α、IL-6及IL-1β的表达水平。其中,Anti-inflammatory agent 54 能够在RAW264.7巨噬细胞中通过抑制LPS诱导的NO产生(IC50: 0.8 μM)来发挥其抗炎作用,并在小鼠耳廓水肿模型中证实了其体内抗炎效果。 | |||
T83734 |
PapRIV TFA
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PapRIV是最初从B. cereus分离出的一种群体感应七肽。它被转译为一个48-氨基酸多肽,由NprB蛋白酶在细胞外分泌和加工形成活性七肽。PapRIV(1-25 µM)在BV-2微胶质细胞中诱导IL-6和TNF-α的产生,并促使NF-κB转移。 | |||
T72017 |
6(5H)-Phenanthridinone
|
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6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-κB-induced transcription of the genes encoding TNF-α, IL-2, and IFN-γ in rat lymphocytes. In vivo, 6(5H)-phenanthridinone reduces spinal cord expression of inducible nitric oxide synthase (iNOS), IL-1β, TNF-α, IL-2, and IFN-γ and reduces disease score in a rat model of experimenta... | |||
T36995 |
MRT 68601 hydrochloride
|
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Potent TBK1 (TANK-binding kinase-1) inhibitor (IC50 = 6 nM). Inhibits the formation of autophagosomes in lung cancer cells. Newman et al (2012) TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. PLoS ONE 7 e50672 PMID:23209807 |McIver et al (2012) Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKe kinases. Bioorg.Med.Chem.Lett. 22 7169 PMID:23099093 | |||
T62317 |
α7 nAchR-JAK2-STAT3 agonist 1
|
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α7 nAchR-JAK2-STAT3 agonist 1 是一种 α7 nAchR-JAK2-STAT3 通路的有效抑制剂,能够作用于一氧化氮 (NO) (IC50: 0.32 μM)。α7 nAchR-JAK2-STAT3 agonist 1 在小鼠巨噬细胞 RAW264.7 中对 iNOS、IL-1β 和 IL-6 的表达具有有效的抑制作用。α7 nAchR-JAK2-STAT3 agonist 1 对 LPS 诱导的 NO 释放、NF-κB 激活和细胞因子产生具有抑制作用。α7 nAchR-JAK2-STAT3 agonist 1 能够用于研究败血症。 | |||
T36408 |
Rhein-13C4
Rhein-13C4 |
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Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i... | |||
T36192 |
CAY10682
|
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(±)-Nutlin-3 blocks the interaction of p53 with its negative regulator Mdm2 (IC50 = 90 nM), inducing the expression of p53-regulated genes and blocking the growth of tumor xenografts in vivo. CAY10682 is a pyrrolo[3,4c]pyrazole derivative that inhibits the p53-Mdm2 interaction as potently as (±)-nutlin-3 (Ki = 83 nM) and also dose-dependently reduces activation of the NF-κB pathway. It specifically prevents phosphorylation of IκBα by the kinases IKKα, IKKβ, and IKK (IC50s = 80.5, 78.2, and 57.1... | |||
T83895 |
NCI 126224
NSC 126224 |
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NCI 126224 是一种 toll-like receptor 4 (TLR4) 的拮抗剂。它在 RAW 264.7 巨噬细胞中,选择性抑制由 TLR4 激动剂 LPS 引起的一氧化氮 (NO) 产生(IC50 = 0.31 µM),而对 TLR7/8 激动剂 R-848、TLR1/2 激动剂 Pam3CSK4 以及 TLR3 激动剂 poly(I:C) 的影响较小;但对于相同细胞中由 TLR2/6 激动剂 FSL-1 引起的 NO 产生,其抑制作用在 0.6 µM 时亦显现。此外,NCI 126224 在 BV-2 微胶质细胞的报告实验中抑制了 LPS 引起的 NF-κB 活性,并在 RAW 264.7 巨噬细胞中降低了 LPS 引起的 IL-1β 和 TNF-α 水平(IC50s = 5.92, 0.42, 和 1.54 µM,分别)。 | |||
T71303 |
Flufenamic Acid-d4
|
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Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear... | |||
T35406 |
α-MSH TFA
|
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α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube fo... | |||
T23028 |
MRT67307 HCl (1190378-57-4 free base)
MRT67307 HCl |
Others | Others |
MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.<br />SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and oth... | |||
T36486 |
Benpyrine
|
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Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. Benpyrine (5-20 μM; 14 hours; RAW264.7 cells) pretreatment results in a dose-dependent decrease in the phosphorylation of IκBα in RAW264.7 cells (stimulated with 10 ng/mL TNF-α or 1 μg/mL LPS). Benpyrine abo... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T27012 |
Chrysotoxine
Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-,4-[2-(3,4-Dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol,鼓槌石斛素 |
NF-κB | NF-κB |
Chrysotoxine (Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-) 通过 NF-κB 调节和线粒体保护抑制 SH-SY5Y 细胞中 6-羟基多巴胺诱导的细胞凋亡。 | |||
T3816 |
Velutin
|
NF-κB; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; NF-κB |
Velutin 是一种苷元,提取自槲寄生中,能够抑制黑色素生物合成。它利用 NF-κB 途径减少破骨细胞分化和下调 HIF-1α。 | |||
T4S2063 |
Tetrahydrocoptisine
人血草碱,STYLOPINE |
ERK; p38 MAPK; NF-κB | MAPK; NF-κB |
Tetrahydrocoptisine (STYLOPINE) 具有抑制炎症的有效作用。它通过抑制 NF-κB 信号通路对 LPS 诱导的 ALI 具有保护作用,这可能涉及抑制肺部炎症过程。它具有胃保护活性,归因于减少 NO 产生和调节促炎细胞因子,抑制中性粒细胞积累和 NF-κB 表达。它是一种活性抗炎成分,通过下调 NF-κB 活化、磷酸化 ERK1/2 和磷酸化-p38MAPK 信号通路抑制 TNF-α、IL-6 和 NO 的产生。 | |||
T7030 |
anemarsaponin B
知母皂苷B,知母皂苷 B |
p38 MAPK; NF-κB; MEK; COX; NO Synthase | Immunology/Inflammation; MAPK; Neuroscience; NF-κB |
Anemarsaponin B 是一种甾体皂苷,可降低iNOS 和COX-2的蛋白和 mRNA 水平,减少促炎细胞因子的表达和产生。它通过阻断 IκBα 的磷酸化来抑制NF-κB 的 p65 亚基的核转位,还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 的磷酸化。 | |||
T6S1917 |
Schisandrol B
Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B |
P450; Reactive Oxygen Species; Autophagy | Autophagy; Immunology/Inflammation; Metabolism; NF-κB |
Schisandrol B (Besigomsin) 是华中五味子的主要活性成分,具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生,也抑制 P-糖蛋白和CYP3A 的活性。 | |||
T6S1371 |
Isovitexin
Homovitexin,Saponaretin,Apigenin-6-C-Glucoside,异牡荆黄素 |
NF-κB; JNK; Glucosidase | MAPK; Metabolism; NF-κB |
Isovitexin (Apigenin-6-C-Glucoside) 是从亚洲水稻种得到的一种黄酮,具有抗氧化和抗炎活性。它的作用与JNK1/2的抑制剂类似,抑制NF-κB 的活化。 | |||
T6S1699 |
Shogaol
[6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol |
Lipoxygenase; Autophagy | Autophagy; Metabolism |
6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物,具有抗癌、抗炎和抗氧化的多种生物活性。 | |||
T4S1962 |
beta-Asarone
β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin |
NF-κB; JNK | MAPK; NF-κB |
beta-Asarone (Cis-Isoelemicin) 是一种石菖蒲中的主要成分,具有免疫抑制、促进安定、中枢神经系统抑制、降温等功能。它可透过血脑屏障,能够预防帕金森病。 | |||
T2S2264 |
Linalool
Linalol,(±)-Linalool,Phantol,沉香醇 |
Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物,是竞争性NMDA 受体拮抗剂,具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤,具有镇痛、抗菌和抗炎的特性。 | |||
T6S1315 |
Oroxylin A
千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether |
Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy | Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。 | |||
T6S1597 |
Mulberroside A
桑皮苷 A,桑皮苷A |
TNF; Tyrosinase; Interleukin | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Mulberroside A 是桑中的一种主要活性成分,可降低TNF-α、IL-1β和IL-6的表达,抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化 。它抑制蘑菇酪氨酸酶,具有抗炎和抗细胞凋亡作用。 | |||
T26545 |
Acanthoic acid
NP1302,NP 1302: NP-1302 |
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Acanthoic acid is a pimaradiene diterpene isolated from Acanthopanax koreanum with anti-inflammatory activities. Acanthoic acid downregulates LPS-induced IL-1β, IL-6 and TNF-α production in BALF, attenuates lung histopathologic changes, and inhibits infla |