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Search Results for " ltb4 "

61

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10917	LTB4-IN-1 Anti-inflammatory agent 2	LTR	Immunology/Inflammation
	LTB4-IN-1 (Anti-inflammatory agent 2) 是白三烯 (LTB4) 合成抑制剂，IC50 为 70 nM。
T78678	LTB4 antagonist 3	Leukotriene Receptor	GPCR/G Protein
	LTB4 antagonist 3 (compound 24e)为一种具有抗炎活性的LTB4拮抗剂，其IC50为477 nM。
T78677	LTB4 antagonist 2	Leukotriene Receptor	GPCR/G Protein
	LTB4 antagonist 2为甲酰胺化合物，白三烯B4 (LTB4) 拮抗剂，显示抗炎潜能。该化合物对LTB4受体亲和力高，IC50值为439 nM。
T72625	LTB4 antagonist 1	Leukotriene Receptor	GPCR/G Protein
	LTB4 antagonist 1为甲酰胺化合物，高效拮抗白三烯B4 (LTB4)，IC50值为288 nM，呈现出明显的抗炎活性。
T79389	LTB4-IN-2	FLAP	Immunology/Inflammation
	LTB4-IN-2（Compound 6x）是一种选择性的5-脂氧合酶激活蛋白（FLAP）抑制剂，旨在抑制白三烯B4（LTB4）的形成（IC50：1.15 μM），适用于抗炎研究。
T22946	LY255283 LY 255283	Leukotriene Receptor	GPCR/G Protein
	LY255283 是白三烯 B4 (LTB4) 受体的特异性拮抗剂，抑制人外周血多形核白细胞和由钙离子载体 A23187 激活的单核细胞中 LTB(4) 的产生。
T14045	Leukotriene B4 LTB4,5(S),12(R)-DiHETE	Others	Others
	Leukotriene B4 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
T17191	Bunaprolast U66858	Lipoxygenase; LTR	Immunology/Inflammation; Metabolism
	Bunaprolast (U66858) 是一种新型有效的白三烯 B4 (LTB4) 抑制剂。Bunaprolast 具有氧化降解活性，对脂氧合酶 (lipoxygenase)和 TXB2 释放具有抑制作用。
T15002	CP-105696 Pfizer 105696	LTR	Immunology/Inflammation
	CP-105696 是一种具有强效性和选择性白三烯 B4 (LTB4) 受体拮抗剂，可用于研究异体移植物排斥反应。
T11487	Fiboflapon GSK2190915,AM-803	FLAP	Immunology/Inflammation
	Fiboflapon (GSK2190915) 是一种可口服且具有有效性 5-脂氧合酶激活蛋白 (FLAP) 抑制剂，结合 FLAP 的效价为 2.9 nM，对人血中 LTB4 有抑制作用， IC50 值为 76 nM。
T28974	Ticolubant	Calcium Channel; LTR	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Ticolubant 是一种具有口服活性的白三烯 B4 拮抗剂，对人类中性粒细胞 LTB4 受体具有很高的亲和力（Ki = 0.78 nM），能阻断 LTB4 诱导的 Ca2+ 迁移，IC50 为 6.6±1.5 nM，并在小鼠皮肤炎症模型中显示出局部抗炎活性。
T22358	Etalocib LY293111,VML295	Apoptosis; Leukotriene Receptor; LTR	Apoptosis; GPCR/G Protein; Immunology/Inflammation
	Etalocib (LY293111) 是一种具有口服活性的白三烯(LTB4)受体的拮抗剂，抑制 [3H]LTB4结合的 Ki 值为 25 nM。它还可诱导凋亡。它抑制 LTB4诱导的钙动员，lC50值为 20 nM。
T10960L	Darbufelone mesylate CI-1004 mesylate	Prostaglandin Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	Darbufelone mesylate (CI-1004 mesylate) 对细胞中 PGF2α 和 LTB4 产生有抑制作用。Darbufelone mesylate 对 PGHS-2 有抑制作用，IC50 值为 0.19 μM，对 PGHS-1 的IC50 值为 20 μM。
T9878	Croconazole	Lipoxygenase; LTR	Immunology/Inflammation; Metabolism
	Croconazole 对中性粒细胞的 5-脂氧合酶 (5-LOX) 表现出剂量依赖性抑制活性。Croconazole 是一种抗真菌剂。Croconazole 对合成白三烯 B4 (LTB4) 和 5-羟基二十碳四烯酸 (5-HETE) 的 IC50 分别为 7.8 ± 1.7 和 7.6 ± 0.3 μM。
T68155	Tebufelone	Prostaglandin Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	Tebufelone 是一种体外高效的CO 抑制剂，是一种新型的非甾体抗炎药（NSAID），属于二叔丁基苯酚（DTBP）类，在各种动物模型中显示出强大的抗炎、镇痛和抗网膜炎特性。Tebufelone 能有效地抑制前列腺素（PGE2）的形成，阻止大鼠巨噬细胞（IC50 = 20 microM）和人类全血（IC50 = 22 microM）中脂氧酶途径的产物[白三烯（LTB4）]的体外形成。
T10960	Darbufelone 达布非酮,CI-1004	Prostaglandin Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	Darbufelone (CI-1004) 是 PGF2α 和 LTB4 的非竞争性双重抑制剂。 Dabfilon 有效抑制 PGHS-2，对 PGHS-2 和 PGHS-1 的 Ki 为 10 μM，IC50 为 0.19 μM 和 20 μM。
T11699	J-113863	CCR	Immunology/Inflammation; Microbiology/Virology
	J-113863 是选择性的 CCR1 (CD18)拮抗剂，有抗炎作用，对人和小鼠 CCR1受体的 IC50值分别为 0.9 和 5.8 nM。它是人 CCR3的强效拮抗剂，还是小鼠 CCR3的弱效拮抗剂，IC50分别为 0.58 和 460 nM。
T16395	ONO4057 ONO-LB457	Leukotriene Receptor	GPCR/G Protein
	ONO4057 是一种具有有效性和口服活性的 Leukotriene B4 受体拮抗剂，其 IC50 值为 0.7±0.3 μM。 ONO4057 对大鼠同种异体移植的免疫抑制作用。
T15801	LY210073	Others	Others
	LY210073 is an antagonist of the Leukotriene B4 (LTB4) receptor (IC50: 6.2 nM).
T10208	A-69412 N-1-(Fur-3-ylethyl)-N-hydroxyurea	Lipoxygenase	Metabolism
	A-69412 (N-1-(Fur-3-ylethyl)-N-hydroxyurea) 是一种特异性的 5-脂氧合酶 (5-LO) 的可逆抑制剂。 A-69412 能用于哮喘和溃疡性结肠炎，以及其他炎症和过敏症状的研究。
T15803	LY223982 SKF107324,CGS23131	Others	Others
	LY223982 is an effective and specific inhibitor of the leukotriene B4 receptor (IC50: 13.2 nM). It also can against [3H]LTB4 binding to LTB4 receptor.
T38087	20-hydroxy Leukotriene B4 20-hydroxy Leukotriene B4
	20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2...
T11487L	Fiboflapon sodium GSK2190915 sodium salt,AM-803 sodium	LTR	Immunology/Inflammation
	Fiboflapon sodium (GSK2190915) is an orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition of LTB4 in human blood.
T1544	Olsalazine disodium Dipentum,奥沙拉秦钠,Olsalazine Sodium	Others; COX; Antibacterial; Antibiotic	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Others
	Olsalazine disodium (Dipentum) 是抗炎化合物，可作用于溃疡性结肠炎和炎症性肠病。
T10543	BIIL-260 hydrochloride	Others	Others
	BIIL-260 hydrochloride is a potent and long-acting orally active antagonist of leukotriene B4 (LTB4) receptor with anti-inflammatory activity. It has a high affinity to the LTB4 receptor on isolated human neutrophil cell membranes (Ki: 1.7 nM).
T14210	Amelubant BIIL 284	LTR	Immunology/Inflammation
	Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM
T34555	SC 45694 SC45694,SC-45694
	SC 45694 is a leukotriene B4 (LTB4) analog.
T37619	Leukotriene B4 Ethanolamide
	The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT2 is more enigmatic, in that LTB4 is not a high-affinity ligand, nor is it clear that BLT2 activation promotes inflammation. LTB4 ethanolamide (LTB4-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB4...
T37260	14,15-dehydro Leukotriene B4 14,15-dehydro Leukotriene B4
	Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value ...
T22526	BML-111 5(S),6(R)-7-trihydroxymethyl Heptanoate	Others	Others
	inhibits leukotriene B4 (LTB4)-induced polymorphonuclear neutrophils (PMN) chemotaxis
T73793	20-Carboxy-Leukotriene B4
	20-Carboxy-Leukotriene B4 (20-COOH LTB4) 是 Leukotriene B4 (LTB4) 的代谢物。20-Carboxy-Leukotriene B4 以高亲和力与 BLT1 受体结合。20-Carboxy-Leukotriene B4 抑制 LTB4 介导的中性粒细胞反应，迁移、脱粒、白三烯生物合成。
T37256	12-oxo Leukotriene B4 12-oxo Leukotriene B4
	Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give ...
T37970	12-epi Leukotriene B4 12-epi Leukotriene B4
	Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic pr...
T38157	Ricinelaidic Acid
	Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes). It inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neutrophils (IC50s = 10 and 7 μM, respectively). Ricinelaidic acid (1 mg/kg, i.v.) inhibits bronchoconstriction induced by LTB4 in rats by 46%.
T15182	DW-1350	LTR	Immunology/Inflammation
	DW-1350 is an antagonist of LTB4 receptor.
T37618	Leukotriene B4 dimethyl amide Leukotriene B4 dimethyl amide
	LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on guinea pig lung membranes.
T70799	SC-50605
	SC-50605 is a second-generation LTB4 receptor antagonist.
T71499	NZ-107
	NZ-107 is an LTB4, LTC4 and LTD4 antagonist.
T28602	RO5101576 RO-5101576,RO 5101576
	RO5101576 is a potent antagonist of LTB4 receptor.
T37617	Leukotriene B3
	LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. LTB3 and LTB4 are equipotent in their pro-inflammatory effects. However, LTB3 is five times less potent than LTB4 in eliciting chemotaxis of human neutrophils.
T71283	JNJ-40929837
	JNJ-40929837 is an oral inhibitor of LTA4 hydrolase, which catalyzes LTB4 production.
T70563	KC-11404
	KC-11404 is an LTB4 inhibitor for the treatment of b-cell leukemias and lymphomas, potently inhibiting histamine, platelet activating factor and 5-lipoxygenase.
T23895	WF 11605 WF11605,WF-11605
	WF 11605 is an antagonist of leukotriene B4 produced by a fungus and is a specific antagonist of LTB4.
T15825	LY 178002	Retinoid Receptor	Metabolism
	LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of LTB4 by human polymorphonuclear leukocytes and displays relatively weak inhibition on cycloox
T37460	Lipoxin B4 Lipoxin B4
	Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.
T37156	8(S),15(S)-DiHETE
	8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO. It causes eosinophil chemotaxis with an ED50 value of 1.5 μM but is not chemotactic for neutrophils. 8(S),15(S)-DiHETE antagonizes the hyperalgesic activity of 8(R),15(S)-DiHETE and LTB4 in the rat hind paw pain model.
T24970	1'-Ethylascorbigen
	1'-Ethylascorbigen releases ascorbic acid in acidic solution results in an increase in the cells' ability to produce PGE2 & LTB4. It has been shown to inhibit the growth of experimental murine tumors.
T71053	AHR-5333 mandelate
	AHR-5333 mandelate is an anti-allergy compound which has been shown to protect against antigen-induced anaphylactic collapse and ascaris antigen-induced skin hypersensitivity. AHR-5333 mandelate has also been shown to inhibit 5-HETE, LTB4 and LTC4 synthesis.
T38308	Lipoxin B4 methyl ester
	Lipoxin B4 (LXB4) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB4 . LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.
T37650	5(S),15(S)-DiHETE
	5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 μM.

化合物

Cat.No: T10917

Synonym: Anti-inflammatory agent 2

Target: LTR

LTB4 antagonist 3

Cat.No: T78678

Target: Leukotriene Receptor

LTB4 antagonist 2

Cat.No: T78677

Target: Leukotriene Receptor

LTB4 antagonist 1

Cat.No: T72625

Target: Leukotriene Receptor

Cat.No: T79389

Target: FLAP

Cat.No: T22946

Synonym: LY 255283

Target: Leukotriene Receptor

Cat.No: T14045

Synonym: LTB4,5(S),12(R)-DiHETE

Target: Others

Cat.No: T17191

Synonym: U66858

Target: Lipoxygenase, LTR

Cat.No: T15002

Synonym: Pfizer 105696

Target: LTR

Cat.No: T11487

Synonym: GSK2190915,AM-803

Target: FLAP

Cat.No: T28974

Target: Calcium Channel, LTR

Cat.No: T22358

Synonym: LY293111,VML295

Target: Apoptosis, Leukotriene Receptor, LTR

Darbufelone mesylate

Cat.No: T10960L

Synonym: CI-1004 mesylate

Target: Prostaglandin Receptor, LTR

Cat.No: T9878

Target: Lipoxygenase, LTR

Cat.No: T68155

Target: Prostaglandin Receptor, LTR

Cat.No: T10960

Synonym: 达布非酮,CI-1004

Target: Prostaglandin Receptor, LTR

Cat.No: T11699

Target: CCR

Cat.No: T16395

Synonym: ONO-LB457

Target: Leukotriene Receptor

Cat.No: T15801

Target: Others

Cat.No: T10208

Synonym: N-1-(Fur-3-ylethyl)-N-hydroxyurea

Target: Lipoxygenase

Cat.No: T15803

Synonym: SKF107324,CGS23131

Target: Others

20-hydroxy Leukotriene B4

Cat.No: T38087

Synonym: 20-hydroxy Leukotriene B4

Fiboflapon sodium

Cat.No: T11487L

Synonym: GSK2190915 sodium salt,AM-803 sodium

Target: LTR

Olsalazine disodium

Cat.No: T1544

Synonym: Dipentum,奥沙拉秦钠,Olsalazine Sodium

Target: Others, COX, Antibacterial, Antibiotic

BIIL-260 hydrochloride

Cat.No: T10543

Target: Others

Cat.No: T14210

Synonym: BIIL 284

Target: LTR

Cat.No: T34555

Synonym: SC45694,SC-45694

Leukotriene B4 Ethanolamide

Cat.No: T37619

14,15-dehydro Leukotriene B4

Cat.No: T37260

Synonym: 14,15-dehydro Leukotriene B4

Cat.No: T22526

Synonym: 5(S),6(R)-7-trihydroxymethyl Heptanoate

Target: Others

20-Carboxy-Leukotriene B4

Cat.No: T73793

12-oxo Leukotriene B4

Cat.No: T37256

Synonym: 12-oxo Leukotriene B4

12-epi Leukotriene B4

Cat.No: T37970

Synonym: 12-epi Leukotriene B4

Ricinelaidic Acid

Cat.No: T38157

Cat.No: T15182

Target: LTR

Leukotriene B4 dimethyl amide

Cat.No: T37618

Synonym: Leukotriene B4 dimethyl amide

Cat.No: T70799

Cat.No: T71499

Cat.No: T28602

Synonym: RO-5101576,RO 5101576

Cat.No: T37617

Cat.No: T71283

Cat.No: T70563

Cat.No: T23895

Synonym: WF11605,WF-11605

Cat.No: T15825

Target: Retinoid Receptor

Cat.No: T37460

Synonym: Lipoxin B4

8(S),15(S)-DiHETE

Cat.No: T37156

1'-Ethylascorbigen

Cat.No: T24970

AHR-5333 mandelate

Cat.No: T71053

Lipoxin B4 methyl ester

Cat.No: T38308

5(S),15(S)-DiHETE

Cat.No: T37650

Cat. No.	Product Name	Target	Signaling Pathways
T21504	γ-Linolenic Acid methyl ester Methyl gamma-linolenate,γ-亚麻酸甲酯	LTR	Immunology/Inflammation
	γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) 是一种弱白三烯 B4 (LTB4) 受体拮抗剂。
T7786	Tryptanthrin	DNA gyrase	DNA Damage/DNA Repair
	Tryptanthrin 是一种口服具有活性的细胞内Leukotriene (LT) biosynthesis 抑制剂。它能够降低大鼠胸膜炎模型中的 LTB4 水平，并抑制人全血中Leukotriene 的形成 (IC50= 10 µM)。
T3868	Agnuside 牡荆油,穗花牡荆苷,chasteberry oil	COX; Prostaglandin Receptor; P-gp	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Agnuside (chasteberry oil) 是从黄荆中分离得到的一种天然产物，可下调炎性介质PGE2和LTB4，减少细胞因子的表达，具有抗关节炎活性。
T13661	Docosatrienoic Acid cis-13,16,19-docosatrienoic acid,(13Z,16Z,19Z)-13,16,19-Docosatrienoic acid	Others	Others
	Docosatrienoic acid is a rare omega-3 fatty acid; Ki value is 5×M, which inhibits the binding of LTB4 to porcine neutrophil membrane.
T4114	Diffractaic Acid NSC 5901,地弗地衣酸,NSC 685595	Apoptosis; LTR	Apoptosis; Immunology/Inflammation
	Diffractaic Acid (NSC 685595) 是松萝的主要成分，具有止痛和解热效果，在各种疾病研究中可作为有效的促凋亡剂。
TN5164	trans-Hinokiresinol	IL Receptor; TNF; NOS; LTR	Apoptosis; Immunology/Inflammation
	Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyasol (cis-hinokiresinol) are estrogen

天然产物

γ-Linolenic Acid methyl ester

Cat.No: T21504

Synonym: Methyl gamma-linolenate,γ-亚麻酸甲酯

Target: LTR

Cat.No: T7786

Target: DNA gyrase

Cat.No: T3868

Synonym: 牡荆油,穗花牡荆苷,chasteberry oil

Target: COX, Prostaglandin Receptor, P-gp

Docosatrienoic Acid

Cat.No: T13661

Synonym: cis-13,16,19-docosatrienoic acid,(13Z,16Z,19Z)-13,16,19-Docosatrienoic acid

Target: Others

Diffractaic Acid

Cat.No: T4114

Synonym: NSC 5901,地弗地衣酸,NSC 685595

Target: Apoptosis, LTR

trans-Hinokiresinol

Cat.No: TN5164

Target: IL Receptor, TNF, NOS, LTR

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