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54

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36841	IPI-9119	Fatty Acid Synthase	Metabolism
	IPI-9119 是一种具有口服活性、选择性和不可逆的 FASN 抑制剂 (IC50 = 0.3 nM)。
T2430	HPOB	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	HPOB 是一种高选择性HDAC6抑制剂，IC50为 56 nM，其选择性是其他 HDAC 的 30 倍以上。它提高 DNA 损伤抗癌药物在转化细胞中的有效性。
T6400	AZD3514	Androgen Receptor	Endocrinology/Hormones
	AZD3514 是一种口服雄激素受体下调剂(Ki :2.2 μM)，能够减少 AR 蛋白表达。
T6002	Enzalutamide MDV3100,恩杂鲁胺	Androgen Receptor; Autophagy	Autophagy; Endocrinology/Hormones
	Enzalutamide (MDV3100) 是一种雄激素受体 (AR) 拮抗剂 (IC50=36 nM in LNCaP)。Enzalutamide 可以激活自噬，具有抗肿瘤活性，常用于去势抵抗性前列腺癌的治疗。
T21740	RD162	Androgen Receptor	Endocrinology/Hormones
	RD162 是一种与雄激素受体 (AR) 特异性结合的非甾体抗雄激素 (NSAA)。
T12928	SK33	Androgen Receptor	Endocrinology/Hormones
	SK33 是一种有效的组织选择性抗雄激素药物，是一种肌醇类似物，能够降低雄激素受体 (AR) 的转录活性。
T4697	ABBV-744 ABBV744	Epigenetic Reader Domain; HIV Protease	Chromatin/Epigenetic; Microbiology/Virology; Proteases/Proteasome
	ABBV-744 是一种 BDII 选择性 BET 溴结构域抑制剂，可抑制 BRD2/3/4。它可研究炎症性疾病、癌症和艾滋病。
T9246	JNJ-63576253	Androgen Receptor	Endocrinology/Hormones
	JNJ63576253 是具有口服活性的、有效的雄激素受体的完全拮抗剂，在 LNCaP 细胞中对 F877L 突变型 AR 和野生型 AR 的IC50值分别为 37 和 54 nM。它可用于研究去势抵抗性前列腺癌。
T1267	Abacavir Epzicom,Ziagen,阿巴卡韦,Abacavir sulfate	Apoptosis; HIV Protease; Reverse Transcriptase	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Abacavir (Ziagen) 是一种核苷类似物逆转录酶抑制剂。
T10359	AR antagonist 1	Androgen Receptor; Ligand for E3 Ligase; Ligands for Target Protein for PROTAC	Endocrinology/Hormones; PROTAC
	AR antagonist 1 是 AR 拮抗剂，能够与 E3 连接酶配体结合，与 VHL 蛋白结合亲和力较弱，用于 PROTACARD-266 合成。
T8933	JNJ-63576253 free base TRC253,JNJ-63576253	Androgen Receptor	Endocrinology/Hormones
	JNJ-63576253 free base (TRC253) 是具有口服活性的、有效的雄激素受体的完全拮抗剂，在 LNCaP 细胞中对 F877L 突变型 AR 和野生型 AR 的 IC50值分别为 37 和 54 nM。它可用于研究去势抵抗性前列腺癌 (CRPC) 。
T60019	VPC-70063 Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-	Apoptosis; PARP; c-Myc	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair
	VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) 是 c-Myc-MAX 的抑制剂。 VPC-70063 的 Myc-Max 转录活性抑制率为 106%，IC50 为 8.9 μM，Myc-Max/UBE2C 下游通路抑制率为 94%。 VPC-70063 可用于抗癌研究。
T9179	CLP-3094 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE	Androgen Receptor	Endocrinology/Hormones
	CLP-3094 (2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE) 是一种雄激素受体 BF3(binding function 3) 抑制剂，是一种选择性GPR142拮抗剂。BF3-IN-1 抑制 AR 转录活性 (IC50:4 μM)。
T6367	Abacavir sulfate Abacavir Hemisulfate,硫酸阿巴卡韦,1592U89,ABC sulfate,Ziagen	Apoptosis; HIV Protease; Reverse Transcriptase	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Abacavir sulfate (Ziagen) 是一种核苷类似物逆转录酶抑制剂，可用于 HIV 和 AIDS。
T6909	NSC348884 N1,N1,N2,N2-四[(6-甲基-1H-苯并咪唑-2-基)甲基]-1,2-乙二胺	Apoptosis; p53	Apoptosis
	NSC348884 是一种核磷蛋白抑制剂，可破坏寡聚体形成并诱导细胞凋亡，在不同的癌细胞系中以 IC50 为 1.7-4.0 μM 抑制细胞增殖。
T67705	mTOR inhibitor 9a
	mTOR inhibitor 9a 对人LNCap 细胞的生长具有抑制作用，ic50为80nm。mTOR inhibitor 9a 可能具有抗肿瘤活性。
T29110	VPC-13163 2,3-dihydro-2,3'-Bi-1H-indole,VPC13163,NSC52361,NSC 52361,VPC 13163	Others	Others
	VPC-13163 (NSC-52361) 对 LNCaP 和耐恩杂鲁胺的前列腺癌细胞系 (MR49F) 具有很强的抗增殖活性，而它不影响 AR 独立 PC3 细胞系的生长。它还抑制 LNCaP 和 MR49F 中的前列腺特异性抗原 (PSA) 并降低 AR 靶基因 PSA 和 TMPRSS2 的表达。这些发现表明 VPC-13566 表现出 AR BF3 特定的作用机制。
T39695	ARD-2128	Androgen Receptor	Endocrinology/Hormones
	ARD-2128 是高效的雄激素受体降解剂 PROTAC。它可有效降低雄激素受体蛋白并抑制肿瘤组织中雄激素受体调节的基因，在没有毒性迹象的情况下抑制肿瘤生长。它有用于前列腺癌研究的价值。
T63324	Androgen receptor antagonist 5
	Androgen receptor antagonist 5 是雄激素受体 (AR) 的有效拮抗剂 (IC50: 6.17 μM)。Androgen receptor antagonist 5 能够有效损害 AR 核转位，减少细胞核 AR 水平，扰乱 AR 介导的基因调控。Androgen receptor antagonist 5 对前列腺癌细胞 LNCaP 的增殖具有抑制作用，并在 LNCaP 异种移植小鼠模型中显示出抗肿瘤效果，能够用于研究前列腺癌症。
T24407	LG190119 LG-190119,LG 190119
	LG190119 is a nonsecosteroidal vitamin D receptor modulator. It effectively inhibited LNCaP xenograft tumor growth without increased serum calcium levels or any other apparent side effects. It also inhibits the growth of LNCaP xenograft tumors in athymic
T26323	VPC-3033
	VPC-3033 is an antagonist of the androgen receptor. It acts by inhibiting the LNCaP cell line as well as cell lines with the wild-type androgen receptor.
T60942	MC2652
	MC2652 (compound 1a) 是 LSD1的有效抑制剂，在白血病细胞 MV4-11 和 NB4 中表现出高抑制作用。MC2652 对前列腺癌的 LNCaP 细胞表现出抗增殖活性。
T10320	Androgen receptor antagonist 1	Others	Others
	Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50: 59 nM). It can be used in the synthesis of PROTAC AR degraders, which results in 24% and 47 % AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively.
T63109	Y08284
	Y08284 是一种选择性的、高效的、口服具有活力的 CBP bromodomain 抑制剂 (IC50: 4.21 nM)。Y08284 能够抑制前列腺癌细胞系 LNCaP、C4-2B 和 22Rv1 的增殖，并具有抗肿瘤效果。
T78810	BWA-522	Androgen Receptor	Endocrinology/Hormones
	BWA-522是一种口服有效的小分子PROTACs，针对AR-FL和AR-V7显示出显著的降解活性。该化合物通过对Androgen Receptor的AR-NTD进行拮抗，诱发PC细胞的apoptosis。在LNCaP异种移植模型中，BWA-522以每日60 mg/kg的剂量口服给药，实现了76%的肿瘤生长抑制(TGI=76%)。在VCaP和LNCaP细胞系中对AR-V7和AR-FL的降解效率分别达到77.3%(1 μM)和72.0%(5 μM)。
T67702	mTOR inhibitor 9d	PI3K; mTOR	PI3K/Akt/mTOR signaling
	mTOR inhibitor 9d 是一种蛋白激酶 mTOR 和PI3K 双重抑制剂，对mTOR 的IC50值为0.31nm，可用于治疗白血病、皮肤癌、乳腺癌、肺癌和结肠癌。
T83007	Antitumor agent-120
	Antitumor agent-120 (compound 1) 为一类黄酮化合物，来源于葛根提取。本化合物对LNCaP和PC3癌细胞的抑制作用不明显，表现出IC50s均大于50 μM。
T11208	Enzalutamide-d3 MDV3100 D3	Others	Others
	Enzalutamide D3 is a deuterium labeled Enzalutamide . Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells.
T70962	MHY219
	MHY219 is a novel HDAC inhibitor. MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells. MHY219 was shown to enhance the cytotoxicity on DU145 cells (IC50, 0.36 μM) when compared with LNCaP (IC50, 0.97 μM) and PC3 cells (IC50, 5.12 μM). MHY219 showed a potent inhibition of total HDAC activity when compared with SAHA. MHY219 increased histone H3 hyperacetylation and reduced the expression of class I HDACs (1, 2 and 3) in prostate cancer cells. M...
T9660	Bexlosteride
	Bexlosteride (LY300502) 是一种苯并喹啉酮类人 I 型 5α-还原酶抑制剂。Bexlosteride 在 LNCaP 细胞培养物中显示出代谢抑制、抗增殖和抗分泌作用。Bexlosteride 可用于前列腺癌的研究。
T78989	BET-IN-16	Epigenetic Reader Domain	Chromatin/Epigenetic
	BET-IN-16 (Comp I) 是一种BET抑制剂，展现出抗癌活性。BET-IN-16抑制前列腺癌细胞的生长，其对LNCaP和22Rv1细胞的IC50值分别为0.043 μM和0.034 μM。
T83853	L-K6L9 TFA
	L-K6L9 是由 L-亮氨酸和 L-赖氨酸的L-异构体组成的溶细胞肽。对LNCaP-CL1 雄激素独立型和22Rv1以及LNCaP雄激素依赖型人类前列腺癌细胞具有细胞毒性（LC50分别为4、4和6 µM），同时也对非癌性NIH3T3小鼠成纤维细胞和OL人类包皮成纤维细胞具有细胞毒性（LC50分别为7和5 µM）。在100 µM的浓度下，引起分离的人类红细胞溶血。
T13552	ARD-266	Others	Others
	ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces the degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines (DC50s: 0.2-1 nM).
T61021	LSD1-IN-16
	LSD1-IN-16 (compound 4b) 是 LSD1的有效抑制剂，可抑制 LSD1-CoREST、MAO-A 和 MAO-B，IC50值分别为 0.015、0.024 和 0.366 μM。LSD1-IN-16 在前列腺癌 LNCaP 细胞中表现出细胞生长阻滞，IC50值为 15.2 μM。
T61653	VPC-13789
	VPC-13789 is a highly potent, selective, and orally bioavailable antiandrogen compound that shows promise for studying and developing therapeutics for castration-resistant prostate cancer (CRPC). In LNCaP cells, VPC-13789 effectively inhibits the transcriptional activity of the androgen receptor (AR) with an IC50 value of 0.19 μM [1].
T63200	NTQ1062
	NTQ1062 (compound 22b) 是口服具有活力的、有效的Akt 抑制剂，能够作用于 Akt1 (IC50: 0.4 nM)、Akt2 (IC50: 6.3 nM) 和 Akt3 (IC50: 0.1 nM)。NTQ1062 对多种癌细胞表现出抗增殖作用，能够将细胞周期阻滞在 G0/G1 期，诱导细胞凋亡 (apoptosis)。NTQ1062 在 LNCap 异种移植瘤小鼠模型中显示出显著的的抗肿瘤效果。
T17689	Boc-Pip-alkyne-Ph-COOH	Others	Others
	Boc-Pip-alkyne-Ph-COOH, a PROTAC linker characterized by its alkyl/ether composition, plays a crucial role in synthesizing PROTACs including ARD-266. This compound demonstrates significant efficacy in promoting the degradation of androgen receptor (AR) protein across AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1, showcasing DC50 values ranging from 0.2-1 nM[1].
T78922	ARD-2051	PROTACs	PROTAC
	ARD-2051是一种具有口服活性的高效雄激素受体(AR)蛋白水解靶向嵌合体降解剂。在LNCaP和VCaP前列腺癌细胞系中，ARD-2051实现AR蛋白降解的DC50值仅为0.6 nM，适用于前列腺癌研究。
T78945	WCA-814	Androgen Receptor	Endocrinology/Hormones
	WCA-814是雄激素受体(AR)拮抗剂与Hsp90抑制剂的融合化合物，能够诱导全长AR及AR-V7降解，并展现出对前列腺癌细胞的细胞毒性(IC50: LNCaP细胞为171.2 nM，22Rv1细胞为26.5 nM)。
T61022	LSD1-IN-17
	LSD1-IN-17 (compound 5b) 是 LSD1的有效抑制剂，可抑制LSD1-CoREST、MAO-A 和MAO-B，IC50值分别为 0.005、0.028 和 0.820 μM。LSD1-IN-17 在前列腺癌 LNCaP 细胞中表现出细胞生长阻滞，IC50值为 17.2 μM。
T60941	LSD1-IN-15
	LSD1-IN-15 (compound 1b) 是一种有效的 LSD1抑制剂，可抑制 LSD1-CoREST、MAO-A 和 MAO-B，IC50值分别为 0.149、0.028 和 0.327 μM。LSD1-IN-15 显示前列腺癌 LNCaP 细胞中的细胞生长停滞，IC50值为 9.9 μM。
T24411	Y08060 Y 08060,Y-08060
	Y08060 is an effective and selective BET Inhibitor for the Treatment of Prostate Cancer. Y08060 effectively suppresses cell growth, colony formation, and expression of androgen receptor (AR), AR regulated genes, and MYC in prostate cancer cell lines. Y08060 has IC50 values of 3.23 and 4.41 μM in inhibition of cell viability in the C4 2B and LNCaP cell lines, respectively.
T13958	VHL Ligand 8	Others	Others
	VHL Ligand 8 是一种 von Hippel-Lindau (VHL) 蛋白配体，可用于合成 ARD-266 。ARD-266 是一种基于 VHL E3 连接酶的高效雄激素受体 (AR) PROTAC 降解剂。ARD-266 在 AR 阳性 LNCaP，VCaP 和 22Rv1 前列腺癌细胞系中有效诱导 AR 蛋白降解，DC50值为 0.2-1 nM。
T79674	HDAC-IN-64	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-64 (Compound 13) 为HDAC抑制剂，对HDAC4/6的IC50值为24 nM及85 nM。其对前列腺癌（PCA）细胞表现出抗增殖与抗迁移效果，并能抑制LNCaP和RWPE-1细胞的生长，GI50值分别达到0.32 μM与1.1 μM。
T69438	MT477
	MT477 is PKC-α inhibitor. MT477 interfered with PKC activity as well as phosphorylation of Ras and ERK1/2 in H226 human lung carcinoma cells. It also induced poly-caspase-dependent apoptosis. MT477 had a dose-dependent (0.006 to 0.2 mM) inhibitory effect on cellular proliferation of H226, MCF-7, U87, LNCaP, A431 and A549 cancer cell lines as determined by in vitro proliferation assays.
T38107	JJH260 JJH260
	JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM. JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2. JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysa...
T35668	Neoaureothin
	Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50 = 13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s = 34.3, 47, and 37.2 μg/ml, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50 = 0.84 μg/ml) and...
T69758	Flutamide-d7
	Flutamide-d7 is intended for use as an internal standard for the quantification of flutamide by GC- or LC-MS. Flutamide is an androgen receptor antagonist and prodrug form of 2-hydroxy flutamide. Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. It is cytotoxic to PC3 and LNCaP prostate cancer cells with IC50 values of 98.8 and 81.8 µM, respectively. Flutamide (50 mg/kg per day) reduces tumor growth in a PC-82 mouse xenograft mo...
T35437	(-)-Viriditoxin
	(-)-Viriditoxin is a mycotoxin originally isolated from A. viridinutans that has antibacterial and antiproliferative activity. It is active against methicillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), tetracycline-sensitive and -resistant Staphylococcus, vancomycin-sensitive and -resistant Enterococcus, and penicillin-sensitive and -resistant S. pneumoniae (MICs = 2-32 μg/ml). (-)-Viriditoxin is also active against fish pathogens, including S. iniae and S. parauberis (MI...
T69618	XR3054
	XR3054 is a novel inhibitor of farnesyl protein transferase (FPTase). XR3054 inhibited the proliferation of the prostatic cancer cell lines LnCAP and PC3 and the colon carcinoma SW480 and HT1080 (IC50 values of 12.4, 12.2, 21.4 and 8.8 microM, respectively) but was relatively inactive when tested against a panel of breast carcinoma cell lines. The activity did not relate to the presence of mutant or wild-type ras in the cell lines tested. In conclusion XR3054 inhibits ras farnesylation, MAP kina...

化合物

Cat.No: T36841

Target: Fatty Acid Synthase

Cat.No: T2430

Target: Apoptosis, HDAC

Cat.No: T6400

Target: Androgen Receptor

Cat.No: T6002

Synonym: MDV3100,恩杂鲁胺

Target: Androgen Receptor, Autophagy

Cat.No: T21740

Target: Androgen Receptor

Cat.No: T12928

Target: Androgen Receptor

Cat.No: T4697

Synonym: ABBV744

Target: Epigenetic Reader Domain, HIV Protease

Cat.No: T9246

Target: Androgen Receptor

Cat.No: T1267

Synonym: Epzicom,Ziagen,阿巴卡韦,Abacavir sulfate

Target: Apoptosis, HIV Protease, Reverse Transcriptase

AR antagonist 1

Cat.No: T10359

Target: Androgen Receptor, Ligand for E3 Ligase, Ligands for Target Protein for PROTAC

JNJ-63576253 free base

Cat.No: T8933

Synonym: TRC253,JNJ-63576253

Target: Androgen Receptor

Cat.No: T60019

Synonym: Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-

Target: Apoptosis, PARP, c-Myc

Cat.No: T9179

Synonym: 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE

Target: Androgen Receptor

Abacavir sulfate

Cat.No: T6367

Synonym: Abacavir Hemisulfate,硫酸阿巴卡韦,1592U89,ABC sulfate,Ziagen

Target: Apoptosis, HIV Protease, Reverse Transcriptase

Cat.No: T6909

Synonym: N1,N1,N2,N2-四[(6-甲基-1H-苯并咪唑-2-基)甲基]-1,2-乙二胺

Target: Apoptosis, p53

mTOR inhibitor 9a

Cat.No: T67705

Cat.No: T29110

Synonym: 2,3-dihydro-2,3'-Bi-1H-indole,VPC13163,NSC52361,NSC 52361,VPC 13163

Target: Others

Cat.No: T39695

Target: Androgen Receptor

Androgen receptor antagonist 5

Cat.No: T63324

Cat.No: T24407

Synonym: LG-190119,LG 190119

Cat.No: T26323

Cat.No: T60942

Androgen receptor antagonist 1

Cat.No: T10320

Target: Others

Cat.No: T63109

Cat.No: T78810

Target: Androgen Receptor

mTOR inhibitor 9d

Cat.No: T67702

Target: PI3K, mTOR

Antitumor agent-120

Cat.No: T83007

Enzalutamide-d3

Cat.No: T11208

Synonym: MDV3100 D3

Target: Others

Cat.No: T70962

Cat.No: T9660

Cat.No: T78989

Target: Epigenetic Reader Domain

Cat.No: T83853

Cat.No: T13552

Target: Others

Cat.No: T61021

Cat.No: T61653

Cat.No: T63200

Boc-Pip-alkyne-Ph-COOH

Cat.No: T17689

Target: Others

Cat.No: T78922

Target: PROTACs

Cat.No: T78945

Target: Androgen Receptor

Cat.No: T61022

Cat.No: T60941

Cat.No: T24411

Synonym: Y 08060,Y-08060

Cat.No: T13958

Target: Others

Cat.No: T79674

Target: HDAC

Cat.No: T69438

Cat.No: T38107

Synonym: JJH260

Cat.No: T35668

Cat.No: T69758

(-)-Viriditoxin

Cat.No: T35437

Cat.No: T69618

Cat. No.	Product Name	Target	Signaling Pathways
T41288	Myristoleic acid cis-9-tetradecenoic acid,肉豆蔻酸,9-Tetradecenoic acid,(Z)-Tetradec-9-enoic acid	Apoptosis	Apoptosis
	Myristoleic acid (9-Tetradecenoic acid) 是 Serenoa repens 提取物中的一种细胞毒性成分。Myristoleic acid 诱导人前列腺 LNCaP 细胞凋亡和坏死。
T4601	9-Methoxycanthin-6-one	Others	Others
	9-Methoxycanthin-6-one 是存在于完整植株和不同外植体的愈伤组织中的 Canthin-6-one 生物碱，具有抗肿瘤作用。
T4869	D-Allose 阿洛糖,β-D-Allopyranose,D-(+)-ALLOSE	Others; Endogenous Metabolite	Metabolism; Others
	D-Allose (β-D-Allopyranose) 是内源性代谢产物的一种。
T2795	Amygdalin 苦杏仁苷,Laetrile	Others	Others
	Amygdalin (Laetrile) 是一种植物葡萄糖苷，分离自蔷薇果实的果核中，如杏，桃，杏仁，樱桃和李子。
TN2601	12-O-Methylcarnosic acid	Reductase	Endocrinology/Hormones; Metabolism
	12-O-Methylcarnosic acid 是分离自小叶丹参的丙酮提取物的一种二萜肉桂酸，可抑制 5α-还原酶 (5α-reductase) 活性，IC50为 61.7 μM。它抑制 LNCaP 细胞的增殖。它具有抗微生物活性、抗氧化和抗癌活性。
TN5878	7,2',4'-Trihydroxy-5-methoxy-3-phenylcoumarin
	7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells.
TN3416	Angelol M	Others	Others
	Angelol M shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells.
TMA1841	Dihydrodaidzin	Others	Others
	Dihydrodaidzin shows cytotoxic activities against human stomach carcinoma (Hs 740.T, Hs 756 T), breast adenocarcinoma (Hs 578 T, Hs 742.T), and prostate carcinoma (DU 145, LNCaP-FGC) cell lines.
T36489	Malformin A
	Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 μg/ml, respectively). It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferati...
TMA0918	Neochamaejasmine A	Caspase	Apoptosis; Proteases/Proteasome
	Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating the p21 protein and ultimately pro
TN3310	9,9'-Di-O-(E)-feruloylsecoisolariciresinol	mTOR	PI3K/Akt/mTOR signaling
	1,4-O-Diferuloylsecoisolariciresinol(9,9'-Di-O-(E)-feruloylsecoisolariciresinol),and pierreione B, two novel inhibitors of mTOR signaling, have strong anticancer activity. (+)-9,9'-O-Diferuloylsecoisolariciresinol has significant cytotoxic activity agains
T37452	Stephacidin B
	Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc...
TN5639	Rocaglaol Ferrugin,Aglaiastatin A
	Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis
T38243	Hygrolidin
	Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovan...

天然产物

Myristoleic acid

Cat.No: T41288

Synonym: cis-9-tetradecenoic acid,肉豆蔻酸,9-Tetradecenoic acid,(Z)-Tetradec-9-enoic acid

Target: Apoptosis

9-Methoxycanthin-6-one

Cat.No: T4601

Target: Others

Cat.No: T4869

Synonym: 阿洛糖,β-D-Allopyranose,D-(+)-ALLOSE

Target: Others, Endogenous Metabolite

Cat.No: T2795

Synonym: 苦杏仁苷,Laetrile

Target: Others

12-O-Methylcarnosic acid

Cat.No: TN2601

Target: Reductase

7,2',4'-Trihydroxy-5-methoxy-3-phenylcoumarin

Cat.No: TN5878

Cat.No: TN3416

Target: Others

Cat.No: TMA1841

Target: Others

Cat.No: T36489

Neochamaejasmine A

Cat.No: TMA0918

Target: Caspase

9,9'-Di-O-(E)-feruloylsecoisolariciresinol

Cat.No: TN3310

Target: mTOR

Cat.No: T37452

Cat.No: TN5639

Synonym: Ferrugin,Aglaiastatin A

Cat.No: T38243

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