32
14
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3116 |
Atorvastatin hemicalcium salt
Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,阿托伐他汀钙,Sortis |
Ferroptosis; HMG-CoA Reductase; Autophagy | Apoptosis; Autophagy; Metabolism |
Atorvastatin hemicalcium salt (Atorvastatin Calcium) 是一种口服有效的 HMG-CoA 还原酶抑制剂 ,可用作降低胆固醇的药物。它抑制人 SV-SMC 增殖和侵袭,IC50分别为 0.39 μM 和 2.39 μM。 | |||
T29067 |
Upacicalcet
PLS-240,SK-1403,AJT-240 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Upacicalcet (AJT-240) 是一种静脉内拟钙剂,是一种可用于人血液透析的 SHPT, 通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌,从而降低血液中的 PTH 水平。 3 Upacicalcet 是钙敏感受体的正变构调节剂,可预防大鼠腺嘌呤诱导的继发性甲状旁腺功能亢进模型中的血管钙化和骨骼疾病。 | |||
T69984 |
Ticalopride
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Ticalopride是一种5-HT3 receptor激动剂,可用于治疗消化系统疾病、口颌疾病、耳鼻咽喉疾病,可用于研究神经性贪食症、胃食管反流和肠易激综合征。 | |||
TQ0200 |
Paricalcitol
|
||
Paricalcitol 是一种 vitamin D receptor 激活剂,是一种 vitamin D 类似物,用于研究继发性甲状旁腺功能亢进,该疾病与慢性肾功能衰竭有关。 | |||
T4200 |
Sacubitril hemicalcium salt
AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt |
Neprilysin | Metabolism |
Sacubitril hemicalcium salt (AHU377 calcium salt) 是一种有效的 NEP 抑制剂,IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。 | |||
T29067L |
Upacicalcet HCl
Upacicalcet HCl(1333218-50-0 Free base) |
CaSR | GPCR/G Protein |
Upacicalcet HCl 是一种静脉内拟钙剂,通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌,从而降低血液中的 PTH 水平。Upacicalcet HCl 可用于治疗血液是一种新型继发性甲状旁腺功能亢进化合物,靶向钙敏感受体的氨基酸结合位点。 | |||
T0380 |
Bicalutamide
比卡鲁胺,ICI-176334 |
Androgen Receptor; Autophagy | Autophagy; Endocrinology/Hormones |
Bicalutamide (ICI-176334) 是一种具有口服活性的非甾体雄激素受体拮抗剂,可研究前列腺癌。 | |||
TP2048L |
α-helical CRF 9-41 acetate
肾上腺皮质素释放因子多肽α-helical CRF 9-41乙酸盐,α-helical CRF 9-41 acetate(90880-23-2 Free base) |
CRFR | GPCR/G Protein |
α-helical CRF 9-41 acetate 是 CRF2 的竞争性拮抗剂 (KB = 100 nM) 和 CRF1 的部分激动剂 (EC50 = 140 nM)。 | |||
T62848 |
AMG 837 hemicalcium
|
||
AMG 837 hemicalcium 是一种有效的、口服具有活力的 GPR40/FFA1部分激动剂。AMG 837 hemicalcium 能够抑制 [3H]AMG 837 与人类 FFA1受体的特异性结合 (pIC50: 8.13)。AMG 837 hemicalcium 能够提高啮齿动物的胰岛素分泌,减少葡萄糖水平。 | |||
T82900 |
Bemfivastatin hemicalcium
PPD 10558 hemicalcium |
||
Bemfivastatin (PPD 10558) hemicalcium 作为口服HMG-CoA还原酶抑制剂,具备有效的降脂作用并能增强肝脏提取活性。该化合物的未观察到不良反应水平(NOAEL)在大鼠发育毒性研究中超过320 mg/kg/d,在家兔母体毒性及发育毒性研究中分别超过12.5 mg/kg/d和25 mg/kg/d。Bemfivastatin hemicalcium 适用于对他汀类药物不耐受且患有他汀相关性高胆固醇血症性肌痛的研究。 | |||
T69385 | Baicalein monohydrate | ||
Baicalein monohydrate is an inhibitor of 12-lipoxygenase, leukotriene biosynthesis and release of lysosomal enzymes. It also inhibits cellular Ca2+ uptake and mobilization and adjuvant-induced arthritis. | |||
T72101 |
Atorvastatin hemicalcium trihydrate
阿托伐他汀半钙三水合物,阿托他伐汀半钙三水合物 |
||
Atorvastatin hemicalcium trihydrate 是一种具有口服活性的 HMG-CoA 还原酶抑制剂,具有有效降低血脂的能力。Atorvastatin hemicalcium trihydrate 以 IC50值分别为 0.39 μM 和 2.39 μM 来抑制人 SV-SMC 细胞的增殖和侵袭。 | |||
T75891 |
α-Helical CRF(9-41) TFA
|
||
α-Helical CRF(9-41) TFA 是一种竞争性 CRF2受体拮抗剂,KB 约为 100 nM。α-Helical CRF(9-41) TFA 也是一种 CRF1受体的部分激动剂,EC50为 140 nM。 | |||
TP2048 |
α-Helical CRF(9-41)
α-helical CRF 9-41 |
||
Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively). | |||
T76360 |
a-Helical Corticotropin Releasing Factor (12-41)
|
||
a-Helical Corticotropin Releasing Factor (12-41),一种含有30个氨基酸的α螺旋促肾上腺皮质激素释放因子/激素类似物。作为下丘脑激素的促肾上腺皮质激素释放因子 (CRF) 能促进肾上腺皮质激素 (ACTH) 分泌,而a-Helical Corticotropin Releasing Factor (12-41) 则抑制该刺激效应。 | |||
T79916 |
4-Aminosalicylic acid hemicalcium
|
||
4-Aminosalicylic acid hemicalcium 是一种具有口服活性的抗结核药物,主要用于治疗肺结核。 | |||
T35817 |
Photoswitchable PAD Inhibitor (technical grade)
|
||
Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity.1 Without photoactivation, it is a weak inhibitor of PAD2 (IC50 = >100 μM) and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro (kinact/KIs = 2,300, 600, 1,000, and 10,510 M-1min-1 for PAD1-4, respectively) and does not inhibit histone H3 citrullination in HEK29... | |||
T12283 |
O-Methyl Atorvastatin hemicalcium
|
Others | Others |
O-Methyl Atorvastatin is an impurity of Atorvastatin that is an orally active inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, has the ability to effectively decrease blood lipids. | |||
T62386 |
(R)-Bicalutamide
|
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(R)-Bicalutamide 是一种 Bicalutamide 的 R 型对映体,是一种雄激素受体 (AR) 拮抗剂,表现出抗肿瘤效果。(R)-Bicalutamide 广泛的用于前列腺癌的研究。 | |||
T61232 |
(Rac)-Upacicalcet
|
||
(Rac)-Upacicalcet is a racemate of Upacicalcet, which serves as an intravenous calcimimetic agent. Upacicalcet acts by directly targeting calcium-sensing receptors on parathyroid cell membranes, effectively suppressing the release of excessive parathyroid hormone (PTH) and reducing blood PTH levels. This compound holds the potential for researching secondary hyperparathyroidism (SHPT) [1]. | |||
T12544 |
Proglumide hemicalcium
|
Others | Others |
Proglumide hemicalcium is a antagonist of nonpeptide and orally active cholecystokinin (CCK)-A/B receptors, has antiepileptic and antioxidant activities. | |||
T76204 |
a-Helical Corticotropin Releasing Factor (9-41)
|
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α-Helical Corticotropin Releasing Factor (9-41) 为corticotropin releasing factor (CRF)的拮抗剂,具有降低体内血浆生长激素(GH)水平的功能。 | |||
T36108 |
YW3-56 (hydrochloride) (technical grade)
YW3-56 (hydrochloride) (technical grade) |
||
YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2 1.Wang, Y., Li, P., Wang, S., et al.Anticancer pept... | |||
T39444 | Upacicalcet sodium | ||
Upacicalcet (sodium) is an intravenous calcimimetic agent that acts directly on parathyroid cell membrane calcium-sensing receptors to suppress excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels. It is indicated for the research of secondary hyperparathyroidism (SHPT). | |||
T70899 |
Vidofludimus hemicalcium
4sc-101 hemicalcium,SC12267 hemicalcium,4sc-101 hemicalcium ; SC12267 hemicalcium |
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Vidofludimus (4sc-101 ; SC12267) hemicalcium 是一种口服有效的二氢乳清酸脱氢酶 (DHODH) 的抑制剂,也是法尼醇 X 受体 (FXR) 调节剂。Vidofludimus hemicalcium 作为一种免疫调节剂,可用于研究自身免疫性疾病,如炎症性肠病 (IBD)。Vidofludimus hemicalcium 还可通过靶向FXR 用于脂肪肝的研究。 | |||
T79848 |
Icalcaprant
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Icalcaprant为κ阿片受体拮抗剂。 | |||
T12363 |
Paricalcitol-D6
|
Others | Others |
Paricalcitol-D6 is the deuterated form of Paricalcitol, which is used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. | |||
T82372 |
Free radical scavenger 1
|
||
Free radical scavenger 1 (compound 8) 显示出对DPPH自由基的清除能力,其半数抑制浓度(IC50)为43.39 μg/ml。 | |||
T83665 |
α-Helical CRF (9-41) TFA
α-Helical Corticotropin-Releasing Factor (9-41) |
||
α-Helical CRF (9-41) 是一种合成的皮质酮释放因子(CRF)拮抗剂。它在0.5至5 µM浓度范围内,能抑制CRF诱导的大鼠前叶垂体细胞释放促肾上腺皮质激素(ACTH)。在体内研究中,α-Helical CRF (9-41) (0.02-0.6 µmol/kg) 能够抑制未经麻醉的完整大鼠体内CRF诱导的ACTH释放,并在0.6 µmol/kg剂量下抑制大鼠应激诱导的ACTH释放。此外,α-Helical CRF (9-41) 在尼古丁诱导的条件性焦虑大鼠模型中增加社交互动时间,并减少小鼠的类似暴饮暴食的乙醇消费。 | |||
T79817 |
S1P1 agonist 6 hemicalcium
|
LPL Receptor | GPCR/G Protein |
S1P1 agonist 6 hemicalcium (Compound I) 为一S1P1激动剂,其通过抑制淋巴细胞迁移而降低免疫反应,适用于自身免疫性疾病研究中的免疫抑制剂。 | |||
T60496 |
Ketorolac hemicalcium
|
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Ketorolac (RS37619) hemicalcium 是一种非选择性的 COX 抑制剂,对 COX-1 的 IC50 为 20 nM,对 COX-2 的 IC50 为 120 nM。 Ketorolac hemicalcium 是一种非甾体类抗炎药 (NSAID),可用作 0.5% 滴眼液,用于研究过敏性结膜炎、黄斑囊样水肿、术中瞳孔缩小和术后眼部炎症和疼痛等。 Ketorolac hemicalcium 也是一种可用于癌症研究的 DDX3 抑制剂 [1] [4]。 | |||
T125615 |
Floricaline
|
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Floricaline 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125615。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8206 |
Cycleanine
|
Others | Others |
Cycleanine 是一种高效血管选择性Ca- 拮抗剂,具有缓解疼痛、肌肉松弛和抗炎作用。它还具有有效的抗菌、抗真菌、抗疟原虫和细胞毒活性。 | |||
T2775 |
Baicalin
黄芩苷,黄岑苷,Baicalein 7-O-β-D-glucuronide |
NF-κB; HIV Protease; GABA Receptor; Autophagy | Autophagy; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome |
Baicalin (Baicalein 7-O-β-D-glucuronide) 是一种从黄芩中分离出来的脯氨酰内肽酶抑制剂,具有抗氧化、抗肿瘤、抗 HIV 的特性。 | |||
T3921 |
Punicalagin
安石榴甙,安石榴苷 |
SARS-CoV; HBV | Microbiology/Virology |
Punicalagin 是一种在石榴中发现的主要鞣花单宁,是可逆且非竞争性的3CLpro 抑制剂,有抗氧化、抗炎和抗癌作用。它有潜力研究 COVID-19 。 | |||
T4S1718 |
Punicalin
|
HBV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Punicalin 是从Punica granatumL. 或Terminalia catappaL. 的叶子中分离的,一种可水解的单宁,具有抗炎活性。它是一种抗乙型肝炎病毒药物。 | |||
TN1427 |
Baicalin methyl ester
|
Anti-infection | Microbiology/Virology |
Baicalin methyl ester 是黄芩苷根的一种成分。 | |||
T2858 |
Baicalein
5,6,7-Trihydroxyflavone,黄芩素,黄芩黄素 |
Ferroptosis; Influenza Virus; ROS; Xanthine Oxidase | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology |
Baicalein (5,6,7-Trihydroxyflavone) 是一种黄嘌呤氧化酶抑制剂,其IC50值为 3.12 μM。 | |||
TN3848 |
Dihydrobaicalein
|
PLK | Cell Cycle/Checkpoint |
Dihydrobaicalein 是 一种来自黄芩的天然产物, 一种PLK1抑制剂(IC50:6.3μM)。Dihydrobaicalein 对VRK2和PLK2有抑制作用。 | |||
T3551 |
D-Pantothenic acid hemicalcium salt
泛酸钙,D-Pantothenic Acid Calcium,D-泛酸半钙,Calpanate,Calcium D-pantothenate,Vitamin B5 calcium salt,Calcium pantothenate,Calcium D-Panthotenate |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
D-Pantothenic acid hemicalcium salt (Calcium pantothenate) 是一种水溶性维生素,能够减少苹果汁中的棒曲霉素。 | |||
TN3480 |
Baicalein 7-O-beta-D-ethylglucuronide
|
Others | Others |
Baicalein 7-O-beta-D-ethylglucuronide is a natural product from Scutellaria baicalensis Georgi. | |||
TN3268 |
8,8''-Bibaicalein
|
Others | Others |
8,8''-Bibaicalein is a natural product from Scutellaria baicalensis. | |||
TN1426 |
Baicalein 6-O-glucoside
|
Others | Others |
Baicalein 6-O-glucoside is a natural product from Thymus serpyllum L. | |||
T80862 |
Vitamin B15 hemicalcium
Pangamic Acid hemicalcium |
||
Vitamin B15 (Pangamic Acid) hemicalcium 是一种自然存在于植物种子中的化合物,具有促进细胞呼吸的作用。它包含了D-葡萄糖基二甲基氨基乙酸,并可作为免疫校正剂。Vitamin B15 hemicalcium 在多种疾病研究中有应用。 | |||
T10662 |
Calcimycin hemicalcium salt
Antibiotic A-23187 hemicalcium salt,A-23187 hemicalcium salt |
Others | Others |
Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca2+-dependent cell death by increasing intracellular calcium concentration. | |||
T82558 |
Dihydrobaicalin
|
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Dihydrobaicalin,一种从黄芩(Scutellaria lateriflora L.) 中分离出的黄酮苷。 |