45
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21
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8955 |
PCNA-I1
|
Others | Others |
PCNA-I1 是PCNA(增殖细胞核抗原)抑制剂。它能够直接与 PCNA 三聚体结合(Kd:0.41 μM),在体内外均表现出抗肿瘤活性。 | |||
T25951 |
Phox-I1
Phox I1 |
||
Phox-I1 is a NOX2 inhibitor targeting the interactive site of p67phox with Rac GTPase. | |||
T32089 |
HMS-I1 Hydrobromide
HMS-I1 HBr |
||
HMS-I1 Hydrobromide is a probe that works by destroying heterochromatin mediated transcriptional gene silencing and is used for studies of heterochromatin formation and function. | |||
T36239 |
6β-Prostaglandin I1
6β-Prostaglandin I1 |
||
6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 μM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2. | |||
T36238 |
6α-Prostaglandin I1
6α-Prostaglandin I1 |
||
6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response. 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI... | |||
T24394 |
LDN-0028574
SIRT1-I1,SIRT1-Inhibitor-I1,LDN-28574,LDN 0028574 |
||
LDN-0028574 is a SIRT1 inhibitor that also acts as an inhibitor of the human MDM2-p53 interaction. | |||
T6347 | Ki16198 | LPA Receptor; LPL Receptor | GPCR/G Protein |
Ki16198 是一种可口服的 LPA 受体拮抗剂,是 Ki16425 的甲酯衍生物。它抑制 LPA1 和 LPA3 诱导的肌醇磷酸的Ki 值分别为 0.34 和 0.93 μM,可用于胰腺癌发生和转移的研究。 | |||
T16290 |
NIK SMI1
|
NF-κB | NF-κB |
NIK SMI1 是 NF-κB 诱导激酶 (NIK) 的选择性抑制剂,能够抑制 NIK 催化的 ATP 水解为 ADP,IC50=0.23±0.17 nM。 | |||
T9753 |
LEI110
|
Phospholipase | Metabolism |
LEI110 是一种有效的 Phospholipase A2, group XVI (PLA2G16) 抑制剂,Ki 值为 20 nM。 LEI110 是 HRASLS 硫醇水解酶家族(即 PLA2G16、HRASLS2、RARRES3 和 iNAT)的选择性泛抑制剂。 | |||
T6484 |
EI1
KB-145943,Ezh2 inhibitor |
Apoptosis; Histone Methyltransferase | Apoptosis; Chromatin/Epigenetic |
EI1 (Ezh2 inhibitor) 是一种EZH2抑制剂,能够作用于 EZH2 (WT) 和 EZH2 (Y641F),IC50值分别为 15 nM 和 13 nM。 | |||
T67930L |
CWI1-2 HCL
|
Apoptosis | Apoptosis |
CWI1-2 HCL 是一种有效的 IGF2BP2 抑制剂,结合 IGF2BP2 并抑制其与 m6A 修饰的靶转录物的相互作用,可诱导细胞凋亡和分化,具有治疗白血病的作用。 | |||
T5210 |
BAI1
|
Apoptosis; BCL | Apoptosis |
BAI1 是一种选择性凋亡因子BAX 变构抑制剂。它结合 BAX 并变构抑制其激活,具有潜力研究 BAX 依赖性细胞死亡介导的疾病。 | |||
T17350 |
ACBI1
|
Apoptosis; Epigenetic Reader Domain; PROTACs | Apoptosis; Chromatin/Epigenetic; PROTAC |
ACBI1 是一种基于PROTAC 技术的 BAF ATPase 亚基SMARCA2和SMARCA4降解剂,也是 PBAF 成员PBRM1的降解剂。它由一个 bromodomain 配体、linker 和 E3 泛素连接酶von Hippel-Lindau 构成,能诱导抗增殖作用和凋亡。 | |||
T12235 |
NMDI14
|
Others | Others |
NMDI14 是无义介导的 RNA 衰变抑制剂。 | |||
T2439 |
O4I1
|
OCT | Membrane transporter/Ion channel |
O4I1 是一种Oct3/4诱导剂。 | |||
T1833 |
NSI189
NSI-189,NSI 189 |
Others | Others |
NSI189 (NSI-189) 是一种促智和神经源性研究化学品,源自烟酰胺和吡嗪。 | |||
T3561 |
CPI1189
CPI-1189,REN-1189,CPI 1189 |
TNF | Apoptosis |
CPI1189 (REN-1189) 是 TNF-α 释放抑制剂,具有神经保护作用及抗氧化作用。它可用于研究 HIV 相关神经毒性,具有成为 HIV 相关 CNS 疾病患者神经保护治疗药物的潜能。 | |||
T9960 |
MCU-i11
|
Others | Others |
MCU-i11 是一种新型的 MCU 负调节剂,可结合 MICU1 并损害肌肉细胞生长。 | |||
T9588 |
JI130
|
Others | Others |
JI130 能够削弱 Hes1 抑制转录的能力。 JI130 治疗显著减少了小鼠胰腺肿瘤异种移植模型中的肿瘤体积。 | |||
T6108 |
Ki16425
Debio 0719 |
LPA Receptor; LPL Receptor | GPCR/G Protein |
Ki16425 (Debio 0719) 是一种竞争性、有效和可逆的 LPA1、LPA2 和 LPA3 拮抗剂,Ki 分别为 0.34、6.5 和 0.93 μM。它可抑制LPA 诱导的 HEK293A 细胞中 YAP/TAZ 的去磷酸化,降低LPA 诱导的 p42/p44 MAPK 激活。 | |||
T61016 |
EMI1
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
EMI1 是 EGFR 三重突变体 (EGFR ex19del/T790M/C797S, EGFR L858R/T790M/C797S) 的有效抑制剂。EMI1 可用于 EGFR 突变相关的耐药型非小细胞肺癌 (NSCLC) 的研究。 | |||
T15500 |
HPi1
|
Others; Antibacterial | Microbiology/Virology; Others |
HPi1 是一种有口服活性的,针对幽门螺杆菌的选择性抗菌剂,IC50为 0.24 μM,MIC 为 0.08-0.16 μg/mL。 | |||
T2011 |
RKI1313
RKI 1313,RKI-1313 |
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
RKI1313 (RKI-1313) 是一种选择性抑制剂,可抑制 ROCK 依赖性信号传导、细胞骨架变化、不依赖锚定的集落形成、迁移和侵袭。 | |||
T62692 | ML-SI1 | ||
ML-SI1 是一种非对映异构体的外消旋混合物,是一种 TRPML 抑制剂,作用于 TRPML1 (IC50: 15 μM)。 | |||
T23788 |
BI1002494
BI 1002494,BI-1002494 |
||
BI1002494 is an effective and selective Syk inhibitor. | |||
T74970 | 306Oi10 | ||
306Oi10 是一种支链可电离脂质体,可用于构建脂质纳米颗粒 (LNPs),用于信使 RNA 的传递。 | |||
T38392 |
JAMI1001A
|
||
JAMI1001A is a positive allosteric modulator of the AMPA receptor, effectively modulating the deactivation and desensitization of both flip and flop receptor isoforms. | |||
T34089 |
PLI14
PLI-14,PLI 14 |
||
PLI14 is a bioactive chemical. | |||
T10700 |
(+)-CBI-CDPI1
|
Others | Others |
(+)-CBI-CDPI1 is an enhanced functional analog of CC-1065. It is a DNA alkylating agent and an antibody-drug conjugates (ADCs) toxin. | |||
T38377 |
ADTL-EI1712
ADTL-EI1712 |
||
ADTL-EI1712 is a dual inhibitor of ERK1 and ERK5 (IC50s = 40.43 and 64.5 nM, respectively).1It reduces ERK1 and ERK5 activity by 93.5% and 89.4%, respectively, but also inhibits ERK2 activity by 92.7%, in a panel of 100 kinases at 1 μM. ADTL-EI1712 inhibits proliferation of HL-60 and MKN74, but not HeLa, cancer cells (IC50s = 1.26, 2.55, and >50 μM, respectively). It reduces tumor growth and intratumor phosphorylation of ERK1/2 and ERK5 in an MKN74 mouse xenograft model when administered at a do... | |||
T79199 |
F-CRI1
|
STING | Immunology/Inflammation |
F-CRI1为高效STING激动剂,Kd值达40.62 nM。该化合物通过18F标记成为放射性探针,适用于肿瘤微环境中STING可视化的研究。 | |||
T12195 |
NCI172112
NSC268497,NSC172112 |
Others | Others |
NCI172112 is is used to develop antitumor agents effective against CNS tumors. | |||
T67930 |
CWI1-2
|
Apoptosis | Apoptosis |
CWI1-2 是一种有效的 IGF2BP2 抑制剂,通过结合 IGF2BP2 抑制其与 m6A 修饰的靶转录物的相互作用。CWI1-2 具有抗白血病活性,可诱导细胞凋亡 (apoptosis)和分化。 | |||
T41204 |
TAT-Gap19(I130A)
TAT-Gap19(I130A) |
||
TAT-Gap19(I130A) is a control peptide for TAT-Gap19, a Cx43 hemichannel blocker. TAT-Gap19(I130A) consists of TAT-GAP19 with a I130A amino acid residue change at a key residue for GAP19 activity. In C6 glioma cells expression Cx43, TAT-GAP19(1130A) does not inhibit [Ca2+]i-triggered ATP release at 200 μM. TAT-Gap19(I130A) is cell permeable. | |||
T27810 |
LEI105
LEI-105,LEI 105 |
||
LEI105 is a potent, highly selective, and reversible inhibitor of DAGL-α and DAGL-β. | |||
T6009 |
TAPI1
TAPI 1,TAPI,TAPI-1 |
MMP | Proteases/Proteasome |
TAPI1 (TAPI) 是一种 ADAM17/TACE 抑制剂,可抑制细胞因子受体的脱落。 | |||
T80402 |
Api137
|
||
Api137是一种抗生肽,其作用机制为通过抑制翻译干预细菌生长。具体来说,Api137在新生多肽链水解后,通过俘获释放因子于70S核糖体,从而抑制了蛋白质的合成。 | |||
T74402 |
FAP-PI3KI1
|
||
FAP-PI3KI1 是一种成纤维细胞活化蛋白 (FAP) 靶向 PI3K 抑制剂,可选择性靶向表达 FAP 的人特发性肺纤维化 (IPF)细胞并有效抑制胶原蛋白合成,减少胶原蛋白沉积。 | |||
T69866 |
photoGBI1
|
||
photoGBI1 is a photocontrol inhibitor of the voltage-gated proton channel Hv1. | |||
T6641 |
Rilmenidine Phosphate
|
Apoptosis; Adrenergic Receptor; Autophagy; Imidazoline Receptor | Apoptosis; Autophagy; GPCR/G Protein; Neuroscience |
Rilmenidine phosphate 是一种新型的抗高血压药物和口服活性选择性 I1 咪唑啉受体激动剂。它可调节白血病细胞增殖,刺激促凋亡蛋白 Bax,从而诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。它可通过减少交感神经过度活跃而发挥中枢作用,并通过抑制 Na+/H+反向转运而在肾脏中发挥作用。 | |||
T63968 | AZ14145845 | ||
AZ14145845 是一种具有体内药效的、高度选择性的 I1/2 型 Mer/Axl 双特异性激酶抑制剂。 | |||
T22760 |
Efaroxan hydrochloride
|
Others | Others |
α2 adrenoceptor antagonist and imidazoline I1 receptor ligand | |||
T27155 |
Dexisometheptene
TNX 201,TNX-201,(R)-Isometheptene,TNX201 |
||
Dexisometheptene is an antimigraine drug candidate. Dexisometheptene significantly increases the pain threshold of acute pain response, and potently and selectively binds to receptors in the central nervous system known as imidazoline type-1 (I1) receptor | |||
T21911 |
Rilmenidine hemifumarate
Rilmenidine (hemifumarate),S-3341 hemifumarate |
Apoptosis; Imidazoline Receptor | Apoptosis; Neuroscience |
Rilmenidine hemifumarate (S-3341 hemifumarate) 是一种新型且具有口服活性和选择性 的 I1咪唑啉受体 (I1 imidazoline receptor) 和α2肾上腺素受体激动剂,可诱导自噬 ,调节白血病细胞增殖,刺激促凋亡蛋白 Bax,诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。 | |||
T40869 |
Moxonidine hydrochloride
BDF5895hydrochloride,盐酸莫索尼定 |
||
Moxonidine Hydrochloride is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent. Target: I1-R Moxonidine Hydrochloride is a centrally acting antihypertensive agent. Mixed Nischarin (I1 imidazoline receptor) and α2-AR (adrenergic) agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors. Moxonidine reduced stimulated NE overflow (log EC50: -6.15 +/- 0.14). AGN192403, a selective ligand at I1-R, had no influence on the dose-response... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3158 |
Harmane
Loturine,Harman,Aribine,哈尔满碱 |
Adrenergic Receptor; Monoamine Oxidase; Imidazoline Receptor | GPCR/G Protein; Neuroscience |
Harmane (Loturine) 是一种在咖啡和烟草烟雾中发现的 β-咔啉生物碱,是有效的神经毒素,可引起严重的动作震颤和精神病学表现。它还是选择性的单胺氧化酶抑制剂,具有致突变作用,对 MAO A/B 的 IC50值分别为 0.5 和 5 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01241 |
Neuroserpin Protein, Human, Recombinant (His)
PI12,Serpin I1,serpin peptidase inhibitor,... |
Human | HEK293 Cells |
Neuroserpin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is A0A0S2Z455. | |||
TMPY-02628 |
Neuroserpin Protein, Mouse, Recombinant (His)
PI12,serpin peptidase inhibitor, clade I (neuroserp... |
Mouse | HEK293 Cells |
Neuroserpin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is O35684. | |||
TMPJ-00528 |
PPP1R1A Protein, Human, Recombinant (His)
PPP1R1A,I-1,IPP-1,Protein Phosphatase Inhibitor 1,Protein Ph... |
Human | E. coli |
Protein Phosphatase 1 Regulatory Subunit 1A (PPP1R1A) is an inhibitor of protein-phosphatase 1. PPP1R1A is a cellular regulator of eIF2 alpha phosphorylation. In hormonal control of glycogen metabolism, IPP-1 protein plays important function. Hormones can elevate intracellular cAMP level and elevate IPP-1 activity. PPP1R1A activation caused cAMP increase , cAMP control over proteins that are not directly phosphorylated by PKA following a rise in intracellular calcium. IPP-1 is inactivated by cal... | |||
TMPY-01382 |
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Nucleoprotein/NP Protein (I116M, His)
NP Protein |
H1N1 | Baculovirus Insect Cells |
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Nucleoprotein/NP Protein (I116M, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P03466. | |||
TMPJ-01464 |
IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F)
TCGF,Aldesleukin,T-Cell Growth Factor,IL-2,Interleukin-2,IL2 |
Human | HEK293 Cells |
Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system,belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages... | |||
TMPY-00101 |
Influenza A H1N8 (A/Egyptian goose/South Africa/AI1448/2007) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H1N8 | HEK293 Cells |
Influenza A H1N8 (A/Egyptian goose/South Africa/AI1448/2007) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.6 kDa and the accession number is D5HT25. | |||
TMPY-06539 |
Monkeypox Virus (MPXV) I1L Protein (His)
|
MPXV | E. coli |
Monkeypox Virus (MPXV) I1L Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 37.71 kDa. | |||
TMPH-01609 |
LGI1 Protein, Human, Recombinant (His & Myc)
|
Human | E. coli |
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. | |||
TMPY-06912 |
PU.1/SPI1 Protein, Mouse, Recombinant (His)
Tfpu.1,Dis-1,Tcfpu1,Spi-1,Sfpi-1,Dis1,PU.1,Sfpi1,sp... |
Mouse | E. coli |
PU.1/SPI1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 32.31 kDa and the accession number is P17433. | |||
TMPY-00526 |
VTI1A Protein, Human, Recombinant (mFc)
MVti1,Vti1-rp2,VTI1RP2,vesicle tr... |
Human | HEK293 Cells |
VTI1A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 48.5 kDa and the accession number is Q96AJ9-2. | |||
TMPH-01264 |
PELI1 Protein, Human, Recombinant (His)
|
Human | Baculovirus Insect Cells |
PELI1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 48.8 kDa and the accession number is Q96FA3. | |||
TMPH-01196 |
DYNC1I1 Protein, Human, Recombinant (His)
DH IC-1,DNCIC1,Cytoplasmic dynein 1 intermediate chain 1,DYN... |
Human | Baculovirus Insect Cells |
DYNC1I1 Protein, Human, Recombinant (His) is expressed in Baculovirus. | |||
TMPH-02956 |
TNNI1 Protein, Mouse, Recombinant (Flag & His & Myc)
|
Mouse | E. coli |
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TNNI1 Protein, Mouse, Recombinant (Flag & His & Myc) is expressed in E. coli expression system with N-10xHis-Flag and C-Myc tag. The predicted molecular weight is 29.6 kDa and the accession number is Q9WUZ5. | |||
TMPY-06917 |
PU.1/SPI1 Protein, Human, Recombinant (His)
SFPI1,SPI-A,spleen focus forming virus (SFFV) provi... |
Human | E. coli |
PU.1/SPI1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 32.04 kDa and the accession number is P17947. | |||
TMPY-02230 |
Influenza A H5N2 (A/ostrich/South Africa/AI1091/2006) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H5N2 | HEK293 Cells |
Influenza A H5N2 (A/ostrich/South Africa/AI1091/2006) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.2 kDa and the accession number is B0F0B2. | |||
TMPY-06140 |
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Nucleoprotein/NP Protein (I116M, His), Biotinylated
NP Protein |
H1N1 | Baculovirus Insect Cells |
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Nucleoprotein/NP Protein (I116M, His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P03466. | |||
TMPH-02220 |
SPI1 Protein, Human, Recombinant (His)
|
Human | E. coli |
Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing. | |||
TMPH-02321 |
GLI1 Protein, Human, Recombinant (His)
|
Human | E. coli |
Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling.; Acts as a transcriptional activator, but activates a different set of genes tha... | |||
TMPH-02306 |
VTI1B Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. | |||
TMPH-01179 |
COX4I1 Protein, Human, Recombinant (His & SUMO)
Cytochrome c oxidase polypeptide IV,COX4I1,Cytochro... |
Human | E. coli |
COX4I1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-04072 |
VTI1A Protein, Human, Recombinant (His)
Vti1-rp2,MVti1,vesicle transport through i... |
Human | HEK293 Cells |
VTI1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.2 kDa and the accession number is Q96AJ9-2. |