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11
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21981 |
Phthalazinone pyrazole
|
Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
Phthalazinone pyrazole 是强效、选择性和口服生物可利用的 Aurora-A 激酶抑制剂,IC50值为 0.031 μM。它抑制人胚胎干细胞向肝细胞样细胞分化过程中的上皮间质转化。它还可阻止有丝分裂并随后通过增殖细胞的凋亡抑制肿瘤生长。 | |||
T21867 |
BI-6015
2-甲基-1-(2-甲基-5-硝基苯基磺酰基)-1H-苯并[D]咪唑 |
Others | Others |
BI 6015 是肝细胞核因子 4α (HNF4α) 拮抗剂,可抑制已知 HNF4α 靶基因的表达。它利用 HNF4α 拮抗作用,降低胰岛素启动子活性,可用于研究癌症和糖尿病。 | |||
T5536 |
SJA710-6
|
Others | Others |
SJA710-6 是一种能够特异性地分化 MSCs 为肝细胞样的小分子。 | |||
T39507L |
Fosgonimeton acetate
Fosgonimeton acetate (2093305-05-4 Free base) |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Fosgonimeton acetate 是一种肝细胞生长因子受体激动剂。 | |||
T37596 |
Terevalefim
|
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Terevalefim 是干细胞生长因子的一种类似物,对c-Met 受体有选择性激活作用。 | |||
T7376 |
Dihexa
PNB-0408,Hexanoyl-Tyr-Ile-Ahx-NH2,N-hexanoic-Try-Ile-(6)-amino hexanoic amide |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Dihexa (Hexanoyl-Tyr-Ile-Ahx-NH2) 是肝细胞生长因子/c-Met (HGF/c-Met) 系统的激活剂,它与 HGF (Kd = 65 pM) 结合,是肽血管紧张素 IV 的类似物。 | |||
T17018 |
TCPOBOP
|
BCL | Apoptosis |
TCPOBOP 是一种组成型雄烷受体激动剂,可诱导强大的肝细胞增殖和肝肿大。它通过改变 Bcl-2 蛋白来减少 Fas 诱导的小鼠肝损伤。 | |||
T77437 |
Telisotuzumab
ABT-700,Mab-224G11 |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Telisotuzumab(ABT-700) 是一种人源化重组抗体,靶向治疗性肝细胞生长因子受体(MET)的抗体,对 c-Met 具有很高的亲和力 。Telisotuzumab 对 c-Met 信号传导具有抑制作用且具有抗肿瘤活性。 | |||
T35373L |
Bulevirtide (Myrcludex B) acetate
|
HBV | Microbiology/Virology |
Bulevirtide (Myrcludex B) acetate 是一种病毒粒子进入抑制剂,可阻断病毒粒子的肝细胞进入途径,即肝钠/牛磺胆酸盐协同转运多肽 (NTCP) 受体。它可用于 HBV 和 HDV 感染研究。 | |||
T76758 |
Rilotumumab
AMG 102 |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Rilotumumab (AMG 102) 是一种针对肝细胞生长因子的单克隆抗体,对 HGF/MET 驱动的信号传导有抑制作用。Rilotumumab 具有抗肿瘤作用,可用于研究去势抵抗性前列腺癌 (CRPC) 和胃癌。 | |||
T19389 |
L-Ascorbic acid 2-phosphate magnesium
2-Phospho-L-ascorbic acid magnesium,维生素C磷酸酯镁,维生素 C 磷酸酯镁 |
Phosphatase; Phosphorylase | Metabolism |
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) 是长效的维生素 C 衍生物,能够以刺激胶原蛋白的表达和形成。它提高成骨细胞分化过程中 hASC 中的碱性磷酸酶特性和 runx2A 的表达。它能够以作为培养基补充人脂肪干细胞的成骨分化。 | |||
T6517 |
Golvatinib
E-7050,戈伐替尼 |
VEGFR; c-Met/HGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Golvatinib (E-7050) 是一种 c-Met (IC50:14 nM) 和 VEGFR2 (IC50:16 nM) 的双重抑制剂。 | |||
T39507 |
Fosgonimeton
ATH-1017 |
||
Fosgonimeton is a hepatocyte growth factor receptor agonist (WO2017210489). | |||
T1661L |
Crizotinib acetate
PF02341066,PF-2341066,PF 02341066,PF-02341066,PF2341066 |
||
Crizotinib, an orally bioavailable agent, belongs to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity. | |||
T13108L |
Pamufetinib mesylate
TAS-115 mesylate,TAS-115 methanesulfonate |
Others | Others |
TAS-115 mesylate is a potent inhibitor of VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase(IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively). | |||
T69218 | PUMAi HCl | ||
PUMAi is an inhibitor of p53 up-regulated modulator of apoptosis (PUMA), a BH3-only Bcl-2 family member, mitigating acetaminophen (APAP)-induced hepatocyte necrosis and liver injury. | |||
T39347 | RG-101 | ||
RG-101 is a hepatocyte-targeted N-acetylgalactosamine conjugated oligonucleotide that functions as an antagonist for miR-122, an essential host factor in the replication of the hepatitis C virus (HCV). | |||
T40259 |
AB-729
|
||
AB-729, a nucleoside analogue functioning as an RNA interference (RNAi), links to a GalNAc (N-acetylgalactosamine) trimer ligand facilitating hepatocyte uptake through the asialoglycoprotein receptor (ASGR). This compound effectively impedes viral replication and diminishes HBV antigens. | |||
T83006 |
Antitumor agent-29
|
||
Antitumor agent-29为新型肝细胞靶向抗肿瘤前体,表现出优异抗肿瘤活性及低毒性副作用。 | |||
T71636 | Golvatinib tartrate | ||
Golvatinib tartrate is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. | |||
T83393 |
293P-1
|
||
293P-1是一种特异性靶向肝细胞的组织特异性多肽,其序列为SNNNVRPIHIWP。 | |||
T70844 |
CM-118
|
||
CM-118 is a potent and selective dual inhibitor of c-Met and ALK which potently abrogates hepatocyte growth factor (HGF)-induced c-Met phosphorylation and cell migration, as well as phosphorylation of ALK, EML4-ALK, and ALK resistance mutants in transfected cells. | |||
T70318 | AMG-337 monohydrate | ||
AMG-337 monohydrate is a highly selective small molecule MET inhibitor. Aberrant hepatocyte growth factor (HGF)/MET signaling has been implicated in hepatocarcinogenesis, suggesting that MET may serve as an attractive therapeutic target in hepatocellular carcinoma. | |||
T71792 | Quipazine maleate | ||
Quipazine maleate is a selective 5-HT receptor agonist that promotes the proliferation and apoptosis of human hepatocyte strain of L-02 strain and could also exert an excitatory effect on raphe neurons via stimulation of 5-HT2A receptors. Like quipazine, quipazine derivatives produce contracture of smooth muscle organs and bronchospasm. | |||
T61804 | GSK-3β inhibitor 6 | ||
GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying various diseases including diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder [1]. | |||
T35620 |
Ethoxyquin Dimer
|
||
Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin .1 It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induces microvesicular steatosis and hepatocyte necrosis, as well as increases liver levels of oxidized glutathione and total lipids in mice.2 | |||
T69599 |
ABT-510
|
||
ABT-510 is synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8). | |||
T77948 |
Tri-GalNAc-DBCO
|
PROTACs | PROTAC |
Tri-GalNAc-DBCO是结合ASGPR以驱动蛋白质下调和靶向蛋白质降解的化合物,其中GalNAc作为肝细胞特异性ASGPR的高亲和力配体。 | |||
T71187 |
Foretinib phosphate
|
||
Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers. | |||
T80884 | Val-Cit-amide-Ph-Maytansine | ||
Val-Cit-amide-Ph-Maytansine 是用于肝细胞生长因子受体 c-Met (MET) 或抗体药物偶联物 (ADCs) 的抗体和双特异性抗原结合分子。 | |||
T76745 | Ficlatuzumab | ||
Ficlatuzumab 是一种靶向人肝细胞生长因子 (HGF) 的单克隆抗体 (McAb)。Ficlatuzumab 能够阻断HGF/c-Met 信号通路的激活,抑制c-Met 受体介导的癌细胞增殖、迁移和侵袭。 | |||
T70434 | Vabametkib | ||
Vabametkib为有效的肝细胞生长因子受体(HGFR)抑制剂,以IC50 7 nM抑制Hs746T细胞增殖及c-Met,具有抗肿瘤活性。 | |||
T80885 |
Val-Cit-amide-Cbz-N(Me)-Maytansine
|
||
Val-Cit-amide-Cbz-N(Me)-Maytansine是一种可用于构建抗体和双特异性抗原结合分子,能够特异性结合肝细胞生长因子受体c-Met (MET)以及用于制备抗体药物偶联物(antibody-drug conjugates) (ADCs)的化合物。 | |||
T28240 |
Ono 1301
Ono-1301,Ono1301 |
||
Ono 1301 is a prostaglandin I2 mimetic coumpound with inhibitory activity against thromboxane A2 synthase. Ono 1301 suppresses pancreatic fibrosis in the DBTC-induced CP model by inhibiting monocyte activity not only with induction of HGF but also by Ono | |||
T36098 |
Isovaleryl-L-carnitine (chloride)
|
||
Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM. Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively. Increased levels of isovaleryl carnitine are associated wit... | |||
T75940 |
Norleual TFA
|
||
Norleual TFA 是一种血管紧张素 (Ang) IV 类似物,是一种肝细胞生长因子(HGF)/c-Met 抑制剂,IC50为 3 pM。Norleual TFA 还是一种AT4拮抗剂,具有强大的抗血管生成活性。 | |||
T62301 |
J-1063
|
||
J-1063 是一种选择性、口服具有活力的、有效的 ALK5 抑制剂 (IC50: 0.039 μM)。 J-1063 能够抑制炎症浸润,胶原沉积,肝细胞坏死,表现出抗肝纤维化作用。J-1063 具有潜力进行肝纤维化的研究。 | |||
T82719 | Cisd2 agonist 2 | ||
Cisd2 agonist 2(compound 6)是Cisd2激活剂,具有191 nM的EC50值,其中Cisd2水平与NAFLD相关。在Cisd2hKO-het小鼠(杂合子肝细胞特异性Cisd2敲除)中,Cisd2 agonist 2未显示出显著的体内毒性。 | |||
T62741 | DprE1-IN-1 | ||
DprE1-IN-1 是一种有效的、口服具有活力的 DprE1 抑制剂,表现出良好的肝细胞稳定性、低细胞毒性和低 hERG 通道抑制。DprE1-IN-1 能够有效抗 DprE1-IN-1 对药敏和临床分离的耐药结核菌株 (MICs<0.1 μg/mL)。DprE1-IN-1 在巨噬细胞内具有良好的抗分支杆菌活性,能减少 1.29 log10 CFU。 | |||
T76051 |
NFF-3 TFA
|
||
NFF-3 TFA 肽是一种选择性 MMP 底物。NFF-3 TFA 选择性结合 MMP-3和 MMP-10而被水解。NFF-3 TFA 也被胰蛋白酶、肝细胞生长因子激活剂和因子 Xa 裂解。使用 CyDye Cy3/Cy5Q 标记 NFF-3 TFA,可在细胞实验中产生荧光,而检测细胞活性。 | |||
T35425 |
β-Apooxytetracycline
|
||
β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Baci... | |||
T77144 | Recaticimab | ||
Recaticimab (SHR-1209) 是一种针对 PCSK9 的人源化单克隆抗体。该药物通过结合 PCSK9 并促进其降解,增加肝细胞表面的低密度脂蛋白 (LDL) 受体数量,从而有效降低血浆 LDL 水平,实现降低血脂的效果。Recaticimab 对于治疗高胆固醇血症显示出潜在价值。 | |||
T62598 | Pitavastatin sodium | ||
Pitavastatin (NK-104) sodium 是一种有效的羟甲基戊二酰-CoA(HMG-CoA) 还原酶抑制剂,也是一种高效的肝细胞低密度脂蛋白胆固醇 (LDL-C) 受体诱导剂。Pitavastatin sodium 在 HepG2 细胞中,能够抑制乙酸合成胆固醇 (IC50: 5.8 nM) 。Pitavastatin sodium 表现出抗动脉粥样硬化、抗哮喘、抗骨关节炎、神经保护、抗肿瘤、肝保护和肾保护作用。 | |||
T7072 |
Pitavastatin
|
||
Pitavastatin (NK-104) 是有效的羟甲基戊二酰-CoA(HMG-CoA)还原酶抑制剂。Pitavastatin 抑制乙酸合成胆固醇,在 HepG2 细胞中的IC50为 5.8 nM。Pitavastatin 是一种高效的肝细胞低密度脂蛋白胆固醇 (LDL-C) 受体诱导剂。Pitavastatin 具有抗动脉粥样硬化、抗哮喘、抗骨关节炎、抗肿瘤、神经保护、肝保护和肾保护等作用。 | |||
T70988 |
Ibulocydine
|
||
Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibuloc... | |||
T35712 |
Debutyldronedarone hydrochloride
SR35021 hydrochloride |
||
N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h... | |||
T38844 |
MK-8245 Trifluoroacetate
|
||
MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. IC50 value: 1 nM (hSCD1) Target: SCD1 in vitro: MK-8245, a phenoxy piperidine isoxazole derivative, has been identified as a potent and liver-specific SCD inhibitor. It contains a tetrazole acetic acid moiety, which is the key molecule for OATPs recognition and liver-targeting. MK... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1403 |
Arjunolic acid
|
IL Receptor; TNF; Reactive Oxygen Species; JNK; AChE | Apoptosis; Immunology/Inflammation; MAPK; Metabolism; Neuroscience; NF-κB |
Arjunolic acid 是分离自蓝莓的皂苷,具有抗氧化、抗菌和抗炎症等多种生物活性,在保护细胞和组织免受活性氧的有害作用中发挥重要作用。 | |||
TQ0211 |
Brusatol
(+)-Brusatol,鸦胆子苦醇,NSC 172924 |
Others; Ferroptosis; Nrf2 | Apoptosis; Immunology/Inflammation; Others |
Brusatol (NSC-172924) 是一种从鸦胆子植物中分离出来的天然产物,抑制Nrf2通路,可使多种癌细胞对 Cisplatin 和其他化疗药物敏感。它可开发为辅助化疗化合物,可增加细胞凋亡。 | |||
T4S0217 |
HOMOPLANTAGININ
|
TNF; NF-κB | Apoptosis; NF-κB |
Homoplantaginin 是来自中药荔枝草的一种类黄酮,具有抗炎和抗氧化活性。 | |||
T13108 |
Pamufetinib
H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115 |
VEGFR; c-Met/HGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Pamufetinib (TAS-115) 是VEGFR 和c-Met/HGFR 抑制剂,能够抑制 rVEGFR2 (IC50:30 nM)和 rMET (IC50:32 nM)的活性。 | |||
T6S2246 |
Alisol B 23-acetate
Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B,泽泻醇B乙酸酯 |
Others | Others |
Alisol B 23-acetate (Alisol B Acetate) 是三萜类化合物,能够激活法尼醇受体,诱导受损的肝脏再生。 | |||
TN2147 |
Retrorsine
|
P450; OCT | Membrane transporter/Ion channel; Metabolism |
Retrorsine 特异性地抑制肝细胞增殖,并在肝损伤后唤起小肝细胞样祖细胞。逆转录酶可用于肝细胞损伤的研究。 | |||
TN1732 | Herpetone | HBV | Microbiology/Virology |
Herpetone exhibits protective effects on CCl(4)-induced hepatocyte injury, it shows anti-hepatitis B virus (HBV) activity. | |||
TN4440 |
Limonexic acid
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Limonexic acid shows antinociceptive actions , it produces dose-related inhibition of glutamate- and capsaicin-induced pain. Limonexic acid can effectively protect hepatocyte against CCl4-induced injury. | |||
T72856 |
(+)-Cembrene A
|
||
(+)-Cembrene A 是一种α-glucosidase 抑制剂,IC50为 30.31 μM。(+)-Cembrene A 对人正常肝细胞 (LO2) 无毒性。 | |||
TN4334 | Isotaxiresinol | TNF | Apoptosis |
Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. Isotaxiresinol ma | |||
TN4374 |
Kaerophyllin
(-)-Kaerophylin |
Apoptosis | Apoptosis |
Kaerophyllin ( (-)-Kaerophylin) 是一种从中药柴胡中分离出的木酚素,抑制肝细胞凋亡小体激活肝星状细胞,通过抑制肝脏炎症和抑制 HSC 活化来保护大鼠肝脏免受 TAA 引起的损伤和纤维化。 |