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47

抑制剂 & 化合物

11

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Cat. No. Product Name Target Signaling Pathways
T21981 Phthalazinone pyrazole

Aurora Kinase Cell Cycle/Checkpoint; Chromatin/Epigenetic
Phthalazinone pyrazole 是强效、选择性和口服生物可利用的 Aurora-A 激酶抑制剂,IC50值为 0.031 μM。它抑制人胚胎干细胞向肝细胞样细胞分化过程中的上皮间质转化。它还可阻止有丝分裂并随后通过增殖细胞的凋亡抑制肿瘤生长。
T21867 BI-6015

2-甲基-1-(2-甲基-5-硝基苯基磺酰基)-1H-苯并[D]咪唑

Others Others
BI 6015 是肝细胞核因子 4α (HNF4α) 拮抗剂,可抑制已知 HNF4α 靶基因的表达。它利用 HNF4α 拮抗作用,降低胰岛素启动子活性,可用于研究癌症和糖尿病。
T5536 SJA710-6

Others Others
SJA710-6 是一种能够特异性地分化 MSCs 为肝细胞样的小分子。
T39507L Fosgonimeton acetate

Fosgonimeton acetate (2093305-05-4 Free base)

c-Met/HGFR Tyrosine Kinase/Adaptors
Fosgonimeton acetate 是一种肝细胞生长因子受体激动剂。
T37596 Terevalefim

c-Met/HGFR Tyrosine Kinase/Adaptors
Terevalefim 是干细胞生长因子的一种类似物,对c-Met 受体有选择性激活作用。
T7376 Dihexa

PNB-0408,Hexanoyl-Tyr-Ile-Ahx-NH2,N-hexanoic-Try-Ile-(6)-amino hexanoic amide

c-Met/HGFR Tyrosine Kinase/Adaptors
Dihexa (Hexanoyl-Tyr-Ile-Ahx-NH2) 是肝细胞生长因子/c-Met (HGF/c-Met) 系统的激活剂,它与 HGF (Kd = 65 pM) 结合,是肽血管紧张素 IV 的类似物。
T17018 TCPOBOP

BCL Apoptosis
TCPOBOP 是一种组成型雄烷受体激动剂,可诱导强大的肝细胞增殖和肝肿大。它通过改变 Bcl-2 蛋白来减少 Fas 诱导的小鼠肝损伤。
T77437 Telisotuzumab

ABT-700,Mab-224G11

c-Met/HGFR Tyrosine Kinase/Adaptors
Telisotuzumab(ABT-700) 是一种人源化重组抗体,靶向治疗性肝细胞生长因子受体(MET)的抗体,对 c-Met 具有很高的亲和力 。Telisotuzumab 对 c-Met 信号传导具有抑制作用且具有抗肿瘤活性。
T35373L Bulevirtide (Myrcludex B) acetate

HBV Microbiology/Virology
Bulevirtide (Myrcludex B) acetate 是一种病毒粒子进入抑制剂,可阻断病毒粒子的肝细胞进入途径,即肝钠/牛磺胆酸盐协同转运多肽 (NTCP) 受体。它可用于 HBV 和 HDV 感染研究。
T76758 Rilotumumab

AMG 102

c-Met/HGFR Tyrosine Kinase/Adaptors
Rilotumumab (AMG 102) 是一种针对肝细胞生长因子的单克隆抗体,对 HGF/MET 驱动的信号传导有抑制作用。Rilotumumab 具有抗肿瘤作用,可用于研究去势抵抗性前列腺癌 (CRPC) 和胃癌。
T19389 L-Ascorbic acid 2-phosphate magnesium

2-Phospho-L-ascorbic acid magnesium,维生素C磷酸酯镁,维生素 C 磷酸酯镁

Phosphatase; Phosphorylase Metabolism
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) 是长效的维生素 C 衍生物,能够以刺激胶原蛋白的表达和形成。它提高成骨细胞分化过程中 hASC 中的碱性磷酸酶特性和 runx2A 的表达。它能够以作为培养基补充人脂肪干细胞的成骨分化。
T6517 Golvatinib

E-7050,戈伐替尼

VEGFR; c-Met/HGFR Angiogenesis; Tyrosine Kinase/Adaptors
Golvatinib (E-7050) 是一种 c-Met (IC50:14 nM) 和 VEGFR2 (IC50:16 nM) 的双重抑制剂。
T39507 Fosgonimeton

ATH-1017

Fosgonimeton is a hepatocyte growth factor receptor agonist (WO2017210489).
T1661L Crizotinib acetate

PF02341066,PF-2341066,PF 02341066,PF-02341066,PF2341066

Crizotinib, an orally bioavailable agent, belongs to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity.
T13108L Pamufetinib mesylate

TAS-115 mesylate,TAS-115 methanesulfonate

Others Others
TAS-115 mesylate is a potent inhibitor of VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase(IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively).
T69218 PUMAi HCl

PUMAi is an inhibitor of p53 up-regulated modulator of apoptosis (PUMA), a BH3-only Bcl-2 family member, mitigating acetaminophen (APAP)-induced hepatocyte necrosis and liver injury.
T39347 RG-101

RG-101 is a hepatocyte-targeted N-acetylgalactosamine conjugated oligonucleotide that functions as an antagonist for miR-122, an essential host factor in the replication of the hepatitis C virus (HCV).
T40259 AB-729

AB-729, a nucleoside analogue functioning as an RNA interference (RNAi), links to a GalNAc (N-acetylgalactosamine) trimer ligand facilitating hepatocyte uptake through the asialoglycoprotein receptor (ASGR). This compound effectively impedes viral replication and diminishes HBV antigens.
T83006 Antitumor agent-29

Antitumor agent-29为新型肝细胞靶向抗肿瘤前体,表现出优异抗肿瘤活性及低毒性副作用。
T71636 Golvatinib tartrate

Golvatinib tartrate is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity.
T83393 293P-1

293P-1是一种特异性靶向肝细胞的组织特异性多肽,其序列为SNNNVRPIHIWP。
T70844 CM-118

CM-118 is a potent and selective dual inhibitor of c-Met and ALK which potently abrogates hepatocyte growth factor (HGF)-induced c-Met phosphorylation and cell migration, as well as phosphorylation of ALK, EML4-ALK, and ALK resistance mutants in transfected cells.
T70318 AMG-337 monohydrate

AMG-337 monohydrate is a highly selective small molecule MET inhibitor. Aberrant hepatocyte growth factor (HGF)/MET signaling has been implicated in hepatocarcinogenesis, suggesting that MET may serve as an attractive therapeutic target in hepatocellular carcinoma.
T71792 Quipazine maleate

Quipazine maleate is a selective 5-HT receptor agonist that promotes the proliferation and apoptosis of human hepatocyte strain of L-02 strain and could also exert an excitatory effect on raphe neurons via stimulation of 5-HT2A receptors. Like quipazine, quipazine derivatives produce contracture of smooth muscle organs and bronchospasm.
T61804 GSK-3β inhibitor 6

GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying various diseases including diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder [1].
T35620 Ethoxyquin Dimer

Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin .1 It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induces microvesicular steatosis and hepatocyte necrosis, as well as increases liver levels of oxidized glutathione and total lipids in mice.2
T69599 ABT-510

ABT-510 is synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8).
T77948 Tri-GalNAc-DBCO

PROTACs PROTAC
Tri-GalNAc-DBCO是结合ASGPR以驱动蛋白质下调和靶向蛋白质降解的化合物,其中GalNAc作为肝细胞特异性ASGPR的高亲和力配体。
T71187 Foretinib phosphate

Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers.
T80884 Val-Cit-amide-Ph-Maytansine

Val-Cit-amide-Ph-Maytansine 是用于肝细胞生长因子受体 c-Met (MET) 或抗体药物偶联物 (ADCs) 的抗体和双特异性抗原结合分子。
T76745 Ficlatuzumab

Ficlatuzumab 是一种靶向人肝细胞生长因子 (HGF) 的单克隆抗体 (McAb)。Ficlatuzumab 能够阻断HGF/c-Met 信号通路的激活,抑制c-Met 受体介导的癌细胞增殖、迁移和侵袭。
T70434 Vabametkib

Vabametkib为有效的肝细胞生长因子受体(HGFR)抑制剂,以IC50 7 nM抑制Hs746T细胞增殖及c-Met,具有抗肿瘤活性。
T80885 Val-Cit-amide-Cbz-N(Me)-Maytansine

Val-Cit-amide-Cbz-N(Me)-Maytansine是一种可用于构建抗体和双特异性抗原结合分子,能够特异性结合肝细胞生长因子受体c-Met (MET)以及用于制备抗体药物偶联物(antibody-drug conjugates) (ADCs)的化合物。
T28240 Ono 1301

Ono-1301,Ono1301

Ono 1301 is a prostaglandin I2 mimetic coumpound with inhibitory activity against thromboxane A2 synthase. Ono 1301 suppresses pancreatic fibrosis in the DBTC-induced CP model by inhibiting monocyte activity not only with induction of HGF but also by Ono
T36098 Isovaleryl-L-carnitine (chloride)

Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM. Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively. Increased levels of isovaleryl carnitine are associated wit...
T75940 Norleual TFA

Norleual TFA 是一种血管紧张素 (Ang) IV 类似物,是一种肝细胞生长因子(HGF)/c-Met 抑制剂,IC50为 3 pM。Norleual TFA 还是一种AT4拮抗剂,具有强大的抗血管生成活性。
T62301 J-1063

J-1063 是一种选择性、口服具有活力的、有效的 ALK5 抑制剂 (IC50: 0.039 μM)。 J-1063 能够抑制炎症浸润,胶原沉积,肝细胞坏死,表现出抗肝纤维化作用。J-1063 具有潜力进行肝纤维化的研究。
T82719 Cisd2 agonist 2

Cisd2 agonist 2(compound 6)是Cisd2激活剂,具有191 nM的EC50值,其中Cisd2水平与NAFLD相关。在Cisd2hKO-het小鼠(杂合子肝细胞特异性Cisd2敲除)中,Cisd2 agonist 2未显示出显著的体内毒性。
T62741 DprE1-IN-1

DprE1-IN-1 是一种有效的、口服具有活力的 DprE1 抑制剂,表现出良好的肝细胞稳定性、低细胞毒性和低 hERG 通道抑制。DprE1-IN-1 能够有效抗 DprE1-IN-1 对药敏和临床分离的耐药结核菌株 (MICs<0.1 μg/mL)。DprE1-IN-1 在巨噬细胞内具有良好的抗分支杆菌活性,能减少 1.29 log10 CFU。
T76051 NFF-3 TFA

NFF-3 TFA 肽是一种选择性 MMP 底物。NFF-3 TFA 选择性结合 MMP-3和 MMP-10而被水解。NFF-3 TFA 也被胰蛋白酶、肝细胞生长因子激活剂和因子 Xa 裂解。使用 CyDye Cy3/Cy5Q 标记 NFF-3 TFA,可在细胞实验中产生荧光,而检测细胞活性。
T35425 β-Apooxytetracycline

β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Baci...
T77144 Recaticimab

Recaticimab (SHR-1209) 是一种针对 PCSK9 的人源化单克隆抗体。该药物通过结合 PCSK9 并促进其降解,增加肝细胞表面的低密度脂蛋白 (LDL) 受体数量,从而有效降低血浆 LDL 水平,实现降低血脂的效果。Recaticimab 对于治疗高胆固醇血症显示出潜在价值。
T62598 Pitavastatin sodium

Pitavastatin (NK-104) sodium 是一种有效的羟甲基戊二酰-CoA(HMG-CoA) 还原酶抑制剂,也是一种高效的肝细胞低密度脂蛋白胆固醇 (LDL-C) 受体诱导剂。Pitavastatin sodium 在 HepG2 细胞中,能够抑制乙酸合成胆固醇 (IC50: 5.8 nM) 。Pitavastatin sodium 表现出抗动脉粥样硬化、抗哮喘、抗骨关节炎、神经保护、抗肿瘤、肝保护和肾保护作用。
T7072 Pitavastatin

Pitavastatin (NK-104) 是有效的羟甲基戊二酰-CoA(HMG-CoA)还原酶抑制剂。Pitavastatin 抑制乙酸合成胆固醇,在 HepG2 细胞中的IC50为 5.8 nM。Pitavastatin 是一种高效的肝细胞低密度脂蛋白胆固醇 (LDL-C) 受体诱导剂。Pitavastatin 具有抗动脉粥样硬化、抗哮喘、抗骨关节炎、抗肿瘤、神经保护、肝保护和肾保护等作用。
T70988 Ibulocydine

Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibuloc...
T35712 Debutyldronedarone hydrochloride

SR35021 hydrochloride

N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h...
T38844 MK-8245 Trifluoroacetate

MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. IC50 value: 1 nM (hSCD1) Target: SCD1 in vitro: MK-8245, a phenoxy piperidine isoxazole derivative, has been identified as a potent and liver-specific SCD inhibitor. It contains a tetrazole acetic acid moiety, which is the key molecule for OATPs recognition and liver-targeting. MK...

化合物

Phthalazinone pyrazole
Cat.No: T21981
Synonym:
Target: Aurora Kinase
BI-6015
Cat.No: T21867
Synonym: 2-甲基-1-(2-甲基-5-硝基苯基磺酰基)-1H-苯并[D]咪唑
Target: Others
SJA710-6
Cat.No: T5536
Synonym:
Target: Others
Fosgonimeton acetate
Cat.No: T39507L
Synonym: Fosgonimeton acetate (2093305-05-4 Free base)
Target: c-Met/HGFR
Terevalefim
Cat.No: T37596
Synonym:
Target: c-Met/HGFR
Dihexa
Cat.No: T7376
Synonym: PNB-0408,Hexanoyl-Tyr-Ile-Ahx-NH2,N-hexanoic-Try-Ile-(6)-amino hexanoic amide
Target: c-Met/HGFR
TCPOBOP
Cat.No: T17018
Synonym:
Target: BCL
Telisotuzumab
Cat.No: T77437
Synonym: ABT-700,Mab-224G11
Target: c-Met/HGFR
Bulevirtide (Myrcludex B) acetate
Cat.No: T35373L
Synonym:
Target: HBV
Rilotumumab
Cat.No: T76758
Synonym: AMG 102
Target: c-Met/HGFR
L-Ascorbic acid 2-phosphate magnesium
Cat.No: T19389
Synonym: 2-Phospho-L-ascorbic acid magnesium,维生素C磷酸酯镁,维生素 C 磷酸酯镁
Target: Phosphatase, Phosphorylase
Golvatinib
Cat.No: T6517
Synonym: E-7050,戈伐替尼
Target: VEGFR, c-Met/HGFR
Fosgonimeton
Cat.No: T39507
Synonym: ATH-1017
Target:
Crizotinib acetate
Cat.No: T1661L
Synonym: PF02341066,PF-2341066,PF 02341066,PF-02341066,PF2341066
Target:
Pamufetinib mesylate
Cat.No: T13108L
Synonym: TAS-115 mesylate,TAS-115 methanesulfonate
Target: Others
PUMAi HCl
Cat.No: T69218
Synonym:
Target:
RG-101
Cat.No: T39347
Synonym:
Target:
AB-729
Cat.No: T40259
Synonym:
Target:
Antitumor agent-29
Cat.No: T83006
Synonym:
Target:
Golvatinib tartrate
Cat.No: T71636
Synonym:
Target:
293P-1
Cat.No: T83393
Synonym:
Target:
CM-118
Cat.No: T70844
Synonym:
Target:
AMG-337 monohydrate
Cat.No: T70318
Synonym:
Target:
Quipazine maleate
Cat.No: T71792
Synonym:
Target:
GSK-3β inhibitor 6
Cat.No: T61804
Synonym:
Target:
Ethoxyquin Dimer
Cat.No: T35620
Synonym:
Target:
ABT-510
Cat.No: T69599
Synonym:
Target:
Tri-GalNAc-DBCO
Cat.No: T77948
Synonym:
Target: PROTACs
Foretinib phosphate
Cat.No: T71187
Synonym:
Target:
Val-Cit-amide-Ph-Maytansine
Cat.No: T80884
Synonym:
Target:
Ficlatuzumab
Cat.No: T76745
Synonym:
Target:
Vabametkib
Cat.No: T70434
Synonym:
Target:
Val-Cit-amide-Cbz-N(Me)-Maytansine
Cat.No: T80885
Synonym:
Target:
Ono 1301
Cat.No: T28240
Synonym: Ono-1301,Ono1301
Target:
Isovaleryl-L-carnitine (chloride)
Cat.No: T36098
Synonym:
Target:
Norleual TFA
Cat.No: T75940
Synonym:
Target:
J-1063
Cat.No: T62301
Synonym:
Target:
Cisd2 agonist 2
Cat.No: T82719
Synonym:
Target:
DprE1-IN-1
Cat.No: T62741
Synonym:
Target:
NFF-3 TFA
Cat.No: T76051
Synonym:
Target:
β-Apooxytetracycline
Cat.No: T35425
Synonym:
Target:
Recaticimab
Cat.No: T77144
Synonym:
Target:
Pitavastatin sodium
Cat.No: T62598
Synonym:
Target:
Pitavastatin
Cat.No: T7072
Synonym:
Target:
Ibulocydine
Cat.No: T70988
Synonym:
Target:
Debutyldronedarone hydrochloride
Cat.No: T35712
Synonym: SR35021 hydrochloride
Target:
MK-8245 Trifluoroacetate
Cat.No: T38844
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TN1403 Arjunolic acid

IL Receptor; TNF; Reactive Oxygen Species; JNK; AChE Apoptosis; Immunology/Inflammation; MAPK; Metabolism; Neuroscience; NF-κB
Arjunolic acid 是分离自蓝莓的皂苷,具有抗氧化、抗菌和抗炎症等多种生物活性,在保护细胞和组织免受活性氧的有害作用中发挥重要作用。
TQ0211 Brusatol

(+)-Brusatol,鸦胆子苦醇,NSC 172924

Others; Ferroptosis; Nrf2 Apoptosis; Immunology/Inflammation; Others
Brusatol (NSC-172924) 是一种从鸦胆子植物中分离出来的天然产物,抑制Nrf2通路,可使多种癌细胞对 Cisplatin 和其他化疗药物敏感。它可开发为辅助化疗化合物,可增加细胞凋亡。
T4S0217 HOMOPLANTAGININ

TNF; NF-κB Apoptosis; NF-κB
Homoplantaginin 是来自中药荔枝草的一种类黄酮,具有抗炎和抗氧化活性。
T13108 Pamufetinib

H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115

VEGFR; c-Met/HGFR Angiogenesis; Tyrosine Kinase/Adaptors
Pamufetinib (TAS-115) 是VEGFR 和c-Met/HGFR 抑制剂,能够抑制 rVEGFR2 (IC50:30 nM)和 rMET (IC50:32 nM)的活性。
T6S2246 Alisol B 23-acetate

Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B,泽泻醇B乙酸酯

Others Others
Alisol B 23-acetate (Alisol B Acetate) 是三萜类化合物,能够激活法尼醇受体,诱导受损的肝脏再生。
TN2147 Retrorsine

P450; OCT Membrane transporter/Ion channel; Metabolism
Retrorsine 特异性地抑制肝细胞增殖,并在肝损伤后唤起小肝细胞样祖细胞。逆转录酶可用于肝细胞损伤的研究。
TN1732 Herpetone

HBV Microbiology/Virology
Herpetone exhibits protective effects on CCl(4)-induced hepatocyte injury, it shows anti-hepatitis B virus (HBV) activity.
TN4440 Limonexic acid

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Limonexic acid shows antinociceptive actions , it produces dose-related inhibition of glutamate- and capsaicin-induced pain. Limonexic acid can effectively protect hepatocyte against CCl4-induced injury.
T72856 (+)-Cembrene A

(+)-Cembrene A 是一种α-glucosidase 抑制剂,IC50为 30.31 μM。(+)-Cembrene A 对人正常肝细胞 (LO2) 无毒性。
TN4334 Isotaxiresinol

TNF Apoptosis
Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. Isotaxiresinol ma
TN4374 Kaerophyllin

(-)-Kaerophylin

Apoptosis Apoptosis
Kaerophyllin ( (-)-Kaerophylin) 是一种从中药柴胡中分离出的木酚素,抑制肝细胞凋亡小体激活肝星状细胞,通过抑制肝脏炎症和抑制 HSC 活化来保护大鼠肝脏免受 TAA 引起的损伤和纤维化。

天然产物

Arjunolic acid
Cat.No: TN1403
Synonym:
Target: IL Receptor, TNF, Reactive Oxygen Species, JNK, AChE
Brusatol
Cat.No: TQ0211
Synonym: (+)-Brusatol,鸦胆子苦醇,NSC 172924
Target: Others, Ferroptosis, Nrf2
HOMOPLANTAGININ
Cat.No: T4S0217
Synonym:
Target: TNF, NF-κB
Pamufetinib
Cat.No: T13108
Synonym: H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115
Target: VEGFR, c-Met/HGFR
Alisol B 23-acetate
Cat.No: T6S2246
Synonym: Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B,泽泻醇B乙酸酯
Target: Others
Retrorsine
Cat.No: TN2147
Synonym:
Target: P450, OCT
Herpetone
Cat.No: TN1732
Synonym:
Target: HBV
Limonexic acid
Cat.No: TN4440
Synonym:
Target: GABA Receptor
(+)-Cembrene A
Cat.No: T72856
Synonym:
Target:
Isotaxiresinol
Cat.No: TN4334
Synonym:
Target: TNF
Kaerophyllin
Cat.No: TN4374
Synonym: (-)-Kaerophylin
Target: Apoptosis
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