66
6
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3156 |
Ciliobrevin A
Hedgehog Pathway Inhibitor 4,HPI-4 |
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
Ciliobrevin A (HPI-4) 是Hedgehog(Hh) 信号通路抑制剂,平均抑制浓度 (IC50) 值小于 10 μM。 | |||
T35537 |
Hedgehog Antagonist VIII
|
||
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity ... | |||
T75148 | Hedgehog IN-3 | ||
HedgehogIN-3 (化合物 3) 是一种hedgehog 通路抑制剂 (IC50= 0.01 µM)。HedgehogIN-3 可用于癌症的研究。 | |||
T79055 |
Hedgehog IN-2
|
||
HedgehogIN-2 (Compound 20)为一Hedgehog信号通路抑制剂,其在C3H10T1/2细胞中表现出低于0.003 μM的IC50值。 | |||
T15183 |
Dynarrestin
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
Dynarrestin 是一种细胞质动力蛋白 1 和 2的氨基噻唑抑制剂。它能够快速的、可逆的抑制动力蛋白 1 驱动的微管在体外滑动和细胞内动力蛋白 1 和 2 依赖性过程,且不影响 ATP 水解和干扰纤毛发生。它可抑制神经元前体和肿瘤细胞的刺猬因子依赖性增殖。 | |||
T6891 |
MK-4101
|
Apoptosis; Hedgehog/Smoothened; Smo | Apoptosis; GPCR/G Protein; Stem Cells |
MK-4101 是一种 SMO 拮抗剂 ,对 293 细胞的 IC50为 1.1 µM。它也是一种 hedgehog 信号通路的有效抑制剂 ,对小鼠细胞和KYSE180 食管癌细胞的IC50分别为 1.5 µM 和 1 µM。它能抗肿瘤,抑制肿瘤细胞增殖并诱导细胞凋亡。 | |||
T3588 |
JK184
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
JK184 是 Hedgehog 抑制剂,在哺乳动物细胞中的IC50值为 30 nM。 | |||
T9531 |
MRT-14
|
Smo | Stem Cells |
MRT-14 是有效的 Smo 拮抗剂。Smo 是参与 Hedgehog 形态发生素信号转导的主要成分。MRT-14 在研究与异常 Hh 信号传导相关的多种癌症方面有价值。 | |||
T2450 |
SANT-1
SANT 1 |
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
SANT-1 是Smo 拮抗剂,能够抑制Hedgehog 通路,在 Shh-LIGHT2 和 SmoA1-LIGHT2 实验中,得到的IC50值分别为 20 nM 和 30 nM。 | |||
T14965 |
Ciliobrevin D
|
ATPase; Hedgehog/Smoothened | GPCR/G Protein; Membrane transporter/Ion channel; Stem Cells |
Ciliobrevin D 是细胞渗透性,可逆和特异性的 AAA + ATPase 运动细胞质动力蛋白抑制剂。它在体外抑制依赖于动力蛋白的微管滑动和 ATPase 活性。它抑制Hedgehog 信号和初级纤毛形成。 | |||
T22814 |
GSA-10
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
GSA-10是新型的喹啉甲酰胺衍生物,有效激动平滑受体剂,EC50为 1.2 μM。它作用于Smo,促进多能间充质干细胞分化为成骨细胞。它介导 Hedgehog 信号传导,这可能对癌症疾病的再生医学具有研究意义。 | |||
T2590 |
Vismodegib
Erivedge,GDC-0449,RG 3616,维莫德吉 |
Hedgehog/Smoothened; ABC; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Stem Cells |
Vismodegib (GDC-0449) 是一种刺猬抑制剂,IC50值为 3 nM。它还可抑制 P-gp 和ABCG2的活性,IC50值分别为 3.0 μM 和 1.4 μM。 | |||
T26296 |
Triparanol
曲帕拉醇,MER-29,NSC 65345,NSC-65345,NSC65345 |
Apoptosis; Hedgehog/Smoothened | Apoptosis; GPCR/G Protein; Stem Cells |
Triparanol (NSC-65345) 干扰 Hedgehog 信号分子的翻译后修饰以及其受体 PTCH1 的甾醇传感域,导致 Hedgehog 信号的下调。 Triparanol 抑制人类肿瘤生长,是一种具有高眼毒性的抗血脂剂。 | |||
T20723 |
LGE-899
Sonidegib metabolite M48,LGE 899 |
Drug Metabolite | Metabolism |
LGE-899 (Sonidegib metabolite M48) 是 Sonidegib 的主要代谢物,是一种刺猬通路抑制剂。 LGE-899 (60 h) 的 Tmax 比 Sonidegib 长得多。 | |||
T22089 |
HPI 1
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
HPI 1 是一种刺猬 (Hh) 信号抑制剂。在 Shh-LIGHT2 细胞中抑制 Sonic Hedgehog (Shh)-、SAG- 和 Gli 诱导的 Hh 通路激活(Shh-、SAG-、Gli2- 和 Gli1 诱导的激活的 IC50 值为 1.5、1.5、4 和 6 μM) . | |||
T15019 |
CUR61414
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
CUR61414 是 Hedgehog 信号通路的细胞渗透性抑制剂 (IC50 = 100-200 nM),并选择性地结合 smoothened (Ki = 44 nM)。 | |||
T24754 |
Hh-Ag1.5
SAG-1.5,SAG1.5,SAG 1.5 |
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
Hh-Ag1.5 (SAG-1.5) 是一种高效的 Hedgehog (Hh) 激动剂(EC50: 1 nM)和Smoothened (Smo)受体激动剂,对Smo的 EC50 为 1 nM、 Ki值在 0.5 和 2.3 nM 之间。Hh-Ag1.5 介导的重编程打破了非损伤肝脏干细胞的静止状态,从而挽救了肝衰竭。Hh-Ag1.5 诱导 hiPSCs 分化为皮肤前体细胞、脊髓运动神经元和脊髓感觉神经元。 | |||
T2666 |
Taladegib
LY2940680 |
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
Taladegib (LY2940680) 是smoothened 受体拮抗剂。 | |||
T77603 |
WAY-313170
|
PDE | Metabolism |
WAY-313170 对刺猬信号传导和磷酸二酯酶有抑制作用。 | |||
T64351 |
GI-560192
RL-0070933 |
Smo | Stem Cells |
GI-560192 (RL-0070933) 是一种有效的纤毛调节剂。GI-560192 通过 hedgehog 信号通路调节 smoothed (Smo) 向初级纤毛的易位和/或积累。 | |||
T1779 |
SAG
Smoothened Agonist (SAG) HCl,Smoothened Agonist |
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
SAG (Smoothened Agonist) 是一种 Smo 受体激动剂 (EC50=3 nM),具有细胞渗透性和选择性。SAG 可以直接结合 Smo 螺旋束调节 Smo 活性,可以活化 Hedgehog 信号通路。 | |||
T35559 |
SAG 21k
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
SAG 21k 是一种可透过血脑屏障且具有口服生物活性和有效性的 Hedgehog 信号激活剂,可用于研究软骨再生。 | |||
T1926 |
Sonidegib
Erismodegib,NVP-LDE225,LDE225 |
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
Sonidegib (Erismodegib) 是一种Smo 的选择性拮抗剂,能够抑制鼠 Smo (IC50:1.3 nM)和人 Smo (IC50:2.5 nM)。 | |||
T3460 |
HhAntag
|
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
HhAntag 是高效的、特异性的、具有口服活性的 Hh 通路的SMO 拮抗剂。 | |||
T63429 |
SMO-IN-2
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
SMO-IN-2 是一种有效的 smoothened (SMO) 抑制剂,对 hedgehog (Hh) 信号传导有抑制作用。SMO-IN-2 对人髓母细胞瘤细胞系 显示出抗增殖活性和抗癌活性。SMO-IN-2 可用于研究癌症。 | |||
T15019L |
CUR61414 hydrochloride
CUR61414 hydrochloride (334998-36-6 Free base) |
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
CUR61414 hydrochloride 是属于氨基脯氨酸类化合物的小分子。CUR61414 hydrochloride 是一种细胞渗透性的 Hedgehog 信号通路抑制剂(IC50= 100-200 nM),可选择性结合 Smoothened (Smo, Ki= 44 nM)。CUR61414 hydrochloride 可以诱导癌细胞凋亡 (apoptosis) 而不影响非癌症细胞。 | |||
T21325 |
TAK-441
TAK441 |
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
TAK-441 是一种具有口服活性的 Hedgehog 信号抑制剂 (IC50 = 4.4 nM),具有有效的抗肿瘤活性。 TAK-441 抑制转录因子 Gli1 mRNA 表达和肿瘤生长。 | |||
T9532 |
MRT-81
|
Others | Others |
MRT-81 是一种人和啮齿动物 smoothened 受体的有效拮抗剂,能够抑制 hedgehog 的活性,在 Shh-light2 细胞中的IC50值为 41 nM。它可用于研究癌症。 | |||
T35548 |
Dynapyrazole A
|
Dynamin | Cytoskeletal Signaling |
Dynapyrazole A 是微管动力蛋白的特异性抑制剂,对动力蛋白 1 和动力蛋白 2 依赖性微管滑动的 IC50 分别为 2.3 和 2.6 μM。 Dynapyrazole A 抑制 Hedgehog 信号传导,IC50 为 1.9 μM。 | |||
T24159 |
IHR-1
IHR 1 |
Smo | Stem Cells |
IHR-1 是一种Smo 拮抗剂,不能透过细胞膜。 | |||
T3070 |
GANT 61
NSC 136476,GANT61 |
Hedgehog/Smoothened; Autophagy | Autophagy; GPCR/G Protein; Stem Cells |
GANT 61 (GANT61) 是一种Gli1和Gli2抑制剂,靶向Hedgehog/GLi 通路。 | |||
T40465 |
SAG dihydrochloride
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
SAG dihydrochloride 是一种强效的 Smoothened(Smo)受体激动剂(EC 50 =3 nM;K d =59 nM)。SAG dihydrochloride 可激活刺猬信号通路并抵消环丙胺对 Smo 的抑制。 | |||
T12109 |
MRT-83
|
Smo | Stem Cells |
MRT-83 是一种 Smo 拮抗剂,其IC50值在纳摩尔级别。它能够抑制 Hedgehog 信号通路。 | |||
T23027 |
MRT-10
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
MRT 10 是一种七跨膜平滑受体 (Smo) 拮抗剂,通过多种 Hedgehog (Hh) 测定,其IC50=0.65 μM。它与Smo 受体结合的位点是 Bodipycyclopamine。它可用于研究癌症。 | |||
T12797 |
RU-SKI 43
RUSKI 43 |
Hedgehog/Smoothened; Acyltransferase | GPCR/G Protein; Metabolism; Stem Cells |
RU-SKI 43 是一种有效的选择性刺猬酰基转移酶 (Hhat) 抑制剂,IC50 为 850 nM。RU-SKI 43 具有抗癌活性,是治疗肺腺癌的潜在化合物。RU-SKI 43 通过独立于平滑化的非规范信号传导降低 Gli-1 激活,并抑制 Akt 和 mTOR 通路活性。 | |||
T5465 |
PF-5274857
PF-5274857 freebase |
Smo | Stem Cells |
PF-5274857 (PF-5274857 free base) freebase 是有效的、具有口服活性的、选择性的、可透过血脑屏障的 Smo 拮抗剂,其 IC50=5.8 nM,Ki=4.6 nM。它有用于包括激活的 Hh 途径驱动的脑肿瘤和脑转移在内的多种肿瘤的研究潜力。 | |||
T71299 |
M-25
|
||
M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway. | |||
T12797L |
RU-SKI 43 hydrochloride
|
Others | Others |
RU-SKI 43 hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat)(IC50 of 850 nM), has anti-cancer activity. | |||
T26899 |
BRD50837
BRD-50837,BRD 50837 |
||
BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh). | |||
T23307 |
SANT 2
SANT-2 |
Others | Others |
SANT-2 is an inhibitor of Sonic hedgehog signaling and also antagonizes smoothened receptor activity (KD = 12 nM). | |||
T26901 |
BRD-9526
BRD 9526 |
||
BRD-9526 is a potent and selective inhibitor of Sonic Hedgehog (Shh). | |||
T34451 |
RUSKI-201
RU-SKI-201 |
||
RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells. | |||
T16843 |
Saridegib
IPI-926,Patidegib |
Others | Others |
Saridegib is an effective and specific inhibitor of Smoothened and a key signaling transmembrane protein in the Hedgehog pathway. | |||
T71455 | Glasdegib hydrochloride | ||
Glasdegib hydrochloride is a small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. | |||
T25918 |
Palmitoyl-L-aspartic acid
L-N-Palmitoylaspartic acid |
||
Palmitoyl-L-aspartic acid is a natural N-acylaspartate that suppresses Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog. It does not alter the activity of cannabinoid receptors or fatty acid amide hydrolas | |||
T3363L |
Jervine HCl
Jervine hydrochloride |
||
Jervine is a naturally occurring steroidal alkaloid derived from the Veratrum plant species. Over the Hedgehog signaling pathway, Jervine effectively inhibits tumor growth using three human tumor xenograft models. Jervine has the potential to advance to t | |||
T28388 |
PF-5274857 mseylate (1373615-35-0 free base)
PF5274857 HCl,PF 5274857,PF-5274857,PF-5274857 mesylate,PF-5274857 mseylate |
||
PF-5274857 is a potent, orally active and selective inhibitor of hedgehog (Hh) signaling pathway (IC50 = 5.8 nM, Ki = 4.6 nM) . PF-5274857 effectively penetrates the blood-brain barrier and inhibits Smo activity in the brain of primary medulloblastoma mic | |||
T40755 |
Glabrescione B
|
||
Glabrescione B is a novel compound that specifically binds to Gli1, an important modulator of the Hedgehog (Hh) signaling pathway. By disrupting the Gli1-DNA interaction, Glabrescione B effectively impairs the activity of Gli1. Moreover, Glabrescione B demonstrates potent inhibitory effects on the growth of tumor cells that rely on Hedgehog signaling, as well as on the self-renewal capacity and clonogenicity of tumor-derived stem cells. | |||
T74278 | HSP70-IN-3 | ||
HSP70-IN-3 是一种有效的热休克蛋白 (HSP70) 抑制剂 (ASZ001 和 C3H10T1/2 的 IC50分别为1.1和1.9 μM)。HSP70-IN-3 具有抗 Hedgehog 信号转导通路活性和抗增殖活性,并降低致癌转录因子 GLI1 的表达。 | |||
T71520 |
LEQ-506
|
||
LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway, thereby inhibiting tumor cell growth. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2825 |
Cyclopamine
环巴胺,11-Deoxojervine |
Hedgehog/Smoothened; Endogenous Metabolite; Smo | GPCR/G Protein; Metabolism; Stem Cells |
Cyclopamine (11-Deoxojervine) 是Hedgehog 通路的拮抗剂,细胞实验中IC50=46 nM。它还是选择性Smo 抑制剂。 | |||
T3912 |
Saikosaponin B1
柴胡皂苷B1,柴胡皂苷 B1 |
Others | Others |
Saikosaponin B1 是柴胡的生物活性成分,具有抗癌作用。它能够靶向SMO 抑制 Hedgehog 通路,显著抑制髓母细胞瘤模型中的肿瘤生长。 | |||
T3363 |
Jervine
蒜黎芦碱,Iervin,11-Ketocyclopamine,Jerwiny |
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
Jervine (Jerwiny) 是一种有效的刺猬 (Hh) 抑制剂(IC50:500-700 nM)。它是一种天然致畸性甾体生物碱,来自于 Veratrumalbum 的根茎,具有抗炎和抗氧化作用。 | |||
T1011 |
Itraconazole
伊曲康唑,R51211 |
P450; Hedgehog/Smoothened; Antibiotic; Autophagy; Antifungal | Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Stem Cells |
Itraconazole (R51211) 是三唑类抗真菌药,也是口服活性的Hedgehog 信号通路拮抗剂,IC50约为 800 nM。它也是 oxysterol-binding protein 抑制剂。它抑制羊毛甾醇 14α-脱甲基酶,从而抑制羊毛甾醇向麦角固醇的氧化转化。它有抗癌和抗血管作用。 | |||
T1155 |
Mebendazole
甲苯达唑,甲苯咪唑,Telmin,Mebenvet,Vermox,Pantelmin |
Apoptosis; Microtubule Associated; Parasite | Apoptosis; Cytoskeletal Signaling; Microbiology/Virology |
Mebendazole (Mebenvet) 是一种 hedgehog 抑制剂,用作驱虫药。 | |||
T4592 |
TOMATIDINE HYDROCHLORIDE
Tomatidine,Tomatidine HCl,盐酸番茄碱 |
Others; NF-κB; JNK; Autophagy | Autophagy; MAPK; NF-κB; Others |
Tomatidine hydrochloride (Tomatidine HCl) 是一种甾体生物碱,可防止肌肉萎缩并促进肌肉生长。它通过阻断 NF-κB 和JNK 信号发挥抗炎作用,可激活哺乳动物细胞或秀丽隐杆线虫中的自噬。 |