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15

抑制剂 & 化合物

19

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6516	Golgicide A	Others; Virus Protease	Microbiology/Virology; Others
	Golgicide A 可抑制柯萨奇病毒 B3 和其他人类肠道病毒的复制。它是一种高度特异性可逆的顺式高尔基体 ADP-核糖基化因子鸟嘌呤核苷酸交换因子抑制剂。
T16967	T-00127_HEV1	PI4K	PI3K/Akt/mTOR signaling
	T-00127_HEV1 是有效的phosphatidylinositol 4-kinase III beta 抑制剂，IC50为 60 nM。
T2432	PD 169316	Virus Protease; p38 MAPK; Autophagy	Autophagy; MAPK; Microbiology/Virology
	PD 169316 是一种细胞渗透性 p38 MAP 激酶抑制剂，IC50值为 89 nM。它可选择性地抑制磷酸化 p38 的激酶活性。
T4061	LY2334737	Nucleoside Antimetabolite/Analog; Others; Virus Protease	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	LY2334737 是一种具有口服活性的 Gemcitabine 的前药，也是核苷类似物。它抑制肠道病毒 A71 感染，有抗病毒和抗癌活性。
T1750	Pirodavir R77975,吡罗达韦	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	Pirodavir (R77975) 是一种广谱抗小核糖核酸病毒抑制剂，有效抑制人鼻病毒衣壳的结合。
T18928	Brilliant Black BN 亮黑1,E 151	Others; Virus Protease	Microbiology/Virology; Others
	Brilliant Black BN (E 151) 是一种偶氮染料和一种食品着色剂。它抑制 EV71 与其细胞脱壳因子亲环蛋白 A 之间的相互作用，是一种很有前途的抗 EV71 感染的抗病毒药物。
T4536	Pleconaril VP 63843,Win 63843,Picovir,普可那利	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	Pleconaril (VP 63843) 是一种有潜力研究肠病毒的衣壳抑制剂,，它可有效抑制复制, IC50值为 50 nM。
T4492	pocapavir SCH-48973,V-073	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	Pocapavir (SCH-48973) 是一种具有口服活性的研究性肠道病毒衣壳抑制剂，可防止病毒粒子进入细胞后脱壳。
T0188	Fluticasone (propionate) 丙酸氟替卡松,CCI-187881,氟替卡松丙酸酯,Fluticasone propionate	Glucocorticoid Receptor; Virus Protease; Estrogen/progestogen Receptor; Phospholipase; Endogenous Metabolite	Endocrinology/Hormones; Metabolism; Microbiology/Virology
	Fluticasone propionate (CCI-187881) 是一种选择性糖皮质激素受体激动剂，是一种局部抗炎激素，亲和力KD 为 0.5 nM。具有抗病毒活性。
T8498	EIDD-1931 Beta-d-N4-hydroxycytidine	Virus Protease; HCV Protease; SARS-CoV; Topoisomerase	DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	EIDD-1931 (Beta-d-N4-hydroxycytidine) 是一种核苷类抗病毒试剂，可抑制丙型肝炎病毒、基孔肯亚病毒和委内瑞拉马脑炎病毒的复制活性。
T36814	Chevalone B
	Chevalone B is a meroterpenoid originally isolated from the fungus E. chevalieri. It is cytotoxic to KB and NCI-H187 cells with IC50 values of 2.9 and 9.8 μg/ml, respectively.
T34840	Thevetose, L- Thevetose L-form
	Thevetose, L- is a bioactive chemical.
T124930	Thevetin A
	Thevetin A 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124930，CAS号为 37933-66-7。
T131628	Digitoxigenin (Thevetigenin; Echujetin; Cerberigenin)
	Digitoxigenin (Thevetigenin; Echujetin; Cerberigenin) 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131628。
T34026	Phevamine A PHVA	Others	Others
	Phevamine A (PHVA) 是植物免疫反应的抑制剂。

化合物

Cat.No: T6516

Target: Others, Virus Protease

Cat.No: T16967

Target: PI4K

Cat.No: T2432

Target: Virus Protease, p38 MAPK, Autophagy

Cat.No: T4061

Target: Nucleoside Antimetabolite/Analog, Others, Virus Protease

Cat.No: T1750

Synonym: R77975,吡罗达韦

Target: Virus Protease, Antiviral

Brilliant Black BN

Cat.No: T18928

Synonym: 亮黑1,E 151

Target: Others, Virus Protease

Cat.No: T4536

Synonym: VP 63843,Win 63843,Picovir,普可那利

Target: Virus Protease, Antiviral

Cat.No: T4492

Synonym: SCH-48973,V-073

Target: Virus Protease, Antiviral

Fluticasone (propionate)

Cat.No: T0188

Synonym: 丙酸氟替卡松,CCI-187881,氟替卡松丙酸酯,Fluticasone propionate

Target: Glucocorticoid Receptor, Virus Protease, Estrogen/progestogen Receptor, Phospholipase, Endogenous Metabolite

Cat.No: T8498

Synonym: Beta-d-N4-hydroxycytidine

Target: Virus Protease, HCV Protease, SARS-CoV, Topoisomerase

Cat.No: T36814

Cat.No: T34840

Synonym: Thevetose L-form

Cat.No: T124930

Digitoxigenin (Thevetigenin; Echujetin; Cerberigenin)

Cat.No: T131628

Cat.No: T34026

Synonym: PHVA

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5779	MOSLOFLAVONE	IL Receptor; Virus Protease; TNF; Antibacterial	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Mosloflavone 从Scutellaria baicalensis Georgi 中分离出的类黄酮，具有抗EV71活性。它可抑制铜绿假单胞菌的毒力和生物膜形成，有作为杀菌剂的潜力。它在病毒感染的初始阶段抑制 VP2 病毒复制和蛋白质表达，并抑制病毒 VP2 衣壳蛋白合成。
T5S2360	Corydaline Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline	P450; Virus Protease; Opioid Receptor; AChE	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Corydaline (Corydalin) 是从 Corydalis yanhusuo 提取的一种异喹啉生物碱，是一种新型促动力植物药的主要活性成分之一。它促进胃排空和小肠转运，促进胃的调节，具有抗乙酰胆碱酯酶、抗过敏和镇痛活性。
T8205	Norwogonin 5,7,8-Trihydroxyflavone,去甲汉黄芩素	Virus Protease	Microbiology/Virology
	Norwogonin (5,7,8-Trihydroxyflavone) 是从黄芩中分离出来的，对肠道病毒 71 具有抗病毒活性，IC50为 31.83 μg/ ml。
T3345	Hederasaponin B 常春藤皂苷B,Eleutheroside M,刺五加叶中,Hederacoside B	Others; Virus Protease	Microbiology/Virology; Others
	Hederasaponin B (Hederacoside B) 是从Hedera helix 中分离的，有广谱抗病毒活性。
T1670	Lanatoside C Cedilanid,Ceglunate,Isolanid,毛花甙丙,毛花苷C	ATPase; Virus Protease; Autophagy	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Lanatoside C (Ceglunate) 是一种可用于治疗充血性心力衰竭和心律失常的强心苷类药物。它作用于 HuH-7细胞，可抗登革病毒感染， IC50为0.19 μM。
TN2111	Prunin Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷	Phosphatase; Anti-infection; Virus Protease	Metabolism; Microbiology/Virology
	Prunin (Naringenin 7-0-glucoside) 是一种人肠道病毒 A71 抑制剂。它抑制蛋白酪氨酸磷酸酶 1B，IC50值为 5.5 μM。
T79982	2'-epi-2'-O-Acetylthevetin B GHSC-74	Apoptosis	Apoptosis
	2'-epi-2'-O-Acetylthevetin B (GHSC-74) 为源自Cerbera manghas L种子的强心苷，其抑制HepG2细胞增殖并诱导细胞凋亡(apoptosis)及线粒体膜电位降低。
TN5297	Glaucogenin C mono-D-thevetoside
	Glaucogenin C mono-D-thevetoside is a natural product from Cynanchum stauntonii.
T36815	Chevalone C
	Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). Chevalone C inhibits the growth of multidrug-resistant isolates of E. coli, S. aureus, and E. faecium in a disc diffusion assay when used at a concentration of 15 μg/disc. It also induces cell death in HCT116 colorectal carcinoma cells.
TN1734	Heveaflavone 橡胶树双黄酮	Antioxidant; Topoisomerase	DNA Damage/DNA Repair; oxidation-reduction
	Heveaflavone 抑制拓扑异构酶 I 并清除 DPPH 自由基，具有抗增殖和抗氧化作用。
TN2656	17alpha-Thevebioside	Others	Others
	17alpha-Thevebioside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2656，CAS号为 114613-59-1。
T82782	Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside
	Cannogenol 3-O-β-gentiobisyl-(1→4)-α-L-thevetoside (Compound 12) 是从Thevetia peruvian的种子中分离得到的强心苷化合物。它对SW1990和MGC-803细胞表现出细胞毒性，其IC50分别为9.52 μM和7.70 μM。
T13922	Thevetiaflavone 2-Genistein-5-methyl ether,Apigenin-5-methyl ether	BCL; Caspase	Apoptosis; Proteases/Proteasome
	Thevetiaflavone (2-Genistein-5-methyl ether) 是一种来自 Wikstroemia indica 的天然类黄酮，可抑制乳酸脱氢酶从细胞质中泄漏并提高细胞活力。
T83189	Acetylthevetin A
	Acetylthevetin A，一种从夹竹桃(Cascabela thevetioides)中分离出的天然产物。
TQ0102	Theviridoside	Others	Others
	Theviridoside is a natural product found in the leaves of Cerbera odollam.
TN2696	2,3-Dihydroheveaflavone	Others	Others
	2,3-Dihydroheveaflavone 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2696，CAS号为 110382-42-8。
TN5141	Thevetin B	ATPase; Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Thevetin B 是一种强心苷，是Na+-, K+-依赖性腺苷三磷酸酶 (Na+,K+-ATPase) 的抑制剂，来自 Thevetia peruviana。
TN5289	Thevebioside Digitoxigenin glucosylthevetoside
	Thevebioside and digitoxin are cardiac glycosides, have cardiac action.
T80702	α-Thevetin B
	α-Thevetin B（Compound 24）, 一种从Thevetia peruviana分离得到的心脏苷，用于肺癌、胃癌和胰腺癌的研究。

天然产物

Cat.No: T5779

Target: IL Receptor, Virus Protease, TNF, Antibacterial

Cat.No: T5S2360

Synonym: Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline

Target: P450, Virus Protease, Opioid Receptor, AChE

Cat.No: T8205

Synonym: 5,7,8-Trihydroxyflavone,去甲汉黄芩素

Target: Virus Protease

Hederasaponin B

Cat.No: T3345

Synonym: 常春藤皂苷B,Eleutheroside M,刺五加叶中,Hederacoside B

Target: Others, Virus Protease

Cat.No: T1670

Synonym: Cedilanid,Ceglunate,Isolanid,毛花甙丙,毛花苷C

Target: ATPase, Virus Protease, Autophagy

Cat.No: TN2111

Synonym: Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷

Target: Phosphatase, Anti-infection, Virus Protease

2'-epi-2'-O-Acetylthevetin B

Cat.No: T79982

Synonym: GHSC-74

Target: Apoptosis

Glaucogenin C mono-D-thevetoside

Cat.No: TN5297

Cat.No: T36815

Cat.No: TN1734

Synonym: 橡胶树双黄酮

Target: Antioxidant, Topoisomerase

17alpha-Thevebioside

Cat.No: TN2656

Target: Others

Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside

Cat.No: T82782

Thevetiaflavone

Cat.No: T13922

Synonym: 2-Genistein-5-methyl ether,Apigenin-5-methyl ether

Target: BCL, Caspase

Acetylthevetin A

Cat.No: T83189

Cat.No: TQ0102

Target: Others

2,3-Dihydroheveaflavone

Cat.No: TN2696

Target: Others

Cat.No: TN5141

Target: ATPase, Potassium Channel, Sodium Channel

Cat.No: TN5289

Synonym: Digitoxigenin glucosylthevetoside

Cat.No: T80702

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