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16

抑制剂 & 化合物

27

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1267L	CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate(254110-79-7 free base)	Others	Others
	CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate(254110-79-7 free base) 对应于 BRLF1 的氨基酸 148-156。 BRLF1 是一种转录激活因子，可直接与一些 Epstein-Barr 病毒 (EBV) 裂解基因启动子中的富含 GC 的基序结合。
TP1268	CEF19, Epstein-Barr Virus latent NA-3A (458-466) CEF19,Epstein-Barr Virus latent NA-3A 458-466
	CEF19, Epstein-Barr Virus latent NA-3A (458-466) is a single peptide epitope, YPLHEQHGM, representing residues 458-466 of the type 1 Epstein-Barr Virus (EBV) nuclear antigen 3A protein (B95.8 strain).
TP1267	CEF27, Epstein-Barr Virus BRLF-1 lytic (148-156) CEF27,Epstein-Barr Virus BRLF-1 lytic 148-156
	HLA-A0301-restricted epitope from Epstein-Barr* Virus , EBV BRLF-1 (148-156).
T16911	Sorivudine BV-araU,索立夫定	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Sorivudine (BV-araU) 是口服有效的，嘧啶核苷抗代谢药物。它的抗病毒活性来自某些 DNA 病毒中存在的特定胸苷激酶选择性转化为核苷酸，从而反过来会干扰病毒 DNA 合成。
TP1822L	CEF6 acetate(913545-15-0 free base)	Influenza Virus	Microbiology/Virology
	CEF6 acetate(913545-15-0 free base) 是 HLA-B7限制性流感病毒核蛋白表位，属于 CEF 对照肽。 CEF 对照肽长度为 8-12 个氨基酸，其序列来自人类巨细胞病毒、爱泼斯坦-巴尔病毒和流感病毒。
T10615	BRL44385	HSV	Microbiology/Virology
	BRL44385 is an effective and selective inhibitor of the replication of HSV-1 and HSV2, Epstein-Barr virus (EBV), and varicella-zoster virus (VZV).
T62921	EBNA1-IN-SC7
	EBNA1-IN-SC7 (compound SC7) 是一种 Epstein-Barr nuclear antigen 1 (EBNA1) 的选择性抑制剂，能够干扰 EBNA1-DNA 结合活性 (IC50: 23 μM)。EBNA1-IN-SC7 能够用于研究 EBV (Epstein-Barr virus) 相关癌症。
TP1507	CEF14, EBV Rta Protein (28-37) CEF14, EBV Rta Protein 28-37
	CEF14, EBV Rta Protein (28-37) is the HLA a24-restricted epitope from the epstein-barr virus Rta Protein (28-37).
T36412	Multiflorenol
	Multiflorenol is a triterpene that has been found in T. kirilowii seeds.1 It inhibits in vitro activation of Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter phorbol 12-myristate 13-acetate in a concentration-dependent manner. \|1. Akihisa, T., Tokuda, H., Ichiishi, E., et al. Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines. Cancer Lett. 173(1), 9-14 (2001).
T37277	2-Amino-6-chloropurine
	2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).1 1.Qiu, Y.-L., Ksebati, M.B., Ptak, R.G., et al.(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activityJ. Med. Chem.41(1)10-23(1998)
T11498	GSK682753A	Others	Others
	GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2; IC50: 53.6 nM).
TP1822	CEF6
	CEF6, a HLA-B7 restricted influenza virus nucleoprotein epitope, belongs to the CEF control peptides. The CEF control peptides are 8-12 amino acids in length, with sequences derived from the human cytomegalovirus, Epstein-Barr virus and influenza virus.
T29093	Valomaciclovir stearate A-174606.0,RP-606,EPB-348,ABT-606,MIV-606
	Valomaciclovir stearate is a DNA polymerase inhibitor. Valomaciclovir stearate is an orally available drug with broad-spectrum antiviral activity against a variety of important herpesviruses, including Epstein-Barr virus, or EBV (the first virus to be dir
TNU1050	3-Deoxy-1,2;5,6-di-O-isopropylidene-D-glucofuranose
	3-Deoxy-1,2;5,6-di-O-isopropylidene-D-glucofuranose 是一种多糖类的低聚糖。它用于糖基化的合成，可以定制合成用作药物中的碳水化合物。它通过抑制病毒蛋白合成而对Epstein-Barr 病毒具有抗病毒活性。
T61080	L-I-OddU
	L-I-OddU, a potent and selective anti-Epstein-Barr virus (EBV) agent, is a L-5'-halo-dioxolane nucleoside analogue. It demonstrates antiviral activity by effectively suppressing replicative EBV DNA and viral protein synthesis [1] [2]. With an EC 50 value of 0.03 μM, L-I-OddU exhibits high potency against EBV while maintaining low cytotoxicity, as indicated by its CC 50 value of 1000 nM.
T35434	β-Cembrenediol
	β-Cembrenediol (β-CBT) is a natural product from tobacco plants that is found in cigarette smoke condensate. β-CBT inhibits induction of the early antigen of Epstein-Barr virus (EA-EBV) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro (IC50 = 21.9 μM). It inhibits tumor promoting effects of TPA on 7,12-demethylbenz[a]anthracene-induced papilloma formation in vivo. β-CBT is also released into soil by flue-cured tobacco plants and exerts autotoxicity as well as phytotoxic activity against L....

化合物

CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate

Cat.No: TP1267L

Synonym: CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate(254110-79-7 free base)

Target: Others

CEF19, Epstein-Barr Virus latent NA-3A (458-466)

Cat.No: TP1268

Synonym: CEF19,Epstein-Barr Virus latent NA-3A 458-466

CEF27, Epstein-Barr Virus BRLF-1 lytic (148-156)

Cat.No: TP1267

Synonym: CEF27,Epstein-Barr Virus BRLF-1 lytic 148-156

Cat.No: T16911

Synonym: BV-araU,索立夫定

Target: DNA/RNA Synthesis

CEF6 acetate(913545-15-0 free base)

Cat.No: TP1822L

Target: Influenza Virus

Cat.No: T10615

Target: HSV

Cat.No: T62921

CEF14, EBV Rta Protein (28-37)

Cat.No: TP1507

Synonym: CEF14, EBV Rta Protein 28-37

Cat.No: T36412

2-Amino-6-chloropurine

Cat.No: T37277

Cat.No: T11498

Target: Others

Cat.No: TP1822

Valomaciclovir stearate

Cat.No: T29093

Synonym: A-174606.0,RP-606,EPB-348,ABT-606,MIV-606

3-Deoxy-1,2;5,6-di-O-isopropylidene-D-glucofuranose

Cat.No: TNU1050

Cat.No: T61080

β-Cembrenediol

Cat.No: T35434

Cat. No.	Product Name	Target	Signaling Pathways
T3S0872	Paederoside	Antiviral; HBV	Immunology/Inflammation; Microbiology/Virology
	Paederoside 是从Paederia pertomentosa 分离的一种单萜 S-甲基硫代碳酸酯。它抑制 Epstein-Barr 病毒的激活，有抗肿瘤促进作用。
TN1025	3,29-O-Dibenzoyloxykarounidiol	Others	Others
	3,29-O-Dibenzoyloxykarounidiol 是一种苯甲酸三萜烯酯，从 Momordica grosvenori 果实中提取。它能够抑制肿瘤启动子 TPA 诱导的 EB 病毒早期抗原活化。
T5712	zerumbone 花薑酮,球姜酮	Antioxidant; HSV	Microbiology/Virology; oxidation-reduction
	Zerumbone 是从Zingiber zerumbetSmith 的根茎中分离的一种单环倍半萜烯，可有效抑制Epstein-Barr 病毒的激活，IC50为 0.14 mM，具有抗癌、抗炎、抗氧化和抗增殖的作用。
TN1031	Poricoic acid B 茯苓酸B,茯苓新酸 B	Others	Others
	Poricoic acid B 是提取自 Poria cocos 中，拥有抗肿瘤作用。
TN1661	Ganoderic acid C2 灵芝酸 C2	Reductase; Histamine Receptor; Immunology/Inflammation related	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Ganoderic acid C2 是分离自灵芝的一种三萜化合物，具有潜在的抗肿瘤生物活性，以及抗组胺、抗衰老和细胞毒性作用。它对rat lens aldose reductase 具有很高的抑制活性，IC50为 3.8 µM。
TN1059	Ganoderic acid B	IL Receptor; HIV Protease; JAK; STAT	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells
	Ganoderic acid B 是从灵芝中分离的一种三萜类天然产物。它是端粒酶抑制剂，抑制 Epstein-Barr 病毒抗原的活化。它是 HIV-1 蛋白酶抑制剂。
T81813	Methyl lucidenate Q
	Methyl lucidenate Q，一种灵芝甲酯，展现了显著的抑制作用于EBV-EA诱导活性。
TN3309	9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid	Others	Others
	9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.
TN3321	9-Methoxy-alpha-lapachone	Others	Others
	9-Methoxy-alpha-lapachone has antitumor-promoting effect, it exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein- Barr virus early antigen (EBV-EA) activation in Raji cells.
T75567	Cabenoside D
	Cabenoside D（化合物 8）是从苔藓根的甲醇提取物中分离的一种三萜苷，显示出对12-O-十四烷酰基激素-13-乙酸酯（TPA）诱导的小鼠炎症的抗炎活性，并能抑制TPA促使的Epstein-Barr病毒（EBV）早期抗原（EBV-EA）激活。
TN5578	Abieta-8,11,13-triene-7,15,18-triol
	Abieta-8,11,13-triene-7alpha,15,18-triol,7alpha,8alpha,13beta,14beta-diepoxyabietan-18-oic acid, and 18-nor-abieta-8,11,13-triene-4alpha,7alpha,15-triol may have inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tum
TN2928	Pygenic acid A 3-Epicorosolic acid,脓毒酸A
	3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction, it has potential anti-inflammatory activities as well as cancer chemopreventive activity.3-Epicorosolic acid shows both potent α-glucosidase and pro
TN2839	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and causes a significant delay o
TN2926	3-Epicabraleahydroxylactone	Others	Others
	3-Epicabraleahydroxylactone has anti-tumor promoting effect, it has anti-carcinogenic activity by the inhibitory effect on the induction of Epstein-Barr virus early antigen(EBV-EA) by the tumor promoter.
TN3736	Cycloart-25-ene-3,24-diol	Others	Others
	(24R)-Cycloart-25-ene-3beta,24-diol may be an anti-tumor promoter, it exhibits inhibitory effects on both Epstein-Barr virus early antigen (EBV-EA) and (+/-)-(E)-methtyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3- hexemide (NOR 1) activation.
T14368	Azadirachtin B	Others	Others
	Azadirachtin B, a limonoid derived from the seed kernels of Azadirachta indica, exhibits a broad spectrum of biochemical activities, including insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral, and osteogenic effects. It is effective against the Epstein-Barr virus early antigen (EBV-EA), enhances alkaline phosphatase (ALP) activity, and promotes osteoblast differentiation[1][2][3].
TN2500	1,5,15-Tri-O-methylmorindol	Others	Others
	1,5,15-Tri-O-methylmorindol has effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA.
TN3019	4,9-Dihydroxy-alpha-lapachone	Others	Others
	4,9-Dihydroxy-alpha-lapachone has antitumor-promoting effects, it exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells. 4,9-Dihydroxy-alpha-l
TN4421	Latisxanthone C	Others	Others
	Latisxanthone C shows inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, it may be a valuable antitumor promoter.
T5157	9,13-Epidioxy-8(14)-abieten-18-oic acid	Others	Others
	9,13β-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 ± 0.2 uM. It is also a potential antitumor-promoting diterpenoid, it shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. 9 α ,13 β -Epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory...
T75566	11-Oxomogroside II A1
	11-Oxomogroside II A1（化合物 7）是一种从罗汉果乙醇提取物中分离的氧化葫芦苷，对12-O-十四烷酰基激素-13-乙酸酯（TPA）诱导的Epstein-Barr病毒（EBV）早期抗原（EBV-EA）活化具有抑制效果，并对一氧化氮（NO）供体（+/-）-(E)-甲基-2-[(E)羟基亚氨基]-5-硝基-6-甲氧基-3-己酰胺（NOR 1）的活化也展示出轻微的抑制作用。
TN4999	Serratenediol	BCL; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects being stronger than that of a representative control, oleanolic acid. Serratenediol can promote
TN3607	Catalpalactone	cAMP	GPCR/G Protein
	Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone can inhibit dopamine biosynthesis by
TN4277	Isocupressic acid	cAMP; P450; PKA	GPCR/G Protein; Metabolism; Tyrosine Kinase/Adaptors
	Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reproductive system, the decrease in blood flow and apoptosis of corpus luteum-derived endothelial ce
TN4592	Murrangatin	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line,
TN4140	Glochidiol	Others	Others
	Glochidiol exhibits strong inhibitory effects against all three human tumor cell lines (MCF-7, NCI-H-460 and SF-268), it exerts its antiproliferative activity through the involvement of apoptosis. It exhibits a strong inhibitory effect on mouse skin tumor
TN2977	3-O-trans-p-Coumaroyltormentic acid	Caspase; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, an...

天然产物

Cat.No: T3S0872

Target: Antiviral, HBV

3,29-O-Dibenzoyloxykarounidiol

Cat.No: TN1025

Target: Others

Cat.No: T5712

Synonym: 花薑酮,球姜酮

Target: Antioxidant, HSV

Poricoic acid B

Cat.No: TN1031

Synonym: 茯苓酸B,茯苓新酸 B

Target: Others

Ganoderic acid C2

Cat.No: TN1661

Synonym: 灵芝酸 C2

Target: Reductase, Histamine Receptor, Immunology/Inflammation related

Ganoderic acid B

Cat.No: TN1059

Target: IL Receptor, HIV Protease, JAK, STAT

Methyl lucidenate Q

Cat.No: T81813

9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid

Cat.No: TN3309

Target: Others

9-Methoxy-alpha-lapachone

Cat.No: TN3321

Target: Others

Cat.No: T75567

Abieta-8,11,13-triene-7,15,18-triol

Cat.No: TN5578

Cat.No: TN2928

Synonym: 3-Epicorosolic acid,脓毒酸A

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

Cat.No: TN2839

Target: HIV Protease

3-Epicabraleahydroxylactone

Cat.No: TN2926

Target: Others

Cycloart-25-ene-3,24-diol

Cat.No: TN3736

Target: Others

Cat.No: T14368

Target: Others

1,5,15-Tri-O-methylmorindol

Cat.No: TN2500

Target: Others

4,9-Dihydroxy-alpha-lapachone

Cat.No: TN3019

Target: Others

Latisxanthone C

Cat.No: TN4421

Target: Others

9,13-Epidioxy-8(14)-abieten-18-oic acid

Cat.No: T5157

Target: Others

11-Oxomogroside II A1

Cat.No: T75566

Cat.No: TN4999

Target: BCL, PARP, Caspase

Cat.No: TN3607

Target: cAMP

Isocupressic acid

Cat.No: TN4277

Target: cAMP, P450, PKA

Cat.No: TN4592

Target: IL Receptor, TNF, COX, Prostaglandin Receptor

Cat.No: TN4140

Target: Others

3-O-trans-p-Coumaroyltormentic acid

Cat.No: TN2977

Target: Caspase, Antifection

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