75
25
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20110 |
Ethylene thiourea
ETU,Imidazolidinethione,NCI C03372,NCIC03372,NCI-C03372,亚乙基硫脲 |
Others | Others |
Ethylene thiourea (NCIC03372) 是一种用于水果和蔬菜生产的农药。它还用作基于质子化学交换依赖性饱和转移的 MRI 研究的新型造影剂。 | |||
T14524 |
Befetupitant
Ro67-5930 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Befetupitant (Ro67-5930) 是一种具有有效性和选择性的速激肽 1 受体 (NK1R) 拮抗剂,可用于研究角膜新生血管形成。 | |||
T76766 |
Mirvetuximab
M9346A |
Antifolate | Cell Cycle/Checkpoint |
Mirvetuximab (M9346A) 是一种新型叶酸受体α (FRα) 靶向 anti-FOLR1 (folate receptor 1) 的单克隆抗体。Mirvetuximab soravtansine 常与铂类化合物或与其他化合物偶联成为抗体-药物偶联物用来治疗卵巢癌和其他 FRα 阳性的癌症。 | |||
T76692 |
Mosunetuzumab
BTCT-4465A |
Others | Others |
Mosunetuzumab (BTCT-4465A) 是一种基于免疫球蛋白 G1 且靶向 CD20 (B 细胞) 和 CD3 (T 细胞) 的人源化抗体。Mosunetuzumab 重定向 T 细胞以接合和消除恶性 B 细胞,可用于研究复发或难治性 (R/R) B 细胞非霍奇金淋巴瘤 (B-NHL)和难治性滤泡性淋巴瘤。 | |||
T76743 |
Emibetuzumab
LY2875358 |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Emibetuzumab 是一种有效的人源化二价 MET 抗体 (IgG4 型)。Emibetuzumab 具有抗肿瘤活性,对 HGF 依赖性和非依赖性 MET 通路的激活和肿瘤生长有抑制作用可用于研究晚期去势抵抗性前列腺癌。 | |||
T9905 |
Cetuximab
Cetuximab (anti-EGFR),C225,西妥昔单抗 |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Cetuximab (C225) 属于单克隆抗体,是一种人源表皮生长因子受体 (EGFR) 的抑制剂 (Kd=0.201 nM)。Cetuximab 具有抗肿瘤活性,可以抑制肿瘤细胞增殖,诱导细胞凋亡。 | |||
T9901A-005 |
Zolbetuximab
IMAB362 |
Others | Others |
Zolbetuximab(IMAB362) 是一种特异性靶向 Claudin-18.2 的单克隆抗体。Zolbetuximab 具有潜在的抗肿瘤活性,通过免疫效应机制介导对 Claudin-18.2 阳性细胞的杀伤作用。Zolbetuximab 可用于研究胃肠道腺癌和胰腺肿瘤。 | |||
T1145 |
Diminazene Aceturate
|
Others; Serine Protease; Parasite | Microbiology/Virology; Others; Proteases/Proteasome |
Diminazene aceturate 是血管紧张素转化酶 2 的激活剂,具有强效抗炎特性。它还是一种抗锥虫药物,适用于牲畜。它主要生化机理是通过与富含腺嘌呤-胸腺嘧啶碱基对的位点发生特异性相互作用,以非插入方式与锥虫动子体 DNA 结合。 | |||
T76720 |
Farletuzumab
MORAb-003 |
Antifolate | Cell Cycle/Checkpoint |
Farletuzumab (MORAb-003) 是一种有效的叶酸受体-α (FRα) 抑制剂。Farletuzumab 是一种对 FRα 具有高亲和力的人源化单克隆抗体。Farletuzumab 抑制过表达 FRα 的细胞的生长。Farletuzumab 可用于研究癌症。 | |||
T9901A-004 |
Labetuzumab
IMMU-14,hMN-14,IMMU-100 |
||
Labetuzumab (hMN-14) 是一种人源化抗癌胚抗原 (CEA) 单克隆抗体,具有抗癌活性,可抑制肿瘤生长,可用于研究甲状腺癌和结直肠癌 (CRC)。 | |||
T19761 |
Sulfometuron-methyl
DXP 5648,DXP-5648,甲嘧磺隆,DXP5648 |
Antibacterial | Microbiology/Virology |
Sulfometuron-methyl (DXP-5648) 是一种除草剂,也是一种活性抗菌剂。它是乙酰乳酸合酶 II 的有效抑制剂,因此具有抗菌特性。 | |||
T77362 |
Vorsetuzumab
SGN-70 |
Immunology/Inflammation related | Immunology/Inflammation |
Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) 是靶向 CD70 抗体的单克隆抗体。Vorsetuzumab 具有抗癌活性,能够加强肾癌细胞巨噬相关吞噬作用,抑制 Burkitt 淋巴瘤。 | |||
T76857 |
Anetumab
|
Others | Others |
Anetumab 是一种新型全人源抗间皮素 IgG1抗体,是 Anetumab ravtansine的裸抗。Anetumab 可用于合成抗体-活性分子偶联物 Anetumab ravtansine。Anetumab 可用于研究治疗转移性胸膜间皮瘤。 | |||
T6905 |
Netupitant
Ro 67-31898/000,奈妥吡坦,CID 6451149 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Netupitant (CID 6451149) 是一种高效选择性、可口服的神经激肽 1 受体 (NK1) 拮抗剂,具有止吐作用,在 CHO 细胞中对 hNK1的 Ki 值为 0.95 nM。 | |||
T8594 |
Pheneturide
2-PHENYLBUTYRYLUREA,S-46,Benuride,苯丁酰脲 |
Others | Others |
Pheneturide (Benuride) 是Phenobarbita l 脱羧后的产物,可阻止精神运动性癫痫发作。 | |||
T124388 | 8-O-Methylretusin-7-O-beta-D-glucopyranoside | ||
8-O-Methylretusin-7-O-beta-D-glucopyranoside 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124388。 | |||
T78104 |
Fosnetupitant chloride monohydrochloride
Pronetupitant chloride monohydrochloride |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Fosnetupitant chloride monohydrochloride(Pronetupitant chloride monohydrochloride)为NK1受体拮抗剂,对人NK1受体和NK3受体的pKi分别为9.5和6.1。它是奈妥匹坦的亚甲基磷酸酯前体。 | |||
T76693 | Moxetumomab | ||
Moxetumomab 是一种靶向重组CD22的免疫毒素。可用于研究毛细胞白血病 (HCL)。 | |||
T76677 | Dacetuzumab | ||
Dacetuzumab (SGN-40) 是一种人源化的 IgG1,抗 CD40单克隆抗体,具有抗淋巴瘤活性。Dacetuzumab 通过免疫效应作用(抗体依赖性细胞毒性和吞噬作用[ADCC/ADCP]) 杀死肿瘤细胞。Dacetuzumab ((SGN-40) 可用于多发性骨髓瘤研究。 | |||
T37039 |
Betulinic Aldehyde oxime
|
||
Betulinic aldehyde oxime is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It is active againstE. aerogenes,E. coli,E. faecalis,P. aeruginosa,S. aureus, andC. albicans, as well asL. donovaniamastigotes, when used at a concentration of 50 μM.1,2Betulinic aldehyde oxime (50 μM) is cytotoxic to Huh7 hepatocellular carcinoma cells.2 | |||
T123939 |
Gnetucleistol F
|
||
Gnetucleistol F 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T123939。 | |||
T40328 |
Betulinic acid derivative-1
|
||
Betulinic acid derivative-1 demonstrates potent inhibition of osteoclast (OC) differentiation, achieving an IC50 value of 1.86 μM. | |||
T31466 |
Dihydrobetulinic acid
|
||
Dihydrobetulinic acid is a bioactive chemical. | |||
T12213 |
Netupitant metabolite Netupitant N-oxide
Netupitant N-oxide |
Others | Others |
Netupitant N-oxide is a highly selective antagonist of NK1 receptor, is Netupitant metabolite. | |||
T31819 |
Fluometuron
NCI C08695,Ciba 2059,C 2059,NCI-C08695,NCIC08695 |
||
Fluometuron is an herbicide. In the United States it was approved for use on cotton and sugarcane crops in 1974, but since 1986 is only approved for use on cotton. | |||
T35678 |
2,3-Indolobetulinic glycine amide
|
||
2,3-Indolobetulinic glycine amide is a pentacyclic triterpene and derivative of betulinic acid .1It has been used in the synthesis of betulinic acid derivatives with anticancer activity. 1.Kumar, V., Rani, N., Aggarwal, P., et al.Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivativesBioorg. Med. Chem. Lett.18(18)5058-5062(2008) | |||
T19474 |
Netupitant N-oxide D6
|
Others | Others |
Netupitant N-oxide D6 is a Netupitant metabolite, is the deuterium labeled Netupitant N-oxide. | |||
T19434 |
Monohydroxy Netupitant D6
|
Others | Others |
Monohydroxy Netupitant D6 is a metabolite of Netupitant. | |||
T124184 | Gnetumontanin B | ||
Gnetumontanin B 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124184。 | |||
T124066 | Gnetucleistol B | ||
Gnetucleistol B 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124066。 | |||
T77825 |
Mirvetuximab soravtansine
IMGN853 |
||
Mirvetuximab soravtansine (IMGN853)是一种抗体药物偶联物(ADC),包含与人源化单克隆抗体M9346A共价连接的细胞毒素maytansoid DM4。该药物特异性地结合于叶酸受体1 (FOLR1),显示出抑制细胞生长和增强DNA损伤的抗增殖效果。 | |||
T76812 | Intetumumab | ||
Intetumumab (CNTO 95) 是一种有效的抗EGFR 单克隆抗体,是糖工程增强抗体依赖性细胞毒性 (ADCC)。Intetumumab 可用于癌症的研究。 | |||
T76818 | Lumretuzumab | ||
Lumretuzumab (Anti-Human ERBB3 Recombinant Antibody)为人源化抗HER3 (ERBB3)单克隆抗体,应用于癌症研究。 | |||
T69244 |
Betulonaldehyde
|
||
Betulonaldehyde is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found in Betula. It is active against P. falciparum (IC50 = 3.36 µg/ml) and cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC50s = 19.23 and 17.09 µg/ml, respectively). Topical application of betulonaldehyde (1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice. It has also been used a precursor in t... | |||
T36318 |
28-Acetylbetulin
|
||
28-Acetylbetulin is a lupane triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found inM. chiapensisand has anti-inflammatory and anticancer activities.1,2It inhibits LPS-induced nitric oxide (NO) and prostaglandin E2production by 55.9 and 69.5%, respectively, in RAW 264.7 cells (IC50s = 4.7 and 1.7 μM, respectively).128-Acetylbetulin induces cytotoxicity in a variety of cancer cells, including A549, HT-29, and MCF-7 cells (IC50s = 14.37, 10.96, and 11.3... | |||
T37038 |
Betulinic Acid propargyl ester
|
||
Betulinic acid propargyl ester is a pentacyclic lupane triterpene and alkyne derivative of betulinic acid .1,2It has been used in click chemistry reactions for the synthesis of cytotoxic anticancer betulinic acid derivatives. | |||
T124515 |
Gnetucleistol D
|
||
Gnetucleistol D 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124515。 | |||
T29655 |
Adeturon
|
||
Adeturon can play radioprotective effect. | |||
T35686 |
3-Acetyl Betulinaldehyde
|
||
3-Acetyl betulinaldehyde is a triterpene and derivative of the cholesterol biosynthesis inhibitor betulin that has been found inA. japonica.1It is an intermediate in the synthesis of 3-acetylbetulinic acid, as well as various lupine and germanicane triterpenes and saponins with anticancer activity.2 1.Tung, N.H., Kwon, H.-J., Kim, J.-H., et al.An anti-influenza component of the bark of Alnus japonicaArch. Pharm. Res.33(3)363-367(2010) 2.Thibeault, D., Gauthier, C., Legault, J., et al.Synthesis a... | |||
TMIH-0355 |
Monohydroxy Netupitant-d6
|
||
Monohydroxy Netupitant-d6 是 Monohydroxy Netupitant 的氘代化合物。Monohydroxy Netupitant 的 CAS 号为 910808-12-7。 | |||
T126306 | 2alpha-hydroxy-3beta-acetyloxy-betulic acid | ||
2alpha-hydroxy-3beta-acetyloxy-betulic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T126306。 | |||
T76783 | Moxetumomab pasudotox | ||
Moxetumomab pasudotox (CAT 8015) 是一种抗CD22免疫毒素,含有抗CD22Fv 和Pseudomonas exotoxin。CD22是在多种恶性 B 细胞上表达的细胞表面受体。Moxetumomab pasudotox 可用于毛细胞白血病 (HCL) 的研究。 | |||
T80563 |
Sabirnetug
|
||
Sabirnetug为人源化IgG2κ型抗体,专一性靶向Amyloid-β A4前体蛋白。 | |||
T33334 |
Methyl acetyl betulinate
|
||
Methyl acetyl betulinate is a bioactive chemical. | |||
T125017 |
Gnetuhainin N
|
||
Gnetuhainin N 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125017。 | |||
T35693 |
N-(2-Azidoethyl)betulonamide
|
||
N-(2-Azidoethyl)betulonamide is a pentacyclic triterpenoid, a derivative of betulonic acid , and an intermediate in the synthesis of betulonic acid derivatives within vitrocancer cell cytotoxicity.1 1.Suman, P., Patel, A., Solano, L., et al.Synthesis and cytotoxicity of Baylis-Hillman template derived betulinic acid-triazole conjugatesTetrahedron73(29)4214-4226(2017) | |||
T82696 |
Cofetuzumab
PF-06523435,hu24 |
||
Cofetuzumab (PF-06523435)为针对PTK7的人源化IgG1-κ亚型单克隆抗体,常在CHO(中国仓鼠卵巢)细胞表达体系中生产。 | |||
T12211 |
Netupitant metabolite Monohydroxy Netupitant
Monohydroxy Netupitant |
Others | Others |
Monohydroxy Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite. | |||
T131503 |
Betulinic acid (Mairin; Gratiolone; Platanol)
|
||
Betulinic acid (Mairin; Gratiolone; Platanol) 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131503。 | |||
T82575 |
Devextinetug
IXT-M200 |
||
Devextinetug (IXT-M200) 是一种小鼠源IgG2κ抗体,其特异性针对嵌合抗甲基苯丙胺 (Methamphetamine)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2148 |
Retusin
5-Hydroxy-3,7,3',4'-tetramethoxyflavone,Quercetin-3,7,3',4'-tetramethyl ether |
ATPase; Free radical scavengers; Tyrosinase | Membrane transporter/Ion channel; oxidation-reduction; Proteases/Proteasome |
Retusin 是从 Talinum triangulare 的叶子中提取的。 Retusin Retusin 可用于作为芽前和芽后除草剂的研究。 | |||
T5S0018 |
Betulonic acid
路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid |
Parasite; HSV | Microbiology/Virology |
Betulonic acid (Liquidambaric acid) 是一种在许多植物中存在的三萜类天然产物,具有抗肿瘤,抗炎,抗寄生虫和抗病毒的活性。 | |||
T2830 |
Betulinic acid
白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid |
Apoptosis; Mitophagy; NF-κB; HIV Protease; Topoisomerase; Endogenous Metabolite; Aminopeptidase; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物,是真核细胞拓扑异构酶 I 的抑制剂,IC50值为 5 μM,具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。 | |||
T3121 |
Betulin
Trochol,betulinic alcohol,betuline,betulinol,桦木醇,Betulol,白桦脂醇 |
Apoptosis; Endogenous Metabolite; Lipid; Fatty Acid Synthase | Apoptosis; Metabolism |
Betulin (betulinol) 是从桦树树皮中分离出来的一种天然三萜,是 SREBP 抑制剂。 | |||
T3S2152 |
23-Hydroxybetulinic acid
Anemosapogenin,23-羟基白桦酸 |
Others | Others |
23-Hydroxybetulinic acid (Anemosapogenin) 是一种具有抗癌作用的生物化合物。 | |||
T2S0765 |
Epibetulinic acid
|
NO Synthase; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Epibetulinic acid 对细菌内毒素刺激的小鼠巨噬细胞 (RAW 264.7) 中 NO 和前列腺素 E(2) 的产生具有有效的抑制作用,IC50分别为 0.7 和 0.6 μM,具有抗炎活性。 | |||
T3796 |
Betulinaldehyde
Betulinic aldehyde,Betulinal,Betunal,白桦脂醛 |
Apoptosis; Antibacterial | Apoptosis; Microbiology/Virology |
Betulinaldehyde (Betunal) 是五环三萜,有抗金黄色葡萄球菌等细菌和真菌作用。 | |||
TN1442 | Betulinic acid methyl ester | Antifection | Microbiology/Virology |
Betulinic acid methyl ester showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro.It also inhibited B16 2F2 cell proliferation by induction of apoptosis. | |||
TN2972 | 3-O-(E)-p-Coumaroylbetulin | Others | Others |
3-β-O-trans-p-coumaroylbetulinol has anti-angiogenic effect, it possesses significant anti-proliferative activity with 66.7% inhibition at 100uM. | |||
TN3509 | Betulin caffeate | Others | Others |
Betulin-3β-caffeate shows moderate antioxidant activity with IC50 value 108.0 ug/ml. | |||
T82274 |
Gnetuhainin I
|
||
Gnetuhainin I (Compound 5)是源自Pouzolzia zeylanica的木质素化合物,展现出对ATP柠檬酸裂解酶(ACLY)的显著抑制效果,其半抑制浓度(IC50)值为2.63 μM。 | |||
T20990 | Betulin diacetate | ||
Betulin diacetate is a bioactive chemical. | |||
T81507 |
Petunidin 3-rutinoside
|
||
Petunidin 3-rutinoside,一种可从Sambucus canadensis分离的天然产物。 | |||
TN3510 |
Betulin palmitate
|
Others | Others |
Betulin palmitate 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3510,CAS号为 582315-55-7。 | |||
TN5987 |
Betulinic acid palmitate
|
||
Betulinic acid palmitate 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5987,CAS号为 19833-15-9。 | |||
TN2061 |
Petunidin chloride
|
Others | Others |
Petunidin chloride has antioxidant, and anti-carcinogenesis activities. | |||
T41033 |
Fetuin, Fetal Bovine Serum
|
||
Fetuin, Fetal Bovine Serum is a glycoprotein weighing 64 kDa that is secreted by the liver and obtained from fetal bovine serum. It acts as an inhibitor of trypsin activity and facilitates cellular attachment, growth, and differentiation. | |||
TN2059 |
Petunidin-3-O-galactoside chloride
氯化矮牵牛素半乳糖苷,氯化矮牵牛素-3-O-半乳糖苷 |
Others | Others |
Petunidin-3-O-galactoside chloride has antioxidant activity. | |||
TN2814 |
23-Hydroxybetulin
|
Others | Others |
23-Hydroxybetulin is a natural product from Betula alba L. | |||
T34306 |
Retusine
|
||
Retusine is a compound extracted from the herb of Pogostemon cablin. | |||
T8522 |
Gnetulin
|
||
Gnetulin是一种天然产物,属于买麻藤科买麻藤属,其产品编号为 T8522,CAS号为 152340-24-4。Gnetulin可用作对照参考。 | |||
TN6621 |
Petunidin-3-O-arabinoside chloride
|
||
1. Petunidin-3-O-arabinoside chloride has antioxidant activity . | |||
T81506 |
Petunidin-3-O-(6-O-p-coumaryl)-5-O-diglucoside
|
||
Petunidin-3-O-(6-O-p-coumaryl)-5-O-diglucoside 是葡萄中可分离提取的天然产物。 | |||
TN2446 |
3-Oxobetulin
Betulone |
Antiviral | Immunology/Inflammation |
Betulone is a triterpenoid. It has a role as a metabolite. It derives from a hydride of a lupane. | |||
TN2060 |
Petunidin-3-O-glucoside chloride
|
Others | Others |
Petunidin-3-O-glucoside chloride has significantly higher antioxidant activity than the Fe2+ control. Petunidin-3-O-glucoside causes problems in digestibility, may be important dietary supplements with beneficial health effects. |