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38

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13613	ChX710	STING	Immunology/Inflammation
	ChX710可以引发 I 型干扰素对细胞溶质 DNA 的反应，其特异性细胞干扰素刺激基因 (ISG) 诱导 ISRE 启动子序列和干扰素调节因子 (IRF) 3 的磷酸化。
T7329	C-178	STING	Immunology/Inflammation
	C-178 是 STING 选择性共价抑制剂，与 Cys91 结合抑制小鼠中由不同的激活剂引起的 STING 反应。
T13015	STING agonist-4	STING	Immunology/Inflammation
	STING agonist-4 是是干扰素基因 (STING) 受体刺激剂的激动剂，IC50为 20 nM。
T9853	STING activator Compound 53	STING	Immunology/Inflammation
	基于 oxindole 核心结构的 STING activator Compound 53 在永生化细胞和原代细胞中表现出强大的 STING（人 EC50 185 nM）的靶向功能激活以及与 STING 激活一致的细胞因子诱导指纹。
T9554	SN-008	STING	Immunology/Inflammation
	SN-008 是 SN-011 的低活性类似物，可作为阴性对照。
T5674	H-151	STING	Immunology/Inflammation
	H-151 是一种 STING 拮抗剂，具有高效性和选择性。H-151 与 STING 的 Cys91 共价结合，抑制 Cys91 的棕榈酰化，从而抑制 STING 的活性。H-151 可用于体内外自身炎症性疾病的研究。
T5516	diABZI STING agonist-1 trihydrochloride	STING	Immunology/Inflammation
	diABZI STING agonist-1 trihydrochloride 是选择性的干扰素基因刺激受体(STING)激动剂，在人和小鼠中的 EC50值分别为 130 和 186 nM。
T8798	MSA-2	STING	Immunology/Inflammation
	MSA-2 是可口服的非核苷酸 STING 激动剂，以具有纳摩尔亲和力的非共价二聚体形式与 STING 结合。它在同基因小鼠肿瘤模型中显示抗肿瘤活性，与抗 PD-1 协同作用，可刺激肿瘤分泌干扰素-β，诱导肿瘤消退，具有持久的抗肿瘤免疫。
T6919	Omaveloxolone RTA-408	Apoptosis; Others; Nrf2; STING	Apoptosis; Immunology/Inflammation; Others
	Omaveloxolone (RTA-408) 是一种抗氧化炎症调节剂，可激活Nrf2并抑制一氧化氮。它通过抑制 STING 依赖的 NF-κb 信号通路，来抑制破骨细胞的生成。
T5154	C-176 C176,STING inhibitor 1	STING	Immunology/Inflammation
	C-176 (STING inhibitor 1) 是干扰素基因刺激受体的一种强效共价抑制剂。
T8655	SR-717	STING	Immunology/Inflammation
	SR-717 是一种 cGAMP 的类似物，一种非核苷类 STING 激动剂，可以诱导 STING 形成“封闭”的激活构象。SR-717 具有抗肿瘤活性，可以促进免疫细胞的激活以及抗原的交叉提呈。
T9029	STING-IN-3 C-171	STING	Immunology/Inflammation
	STING-IN-3 (C-171) 是干扰素基因刺激物 (STING) 的抑制剂。它与 STING 结合，抑制其棕榈酰化，并阻止 TBK1 的募集和磷酸化。
T9028	STING-IN-2 C-170	STING	Immunology/Inflammation
	STING-IN-2 (C-170) 是一种 STING 共价抑制剂，可抑制小鼠 STING (mmSTING) 和人类 STING (hsSTING)，可用于自身炎症性疾病的研究。
T8328	STING agonist-1 G10	Virus Protease; STING	Immunology/Inflammation; Microbiology/Virology
	STING agonist-1 (G10)是一种人类特异性 STING 激动剂，可引发针对新兴甲病毒的抗病毒活性。它抑制甲病毒属 VEEV 复制，IC90值为 24.57 μM。
T10252L2	ADU-S100 ammonium salt ML RR-S2 CDA ammonium salt,MIW815 ammonium salt	STING	Immunology/Inflammation
	ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) 是干扰素基因刺激物的激活剂。 ADU-S100 ammonium salt 可导致有效的全身性肿瘤消退和免疫。
T9137	SN-011 [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901	STING	Immunology/Inflammation
	SN-011 (GUN35901) 是选择性 STING 抑制剂，可与环状二核苷酸 (CDN) 竞争 STING 二聚体的结合口袋，从而阻断 CDN 结合和 STING 激活。它用于 STING 驱动的自身免疫和炎症性疾病的研究，抑制 STING 信号传导的 IC50值为 76 nM。
T7081	CCCP Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone,羰基氰化氯苯腙	Apoptosis; IκB/IKK; COX; Mitochondrial Metabolism; STING; IFNAR; Antibacterial	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) 是一种氧化磷酸化 (OXPHOS) 抑制剂，线粒体质子载体解偶联剂。CCCP 抑制 STING 及其下游信号分子 TBK1 和 IRF3 的激活。
T6273	Vadimezan DMXAA,伐地美生,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404	Influenza Virus; VDA; STING; IFNAR	Angiogenesis; Immunology/Inflammation; Microbiology/Virology
	Vadimezan (DMXAA) 是一种血管破坏剂，一种鼠 STING 激动剂，也是一种细胞因子如 I 型 IFN 的诱导剂。Vadimezan 具有抗肿瘤活性，可以诱导肿瘤中的血流快速停止，但不影响正常组织中的血流。
T28159	Nerisopam EGIS-6775,GYKI 52322,GYKI52322,EGIS6775,GYKI-52322	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Nerisopam 是一种γ-氨基丁酸（GABA）受体激动剂。
T8441	Lerisetron	5-HT Receptor	GPCR/G Protein; Neuroscience
	Lerisetron 是5-HT3拮抗剂，与 5-HT3受体具有高亲和力(pKi:9.2)。它对尿烷麻醉大鼠的 5-HT 引发的反射性心率过缓具有抑制作用。
T0511	Tolperisone hydrochloride 盐酸托哌酮,Muscalm,Midocalm,托哌酮盐酸盐,Tolperisone HCl	Sodium Channel	Membrane transporter/Ion channel
	Tolperisone hydrochloride (Muscalm) 是中枢作用肌肉松弛剂，可用于研究神经疾病引起的病理性横纹肌硬化(锥体束损伤、脊髓病、多发性硬化症、脑脊髓炎)、痉挛性麻痹及其他肌肉张力障碍相关的脑病。
T68087	Inaperisone	Others	Others
	Inaperisone 是一种新型的中枢作用的肌肉松弛剂，对排尿反射有抑制作用。Inaperisone 可能通过间接作用于脑干的GABAB 受体来抑制排尿反射。
T70489	Enerisant HCl	P450; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Enerisant HCl是一种新型强效选择性组胺H3受体拮抗剂，是P-gp的底物，由细胞色素P450（CYP）和转运蛋白介导。
T28778	Silperisone HCl RGH5002,SILA336,RGH-5002,Silperisone hydrochloride,SILA-336
	Silperisone HCl (RGH-5002) 阻断细胞中的钠和钙通道，使肌肉细胞的兴奋度和收缩度降低，降低外周张力，充当肌肉松弛剂和外周血管扩张剂。 Silperisone HCl 可用于治疗脊髓损伤引起的复发性疼痛性肌阵挛、脑血管病引起的异常高肌张力、肌张力症状、锥体紧张综合征、多发性硬化症肌痉挛和脊髓炎。Silperisone 是钠通道蛋白2型α通道阻滞剂。Silperisone 是一种类似于tolperisone 的有机硅化合物，具有中枢作用的肌肉松弛剂特性。
T11035	diABZI STING agonist-1 (Tautomerism) diABZI STING agonist (Compound 3)	STING	Immunology/Inflammation
	diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂，其在人和小鼠中的 EC50 值分别为 130 nM 和 186 nM。。
T5005	Eperisone hydrochloride	Others	Others
	Eperisone Hydrochloride 是一种抗痉挛试剂，用于肌肉僵硬和疼痛为特征的疾病的相关研究。它是一种中枢作用的肌肉松弛剂，抑制疼痛反射通路，具有血管扩张作用。它通过放松骨骼肌和血管平滑肌来起作用，例如减少肌张力，改善循环和抑制疼痛反射。
T67828	Enerisant
	Enerisant 是一种组胺H3受体拮抗剂/逆激动剂。体外研究表明，Enerisant 是一种有效的、高选择性的、竞争性的组胺H3受体拮抗剂，其选择性比其他组胺受体亚型高3000倍以上。
T124126	Asteriscunolide A
	Asteriscunolide A 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124126。
T125924	Pterisolic acid B
	Pterisolic acid B 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125924。
T32561	Lanperisone
	Lanperisone is a muscle relaxant.
T125921	Monnieriside A
	Monnieriside A 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125921。
T28160	Nerispirdine HCl HP-184,HP 184,Nerispirdine hydrochloride,HP184
	Nerispirdine is a acetylcholine release enhancer, sodium channel blocker and K(V) 2.1 channel blocker. Nerispirdine inhibits voltage-dependent Na(+) channel currents recorded from human SH-SY5Y cells with an IC(50) of 11.9 micromol/L when measured from a
T125082	Pierisformoside B
	Pierisformoside B 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125082，CAS号为 308335-44-6。
T71356	Lanperisone HCl
	Lanperisone, also known as NK433, is a muscle relaxant. NK433 inhibited the facilitation of the flexor reflex mediated by group II afferent fibers that was induced by intrathecal administration of noradrenaline-HCl. NK433 had effects more than three times stronger and tending to be longer-lasting than those of eperisone-HCl. These results suggest that NK433 exerts a non-selective inhibition on spinal reflexes and that inhibition of the descending noradrenergic tonic facilitation within the spina...
T81509	Perisulfakinin
	Perisulfakinin为一神经肽，能传递饱腹信号并抑制促进常规活动的中枢神经元活动。
T40744	Eperisone
	Eperisone is a centrally acting muscle relaxant and antispastic agent utilized in the treatment of conditions distinguished by muscle stiffness and pain. Its mechanism of action involves the relaxation of skeletal muscles and vascular smooth muscles, resulting in a range of beneficial effects including reduction of myotonia, enhancement of circulation, and suppression of the pain reflex. Additionally, Eperisone exhibits inhibitory properties on the pain reflex pathway and exerts a vasodilator ef...
T71281	Nerispirdine
	Nerispirdine is a biochemical that inhibits batrachotoxin binding to voltage-dependent sodium channels.
T21077	Tolperisone free base Mydeton,Atmosgen free base,Mideton,Menopatol,Besnoline free base,Mydocalm
	Tolperisone free base, a centrally acting muscle relaxant, has been used for the symptomatic treatment of spasticity and muscle spasm.

化合物

Cat.No: T13613

Target: STING

Cat.No: T7329

Target: STING

STING agonist-4

Cat.No: T13015

Target: STING

STING activator Compound 53

Cat.No: T9853

Target: STING

Cat.No: T9554

Target: STING

Cat.No: T5674

Target: STING

diABZI STING agonist-1 trihydrochloride

Cat.No: T5516

Target: STING

Cat.No: T8798

Target: STING

Cat.No: T6919

Synonym: RTA-408

Target: Apoptosis, Others, Nrf2, STING

Cat.No: T5154

Synonym: C176,STING inhibitor 1

Target: STING

Cat.No: T8655

Target: STING

Cat.No: T9029

Synonym: C-171

Target: STING

Cat.No: T9028

Synonym: C-170

Target: STING

STING agonist-1

Cat.No: T8328

Synonym: G10

Target: Virus Protease, STING

ADU-S100 ammonium salt

Cat.No: T10252L2

Synonym: ML RR-S2 CDA ammonium salt,MIW815 ammonium salt

Target: STING

Cat.No: T9137

Synonym: [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901

Target: STING

Cat.No: T7081

Synonym: Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone,羰基氰化氯苯腙

Target: Apoptosis, IκB/IKK, COX, Mitochondrial Metabolism, STING, IFNAR, Antibacterial

Cat.No: T6273

Synonym: DMXAA,伐地美生,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404

Target: Influenza Virus, VDA, STING, IFNAR

Cat.No: T28159

Synonym: EGIS-6775,GYKI 52322,GYKI52322,EGIS6775,GYKI-52322

Target: GABA Receptor

Cat.No: T8441

Target: 5-HT Receptor

Tolperisone hydrochloride

Cat.No: T0511

Synonym: 盐酸托哌酮,Muscalm,Midocalm,托哌酮盐酸盐,Tolperisone HCl

Target: Sodium Channel

Cat.No: T68087

Target: Others

Cat.No: T70489

Target: P450, Histamine Receptor

Silperisone HCl

Cat.No: T28778

Synonym: RGH5002,SILA336,RGH-5002,Silperisone hydrochloride,SILA-336

diABZI STING agonist-1 (Tautomerism)

Cat.No: T11035

Synonym: diABZI STING agonist (Compound 3)

Target: STING

Eperisone hydrochloride

Cat.No: T5005

Target: Others

Cat.No: T67828

Asteriscunolide A

Cat.No: T124126

Pterisolic acid B

Cat.No: T125924

Cat.No: T32561

Cat.No: T125921

Nerispirdine HCl

Cat.No: T28160

Synonym: HP-184,HP 184,Nerispirdine hydrochloride,HP184

Pierisformoside B

Cat.No: T125082

Lanperisone HCl

Cat.No: T71356

Cat.No: T81509

Cat.No: T40744

Cat.No: T71281

Tolperisone free base

Cat.No: T21077

Synonym: Mydeton,Atmosgen free base,Mideton,Menopatol,Besnoline free base,Mydocalm

Cat. No.	Product Name	Target	Signaling Pathways
TN5576	Pterisolic acid E
	Pterisolic acid E is a natural product from Pteris semipinnata.
TN4845	Pterisolic acid D	Others	Others
	Pterisolic acid D 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4845，CAS号为 1401419-88-2。
T83260	6β,7β-Epoxyasteriscunolide A
	6β,7β-Epoxyasteriscunolide A 是一种具有细胞毒性的倍半萜类化合物，其对 HL-60 和 MOLT-3 白血病细胞系展现出的 IC50 值介于 4.1-5.4 μM 之间。
TN1948	Monnieriside G	Others	Others
	Monnieriside G is a natural product from Cnidium monnieri.
TN1356	Acetyl Perisesaccharide C 乙酰杠柳寡糖 C,乙酰杠柳寡糖C	Others	Others
	Acetyl Perisesaccharide C is a natural product
T81766	Monnierisides A
	Monnierisides A为来源于Cnidium Monnieri的色酮苷，通过分离工艺得到。
TN2056	Perisesaccharide B	Others	Others
	Perisesaccharide B is a natural product
TN2057	Perisesaccharide C	Others	Others
	Perisesaccharide C is a natural product
TN4843	Pterisolic acid A	Others	Others
	Pterisolic acid A shows moderate activity against HCT-116,Hep G2 and BGC-823 cell lines.
TN4844	Pterisolic acid C	Others	Others
	Pterisolic acid C is a natural product from Pteris semipinnata.
TN4846	Pterisolic acid F	Others	Others
	Pterisolic acid F is a natural product from Pteris semipinnata.

天然产物

Pterisolic acid E

Cat.No: TN5576

Pterisolic acid D

Cat.No: TN4845

Target: Others

6β,7β-Epoxyasteriscunolide A

Cat.No: T83260

Cat.No: TN1948

Target: Others

Acetyl Perisesaccharide C

Cat.No: TN1356

Synonym: 乙酰杠柳寡糖 C,乙酰杠柳寡糖C

Target: Others

Monnierisides A

Cat.No: T81766

Perisesaccharide B

Cat.No: TN2056

Target: Others

Perisesaccharide C

Cat.No: TN2057

Target: Others

Pterisolic acid A

Cat.No: TN4843

Target: Others

Pterisolic acid C

Cat.No: TN4844

Target: Others

Pterisolic acid F

Cat.No: TN4846

Target: Others

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