78
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14935 |
Elexacaftor
VX-445 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
Elexacaftor (VX-445) 是一种囊性纤维化跨膜电导调节因子 (CFTR) 校正剂。它促进CFTR 的加工和转运,增加细胞表面CFTR 的数量。 | |||
T16681 |
Nesolicaftor
PTI-428 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
Nesolicaftor (PTI-428) 特异性增强囊性纤维化跨膜电导调节蛋白合成。 | |||
T9499 |
Icenticaftor
QBW251 |
CFTR | Membrane transporter/Ion channel |
Icenticaftor (QBW251) 是一种具有口服活性CFTR 通道增强剂,可用于慢性阻塞性肺疾病 (COPD) 和囊性纤维化研究,对F508del 和G551D CFTR 的EC50分别为 79 和 497 nM。 | |||
T3135 |
KM11060
|
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
KM11060 是 F508del-CFTR 运输缺陷的新型校正剂,可纠正 F508del-CFTR 运输,增加质膜上功能性 CFTR 的数量。它可用于 F508del-CFTR 加工缺陷的研究和囊性纤维化治疗剂的开发。 | |||
T1634 |
Glibenclamide
格列本脲,Glyburide |
Potassium Channel; Mitochondrial Metabolism; CFTR; P-gp; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Glibenclamide (Glyburide) 是一种具有口服活性的 ATP 敏感的 K+通道抑制剂,可研究糖尿病和肥胖。它抑制 P-糖蛋白,可直接结合并阻断 KATP 的 SUR1亚基并抑制囊性纤维化跨膜传导调节蛋白。它通过诱导膜离子通透性干扰线粒体生物能,可诱导自噬。 | |||
T7083 |
GLPG1837
ABBV-974 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
GLPG1837 (ABBV-974) 是一种有效的 CFTR 增强剂,对其 F508del 和 G551D 的 EC50 分别为 3 nM 和 339 nM。 | |||
T1805 |
Ataluren
PTC124 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
Ataluren (PTC124) 是一种可口服的 CFTR-G542X 无义等位基因抑制剂。 | |||
T2451 |
GlyH-101
GlyH 101 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
GlyH-101 是一种可渗透入细胞的 CFTR 阻断剂,Ki 为1.4 uM。 | |||
T2588 |
Ivacaftor
Ivacaftor (VX-770),VX-770,依伐卡托 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
Ivacaftor (VX-770) 是一种 CFTR 增强剂,靶向G551D-CFTR 和F508del-CFTR 的EC50分别为100 和 25 nM。 | |||
T1874 |
PPQ-102
PPQ102,CFTR Inhibitor,PPQ 102 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
PPQ-102 (CFTR Inhibitor) 是一种CFTR 抑制剂,可以完全抑制CFTR 氯化物电流,IC50为90 nM。 | |||
T10591 |
BPO-27 racemate
BPO-27 (racemate) |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
BPO-27 racemate (BPO-27(racemate)) 是一种CFTR 抑制剂,IC50为8 nM。 | |||
T5312 |
CFTR corrector 2
FDL169 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
CFTR corrector 2 (FDL169) 是一种新型有效的囊性纤维化跨膜电导调节因子(CFTR)调节剂,用于治疗携带 F508del 突变的囊性纤维化患者。 | |||
T4503 |
Talniflumate
Somalgen,他尼氟酯 |
Chloride channel; COX; N-Acetylglucosaminyltransferase; Anion Exchanger | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Talniflumate (Somalgen) 是一种钙激活氯离子通道 (hCLCA1/mCLCA3) 阻滞剂,可减少动物模型和细胞培养中的粘蛋白合成和释放。它通过抑制环氧合酶,并抑制 Cl-/HCO3- 交换活性,具有抗炎作用。它还增加了远端肠梗阻综合征囊性纤维化小鼠模型的存活率。 | |||
T2355 |
CFTR(inh)-172
CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
CFTR(inh)-172 (CFTR Inhibitor-172) 是一种不依赖电压的选择性 CFTR 抑制剂,在2分钟内可逆地抑制CFTR 短路电流的Ki 值为300 nM。 | |||
T2595 |
Lumacaftor
鲁玛卡托,VX-809,VRT 826809 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
Lumacaftor (VRT 826809) 是一种 CFTR 调节剂,可纠正 CFTR 蛋白的折叠和运输。它增强了 FRT 细胞中 F508del-CFTR 蛋白的成熟,EC50为100 nM。 | |||
T2486 |
IOWH-032
IOWH032,IOWH 032 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
IOWH-032 (IOWH032) 是一种合成 CFTR 抑制剂,可用于研究治疗霍乱、腹泻和分泌性腹泻,在T84和CHO-CFTR 细胞实验中IC50为1.01 uM。 | |||
T6540 |
Ibuprofen Lysine
布洛芬赖氨酸盐,Neoprofen |
COX | Immunology/Inflammation; Neuroscience |
Ibuprofen Lysine (Neoprofen) 是一种非甾体抗炎药。 | |||
T1394 |
Ibuprofen
Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil |
COX | Immunology/Inflammation; Neuroscience |
Ibuprofen (Advil) 是一种丙酸衍生物和非甾体抗炎药 (NSAID),具有抗炎、镇痛和解热作用。它是COX-1和COX-2的抑制剂,IC50值分别为 13 和 370 μM,导致前列腺素和血栓素前体的形成减少。 | |||
T2263 |
Tezacaftor
VX661,1-(2,2-二氟-1,3-苯并二氧戊环-5-基)-N-[1-[(2R)-2,3-二羟基丙基]-6-氟-2-(2-羟基-1,1-二甲基乙基)-1H-吲哚-5-基]-环丙烷甲酰胺 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
Tezacaftor (VX661) 是一种小分子,可用作囊性纤维化跨膜电导调节器基因功能的校正剂。 | |||
T15543 |
IA-Alkyne
N-Hex-5-ynyl-2-iodo-acetamide,Iodoacetamide-alkyne |
TRP/TRPV Channel | Membrane transporter/Ion channel |
IA-Alkyne (Iodoacetamide-alkyne) 是TRP 通道 (TRPC) 的激动剂,有用于呼吸道感染相关疾病研究的潜力。IA-Alkyne 可以用于开发同位素标记的探针,在定量的半胱氨酸反应分析 (cysteine-reactivity)有应用的价值。 | |||
T131553 |
Echinocystic acid (Albizziagenin)
|
||
Echinocystic acid (Albizziagenin) 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131553。 | |||
T63806 |
CFTR corrector 8
|
CFTR | Membrane transporter/Ion channel |
CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic disorder primarily affecting the lungs and digestive system [1]. | |||
T26955 |
Cavosonstat
N91115,N 91115,N-91115 |
GSNOR; CFTR | Membrane transporter/Ion channel; Metabolism |
Cavosonstat (N91115) 是一种口服活性 S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂,可促进囊性纤维化跨膜传导调节器(CFTR)成熟和质膜稳定。 | |||
T60653 |
CFTR corrector 9
|
CFTR | Membrane transporter/Ion channel |
CFTR corrector 9是一种囊性纤维化跨膜传导调节蛋白 (CFTR)调节剂。CFTR corrector 9 可用于研究囊性纤维化 (CF) 和其他 CFTR 相关疾病。 | |||
T20341 |
DNDS
|
CFTR | Membrane transporter/Ion channel |
DNDS 是电压依赖性囊性纤维化跨膜电导调节剂 (CFTR) 的通道阻滞剂。 | |||
T29041 |
UCCF-853
UCCF853,UCCF 853 |
CFTR | Membrane transporter/Ion channel |
UCCF-853 是一种小分子 CFTR 调节剂,可用于研究囊性纤维化。 | |||
T10776 |
CFTR corrector 4
|
CFTR | Membrane transporter/Ion channel |
CFTR corrector 4是一种高效且可口服的囊性纤维化跨膜电导调节剂 (CFTR),是一种有效的 (R,R) 型活性对映体。CFTR corrector 4 可以增加细胞表面的 CFTR 水平,是用来研究囊性纤维化的潜在化合物。 | |||
T31014 |
Corrector C4
Corr 4a,Corrector C-4,Corr4a,Corrector C 4,Corr-4a |
Others | Others |
Corrector C4 是一种常用于研究囊性纤维化突变体的校正子,通过减轻CFTR跨膜结构域突变体与蛋白稳态的相互作用来发挥作用。 | |||
T29114 |
VRT-532
CFpot-532,CFpot-532) |
CFTR | Membrane transporter/Ion channel |
VRT-532 (CFpot-532)是CFTR 的有效调节剂,常用于CFTR 缺陷引起的囊性纤维化(CF)研究。降解囊性纤维化中积累的硫酸化糖胺聚糖(gag)所必需的Arylsulfatase B (ARSB),小分子调节剂VRT-532对CFTR 的修饰能增加ARSB 并减少4-硫酸软骨素的积累。 | |||
T77604 |
WAY-326766
|
CFTR | Membrane transporter/Ion channel |
WAY-326766通过突变型 CFTR 增加离子转运,可用于改变真核生物的寿命。WAY-326766可用于治疗囊性纤维化(CF)。 | |||
T30293 |
Bamocaftor
VX-659 |
CFTR | Membrane transporter/Ion channel |
Bamocaftor是一种CFTR通道(DeltaF508-CFTR突变)矫正器,适用于 CF 跨膜传导调节器,被设计用于恢复 F508del-CFTR 蛋白功能。联合使用 tezacaftor 和 VX-561 治疗 F508del/MF 的囊性纤维化患者。 | |||
T25376 |
Ensifentrine
Ensifentrina,Ensifentrinum |
PDE | Metabolism |
Ensifentrine (Ensifentrinum) 是首创的吸入式磷酸二酯酶 3 (PDE3) 和PDE4双重抑制剂,IC50分别为 0.4 nM 和 1479 nM。它具有支气管保护和抗炎作用,可用于研究慢性阻塞性肺疾病 (COPD) 。 | |||
T37744 |
N-octanoyl-L-Homoserine lactone
C8-HSL,N-octanoyl-L-Homoserine lactone,OHL |
Antibacterial | Microbiology/Virology |
N-octanoyl-L-Homoserine lactone (C8-HSL) 是一种具有扩散性的外源性鼠疫耶尔森菌群体感应分子,可调节LcrV毒力因子,通过参与群体感应控制基因表达,影响细胞代谢。N-octanoyl-L-Homoserine lactone 是用于研究囊性纤维的感染。 | |||
T111959 |
IFB-088 acetate
|
||
IFB-088 acetate 是一种苄基胍衍生物,可用于治疗与PPP1R15A 途径相关并与蛋白质错误折叠应激相关的疾病和癌症,如tau 病、突触核蛋白病、多谷氨酰胺和多丙氨酸疾病、白质营养不良、囊性纤维化、多发性硬化症、溶酶体储存障碍、淀粉样变性疾病、炎症、代谢障碍、心血管疾病、骨质疏松症、神经系统创伤等等。 | |||
T23648 | AF-2785 | ||
In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels. | |||
T27734 |
KM-003 (sulfite)
KM 003,P-552,KM003,P552,P 552,KM-003 |
||
KM-003, a sodium channel blocker, is used potentially for the treatment of cystic fibrosis. | |||
T74748 | Zatonacaftor | ||
Zatonacaftor 是囊性纤维化跨膜调节剂(CFTR)蛋白的调节剂,主要应用于囊性纤维化的研究。 | |||
T25136 |
Aztreonam lysine
Corus 1020,Corus1020,Corus-1020,Aztreonam lysinate |
||
Aztreonam lysine is an inhaled anti-pseudomonal treatment for people who have pulmonary Pseudomonas aeruginosa infection with cystic fibrosis (CF). | |||
T27098 |
Ivacaftor-D9
deutivacaftor,CTP-656 |
||
CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis. | |||
T36519 |
Posenacaftor sodium
|
||
Posenacaftor (PTI-801) sodium, a cystic fibrosis transmembrane regulator (CFTR) modulator, corrects CFTR protein folding and trafficking. It is utilized in researching cystic fibrosis (CF)[1]. | |||
T13704 |
GLPG-3221
|
Others | Others |
GLPG-3221 can be uesd for the treatment of cystic fibrosis.GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. | |||
T29040 |
UCCF-029
UC(CF)-029,UC(CF) 029,UCCF029,UC(CF)029 |
||
UCCF-029 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR). | |||
T25898 |
Olacaftor
VX 440,VX-440,VX440 |
||
Olacaftor, also known as VX-440, is a protein modulator of cystic fibrosis transmembrane regulator (CFTR). | |||
T13742 |
Ivacaftor benzenesulfonate
VX-770 benzenesulfonate |
Others | Others |
Ivacaftor benzenesulfonate used for cystic fibrosis treatment. is an orally bioavailable CFTR potentiator. | |||
T27146 |
Denufosol tetrasodium
INS37217,INS 37217,INS-37217 |
||
Denufosol is a P2Y2 agonist potentially for the treatment of cystic fibrosis. | |||
T13742L |
Ivacaftor hydrate
VX-770 hydrate |
Others | Others |
Ivacaftor hydrate is an orally bioavailable CFTR potentiator. It also is used for cystic fibrosis treatment. | |||
T13705 | GLPG2451 | Cysteine Protease | Proteases/Proteasome |
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1 nM). | |||
T39633 |
Navocaftor
GLPG 3067,ABBV-3067 |
||
Navocaftor, as a cystic fibrosis transmembrane regulator ( CFTR ), is a protein modulator (US 20200377491 Al, example 1). | |||
T35925 |
(R)-Posenacaftor sodium
|
||
(R)-Posenacaftor ((R)-PTI-801) sodium, the R enantiomer of Posenacaftor, is a cystic fibrosis transmembrane regulator (CFTR) protein modulator. It corrects the folding and trafficking of the CFTR protein, and is utilized in the research of cystic fibrosis (CF)[1]. | |||
T74417 | Vanzacaftor | ||
Vanzacaftor 是一种囊性纤维化跨膜电导调节体(CFTR)的调节剂,用于研究囊性纤维化。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2866 |
Echinocystic acid
|
Apoptosis; Antioxidant; Reactive Oxygen Species | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction |
Echinocystic acid 是从皂角的果实中提取出来的一种五环三萜,有抗氧化,抗炎症和抗肿瘤作用。 | |||
T41139 |
Echinocystic acid 28-O-β-D-glucoside
|
||
Echinocystic acid 28-O-β-D-glucoside is a metabolite resulting from the microbial oxidation and glucosidation of Echinocystic acid. It exhibits inhibitory activity towards the tissue factor pathway, with an IC50 value measured at 10.61 nM. | |||
T2532 |
Tauroursodeoxycholate
Taurolite,牛磺熊去氧胆酸,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA |
Apoptosis; ERK; P450; Caspase; Endogenous Metabolite | Apoptosis; MAPK; Metabolism; Proteases/Proteasome |
Tauroursodeoxycholate (UR 906),又称 ursodoxicoltaurine,是一种高度亲水性的三级胆汁酸,在人体内以低浓度产生。Tauroursodeoxycholate 是 ursodeoxycholic acid 更亲水的形式,而 ursodeoxycholic acid 是人类体内自然产生的更丰富的胆汁酸。Tauroursodeoxycholate 正在研究用于几种疾病,如原发性胆汁性肝硬化(PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症。 | |||
T11124 |
Duramycin
Lancovutide,Moli1901 |
Others | Others |
Duramycin is a cyclic peptide lantibiotic derived from Streptomyces cinnamoneuma. Duramycin interacts with phosphatidylethanolamine (PE) and has antibacterial, antiviral effects. Duramycin stimulates chloride secretion in airway epithelium and has the potential for cystic fibrosis treatment. |