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Search Results for " ca-i "

Targets Recommended: Carbonic Anhydrase

28

抑制剂 & 化合物

7

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36758	CAIX Inhibitor S4 S4	Carbonic Anhydrase	Metabolism
	CAIX Inhibitor S4 (S4) 是一种有效的碳酸酐酶 IX/XII 抑制剂，Ki 分别为 7 nM 和 2 nM。 CA II 和 CA I 的 Ki 分别为 546 和 5600 nM。
T20000	I-XW-053 4-(4,5-二苯基-1H-咪唑-2-基)苯甲酸	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	I-XW-053 是一种针对衣壳的 HIV-1 复制抑制剂，使用基于混合结构的方法以微摩尔亲和力阻断 CA N 末端结构域之间的界面（NTD-NTD 界面）。
T68123	Oxodipine	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Oxodipine 是一种二氢吡啶型钙拮抗剂，抑制了KCl 诱导的兔主动脉收缩，降低了效力较低的大鼠心室试纸收缩的心脏力量。在大鼠培养的新生儿心室肌细胞中，Oxodipine 降低了L 型Ca 电流（I），IC 为0.24μM，对T 型Ca 电流（I）的IC 为0.41μM。Oxodipine 会使小鼠便秘和狗牙龈增生。
T2134	Dorzolamide hydrochloride MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,盐酸多佐胺,Dorzolamide HCl	Carbonic Anhydrase	Metabolism
	Dorzolamide hydrochloride (MK507 hydrochloride) 是一种碳酸酐酶carbonic anhydrase II 抑制剂，能够抑制红细胞CA-II(IC50:0.18 nM) 和CA-I(IC50:600 nM) 。
T6503	Fluorometholone Acetate NSC 47438,Flarex,Eflone,氟米龙醋酸酯,Oxylone acetate	Glucocorticoid Receptor; Carbonic Anhydrase	Endocrinology/Hormones; Metabolism
	Fluorometholone Acetate (Oxylone acetate) 是合成的糖皮质激素皮质类固醇及皮质类固醇酯。它有效抑制碳酸酐酶 (CA) 对 hCA-I(IC50:2.18 μM)和 hCA-II(IC50:17.5 μM)。它具有抗炎活性，可用于研究外部眼部炎症。
T61745	hCAI/II-IN-6	Carbonic Anhydrase	Metabolism
	hCAI/II-IN-6 是一种具有选择性和口服活性的human carbonic anhydrase(CA) 抑制剂。hCAI/II-IN-6对 hCA I，hCA II，hCA VII 和 hCA XII 有抑制作用，Ki 值分别为 220，4.9，6.5 和＞50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性。hCAI/II-IN-6 可以用于研究癫痫。
T23782	Benzolamide CL-11366,W 1803,CL 11366,CL11366,苯唑拉胺,W-1803	Carbonic Anhydrase	Metabolism
	Benzolamide (CL 11366) 是碳酸酐酶 (CA) 抑制剂，抑制hCA I(Ki:15 nM)、hCA II(Ki:9 nM)、EcoCAγ(Ki:94 nM)、VchCAγ(Ki:78 nM)、CAS3(Ki:54 nM)。它可用于研究青光眼和癫痫。
T40376	L-Phenylalanine-15N L-苯丙氨酸 15N,(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) 是 15N 标记的 L-Phenylalanine。L-Phenylalanine 是从大肠杆菌中分离出来的一种必需氨基酸。 L-Phenylalanine 广泛用于食品香精和药物的生产。
T0515	Tioxolone	Carbonic Anhydrase	Metabolism
	Tioxolone 是一种金属酶碳酸酐酶 I 抑制剂，具有抗痤疮作用。
T0106	Methazolamide L584601,醋甲唑胺,CL 8490	Carbonic Anhydrase	Metabolism
	Methazolamide (CL 8490) 是一种磺胺衍生物，用作碳酸酐酶 (carbonic anhydrase) 抑制剂，对人 carbonic anhydrase II 的 Ki=为 14 nM。它是降低眼压的药物，能够抑制由青光眼及其他眼病引起的眼压升高的作用。
T72840	hCAIX/XII-IN-6
	hCAIX/XII-IN-6 是具有口服活性的碳酸酐酶（CA）抑制剂，能够抑制人体 CA 亚型 hCA I、II、IV、IX 及 XII，其 Ki 值分别为 6697 nM、2950 nM、4093 nM、4.1 nM 和 7.7 nM。适用于类风湿关节炎（RA）研究。
T72122	Carbonic anhydrase inhibitor 12	Carbonic Anhydrase	Metabolism
	碳酸酐酶抑制剂12是针对CA II具有高效抑制作用的化合物，其Kis值仅为1.72 nM，对CA I亦表现出有效抑制（Kis为271 nM）。此外，该化合物在多种肿瘤细胞系中显示出显著的抗癌活性。
T74978	DPP IV/hCA II-IN-1
	DPP IV/hCA II-IN-1 是一种有效的选择性二肽肽酶 IV (DPP IV) 和碳酸酐酶 (CA) 抑制剂，抑制 DPP IV 的 IC50值为 0.049 μM, 抑制 CA II、CA VB、CA VA、CA IX、CA I 和 CA IV 的 Ki 值分别为 0.0361、0.0428、0.0941、0.1328、0.2615 和 3.034 μM。
T73030	hCAIX-IN-14
	hCAIX-IN-14 是一种有效的人类CA IX 抑制剂，Ki 值为 134.8 nM。
T79753	hCAIX/XII-IN-8	Carbonic Anhydrase	Metabolism
	hCAIX/XII-IN-8（compound 3g）是一种对人类（碳酸酐酶）CA IX和XII高效的抑制剂，Ki值分别为8.5和6.7 nM。该化合物对与肿瘤相关的膜结合异构体hCA IX和XII表现出显著的抑制作用，且相对于胞内异构体hCA I和II具有较高的选择性。
T40895	Calmodulin antagonist-1
	Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist that effectively inhibits calmodulin-activated Ca 2+ -phosphodiesterase (PDE) with an IC 50 of 28 μM. This compound also competitively inhibits trypsin-treated Ca 2+ -PDE with respect to cyclic GMP, exhibiting an IC 50 of 375 μM and a K i value of 300 μM.
T61842	Carbonic anhydrase inhibitor 14
	Carbonic anhydrase inhibitor 14 (Compound 8b) is a potent CA inhibitor, exhibiting K i values of 1203, 99.7, 9.4, and 27.7 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. Additionally, it effectively inhibits CDK2 with an IC 50 of 20.3 μM. Furthermore, Carbonic anhydrase inhibitor 14 demonstrates significant antitumor activity [1].
T71223	SR-33805
	SR-33805 is a calcium channel antagonist potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes. A SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation. D...
T60602	hCAIX/XII-IN-5
	hCAIX/XII-IN-5 (Coumarin 9a) 是一种碳酸酐酶 (CA) 抑制剂，具有出色的 hCA IX/XII 选择性，对 hCA I 和 hCA II 的Ki 值分别为 93.9 和 85.7 nM。hCAIX/XII-IN-5 对癌细胞具有抗增殖活性，可延迟细胞周期并诱导细胞凋亡。
T76184	Scyllatoxin
	Scyllatoxin (Leiurotoxin I) 为一种从(Leiurus quinquestriatus hebraeus)毒蝎毒液中分离的肽毒素，作为小电导钙激活型钾通道KCa(SK)的阻断剂，有能力增强体内去甲肾上腺素(NE)与肾上腺素(Epi)的释放。
T72213	Efonidipine hydrochloride NZ-105 hydrochloride
	Efonidipine(NZ-105)盐酸盐是T 型和L 型钙离子通道双重阻断剂。
T72699	Cavα2δ1&NET-IN-1
	Cavα2δ1&NET-IN-1 是电压门控钙通道 α2δ-1 亚单位 (Cavα2δ-1) 和去甲肾上腺素转运蛋白 (NET) 的双重抑制剂。Cavα2δ1&NET-IN-1 抑制 Cavα2δ-1 的 Ki 为 112 nM。Cavα2δ1&NET-IN-1 抑制 NET 的 Ki 为 383 nM，IC50为 67 nM。Cavα2δ1&NET-IN-1 可用于疼痛研究。
T72700	Cavα2δ1&NET-IN-2
	Cavα2δ1&NET-IN-2 是电压门控钙通道 α2δ-1 亚单位 (Cavα2δ-1) 和去甲肾上腺素转运蛋白 (NET) 的双重抑制剂。Cavα2δ1&NET-IN-2 抑制 Cavα2δ-1 的Ki 为 454 nM。Cavα2δ1&NET-IN-2 抑制 NET 的Ki 为 59 nM，IC50为 7 nM。Cavα2δ1&NET-IN-2 可用于疼痛研究。
T75936	RVD-Hpα TFA
	RVD-Hpα TFA is the N-terminally extended form of human hemopressin that acts as a selectiveCB1receptoragonist. RVD-Hpα TFA increases intracellular Ca2+levels in cells expressingCB1receptors in vitro. RVD-Hpα TFA also high affinityCB2positive allosteric modulator (Ki=50 nM).
T62243	Bepridil hydrochloride hydrate
	Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) 是一种长效的、非选择性的钙离子通道 (Ca+channel) 拮抗剂。Bepridil hydrochloride hydrate 是一种钠离子、钾离子通道 (Na+,K+channel) 抑制剂，也是心脏 Na+/Ca2+交换 (NCX1) 抑制剂。Bepridil hydrochloride hydrate 具有抗心绞痛和抗 I 型心律失常作用，能够用于研究心血管疾病。
T76021	Myelin Basic Protein TFA
	Myelin Basic Protein (MHP4-14) TFA 是一种合成肽，包含髓鞘碱性蛋白的残基4-14，是一种非常有选择性的 PKC 底物 (Km=7 μM)。Myelin Basic Protein TFA 不被环腺苷酸依赖性蛋白激酶、酪蛋白激酶 I 和 II、Ca2+/钙调素依赖性蛋白激酶 II 或磷酸化酶激酶磷酸化，可常规用于测定粗组织提取物中低背景的蛋白激酶 C。
T37847	Zonisamide-13C2,15N Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...
T69383	NBI-42902
	NBI-42902 is a potent inhibitor of peptide radioligand binding to the human GnRH receptor (K(i) = 0.56 nm). Tritiated NBI-42902 binds with high affinity (K(d) = 0.19 nm) to a single class of binding sites and can be displaced by a range of peptide and nonpeptide GnRH receptor ligands. In vitro experiments demonstrate that NBI-42902 is a potent functional, competitive antagonist of GnRH stimulated IP accumulation, Ca(2+) flux, and ERK1/2 activation. It did not stimulate histamine release from rat...

化合物

CAIX Inhibitor S4

Cat.No: T36758

Synonym: S4

Target: Carbonic Anhydrase

Cat.No: T20000

Synonym: 4-(4,5-二苯基-1H-咪唑-2-基)苯甲酸

Target: HIV Protease

Cat.No: T68123

Target: Calcium Channel

Dorzolamide hydrochloride

Cat.No: T2134

Synonym: MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,盐酸多佐胺,Dorzolamide HCl

Target: Carbonic Anhydrase

Fluorometholone Acetate

Cat.No: T6503

Synonym: NSC 47438,Flarex,Eflone,氟米龙醋酸酯,Oxylone acetate

Target: Glucocorticoid Receptor, Carbonic Anhydrase

Cat.No: T61745

Target: Carbonic Anhydrase

Cat.No: T23782

Synonym: CL-11366,W 1803,CL 11366,CL11366,苯唑拉胺,W-1803

Target: Carbonic Anhydrase

L-Phenylalanine-15N

Cat.No: T40376

Synonym: L-苯丙氨酸 15N,(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N

Target: Calcium Channel

Cat.No: T0515

Target: Carbonic Anhydrase

Cat.No: T0106

Synonym: L584601,醋甲唑胺,CL 8490

Target: Carbonic Anhydrase

Cat.No: T72840

Carbonic anhydrase inhibitor 12

Cat.No: T72122

Target: Carbonic Anhydrase

DPP IV/hCA II-IN-1

Cat.No: T74978

Cat.No: T73030

Cat.No: T79753

Target: Carbonic Anhydrase

Calmodulin antagonist-1

Cat.No: T40895

Carbonic anhydrase inhibitor 14

Cat.No: T61842

Cat.No: T71223

Cat.No: T60602

Cat.No: T76184

Efonidipine hydrochloride

Cat.No: T72213

Synonym: NZ-105 hydrochloride

Cavα2δ1&NET-IN-1

Cat.No: T72699

Cavα2δ1&NET-IN-2

Cat.No: T72700

Cat.No: T75936

Bepridil hydrochloride hydrate

Cat.No: T62243

Myelin Basic Protein TFA

Cat.No: T76021

Zonisamide-13C2,15N

Cat.No: T37847

Synonym: Zonisamide-13C2,15N

Cat.No: T69383

Cat. No.	Product Name	Target	Signaling Pathways
T6856	Halofuginone 卤夫酮,常山酮,Tempostatin,empostatin,RU-19110	Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Stem Cells
	Halofuginone (RU-19110) 是Febrifugine 的衍生物，是一种竞争性脯氨酰-tRNA 合成酶抑制剂。它也是肺血管扩张剂，可激活Kv 通道并阻断电压门控、受体操作和存储操作的钙离子通道。它具有抗炎、抗癌、抗疟疾和抗纤维化作用。
T3524	Halofuginone hydrobromide 卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐	Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells
	Halofuginone hydrobromid 是Febrifugine 的衍生物，是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂，并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。
T4S2326	Cornuside 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside	ERK; p38 MAPK; NF-κB; JNK	MAPK; NF-κB
	Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷，可用于炎症疾病的研究和促进血液循环。它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应，用于炎性过敏性疾病中的潜能。
T3826	Polygalasaponin F 异牡荆苷,瓜子金皂苷己	NF-κB; TLR; Akt; PI3K	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。
TN3844	Didrovaltrate	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Didrovaltrate shows cytotoxic against human cancer cell lines. Didrovaltrate blocks I(Ca-L) in a concentration-dependent manner and probably inhibits I(Ca-L) in its inactive state, which may contribute to its cardiovascular effect.
TN2039	Panaxydol	cAMP; p38 MAPK; JNK	GPCR/G Protein; MAPK
	Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through NADPH oxidase and mitochondria.
TN6458	Acetylshikonin
	Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.

天然产物

Cat.No: T6856

Synonym: 卤夫酮,常山酮,Tempostatin,empostatin,RU-19110

Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Halofuginone hydrobromide

Cat.No: T3524

Synonym: 卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐

Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Cat.No: T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Polygalasaponin F

Cat.No: T3826

Synonym: 异牡荆苷,瓜子金皂苷己

Target: NF-κB, TLR, Akt, PI3K

Cat.No: TN3844

Target: Calcium Channel

Cat.No: TN2039

Target: cAMP, p38 MAPK, JNK

Cat.No: TN6458

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00731	Carbonic Anhydrase 1 Protein, Human, Recombinant (His) Carbonic Anhydrase B,Carbonate De...	Human	E. coli
	Carbonic Anhydrase 1 (CA1) is a cytosolic enzyme, belonging to the alpha-carbonic anhydrase family. It is highly expressed in erythrocytes and acts as an early marker for erythroid differentiation. Carbonic anhydrase 1 plays a improtant role in many biological processes such as calcification, cellular respiration, bone resorption, acid-base balance. It is activated by imidazole, histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. At the same time, It is inhibited by sulfonam...
TMPH-03258	Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO) Cyanamide hydratase CA1,CA-I<...	Rat	E. coli
	Reversible hydration of carbon dioxide. Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.2 kDa and the accession number is B0BNN3.
TMPY-01926	S100A10 Protein, Human, Recombinant (His) ANX2L,S100 calcium bindi...	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S1 proteins have been implicated in a variety of int...
TMPY-02289	CIB2 Protein, Human, Recombinant (His) DFNB48,calcium and integri	Human	E. coli
	Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Sensorineural hearing loss is genetically heterogeneous. The mutations in CIB2, which encodes a calcium- and integrin-binding protein, are associated with nonsyndromic deafness (DFNB48) and Usher syndrome type 1J (USH1J). Furthermore, in zebrafish and Drosophila melanogaster, CIB2 is essential for the function a...

重组蛋白

Carbonic Anhydrase 1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00731

Species: Human

Expression System: E. coli

Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03258

Species: Rat

Expression System: E. coli

S100A10 Protein, Human, Recombinant (His)

Cat.No: TMPY-01926

Species: Human

Expression System: E. coli

CIB2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02289

Species: Human

Expression System: E. coli

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