Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fluorometholone Acetate (Oxylone acetate) 是合成的糖皮质激素皮质类固醇及皮质类固醇酯。它有效抑制碳酸酐酶 (CA) 对 hCA-I(IC50:2.18 μM)和 hCA-II(IC50:17.5 μM)。它具有抗炎活性,可用于研究外部眼部炎症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 289 | 现货 | ||
50 mg | ¥ 455 | 现货 | ||
100 mg | ¥ 663 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 127 | 现货 |
产品描述 | Fluorometholone Acetate (Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. |
靶点活性 | hCA-II:17.5 μM (IC50), hCA-I:1.044 μM (Ki), hCA-II:9.98 μM (Ki), human carbonic anhydrase (hCA)-I:2.18 μM (IC50) |
体外活性 | Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. [1] |
体内活性 | Hourly topical administration of the drug suspension produces an average reduction of 46.8% in the polymorphonuclear leukocytes invading the corneal stroma. In the cornea, fluorometholone acetate appears to have a greater efficacy, as compared to fluorometholone alcohol, for reducing the number of leukocytes invading that tissue following an inflammatory stimulus. Animal toxicity studies of fluorometholone, including acute intraperitoneal LD50s in mice and rats, subacute oral toxicity in rats and dogs, and subacute topical ocular toxicity in rabbits have demonstrated the safety of this drug for human use. [2] |
别名 | NSC 47438, Flarex, Eflone, 氟米龙醋酸酯, Oxylone acetate |
分子量 | 418.5 |
分子式 | C24H31FO5 |
CAS No. | 3801-06-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 84 mg/mL (200.71 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3895 mL | 11.9474 mL | 23.8949 mL | 59.7372 mL |
5 mM | 0.4779 mL | 2.3895 mL | 4.779 mL | 11.9474 mL | |
10 mM | 0.2389 mL | 1.1947 mL | 2.3895 mL | 5.9737 mL | |
20 mM | 0.1195 mL | 0.5974 mL | 1.1947 mL | 2.9869 mL | |
50 mM | 0.0478 mL | 0.2389 mL | 0.4779 mL | 1.1947 mL | |
100 mM | 0.0239 mL | 0.1195 mL | 0.2389 mL | 0.5974 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Fluorometholone Acetate 3801-06-7 Endocrinology/Hormones Metabolism Glucocorticoid Receptor Carbonic Anhydrase Inhibitor Carbonate dehydratase Fluorometholone NSC 47438 hCA-II anti-inflammatory Flarex NSC47438 Eflone corticosteroid inhibit NSC-47438 Cornea Oxylone Acetate 氟米龙醋酸酯 glucocorticoid hCA-I Oxylone acetate inhibitor