98
15
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10269 |
AHR antagonist 2
|
Aryl Hydrocarbon Receptor | Immunology/Inflammation |
AHR antagonist 2 是芳基烃受体的拮抗剂。 人 AHR 和小鼠 AHR 的 IC50 分别为 0.885 和 2.03 nM。 | |||
T39762 |
AHR antagonist 5 free base
|
Aryl Hydrocarbon Receptor | Immunology/Inflammation |
AHR antagonist 5 free base 是一种具有口服活性的 AHR 拮抗剂,在人和啮齿动物细胞系中的 IC50 约为 35-150 nM。 | |||
T5622 |
BAY-218
AHR antagonist 1 |
AhR; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism |
BAY-218 (AHR antagonist 1) 是一种芳基烃受体(AHR)拮抗剂,在人细胞系中的IC50值为 39.9 nM。 | |||
T15302 |
Fluzinamide
AHR-8559 |
Others | Others |
Fluzinamide(AHR-8559)对点燃性杏仁核癫痫发作有抗惊厥作用。 | |||
T16778 |
Rocastine
AHR-11325 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Rocastine(AHR-11325) 是一种具有选择性和有效性的非镇静性 H1 受体拮抗剂。 | |||
T6424 |
Bromfenac Sodium
AHR 10282B,Bronuck,AHR 10282R,溴芬酸钠 |
COX | Immunology/Inflammation; Neuroscience |
Bromfenac Sodium (AHR 10282R) 是可口服的COX 抑制剂,抑制COX-1和COX-2的IC50值分别为 5.56 和 7.45 nM。它是溴化非甾体类抗炎药,通常用于白内障的术后炎症和疼痛以及假晶状体囊状黄斑水肿的研究。 | |||
T23683 |
AHR-5333
AHR 5333,AHR5333 |
||
AHR-5333 an antiallergy agent. | |||
T29751 |
AHR-2244
AHR 2244,AHR2244 |
||
AHR-2244 is a psychotherapeutic agent. | |||
T23679 |
AHR-13268D
AHR 13268D,AHR13268D |
||
AHR-13268D is a new agent of antiallergic/antihistaminic. | |||
T29752 |
AHR-2666
AHR 2666 |
||
AHR-2666 is a skeletal muscle relaxant. | |||
T23681 |
AHR-15010
AHR 15010 |
||
AHR-15010 is a novel anti-arthritic agent. | |||
T29746 |
AHR 376
AHR376,AHR-376 |
||
AHR 376 is a biochemical. | |||
T29747 |
AHR-0914
AHR0914,AHR 0914 |
||
AHR-0914 is a biochemical. | |||
T23677 |
AHR-10718
AHR10718,AHR 10718 |
||
AHR-10718 has an antiarrhythmic effect. | |||
T29750 |
AHR-1900 hydrochloride
AHR-1900 HCl |
||
AHR-1900 hydrochloride is a butyrophenone derivative used in the treatment of schizophrenia. | |||
T23682 |
AHR-16303B oxalate
AHR 16303B oxalate |
||
AHR-16303B oxalate is a novel antagonist of 5-HT2 receptors. | |||
T29750L |
AHR-1900 free base
AHR-1900, |
||
AHR-1900 free base is a butyrophenone derivative which may be used in the treatment of schizophrenia. | |||
T1280 |
Nepafenac
AL 6515,AHR 9434,奈帕芬胺 |
COX | Immunology/Inflammation; Neuroscience |
Nepafenac (AHR 9434) 是一种非甾体抗炎药,可抑制COX-2,是Amfenac 的原药。 | |||
T29748 | AHR-12234 | ||
AHR-12234 affects cardiac action potentials. | |||
T29755 | AHR-5904 | ||
AHR-5904 is a biochemical. | |||
T23680 | AHR-14310C | ||
AHR-14310C is a long-acting and nonsedating H1-antihistamine. | |||
T1409 |
Methocarbamol
Lumirelax,美索巴莫,Metocarbamol,AHR 85,Robaxin |
Sodium Channel; Carbonic Anhydrase | Membrane transporter/Ion channel; Metabolism |
Methocarbamol (AHR 85) 是口服有效的中枢肌肉松弛剂,可阻断肌肉Nav1.4通道,阻断作用具有可逆性。Methocarbamol 具有用于肌肉痉挛和疼痛综合症研究的潜力。 | |||
T23684 |
AHR-6293
|
||
AHR-6293 is used to distinguishing the effect of anti-platelet aggregating drug properties and the effect of anti-inflammatory properties. | |||
T23676 |
AHR-10037
|
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AHR-10037是一种非甾体抗炎药,具有镇痛和解热特性以及高治疗指数,低胃毒性,它在抑制急性(伊文思蓝卡拉胶胸腔积液)和慢性(佐剂诱导的关节炎)炎症方面与吲哚美辛相当。研究表明,它在体内转化为环氧合酶抑制剂的前药。 | |||
T23678 |
AHR-11797
|
||
AHR-11797 is a novel benzodiazepine antagonist. | |||
T29749 |
AHR-16329
AHR16329 |
||
AHR-16329 can be used in ocular pharmacology. | |||
T71053 |
AHR-5333 mandelate
|
||
AHR-5333 mandelate is an anti-allergy compound which has been shown to protect against antigen-induced anaphylactic collapse and ascaris antigen-induced skin hypersensitivity. AHR-5333 mandelate has also been shown to inhibit 5-HETE, LTB4 and LTC4 synthesis. | |||
T29754 |
AHR-5859
|
||
AHR-5859 is a biochemical. | |||
T23685 |
AHR-9294
|
||
AHR-9294 is a novel inhibitor of H, K-ATPase. It also antagonizes gastric HCl secretion in vivo. | |||
T29753 |
AHR-5360
AHR5360 |
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AHR-5360 is a biochemical. | |||
T29754L | AHR-5859 fumarate | ||
AHR-5859 fumarate is a biochemical. | |||
T20986 |
AHR agonist 3
|
||
AHR agonist 3 is an agent with therapeutic activity. | |||
T10273 |
AhR modulator-1
|
Others | Others |
AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrogenic properties in rat uterus. | |||
T10271 |
AHR antagonist 4
|
Others | Others |
AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist(example 293; IC50: 82.2 nM).It has anti-cancer effects. | |||
T10272 | AHR antagonist 5 | Others | Others |
AHR antagonist 5 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist(example 39; IC50 < 0.5 μΜ). It significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1. | |||
T71590 | AHR-5645B fumarate | ||
AHR-5645B fumarate is a substituted benzamide that has been shown to inhibit 3H-spiperone binding to bovine anterior pituitary membranes. | |||
T30984 |
Cloroperone hydrochloride
AHR-6134,AHR6134,AHR 6134 |
||
Cloroperone hydrochloride is a biochemical. | |||
T17364 |
AhR Ligand-Linker Conjugates 1
E3 Ligase Ligand-Linker Conjugates 57 |
Others | Others |
AhR Ligand-Linker Conjugates 1, also known as E3 Ligase Ligand-Linker Conjugates 57, is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a SNIPER linker. It is specifically designed to be used in the development of SNIPER[1]. | |||
T23686 |
AHR-activator-1023
Branching Morphogenesis Modulator 1023,Cpd 1023,Compound 1023,BMM 1023 |
||
AHR-activator-1023 is the aryl hydrocarbon receptor activator. It is also a specific FGF2-induced branching morphogenesis modulator. | |||
T31214 |
Dazopride fumarate
AHR-5531C |
||
Dazopride fumarate is a peristaltic used to enhance gastric emptying and block emesis. | |||
T21352 |
Salmefamol
AHR-3929,AHR3929,AHR 3929 |
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Salmefamol is a beta-adrenergic agonist. It may also be used as a bronchodilator. | |||
T31586 |
Duoperone fumarate
AHR6646,AHR-6646,AHR 6646 |
||
Duoperone fumarate is a biochemical. | |||
T79436 |
AHR agonist 4
|
Aryl Hydrocarbon Receptor | Immunology/Inflammation |
AHR agonist 4 (compound 24e) 是针对芳烃受体AHR的激动剂,关联Th17/22与Treg细胞的免疫调节作用。作为治疗银屑病的潜在先导化合物,它能够缓解由咪喹莫特 (IMQ) 诱发的银屑病样皮肤病变。 | |||
T20197 |
Amfenac sodium
AHR5850,AHR 5850 |
||
Amfenac is a nonsteroidal anti-inflammatory drug. Amfenac also has acetic acid moiety. | |||
T10963 |
Dazopride
达佐必利,AHR-5531 |
Others | Others |
Dazopride is an antiemetic agent. | |||
T61244 | AhR agonist 2 | ||
AhR agonist 2 (Compound 12a) is a highly potent agonist of the aryl hydrocarbon receptor (AhR), exhibiting an EC50 value of 0.03 nM. This compound rapidly induces nuclear enrichment of AhR and initiates transcription of downstream genes, thereby promoting skin barrier repair. AhR agonist 2 shows promising potential for psoriasis research [1]. | |||
T1610 |
Metaxalone
Skelaxin,Methaxalonum,美他沙酮,Zorane,NSC170959,AHR438 |
Others | Others |
Metaxalone (Methaxalonum) 具有肌肉松弛作用。 | |||
T26710 |
Azapropazone
DuP-141,NSC-102824,AHR-3018,AHR 3018,MI-85 |
||
Azapropazone is anti-inflammatory agent. Azapropazone has uricosuric properties used to treat rheumatoid arthritis and ankylosing spondylitis. Azapropazone lowered plasma uric acid but exerted only a modest and variable uricosuric effect without altering | |||
T7202 |
ITE
|
AhR; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism |
ITE 是一种有效的芳烃受体 (AhR) 内源性激动剂,Ki 值为 3 nM。它具有免疫抑制作用。 | |||
T25661 |
Lenperone
Lenperonum,AHR-2277 [as hydrochloride] |
||
Lenperone is a butyrophenone antipsychotic. Like other major tranquilizers, It has some alpha-adrenergic blocking action and is antiemetic. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1451 |
Brevifolincarboxylic acid
|
AhR; Aryl Hydrocarbon Receptor; Glucosidase | Immunology/Inflammation; Metabolism |
Brevifolincarboxylic acid 是从头状蓼中分离得到的一种天然产物,抑制芳烃受体(AhR)。它是一种 α-葡萄糖苷酶抑制剂,IC50 为 323.46 μM。 | |||
T6795 |
Carbidopa
卡比多巴,(S)-(-)-Carbidopa,Lodosyn |
Decarboxylase; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism; Others |
Carbidopa (Lodosyn) 是一种选择性芳香烃受体(AhR)调节剂,是外周型脱羧酶抑制剂,抑制胰腺癌细胞和肿瘤生长,可用于帕金森病的研究。 | |||
T4928 |
L-Kynurenine
L-犬尿氨酸,(S)-Kynurenine |
AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
T0878 |
Diosmin
Venosmine,Diosmil,Barosmin,地奥司明,地奥司明(7-芸香糖甙) |
Aryl Hydrocarbon Receptor; Norepinephrine | Immunology/Inflammation; Neuroscience |
Diosmin (Venosmine) 是在各种柑橘类水果中发现的类黄酮,也是芳烃受体激动剂,有增强血管壁的作用。 | |||
TN2883 |
3',4'-Dimethoxyflavone
|
Others; PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair; Others |
3',4'-Dimethoxyflavone 是类黄酮化合物的参考标准,类黄酮化合物具有多种药用活性。 | |||
T4939 |
Indole-3-pyruvic acid
3-(3-吲哚基)-2-氧代丙酸,3-(3-Indolyl)-2-oxopropanoic acid |
Others | Others |
Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) 是一种参与Indole-3-acetic acid 生物合成的化合物,Indole-3-acetic acid 是一种植物激素,在调节生长和对环境变化的反应中起重要作用。 | |||
T5281 |
Skatole
粪臭素,Scatole,3-Methylindole,3-Methylindole,3-甲基吲哚,3-Methyl-1H-indole,beta-Methylindole |
AhR; p38 MAPK; Aryl Hydrocarbon Receptor; Endogenous Metabolite; Antibacterial; Autophagy; Antifungal | Autophagy; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology |
Skatole (3-Methyl-1H-indole) 是由肠道菌群产生的,通过激活芳基烃受体和 p38调节肠上皮细胞功能。 | |||
T2947 |
Indole-3-carbinol
吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol |
E1/E2/E3 Enzyme; NF-κB; Aryl Hydrocarbon Receptor; Endogenous Metabolite; p53 | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Ubiquitination |
Indole-3-carbinol (I3C) 是樟子松中的一种天然产物,是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂,可抑制 NF-κB 和 IκBα 激酶活化。 | |||
T10938 |
D-Kynurenine
D-尿嘧啶,(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103 |
GPR; AhR; Endogenous Metabolite | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism |
D-Kynurenine (ZINC901103) 是 D-色氨酸的代谢物和 GPR109B 的激动剂。 D-Kynurenine 激活 AhR 并促进上皮细胞向间充质的转化。 D-Kynurenine 在 D-氨基酸氧化酶的荧光分析中用作底物。 | |||
T4938 |
Potassium 1H-indol-3-yl sulfate
硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate |
AhR; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂,Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚,吲哚被吸收到血液中,然后在肝脏中进一步代谢为硫酸吲哚,通常通过尿液排出体外。在肾功能受损的慢性肾病患者中,Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累,诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化,促进大鼠近端小管细胞TGF-β1和Smad3的表达,与促纤维化活性相关。 | |||
TN1222 |
26-Deoxyactein
27-Deoxyactein,脱氧升麻烃,23-epi-26-Deoxyactein,27-脱氧升麻亭 |
NOS; CDK; NO Synthase | Cell Cycle/Checkpoint; Immunology/Inflammation |
23-epi-26-Deoxyactein (27-Deoxyactein) 是一种黑升麻中的主要成分,能够阻止 TCDD 诱导的成骨细胞的损伤。它对 AhR,CYP1A1 和 ERK 的水平升高具有抑制作用。 | |||
T72901 | Indolokine A5 | ||
Indolokine A5, L-半胱氨酸的分解代谢物, 是一种有效的AhR 激动剂。 | |||
T73402 |
Flavipin
|
||
Flavipin 是一种芳香烃受体(Ahr)激动剂,可诱导小鼠 CD4+T 细胞和 CD11b+巨噬细胞表达 Ahr 下游基因。Flavipin 抑制 Arid5a 在 Il23a3'UTR 上的稳定功能,这是一种新发现的靶 mRNA。Flavipin 具有清除 DPPH 自由基的能力,IC50值为7.2 μM,对α-葡萄糖苷酶具有较强的抑制作用,IC50值为 33.8 μM。 | |||
T75433 | Norisoboldine hydrochloride | ||
Norisoboldine hydrochloride是一种口服活性天然芳基烃受体(AhR)激动剂,作为林参中的主要异喹啉类生物碱,适用于类风湿性关节炎和溃疡性结肠炎的研究。 | |||
TN1543 |
Cynaropicrin
|
IL Receptor; Others; TNF | Apoptosis; Immunology/Inflammation; Others |
Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential anticancer agent against some leukocyte cancer cells such as lymphoma or leukemia, through pro- |