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141

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T81589	OVA-A2 Peptide SAINFEKL, OVA (257-264) Variant
	OVA-A2 Peptide（SAINFEKL, OVA (257-264) Variant）是具备生物活性的A2肽（SAINFEKL）变体，具有抗原特性。
T83852	EGFRvIII Peptide TFA PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide
	EGFRvIII peptide是一种合成肽，对应于特异性肿瘤、具有持续激活性的EGFR变体EGFRvIII的融合接头，该变体缺少野生型EGFR的第6至273个氨基酸。在25 µg/ml的浓度下，它能与MHC I类亚型HLA-A*0201阳性的T2细胞结合。在用于分离的人外周血单个核细胞（PBMCs）衍生的树突状细胞中，EGFRvIII peptide可诱导抗原呈递，进而刺激CD8+细胞毒性T淋巴细胞的激活和IFN-γ产生。与toll样受体5（TLR5）激动剂鞭毛蛋白B共同免疫EGFRvIII peptide（15 µg/动物），在正交GL261胶质母细胞瘤小鼠异种移植模型中，增加了CD8+ T细胞数量，减少了调节性T细胞（Tregs）数量，减少了肿瘤体积，并提高了生存率。
T9716	Ensitrelvir S-217622	SARS-CoV	Microbiology/Virology
	Ensitrelvir (S-217622) 是首个口服有效的、非共价的、非肽的SARS-CoV-2 3CL 蛋白酶抑制剂，IC50为13 nM。
T7904	SR 19881	Estrogen/progestogen Receptor	Endocrinology/Hormones
	SR 19881 是 ERRγ 的完全激动剂（结合试验中的 EC50 值为 0.39 μM，基于细胞的试验中 EC50 值为 4.7 μM）。
T64221	Linvencorvir RG7907	HBV; Antibiotic	Microbiology/Virology
	Linvencorvir 是一种乙型肝炎病毒（HBV）核心蛋白变构调节剂，用于治疗慢性HBV 感染。
T7905	PBD-150	Beta Amyloid	Neuroscience
	PBD-150 是一种人谷氨酰胺酰基环化酶 Y115E-Y117E 变体的抑制剂，其 Ki=490 nM。
T40279	GLP-1R modulator L7-028 GLP-1R modulator L7-028	cAMP; Glucagon Receptor	GPCR/G Protein
	GLP-1R modulator L7-028 是一种变构调节剂，增强了对 GLP-1 的亲和力和 cAMP 信号转导。
T4220	BQR-695 BQR695,NVP-BQR695	PI3K; Parasite; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling
	BQR-695 (NVP-BQR695) 是一种磷脂酰肌醇 4-激酶抑制剂，对于人类和疟原虫 PI4KIIIβ 的 IC50值分别为 80 和 3.5 nM。
T77407	Ensituximab NPC-1C,NEO-102,NEO-101
	Ensituximab (NEO-102) 是一种准对 MUC5AC 变体的选择性 IgG1 单克隆抗体，具有抗肿瘤活性，抑制结直肠癌和胰腺癌。
T64387	2-Nitrobenzoic acid o-Nitrobenzoic acid	Others	Others
	2-Nitrobenzoic acid (o-Nitrobenzoic acid) 是一种抗增殖化合物，对表达 T 型钙通道α1H 或其剪接变体δ25的 jurkat 细胞系显示出8.3μM 的 IC50。
T82236	HBED-CC-tris(tert-butyl ester)	Others	Others
	HBED-CC-tris(tert-butyl ester)是HBED-CC的一种单价变体，可用于合成基于非对称 HBED-CC 的放射性化合物，可用于肿瘤成像。
T61191	EAI001	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EAI001 是一种具有有效性和选择性的突变体表皮生长因子受体 (EGFR) 变构抑制剂，对 EGFRL858R/T790M 有抑制作用， IC50 值为 24 nM。EAI001 可用于研究癌症。
T11421	Glutaminase-IN-1 CB839 derivative	transporter	Metabolism
	Glutaminase-IN-1 (CB839 derivative)，是一种新型 1,3,4-硒二氮基肾型谷氨酰胺酶(KGA) 的变构抑制剂，在侵袭性 H22 肝癌异种移植模型中显示出抗肿瘤活性。
T1952	MK-2206 dihydrochloride MK-2206 2HCl	Apoptosis; Akt; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	MK-2206 dihydrochloride (MK-2206 2HCl) 是一种变构 Akt 抑制剂，抑制 Akt1、Akt2 和 Akt3 (IC50=8/12/65 nM)，具有口服活性的、高效选择性。MK-2206 dihydrochloride 具有抗肿瘤活性。
T26863	BMS-929075 BMS 929075,BMS929075	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	BMS-929075是一种具有口服活性 HCV NS5B 复制酶 (HCV NS5B replicase) 手掌位点变构抑制剂，具有有效性、较高的口服生物利用度和药代动力学参数。BMS-929075 显示出细胞毒性。
TP1591L	OVA G4 peptide acetate(148274-82-2 free base) SIIGFEKL acetate	Others	Others
	OVA G4 peptide acetate(148274-82-2 free base) (SIIGFEKL acetate) 是激动剂卵清蛋白 (OVA) 肽 (257-264) SIINFEKL 的变体。 OVA 肽是卵清蛋白的 I 类 (Kb) 限制性肽表位，由 I 类 MHC（主要组织相容性复合物）分子 H-2Kb（小鼠 MHC I 类基因）呈递。
T60835	SKF83959	Dopamine Receptor	GPCR/G Protein; Neuroscience
	SKF83959 是苯并氮平类化合物，是一种具有选择性和有效性的多巴胺D1受体部分激动剂，对大鼠D1，D5，D2和D3受体的Ki 值分别为 1.18, 7.56, 920 和 399 nM。SKF83959 是 sigma (σ)-1受体的有效变构调节剂，可改善认知功能障碍，用于研究抑郁症和阿尔茨海默病。
T10534	BI-4020	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BI-4020 是一种第四代，口服有效，非共价的 EGFR 酪氨酸激酶抑制剂。BI-4020 表现出对三联突变的 EGFR del19 T790M C797S 突变体 ( BaF3 细胞系，IC50=0.2 nM)，双重突变的 EGFR del19 T790M 以及单突变的 EGFR del19 (IC50=1 nM)的抑制剂活性。BI-4020 保留了抑制 EGFR wt 的活性 (IC50=190 nM)。BI-4020 具有高激酶组选择性和良好的 DMPK 性质。
T31145	CycLuc3 Cyc Luc 3,Cyc-Luc-3
	CycLuc3 is a type of mutant firefly luciferase variant with enhanced light emission.
T19185	Aldosterone-d8 醛固酮 D8,Aldosterone D8	Others	Others
	Aldosterone D8, a deuterium-labeled variant of Aldosterone produced in the adrenal zona glomerulosa, regulates blood pressure.
T39093	TCTDSTNCYKAT
	TCTDSTNCYKAT is an engineered-variant peptide of antifreeze protein (AFP).
T12523	Posaconazole-D5 SCH 56592-D5	Others	Others
	Posaconazole-D5, a deuterium-labeled variant of Posaconazole, is a second-generation, broad-spectrum triazole compound with antifungal activity.
T11675	Irbesartan-d4 厄贝沙坦 D4,SR-47436 D4,BMS-186295 D4	Others	Others
	Irbesartan D4, a deuterium-labeled variant of Irbesartan, is a highly potent and specific antagonist of the angiotensin II type 1 (AT1) receptor.
T12522	Posaconazole-D4 SCH 56592-D4	Others	Others
	Posaconazole-D4, a deuterium-labeled variant of Posaconazole, is a broad-spectrum, second-generation triazole with antifungal activity.
T39017	OVA-E1 peptide OVA-E1 peptide
	OVA-E1 peptide, a variant antagonist of SIINFEKL [OVA (257-264)], elicits comparable activation of the p38 and JNK cascades in both mutant and wild-type thymocytes.
T83540	(Gly22)-amyloid beta-protein(1-40)
	(Gly22)-amyloid beta-protein(1-40) (Arctic variant Ab40ARC (E22G)) 是用于阿尔茨海默病研究的肽。
T11867	Loperamide-d6 hydrochloride R-18553 D6 hydrochloride	Others	Others
	Loperamide D6 hydrochloride, a deuterium-labeled variant of Loperamide hydrochloride, acts as an opioid receptor agonist utilized for diarrhea treatment.
T38817	Golgicide A-1 GCA-1,Golgicide A-1
	Golgicide A-1 (GCA-1) is a moderately potent cis-diastereomer variant of Golgicide A (GCA) specifically designed to inhibit mosquito reproduction.
T81977	Kobusine derivative-1
	Kobusine derivative-1，一种Kobusine衍生物，展现出了对癌细胞显著的抗增殖活性。
T11871	Loteprednol Etabonate D5	Others	Others
	Loteprednol Etabonate D5, a deuterium-labeled variant of Loteprednol etabonate (LE), is an orally active, anti-inflammatory soft steroid within a distinctive class of glucocorticoids. It is deployed in optometry and ophthalmology for its anti-inflammatory properties.
T11250	Ezetimibe-d4 SCH 58235 D4	Others	Others
	Ezetimibe D4, a deuterium-labeled variant of Ezetimibe, functions as an inhibitor of Niemann-Pick C1-like1 (NPC1L1) and is recognized for its potent activation of Nrf2.
T76588	(Asp37)-Amyloid β-Protein (1-42)
	(Asp37)-Amyloid β-Protein (1-42) 是野生型 Amyloid-beta (1-42) 肽的 G37D 突变体。
T62672	D5261
	D5261 是一个有效的、类型 III 变构的 tropomyosin-related kinase A (TrkA) 抑制剂。
T70338	Lu AF58786
	Lu AF58786 is a novel potent and selective inhibitor of LRRK2, inhibiting LRRK2 WT, the overactive variant G2019S, and the resistant mutant A2016T56 at 12 nM, 19 nM and 93 nM, respectively.
T39246	Brain Natriuretic Peptide-45, mouse Brain Natriuretic Peptide-45, mouse,BNP-45, mouse
	Mouse Brain Natriuretic Peptide-45 (BNP-45, mouse) is a circulating variant of the mouse brain natriuretic peptide derived from the mouse heart. It exhibits powerful hypotensive and natriuretic properties.
T40568	Fmoc-MMAE
	Fmoc-MMAE, a protective group-conjugated variant of monomethyl auristatin E (MMAE), serves as a powerful inhibitor of tubulin. It finds application in the synthesis of antibody-drug conjugates (ADC).
T81150	SLSLSPG
	SLSLSPG是通过从人Igγ-1的重链C端分离得到的，为IgG中的一种常见变体。
T11195	Enantiomer of Sofosbuvir	Others	Others
	Enantiomer of Sofosbuvir 是Sofosbuvir 的对映异构体，Sofosbuvir 是一种治疗慢性丙型肝炎的处方药，目前尚无enantiomer of Sofosbuvir 的生物活性报道。
T78285	Sofituzumab MMUC 1206A
	Sofituzumab（MMUC 1206A）是一款针对MUC16的重组人源化V-kappa型单克隆抗体。
T38743	Scrambled TRAP Fragment
	Scrambled TRAP Fragment is a variant of the TRAP Fragment compound, characterized by its random amino acid sequence. It is typically employed as a negative control due to its similarity in composition to the active fragment.
T83845	8-(4-azidophenacylthio) NAD+ sodium Click Tag™ 8-(4-azidophenacylthio) NAD+,8-(4-azidophenacylthio) Nicotinamide adenine dinucleotide
	8-(4-azidophenacylthio) NAD+ 是NAD+信号分子及酶辅因子的一种可点击形式。
T76623	(Gln22)-Amyloid β-Protein (1-42)
	'(Gln22)-Amyloid β-Protein (1-42)'，为β-Amyloid (1-42) 的Dutch突变（E22Q）形式，显示出提升的纤维原性及致病性。
T39423	Palmitic acid-13C sodium
	Sodium palmitate-13C is the 13C-labeled variant of palmitic acid, a long-chain saturated fatty acid prevalent in animals and plants. This compound has been shown to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) in mouse granulosa cells.
T61820	Ar-V7-IN-1
	Ar-V7-IN-1 is a highly potent inhibitor specifically targeting Ar-V7, a splice variant of the androgen receptor that exhibits hormone-independent behavior. Its development shows promise for researching various indications, notably cancers such as prostate cancer[1].
T81069	Sulfamidopyrine sodium salt Melaminsulfone sodium salt
	Sulfamidopyrine (Melaminsulfone) sodium salt为活性化学物质，适用于分析研究。
T61329	HP1142
	HP1142 is a highly effective and specific inhibitor targeting the FLT3 receptor tyrosine kinase, with a particular affinity for its mutant variant FLT3/ITD. It exhibits a benzoimidazole scaffold-based structure, making it a promising compound for investigating and studying the FLT3/ITD mutation in the context of leukemia research [1].
T38460	SN52
	SN52 is a powerful, competitive, and cell-permeable inhibitor of NF-κB2. It is a variant of the SN50 peptide. SN52 effectively prevents the nuclear translocation of p52-RelB heterodimers, exhibiting a robust radiosensitization effect on prostate cancer cells. This compound holds significant potential for cancer research purposes.
T11152	Edaravone-d5 MCI-186 D5	Others	Others
	Edaravone, a novel and potent free radical scavenger, effectively prevents MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Its deuterium-labeled variant, Edaravone D5, retains the original compound's attributes while offering isotopic labeling benefits.
T37966	T-91825
	T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2].
T81257	Rosuvastatin zinc salt Rosuvastatin zinc
	Rosuvastatin zinc salt (Rosuvastatin zinc)，为Rosuvastatin的含锌盐形态，属于HMG-CoA还原酶抑制剂类药物，常用于动脉粥样硬化的研究领域。

化合物

Cat.No: T81589

Synonym: SAINFEKL, OVA (257-264) Variant

EGFRvIII Peptide TFA

Cat.No: T83852

Synonym: PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide

Cat.No: T9716

Synonym: S-217622

Target: SARS-CoV

Cat.No: T7904

Target: Estrogen/progestogen Receptor

Cat.No: T64221

Synonym: RG7907

Target: HBV, Antibiotic

Cat.No: T7905

Target: Beta Amyloid

GLP-1R modulator L7-028

Cat.No: T40279

Synonym: GLP-1R modulator L7-028

Target: cAMP, Glucagon Receptor

Cat.No: T4220

Synonym: BQR695,NVP-BQR695

Target: PI3K, Parasite, PI4K

Cat.No: T77407

Synonym: NPC-1C,NEO-102,NEO-101

2-Nitrobenzoic acid

Cat.No: T64387

Synonym: o-Nitrobenzoic acid

Target: Others

HBED-CC-tris(tert-butyl ester)

Cat.No: T82236

Target: Others

Cat.No: T61191

Target: EGFR

Glutaminase-IN-1

Cat.No: T11421

Synonym: CB839 derivative

Target: transporter

MK-2206 dihydrochloride

Cat.No: T1952

Synonym: MK-2206 2HCl

Target: Apoptosis, Akt, Autophagy

Cat.No: T26863

Synonym: BMS 929075,BMS929075

Target: HCV Protease

OVA G4 peptide acetate(148274-82-2 free base)

Cat.No: TP1591L

Synonym: SIIGFEKL acetate

Target: Others

Cat.No: T60835

Target: Dopamine Receptor

Cat.No: T10534

Target: EGFR

Cat.No: T31145

Synonym: Cyc Luc 3,Cyc-Luc-3

Cat.No: T19185

Synonym: 醛固酮 D8,Aldosterone D8

Target: Others

Cat.No: T39093

Posaconazole-D5

Cat.No: T12523

Synonym: SCH 56592-D5

Target: Others

Cat.No: T11675

Synonym: 厄贝沙坦 D4,SR-47436 D4,BMS-186295 D4

Target: Others

Posaconazole-D4

Cat.No: T12522

Synonym: SCH 56592-D4

Target: Others

Cat.No: T39017

Synonym: OVA-E1 peptide

(Gly22)-amyloid beta-protein(1-40)

Cat.No: T83540

Loperamide-d6 hydrochloride

Cat.No: T11867

Synonym: R-18553 D6 hydrochloride

Target: Others

Cat.No: T38817

Synonym: GCA-1,Golgicide A-1

Kobusine derivative-1

Cat.No: T81977

Loteprednol Etabonate D5

Cat.No: T11871

Target: Others

Cat.No: T11250

Synonym: SCH 58235 D4

Target: Others

(Asp37)-Amyloid β-Protein (1-42)

Cat.No: T76588

Cat.No: T62672

Cat.No: T70338

Brain Natriuretic Peptide-45, mouse

Cat.No: T39246

Synonym: Brain Natriuretic Peptide-45, mouse,BNP-45, mouse

Cat.No: T40568

Cat.No: T81150

Enantiomer of Sofosbuvir

Cat.No: T11195

Target: Others

Cat.No: T78285

Synonym: MMUC 1206A

Scrambled TRAP Fragment

Cat.No: T38743

8-(4-azidophenacylthio) NAD+ sodium

Cat.No: T83845

Synonym: Click Tag™ 8-(4-azidophenacylthio) NAD+,8-(4-azidophenacylthio) Nicotinamide adenine dinucleotide

(Gln22)-Amyloid β-Protein (1-42)

Cat.No: T76623

Palmitic acid-13C sodium

Cat.No: T39423

Cat.No: T61820

Sulfamidopyrine sodium salt

Cat.No: T81069

Synonym: Melaminsulfone sodium salt

Cat.No: T61329

Cat.No: T38460

Cat.No: T11152

Synonym: MCI-186 D5

Target: Others

Cat.No: T37966

Rosuvastatin zinc salt

Cat.No: T81257

Synonym: Rosuvastatin zinc

Cat. No.	Product Name	Target	Signaling Pathways
T8083	Pyridoxal 5'-phosphate monohydrate Pyridoxal phosphate monohydrate,Pyridoxal 5-phosphate monohydrate,5-磷酸吡哆醛	Others	Others
	Pyridoxal 5'-phosphate monohydrate 是维生素 B6的活性形式，也是多种酶的重要辅因子。它是维生素 B6 在细胞内磷酸化过程中重要的辅酶变异体，能够与其他变异体（如 PNP 、 PMP）发生互换。
T4757	L-Homoserine (S)-2-氨基-4-羟基丁酸,(S)-(-)-2-AMINO-4-HYDROXYBUTYRIC ACID	Others; Endogenous Metabolite	Metabolism; Others
	L-Homoserine ((S)-(-)-2-AMINO-4-HYDROXYBUTYRIC ACID) 是天然存在的非蛋白丝氨酸，是合成苏氨酸、蛋氨酸和赖氨酸的共有中间体。它是氨基酸丝氨酸的更具反应性的变体。
T72643	Saccharothrixin F
	Saccharothrixin F 是一种高度氧化的糖丝菌，具有抗菌和抗炎活性。
T81813	Methyl lucidenate Q
	Methyl lucidenate Q，一种灵芝甲酯，展现了显著的抑制作用于EBV-EA诱导活性。
T81797	Microcystin-LF
	Microcystin-LF 是 Microcystin-LR 的苯丙氨酸变体，属于细菌代谢物，且对 Caco-2 细胞显示出细胞毒性。

天然产物

Pyridoxal 5'-phosphate monohydrate

Cat.No: T8083

Synonym: Pyridoxal phosphate monohydrate,Pyridoxal 5-phosphate monohydrate,5-磷酸吡哆醛

Target: Others

Cat.No: T4757

Synonym: (S)-2-氨基-4-羟基丁酸,(S)-(-)-2-AMINO-4-HYDROXYBUTYRIC ACID

Target: Others, Endogenous Metabolite

Saccharothrixin F

Cat.No: T72643

Methyl lucidenate Q

Cat.No: T81813

Cat.No: T81797

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