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Cat. No.	Product Name	Target	Signaling Pathways
T21761	HNMPA	IGF-1R	Tyrosine Kinase/Adaptors
	HNMPA 是膜不可渗透的胰岛素受体酪氨酸激酶 (insulin receptor tyrosine kinase) 抑制剂。HNMPA 可以抑制人胰岛素受体的酪氨酸和丝氨酸自磷酸化。HNMPA 对环 AMP 依赖性蛋白激酶或蛋白激酶 C 活性没有影响。
T36287	Pirtobrutinib	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to tumor regression in BTK-dependent lymphoma tumors in mouse xenograft models. Furthermore, Pirtobrutinib exhibits remarkable selectivity for BTK, with more than a 300-fold difference compared to 370 other kinases tested. Notably, at a concentration of 1 μM, Pirtobrutinib demonstrat...
T38562	AKN-028	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	AKN-028 是酪氨酸激酶 FLT3的抑制剂，可剂量依赖性的诱导 FLT3的自磷酸化。
T7673	ATH686 ATH 686	Apoptosis; FLT	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	ATH686 是一种选择性的，ATP 竞争性的FLT3抑制剂，具有抗白血病作用。它靶向突变 FLT3 蛋白激酶活性，并通过诱导凋亡和抑制细胞周期来抑制具有 FLT3 突变的细胞的增殖。
T5168	EGFR-IN-12 EGFR Inhibitor	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-12 (EGFR Inhibitor) 是一种 4,6-二取代的嘧啶，可诱导细胞凋亡，具有抗肿瘤活性。它是ATP 竞争性，不可逆且高度选择性的EGFR 抑制剂，IC50为 21 nM。它对EGFR 的选择性高于 HER4 和 55种其他激酶。它还抑制突变型EGFRL858R 和EGFRL861Q，IC50分别为 63 nM 和 4 nM。
T2655	CEP-37440 CEP37440	FAK; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	CEP-37440 是一种新型的 FAK (IC50:2.3 nM) 和 ALK (IC50:120 nM) 双重抑制剂。
T23127	PD-161570 PD 161570	EGFR; FGFR; PDGFR; Src	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD-161570 是一种有效的 ATP 竞争性人 FGF-1 受体抑制剂，IC50 为 39.9 nM，Ki 为 42 nM。它还是骨形态发生蛋白 (BMPs) 和TGF-β信号抑制剂。它抑制PDGF 刺激的自磷酸化和FGF-1受体磷酸化，IC50分别为 450 和 622 nM。它抑制 PDGFR、EGFR 和 c-Src 酪氨酸激酶，IC50 值分别为 310、240 和 44 nM。
T1667	Tandutinib MLN518,CT53518,NSC726292,坦度替尼	Apoptosis; FLT; CSF-1R; PDGFR; Src; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Tandutinib (CT53518) 是一种选择性 FLT3抑制剂，其 IC50为 0.22 μM。它还抑制c-Kit 和PDGFR，其IC50分别为 0.17 μM 和 0.20 μM。它可穿透血脑屏障，用于急性骨髓性白血病。
T14137	AG 1295	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	AG 1295 是选择性血小板衍生生长因子受体酪氨酸激酶抑制剂。它能抑制 PDGFR 的自磷酸化，对 EGF 受体的自磷酸化无影响。
T3545	RG13022 RG 13022,Tyrphostin RG13022	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	RG13022 (Tyrphostin RG13022) 是一种酪氨酸激酶抑制剂，抑制EGF 受体自身磷酸化的IC50值为4 μM。
T3691	(Rac)-SAR131675 SAR131675	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	(Rac)-SAR131675 是一种有效的、选择性的VEGFR3抑制剂，其IC50=23 nM。
T22462	1,2,3,4,5,6-Hexabromocyclohexane	Others	Others
	The compound effectively and directly inhibits JAK2 tyrosine kinase autophosphorylation and specifically inhibits ligand-dependent JAK2 activation. It has no cytotoxicity at 100 μM. A 16-hour treatment with compound (1 μM) decreases JAK2 tyrosine autophos
T69863	Dihydrogenistein
	Dihydrogenistein is a derivative of Genistein -- a compound that exhibits specific inhibitory activity against tyrosine kinases including autophosphorylation of epidermal growth factor receptor kinase.
T69260	Genistein Diglucuronide
	Genistein Diglucuronide is a metabolite of Genistein which exhibits specific inhibitory activity against tyrosine kinases including autophosphorylation of epidermal growth factor receptor kinase.
T12610L	3-Hydroxy Midostaurin CGP52421	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].
T19119	3-Hydroxy Midostaurin-D5 CGP52421-D5	Others	Others
	3-Hydroxy Midostaurin-D5 (CGP52421-D5) is a deuterium-labeled 3-Hydroxy Midostaurin which is a metabolite of PKC412. PKC412 effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation (IC50s: 132 nM and 9.8 μM in culture medium and plasma).
T40785	Gefitinib impurity 1
	Gefitinib impurity 1 is a compound derived from Gefitinib, a potent and selective EGFR tyrosine kinase inhibitor (IC 50 = 33 nM). This orally active compound selectively inhibits tumor cell growth stimulated by EGF (IC 50 = 54 nM) and inhibits EGFR autophosphorylation induced by EGF in tumor cells. Additionally, Gefitinib induces autophagy and exhibits antitumor activity.
T76019	[pTyr5] EGFR (988-993) (TFA)
	[pTyr5]EGFR(988-993) TFA 来源于表皮生长因子受体 (EGFR 988-993) 的自磷酸化位点 (Tyr992)。[pTyr5] EGFR(988-993) TFA 常与催化活性低的蛋白-酪氨酸磷酸1B (PTP1B) 结合。
T70444	Edicotinib HCl
	Edicotinib, also known as JNJ-40346527, is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527 blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS cannot activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tum...
T1181L	Gefitinib hydrochloride
	Gefitinib hydrochloride (ZD1839 hydrochloride) 是一种有效，选择性和具有口服活性的EGFR 酪氨酸激酶抑制剂，IC50为 33 nM。Gefitinib hydrochloride 选择性抑制 EGF 刺激的肿瘤细胞生长 (IC50为 54 nM)，并阻断 EGF 刺激的肿瘤细胞中EGFR 自磷酸化。Gefitinib hydrochloride 也诱导细胞自噬 (autophagy)，具有抗肿瘤活性。
T61358	AKN-028 acetate
	AKN-028 acetate 是一种新型酪氨酸激酶 (TKI) 抑制剂，是一种有效的口服活性的 FMS 样受体酪氨酸激酶 3 (FLT3) 抑制剂，其 IC50值为 6 nM。AKN-028 acetate 抑制 FLT3 自磷酸化。AKN-028 acetate 诱导剂量依赖性的细胞毒性反应 (平均IC50=1 μM)。AKN-028 acetate 通过激活 caspase 3 诱导细胞凋亡 (apoptosis)。AKN-028 acetate 可用于急性髓系白血病 (AML) 的研究。
T63630	Gefitinib dihydrochloride
	Gefitinib dihydrochloride 是有效的、选择性的、口服具有活力的 EGFR 酪氨酸激酶抑制剂 (IC50: 33 nM)。Gefitinib dihydrochloride 能够选择性抑制 EGF 刺激的肿瘤细胞生长，其IC50值为 54 nM，能够阻断 EGF 刺激的肿瘤细胞中EGFR 自磷酸化。Gefitinib dihydrochloride 可以诱导细胞自噬 (autophagy) 和凋亡 (apoptosis)，能够用于进行癌症相关疾病，如肺癌和乳腺癌的研究。
T35915	Erlotinib-13C6 Erlotinib-13C6
	Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]...
T68389	LY2457546
	LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. LY2457546 demonstrates potent activity against targets that include VEGFR2 (KDR), PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. In vivo, LY2457546 inhibited VEGF-driven autophosphorylation of lung KDR in the mouse and rat in a dose and concentration dependent manner. LY2457546 was well tolerated and exhibited efficacy in a 13762 synge...
T67442	CGP-53716
	The growth factors, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) play major roles in enhanced smooth muscle cells growth in rodent blood vessels after vascular injury. Tyrosine kinase inhibition has been shown to be effective in blocking tyrosine phosphorylation at the PDGF and bFGF receptors in cultured fibroblast and vascular smooth muscle cells which in turn inhibits their proliferation[1]. CGP 53716 is a specific PDGFR tyrosine kinase inhibitor on SMC (smoo...

化合物

Cat.No: T21761

Target: IGF-1R

Cat.No: T36287

Target: BTK

Cat.No: T38562

Target: FLT

Cat.No: T7673

Synonym: ATH 686

Target: Apoptosis, FLT

Cat.No: T5168

Synonym: EGFR Inhibitor

Target: Apoptosis, EGFR

Cat.No: T2655

Synonym: CEP37440

Target: FAK, ALK

Cat.No: T23127

Synonym: PD 161570

Target: EGFR, FGFR, PDGFR, Src

Cat.No: T1667

Synonym: MLN518,CT53518,NSC726292,坦度替尼

Target: Apoptosis, FLT, CSF-1R, PDGFR, Src, c-Kit

Cat.No: T14137

Target: PDGFR

Cat.No: T3545

Synonym: RG 13022,Tyrphostin RG13022

Target: EGFR

(Rac)-SAR131675

Cat.No: T3691

Synonym: SAR131675

Target: VEGFR

1,2,3,4,5,6-Hexabromocyclohexane

Cat.No: T22462

Target: Others

Dihydrogenistein

Cat.No: T69863

Genistein Diglucuronide

Cat.No: T69260

3-Hydroxy Midostaurin

Cat.No: T12610L

Synonym: CGP52421

Target: FLT

3-Hydroxy Midostaurin-D5

Cat.No: T19119

Synonym: CGP52421-D5

Target: Others

Gefitinib impurity 1

Cat.No: T40785

[pTyr5] EGFR (988-993) (TFA)

Cat.No: T76019

Cat.No: T70444

Gefitinib hydrochloride

Cat.No: T1181L

AKN-028 acetate

Cat.No: T61358

Gefitinib dihydrochloride

Cat.No: T63630

Cat.No: T35915

Synonym: Erlotinib-13C6

Cat.No: T68389

Cat.No: T67442

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