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54

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0786	Clidinium bromide 克利溴铵,Ro 2-3773	AChR	Neuroscience
	Clidinium bromide (Ro 2-3773) 是季胺抗毒蕈碱剂，可通过减少胃酸和减慢肠道速度，缓解痉挛和腹部疼痛的症状。
T1575	Nizatidine Axid,Acinon,尼扎替丁,Zanizal	AChE; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Nizatidine (Acinon) 是一种竞争性和可逆的组胺 H2 受体拮抗剂，具有抗酸活性，可用于胃溃疡的研究。
T2455	PFK-015 PFK15,PFK 015	Glucokinase; Autophagy	Autophagy; Metabolism
	PFK-015 (PFK15) 是一种有效的 PFKFB3 抑制剂，对重组PFKFB3的IC50为110 nM。它能抑制 Y 细胞中的 PFKFB3 活性，IC50为20 nM。
T0424	Bismuth Subsalicylate Bismuth subsalicylat,Bismuth(III) salicylate basic,Bismuth oxysalicylate,碱式水杨酸铋,次水杨酸铋	COX; PGE Synthase	Immunology/Inflammation; Neuroscience
	Bismuth Subsalicylate (Bismuth subsalicylat) 是口服抗酸和止泻试剂。它能够抑制体内前列腺素合成，抑制胃和肠道黏膜炎症反应。它广泛用于研究腹泻疾病，如恶心、消化不良、腹泻等。
T0865	Ranitidine Hydrochloride AH19065,盐酸雷尼替丁	P450; Antibacterial; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience
	Ranitidine Hydrochloride (AH19065) 是一种具有口服活性的组胺 H2 受体选择性拮抗剂，IC50为 3.3 μM。它还是一种CYP2C19和CYP2C9的弱抑制剂，可抑制胃液分泌。
TP2030	Gastrin I, human Gastrin I (human)	cholecystokinin	GPCR/G Protein
	Gastrin I, human (Gastrin I (human)) 是胃中产生的内源性肽，通过 CCK2 受体增加大鼠的胃蛋白酶原和酸分泌。
T20914	Simethicone Disflatyl,西甲硅油,Simeticone,Phazyme	Others	Others
	Simethicone (Disflatyl) 是一种口服消泡剂，可用于减少因胃或肠道内过多气体引起的腹胀、疼痛和不适。
T0594	Diphenmanil methylsulfate Diphemanil mesylate,Diphemanil Methylsulfate,甲硫二苯马尼	AChR	Neuroscience
	Diphenmanil methylsulfate (Diphemanil mesylate) 是一种抗胆碱能季铵盐，可与毒蕈碱乙酰胆碱受体结合，从而减少胃酸、汗液和唾液的分泌。
TP2030L1	Gastrin I (human) acetate Gastrin I (human) acetate(10047-33-3 free base),Gastrin-17 acetate,Little gastrin I acetate,胃膜素醋酸盐	cholecystokinin	GPCR/G Protein
	Gastrin I (human) acetate (Gastrin-17 acetate) 是在胃中产生的内源性肽，通过胆囊收缩素 2 (CCK2) 受体增加胃酸分泌。
T6710	Troxipide 曲昔派特,曲昔匹特,Aplace	Others	Others
	Troxipide (Aplace) 是非分泌型胃保护剂，是口服具有活力的胃炎和胃溃疡的防御因子的增强剂，具有抗溃疡、抗炎和粘液分泌作用。
T3937	Methyl L-histidinate dihydrochloride L-Histidine methyl ester dihydrochloride,L-组氨酸甲酯二盐酸盐	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Methyl L-histidinate dihydrochloride (L-Histidine methyl ester dihydrochloride) 在Sprague-Dawley 大鼠胃中组氨酸脱羧酶的抑制作用被评估为 14CO2 产生减少，活性值为 1.8 μM。
T72107	Werner syndrome RecQ helicase-IN-1	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Werner syndrome RecQ helicase-IN-1 是一种有效的 Werne r 综合征 RecQ DNA 解旋酶 (WRN) 抑制剂，可用研究像结肠癌和胃癌等癌症。
T0674	Lansoprazole 兰索拉唑,A-65006,AG-1749	Proton pump; Phospholipase; Antibacterial	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Lansoprazole (A-65006) 是一种可抑制胃酸生成的质子泵抑制剂。它是中性鞘磷脂酶的外泌体抑制剂。
T1651	Rabeprazole sodium Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium	Apoptosis; Proton pump	Apoptosis; Membrane transporter/Ion channel
	Rabeprazole sodium (Habeprazole Sodium) 是一种质子泵抑制剂，不可逆地抑制胃 H+/K+-ATPase，可研究胃溃疡和胃食管反流。它诱导细胞凋亡，也抑制尿苷核苷核糖水解酶，IC50为 0.3 μM。
T0992	Carbenoxolone disodium Biogastrone,Duogastrone,甘珀酸钠,Bioral	Gap Junction Protein	Cytoskeletal Signaling
	Carbenoxolone disodium (Duogastrone) 是甘草酸的活性代谢物和人11β-HSD 和细菌3α, 20β-HSD 的抑制剂。它是一种缝隙连接的解耦剂，可抑制牛痘病毒生长，用于消化性、食道和口腔溃疡和炎症的相关研究。
TP1325L	Gastrin-Releasing Peptide, human(TFA)	Others	Others
	Gastrin-Releasing Peptide, human(TFA） (93755-85-2 free base) 是一种调节性人类肽，可引发胃泌素释放并调节胃酸分泌和肠道运动功能。支配胃G 细胞的迷走神经节后纤维释放GRP，刺激G 细胞释放胃泌素。
T4616	Metoclopramide 甲氧氯普胺,胃复安,5-Chloro-2-methoxyprocainamide	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Metoclopramide (5-Chloro-2-methoxyprocainamide) 是5-HT3和多巴胺D2受体拮抗剂，IC50值分别为 308 和 483 nM，可用于恶心呕吐、胃食管反流和胃轻瘫的研究。
T31743	Famotine hydrochloride Famotine HCl,UK-2054
	Famotine Hydrochloride is a histamine H2 receptor antagonist that suppresses acid production in the stomach and commonly treats peptic ulcer disease and gastroesophageal reflux disease.
T18310	AZ1508 MC-Lys-MMETA	Others	Others
	AZ1508, a tubulin inhibitor[1], serves as a drug-linker conjugate for antibody-drug conjugates (ADC) targeting breast and stomach cancer treatment.
T32599	Lauroylglycyrrhetinic acid BX 24,BX24,BX-24
	Lauroylglycyrrhetinic acid, an analog of carbenoxolone, can be used in the treatment of stomach ulcer.
T34566	Sch 12223 Sch12223,Sch-12223
	SCH 12223 is a unique drug that protects the stomach and intestinal epithelium from harmful irritation.
T20775	Ranitidine-N-oxide
	Ranitidine-N-oxide is a metabolite of Ranitidine. Ranitidine is a antagonist of histamine H2-receptor, it inhibits the normal and meal-stimulated secretion of stomach acid. Ranitidine is a medication decreaseing stomach acid production.
T28331	PD 136450 Cam1189,PD136450,Cam-1189,PD-136450,Cam 1189
	Cholecystokinin type B receptor antagonist PD-136,450 is a partial secretory agonist in the stomach and a full agonist in the pancreas of the rat. Gastrin (cholecystokinin type B (CCK-B)) receptor antagonists may help to elucidate the physiological role o
T61453	Propantheline
	Propantheline is an orally active antagonist of muscarinic acetylcholine receptors (mAChRs), commonly employed to investigate smooth muscle dysfunction, hyperhidrosis, smooth muscle spasms or cramps in the stomach, intestines, or bladder, as well as involuntary urination [1] [2] [3].
T11816	Lansoprazole-d4 AG-1749 D4,Lansoprazole D4	Proton pump	Membrane transporter/Ion channel
	Lansoprazole D4 (AG-1749 D4) is a deuterium labeled Lansoprazole. Lansoprazole is an inhibitor of proton pump which prevents the stomach from producing acid.
T70127	Famotine
	Famotine is a histamine H2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.
T68725	Famotidine propanamide
	Famotidine propanamide is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.
T71509	Famotidine sulfamoyl propanamide
	Famotidine sulfamoyl propanamide is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.
T71049	Famotidine disulfide
	Famotidine disulfide is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.
T70090	Nizatidine amide
	Nizatidine amide is a histamine H2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.
T71485	Famotidine propionic acid
	Famotidine propionic acid is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.
T37588	GIP (1-30) amide, porcine
	This GIP fragment has potent insulinotropic activity in the isolated, perfused rat pancreas but greatly reduced somatostatinotropic activity in the isolated perfused rat stomach. The site responsible for insulinotropic activity apparently lies between residues 19 and 30 of GIP.
T37642	Pravastatin lactone
	Pravastatin lactone is a metabolite of pravastatin , a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor that is a ring-hydroxylated metabolite of mevastatin . Pravastatin lactone is formed when pravastatin undergoes acid-catalyzed non-enzymatic lactonization in the stomach following oral administration.
T28612	RP-72540 RPR 102681,RPR-102681,RPR102681
	RP-72540 is a cholecystokinin B receptor antagonist. RP 72540 showed selectivity factors in express of 200 for CCKA versus CCKB receptors and also had high affinity for gastrin binding sites in the stomach. Administration of RP-72540 resulted in a dose-de
T33314	Methantheline Bromide Frenogastrico,Dixamone bromide,Banthine,Asabaine,Methanthelinium bromide
	Methantheline Bromide is a synthetic spasmolytic used to relieve cramps or spasms of the stomach, bowel, and bladder. It is also useful for intestinal or gastric ulcers (peptic ulcer disease), intestinal problems, pancreatitis, gastritis, biliary dysmotil
T6415	Bismuth Subcitrate Potassium	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Bismuth subcitrate potassium 是针对 12 种幽门螺杆菌菌株的抗生素，MIC50为 8 μg/ml。它用于幽门螺杆菌感染的上胃肠道疾病的研究。
T81224	SALMF amide 2
	SALMF amide 2为源自海星Asterias rubens的神经肽S2，涉及海星心脏胃外翻调控机制。
T40850	[D-Trp11]-Neurotensin [D-Trp11]-Neurotensin
	[D-Trp11]-Neurotensin is a compound that functions as a selective antagonist of Neurotensin (NT) in perfused rat hearts, while exhibiting full agonist properties in guinea pig atria and rat stomach strips. Additionally, this compound can inhibit hypotension induced by NT.
TP1976	Oxyntomodulin 胃泌酸调节素,Oxyntomodulin (porcine, bovine)
	GLP-1 receptor agonist. Endogenous preproglucagon-derived neuropeptide that modulates feeding and metabolism. Also secreted by intestinal L-cells. Increases cAMP production and inhibits gastric acid secretion in rat stomach. Also weak glucagon receptor ag
TP1325	Gastrin-Releasing Peptide, human
	Gastrin-Releasing Peptide, human is a regulatory human peptide that elicits gastrin release and regulates gastric acid secretion and enteric motor function. The post-ganglionic fibers of the vagus nerve that innervate the G cells of the stomach release GRP, which stimulates the G cells to release gastrin.
TP1232	Amylin, amide, rat Amylin (rat)
	Amylin is a peptide that displays 50% homology with calcitonin gene-related peptide (CGRP), Amylin is colocalized with somatostatin in endocrine cells of the gastric fundus. In isolated mouse stomach, amylin caused a concentration-dependent decrease in ac
T36148	13,14-dihydro-15-keto Prostaglandin F1α 13,14-dihydro-15-keto Prostaglandin F1α
	13,14-dihydro-15-keto Prostaglandin F1α (13,14-dihydro-15-keto PGF1α) is a metabolite of PGF1α that has been reported in the rat stomach. The measurement of 13,14-dihydro-15-keto PGF1α can be used as a marker of the in vivo production of PGF1α.
T71980	Omeprazole acid
	Omeprazole acid is a medication used in the treatment of gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton pump inhibitor and as such blocks the release of stomach acid.
T63819	Domperidone monomaleate
	Domperidone (R33812) monomaleate 是选择性的、口服具有活力的多巴胺-2 受体 (dopamine-2 receptor) 拮抗剂。Domperidone monomaleate 能够影响胃和小肠的化学感受器触发区和运动功能，具有止吐和促动力剂作用。
T60493	Guaiacol Carbonate
	Guaiacol Carbonate 是一种祛痰剂，其作用是通过胃的反射作用，通过胃神经到达延髓中枢，然后再通过外周进入呼吸道，从而起到祛痰作用。
T75993	Pepsin A
	Pepsin A 是人和猪胃中的主要蛋白酶，是一种类似胃蛋白酶的胃小蛋白水解酶。Pepsin A 有助于脊椎动物胃中食物蛋白质的蛋白质水解。
T36208	15(R)-Pinane Thromboxane A2 15(R)-Pinane Thromboxane A2
	15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 . 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 μM). It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle.
T75992	Buforin II
	Buforin II，来源于 buforin I，从亚洲蟾蜍 Bufo bufo gargarizans 胃中分离得到的蛋白，是一种高效的抗菌 (antimicrobial) 肽。Buforin II 对广谱的革兰氏阳性和革兰氏阴性细菌具有抗菌活性。
T76107	Urease
	Urease 由多种类型细菌产生，是一些致病菌的有效毒力因子。Urease 还是幽门螺杆菌代谢和毒力的中心，帮助其在胃粘膜中定植。
T71055	Albendazole-d7
	Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Alben...

化合物

Clidinium bromide

Cat.No: T0786

Synonym: 克利溴铵,Ro 2-3773

Target: AChR

Cat.No: T1575

Synonym: Axid,Acinon,尼扎替丁,Zanizal

Target: AChE, Histamine Receptor

Cat.No: T2455

Synonym: PFK15,PFK 015

Target: Glucokinase, Autophagy

Bismuth Subsalicylate

Cat.No: T0424

Synonym: Bismuth subsalicylat,Bismuth(III) salicylate basic,Bismuth oxysalicylate,碱式水杨酸铋,次水杨酸铋

Target: COX, PGE Synthase

Ranitidine Hydrochloride

Cat.No: T0865

Synonym: AH19065,盐酸雷尼替丁

Target: P450, Antibacterial, Histamine Receptor

Gastrin I, human

Cat.No: TP2030

Synonym: Gastrin I (human)

Target: cholecystokinin

Cat.No: T20914

Synonym: Disflatyl,西甲硅油,Simeticone,Phazyme

Target: Others

Diphenmanil methylsulfate

Cat.No: T0594

Synonym: Diphemanil mesylate,Diphemanil Methylsulfate,甲硫二苯马尼

Target: AChR

Gastrin I (human) acetate

Cat.No: TP2030L1

Synonym: Gastrin I (human) acetate(10047-33-3 free base),Gastrin-17 acetate,Little gastrin I acetate,胃膜素醋酸盐

Target: cholecystokinin

Cat.No: T6710

Synonym: 曲昔派特,曲昔匹特,Aplace

Target: Others

Methyl L-histidinate dihydrochloride

Cat.No: T3937

Synonym: L-Histidine methyl ester dihydrochloride,L-组氨酸甲酯二盐酸盐

Target: HDAC

Werner syndrome RecQ helicase-IN-1

Cat.No: T72107

Target: DNA/RNA Synthesis

Cat.No: T0674

Synonym: 兰索拉唑,A-65006,AG-1749

Target: Proton pump, Phospholipase, Antibacterial

Rabeprazole sodium

Cat.No: T1651

Synonym: Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium

Target: Apoptosis, Proton pump

Carbenoxolone disodium

Cat.No: T0992

Synonym: Biogastrone,Duogastrone,甘珀酸钠,Bioral

Target: Gap Junction Protein

Gastrin-Releasing Peptide, human(TFA)

Cat.No: TP1325L

Target: Others

Cat.No: T4616

Synonym: 甲氧氯普胺,胃复安,5-Chloro-2-methoxyprocainamide

Target: Dopamine Receptor, 5-HT Receptor

Famotine hydrochloride

Cat.No: T31743

Synonym: Famotine HCl,UK-2054

Cat.No: T18310

Synonym: MC-Lys-MMETA

Target: Others

Lauroylglycyrrhetinic acid

Cat.No: T32599

Synonym: BX 24,BX24,BX-24

Cat.No: T34566

Synonym: Sch12223,Sch-12223

Ranitidine-N-oxide

Cat.No: T20775

Cat.No: T28331

Synonym: Cam1189,PD136450,Cam-1189,PD-136450,Cam 1189

Cat.No: T61453

Lansoprazole-d4

Cat.No: T11816

Synonym: AG-1749 D4,Lansoprazole D4

Target: Proton pump

Cat.No: T70127

Famotidine propanamide

Cat.No: T68725

Famotidine sulfamoyl propanamide

Cat.No: T71509

Famotidine disulfide

Cat.No: T71049

Nizatidine amide

Cat.No: T70090

Famotidine propionic acid

Cat.No: T71485

GIP (1-30) amide, porcine

Cat.No: T37588

Pravastatin lactone

Cat.No: T37642

Cat.No: T28612

Synonym: RPR 102681,RPR-102681,RPR102681

Methantheline Bromide

Cat.No: T33314

Synonym: Frenogastrico,Dixamone bromide,Banthine,Asabaine,Methanthelinium bromide

Bismuth Subcitrate Potassium

Cat.No: T6415

Target: Others, Antibacterial, Antibiotic

Cat.No: T81224

[D-Trp11]-Neurotensin

Cat.No: T40850

Synonym: [D-Trp11]-Neurotensin

Cat.No: TP1976

Synonym: 胃泌酸调节素,Oxyntomodulin (porcine, bovine)

Gastrin-Releasing Peptide, human

Cat.No: TP1325

Amylin, amide, rat

Cat.No: TP1232

Synonym: Amylin (rat)

13,14-dihydro-15-keto Prostaglandin F1α

Cat.No: T36148

Synonym: 13,14-dihydro-15-keto Prostaglandin F1α

Omeprazole acid

Cat.No: T71980

Domperidone monomaleate

Cat.No: T63819

Guaiacol Carbonate

Cat.No: T60493

Cat.No: T75993

15(R)-Pinane Thromboxane A2

Cat.No: T36208

Synonym: 15(R)-Pinane Thromboxane A2

Cat.No: T75992

Cat.No: T76107

Cat.No: T71055

Cat. No.	Product Name	Target	Signaling Pathways
T5S0384	Rhapontin Ponticin,土大黄苷,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside	Apoptosis; Others	Apoptosis; Others
	Rhapontin (Ponticin) 是药用大黄的一种成分，可减轻KK/Ay 糖尿病小鼠肝脏脂肪变性，改善血糖和血脂，表明其具有显着的降糖作用，有望成为治疗2型糖尿病及其并发症的新药。
T2S1840	Rebaudioside D 莱苞迪苷D,瑞鲍迪甙D	Others	Others
	Rebaudioside D 是一种苷类化合物，存在于甜菊叶中，可用作甜味剂。
TJS0928	Calenduloside E 去葡萄糖竹节参皂苷,Silphioside F	Others	Others
	Calenduloside E (Silphioside F) 是从辽东楤木中提取的一种五环三萜皂苷。它靶向热休克蛋白90 (Hsp90) ，具有抗凋亡作用。
T3S0509	Gaultherin	COX	Immunology/Inflammation; Neuroscience
	Gaultherin 是一种分离自 Gaultheria yunnanensis 中的天然水杨酸酯衍生物。它是一种非甾体类抗炎药，具有止痛和抗炎作用，与 Aspirin 相比没有胃溃疡作用。
T5803	D(-)-Tartaric acid	Others	Others
	D(-)-Tartaric acid 存在于许多植物中，特别是罗望子和葡萄，口服后通过与碳酸氢钠相互作用产生二氧化碳。二氧化碳会延伸胃部并在双造影射线照相期间提供负造影剂。
TN5952	2,3-Dihydro-3α-methoxynimbolide
	2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in stomach (AZ521) cancer cell line.
TMA1841	Dihydrodaidzin	Others	Others
	Dihydrodaidzin shows cytotoxic activities against human stomach carcinoma (Hs 740.T, Hs 756 T), breast adenocarcinoma (Hs 578 T, Hs 742.T), and prostate carcinoma (DU 145, LNCaP-FGC) cell lines.
T82463	Entadamide A 2'-O-(6''-O-β-D-glucopyranosyl)-β-D-glucopyranoside
	Entadamide A 2'-O-(6''-O-β-D-glucopyranosyl)-β-D-glucopyranoside (MFLNH I) (compound 5) 是一种从泰国药用植物 Entada rheedei 的种子仁中提取的化合物，具有抑制胃痛的功效。
TN4937	Sambutoxin	Others	Others
	Sambutoxin, a new mycotoxin produced by toxic Fusarium isolates obtained from rotted potato tubers, it can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, and, finally, death when rats were

天然产物

Cat.No: T5S0384

Synonym: Ponticin,土大黄苷,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside

Target: Apoptosis, Others

Cat.No: T2S1840

Synonym: 莱苞迪苷D,瑞鲍迪甙D

Target: Others

Calenduloside E

Cat.No: TJS0928

Synonym: 去葡萄糖竹节参皂苷,Silphioside F

Target: Others

Cat.No: T3S0509

Target: COX

D(-)-Tartaric acid

Cat.No: T5803

Target: Others

2,3-Dihydro-3α-methoxynimbolide

Cat.No: TN5952

Cat.No: TMA1841

Target: Others

Entadamide A 2'-O-(6''-O-β-D-glucopyranosyl)-β-D-glucopyranoside

Cat.No: T82463

Cat.No: TN4937

Target: Others

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