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Search Results for " ribosome "

46

抑制剂 & 化合物

16

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8645	PF-06446846	Others	Others
	PF-06446846 是口服有活性的 PCSK9抑制剂。它能够在密码子区域附近阻断 80S ribosome，选择性地直接抑制 PCSK9 的翻译。
T19459	N1-Methylpseudouridine N1-甲基-假尿苷,1-Methylpseudouridine	Others	Others
	N1-Methylpseudouridine (1-Methylpseudouridine) 是一种甲基假尿苷，翻译性能比 5 mC 和 5 mC/N1-Methylpseudouridine 高。通过提高核糖体密度，mRNA 中的 N1-Methylpseudouridine 以 eIF2α 依赖性和独立机制增强翻译。
T4267	Tulathromycin A CP 472295,Draxxin,Tulathromycin,托拉菌素 A	Antibacterial; Antibiotic	Microbiology/Virology
	Tulathromycin A (CP 472295) 是一种大环内酯类抗生素，靶向细菌核糖体抑制蛋白质合成 (IC50=0.26 µM)，具有免疫调节作用。它可研究牛和猪的呼吸道疾病。
T0788L	Spectinomycin dihydrochloride pentahydrate 盐酸大观霉素五水合物,Trobicin,Spectogard,Spectinomycin hydrochloride hydrate	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Spectinomycin dihydrochloride pentahydrate (Spectogard) 是一种广谱氨基环糊精抗生素，可以抑制多种革兰氏阳性和革兰氏阴性生物的生长。
T4222	KKL-10 KKL 10	ribosome; Antibacterial	Microbiology/Virology
	KKL-10 是一种核糖体拯救抑制剂，对细菌具有广谱抗菌活性。
T28506	Rbin-2	Phosphatase	Metabolism
	Rbin-2 是一种具有细胞渗透性、强效性、选择性和可逆性的 Midasin(Mdn1) 抑制剂。Rbin-2 直接靶向 AAA+ ATPase Midasin，抑制真核生物核糖体的生成，是研究真核生物核糖体组装过程的强效探针。
T3265	Azathramycin Desmethyl Azithromycin,阿奇霉素 A,6-Demethylazithromycin,去甲基阿奇霉素,Azaerythromycin A,Azaerythromycin	Antibacterial; Antibiotic	Microbiology/Virology
	Azathramycin (Desmethyl Azithromycin) 是一种可靶向核糖体的抗生素。
T7411	Rbin-1 Ribozinoindole-1	ATPase; Phosphatase	Membrane transporter/Ion channel; Metabolism
	Rbin-1 (Ribozinoindole-1) 是一种选择性 Midasin 抑制剂，是一种可逆的、特异性真核核糖体生物合成抑制剂，GI50=136 nM。
T13767	MBX-4132	Others; Antibacterial	Microbiology/Virology; Others
	MBX-4132 通过与细菌核糖体结合来抑制反式翻译，是一种恶二唑类物质。
T1747	Tedizolid TR 700,特地唑胺,DA-7157,泰地唑利,Torezolid	MAO; Antibacterial; Antibiotic	Metabolism; Microbiology/Virology; Neuroscience
	Tedizolid (DA-7157)是一种新型恶唑烷酮类抗生素，可与核糖体50S 亚基的23S 核糖体 RNA 结合抑制细菌的蛋白质合成。
T5189	Omadacycline PTK 0796,Amadacycline	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Omadacycline (Amadacycline) 是一种具有口服活性的氨基甲基环素抗菌剂，是四环素类抗生素。它与 30S 核糖体亚基结合，抑制细菌蛋白质合成。它可用于研究急性细菌性皮肤和皮肤结构感染，感染性肺炎和尿路感染。
T1557	Acetylspiramycin Spiramycin II,Foromacidin B,乙酰螺旋霉素,ASPM,Spiramycin B	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Acetylspiramycin (Spiramycin B) 是口服大环内酯抗生素，由多种链霉菌产生，是螺旋霉素的乙酰化衍生物。它是对革兰氏阳性菌有效的抗菌试剂。它也是一种抗原虫剂，有效抵抗寄生虫感染。
T3052	Sancycline Bonomycin,Norcycline,Sancyclinum,山环素,6-Demethyl-6-deoxytetracycline	Antibacterial	Microbiology/Virology
	Sancycline (Bonomycin) 是半合成四环素，通过可逆地结合 30S 核糖体亚基并通过阻断氨酰-tRNA 进入核糖体 A 位点来抑制蛋白质翻译。
T1569	Tigecycline 替加环素,GAR-936	ribosome; Antibacterial; Antibiotic; Autophagy	Autophagy; Microbiology/Virology
	Tigecycline (GAR-936) 是甘氨酰环素抗生素，对 Acinetobacter baumannii(A. baumannii) 的 MIC50和 MIC90分别为 1 和 2 mg/L。它对 E. coli(MG1655 菌株) 的平均抑制浓度 (MIC) 约 125 ng/ mL。
T2331	Solithromycin 索利霉素,OP-1068,CEM-101	Antibacterial; Antibiotic	Microbiology/Virology
	Solithromycin (OP-1068) 是口服可生物利用的抗菌剂，抑制肺炎链球菌、葡萄球菌、金黄色葡萄球菌和流感嗜血杆菌的细胞活力、蛋白质合成和生长速率， IC50 值分别为 7.5 ng/mL、40 ng/mL 和 125 ng/mL。它可与核糖体的大 50S 亚基结合抑制蛋白质生物合成。
T6638	Retapamulin 瑞他莫林,SB-275833	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Retapamulin (SB-275833) 是一种能结合金黄色葡萄球菌和大肠杆菌核糖体的局部抗生素，Kd 为3 nM。
T11836	Lefamulin acetate BC-3781 acetate,醋酸来法莫林	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Lefamulin acetate (BC-3781 acetate) 是具有口服活性的抗生素。它是用于人体细菌感染的全身研究的半合成截短侧耳素。它与 50S 细菌核糖体的肽基转移酶peptidyl transferase 中心结合抑制蛋白质合成，并阻止了转移RNA 与肽转移的结合。
T22774L	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]（TFA)	Others	Others
	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) 是延伸因子 1 亚基。真核翻译延伸因子 1 alpha 1 (EEF1A1) 编码延伸因子 alpha 亚基的同种型- 1 复合物，负责将氨酰 tRNA 酶促递送至核糖体。这种亚型（α 1）在脑、胎盘、肺、肝、肾和胰腺中表达，另一种亚型（α 2）在脑、心脏和骨骼肌中表达。这种亚型在 66% 的 Felty 综合征患者中被鉴定为自身抗原。已发现该基因在许多染色体上具有多个拷贝，其中一些（如果不是全部）代表不同的假基因。
T22707	Dalfopristin (mesylate) (112362-50-2 free base) Dalfopristin (mesylate)	Others	Others
	Dalfopristin (mesylate) is a streptogramin antibiotic and a 50S ribosome inhibitor. Streptogramins are produced by a variety of Streptomyces sp as a mixture (ratio of 7:3) of two chemically unrelated compounds, type A and B. Dalfopristin, the type A Strep
T71810	Thiamphenicol palmitate
	Thiamphenicol palmitate is a Prodrug of Thiamphenicol, inhibiting the 50S subunit of the bacterial ribosome and protein translation.
T34191	Pulchellin NSC 85244
	Pulchellin is a type-2 Ribosome Inactivating Protein (RIP), whose action mechanism proposed would be initiate by B-chain binding on glycoconjugate onto the cell surface (lectinic chain). pulchellin isoforms toxicity is the interaction between B-chain lect
T70076	NOSO-95C
	NOSO-95C is an antibacterial compound that bind to the bacterial ribosome and kill bacteria through inhibition of the translation. NOSO-95C showed promising in vitro and in vivo efficacy against Enterobacteriaceae.
T19306	ELX-02 disulfate NB-124 disulfate	Others	Others
	ELX-02 disulfate (also referred to as NB-124 disulfate) is a synthetic eukaryotic ribosome selective glycoside (ERSG). This compound is currently in development as a therapy specifically designed to address genetic diseases resulting from nonsense mutations.
T18327	MC-Val-Cit-PAB-Retapamulin	Others	Others
	MC-Val-Cit-PAB-Retapamulin is a drug-linker conjugate for antibody-drug conjugates (ADC) that exhibits potent antitumor activity. This compound utilizes Retapamulin, a ribosome inhibitor, connected through the ADC linker MC-Val-Cit-PAB.
T27165	Diazaborine Diazaborine compound 2b18,Pkf 84.474,Pkf 84474,Pkf-84474,SA-84474
	Diazaborine inhibits maturation of rRNAs for the large ribosomal subunit. Diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1. Diazaborine treatment causes, within minutes, a rapid redistribution of the protein from the nucleolus to t
T9427	Selenocysteine	Others	Others
	Selenocysteine 被认为是核糖体介导的蛋白质合成中的第 21 个氨基酸，其特异性掺入由 UGA 密码子指导。
T38186	6-Amino-8-trifluoromethylphenanthridine
	6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine . It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 μM. 6A-8tFP directly competes with protein substrates for the ribosomal active site.
T19307	ELX-02 sulfate NB-124 sulfate	Others	Others
	ELX-02 sulfate, also known as NB-124 sulfate, is a novel compound currently under development as a therapeutic agent for genetic diseases triggered by nonsense mutations. This investigational compound, an advanced synthetic eukaryotic ribosome selective glycoside (ERSG), shows promising potential for targeted treatment.
T79759	Antifungal agent 74
	Antifungalagent 74 (compound 3c) 是一种高效抗真菌化合物，展现出对C. arachidicola和R. solani的显著杀菌效果。其机制主要通过破坏真核生物的类固醇生物合成及核糖体生物发生来实现。
TP2247	eukaryotic translation initiation factor 3	Others	Others
	Eukaryotic initiation factors (eIF) are proteins involved in the initiation phase of eukaryotic translation. Eukaryotic translation initiation factor 3 binds to the ribosome subunit-mRNA complex. It has been implicated in preventing the large ribosomal subunit from binding the small subunit before it is ready to commence elongation.
T70250	Demeclocycline calcium
	Demeclocycline calcium is a semisynthetic tetracycline antibiotic which was derived from a strain of Streptomyces aureofaciens. Demeclocycline binds to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline also inhibits the effect of vasopressin on the renal tubules, thereby causing diuresis.
T70323	Diethanolamine Fusidate
	Diethanolamine Fusidate is a bacteriostatic antibiotic with similar activity and better absorption after oral administration (in animals) than the sodium salt of Fusidic Acid. This product inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.
T40419	IRES-C11 IRES-C11	c-Myc	Cell Cycle/Checkpoint
	IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.
T75318	Spectinomycin
	Spectinomycin 是广谱性抗生素，能够抑制多种革兰氏阳性及阴性细菌生长。其机制为特异性靶向细菌核糖体，干扰蛋白质合成。Spectinomycin 同时作为 td 内含子 RNA 的非竞争性抑制剂。
T60300	BPH-1086
	BPH-1086 (compound 10) 是一种IspH 抑制剂。IspH 结构域通过与核糖体蛋白 (RPS1) 融合，能够结合 mRNA 或形成细菌核糖体。
T38613	Tigecycline hydrate GAR-936 hydrate
	Tigecycline hydrate (GAR-936 hydrate) is a broad spectrum glycylcycline antibiotic. Tigecycline hydrate is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline hydrate is active against resistant strains of Gram-positive and Gram-negative bacteria .
T22774	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]	Others	Others
	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed
T36706	Bottromycin A2
	Bottromycin A2is an antibiotic originally isolated fromStreptomyces.1It blocks the binding of aminoacyl-tRNA to the A site of the 50S ribosome, inhibiting protein synthesis.2Bottromycin A2is active against clinical isolates of methicillin-resistantStaphylococcus aureus(MRSA) and vancomycin-resistantEnterococciwith MIC values of 1 and 0.5 μg/ml, respectively. 1.Nakamura, S., Yajima, T., Lin, Y., et al.Isolation and characterization of bottromycins A2, B2, C2J. Antibiot. (Tokyo)20(1)1-5(1967) 2.Go...
T80402	Api137
	Api137是一种抗生肽，其作用机制为通过抑制翻译干预细菌生长。具体来说，Api137在新生多肽链水解后，通过俘获释放因子于70S核糖体，从而抑制了蛋白质的合成。
T79015	SEQ-9
	SEQ-9 是一种口服有效的结核分枝杆菌（Mtb）23S rRNA抑制剂，针对未甲基化Mtb核糖体的IC50值约为170 nM。该化合物还可有效作用于A2296甲基化核糖体。SEQ-9 主要用于细菌感染和耐药性方面的研究。
T4543	Telithromycin HMR3647,泰利霉素,Ketek,RU66647	Antibacterial; Antibiotic	Microbiology/Virology
	Telithromycin (HMR3647) 是一种社区获得性肺炎抗生素。
T78055	MYC-RIBOTAC	c-Myc	Cell Cycle/Checkpoint
	MYC-RIBOTAC 是一种针对MYC内部核糖体进入位点（IRES）的核糖核酸酶靶向降解剂（RIBOTAC）。该化合物结合了MYC mRNA的靶向组分以及一种可招募并激活RNA酶L1的小分子。通过降低MYC的mRNA和蛋白质表达水平，MYC-RIBOTAC诱导细胞发生凋亡，应用于抗肿瘤治疗的研究。
T74144	Zifanocycline
	Zifanocycline (KBP-7072) 为半合成第三代氨甲基环素类抗生素，通过抑制细菌核糖体功能而发挥作用。它对革兰氏阳性菌和革兰氏阴性菌[包括多重耐药病原体]显示出广泛的体外抗菌活性。适用于口服和注射形式，Zifanocycline 主要用于研究治疗急性细菌性皮肤及其结构感染、社区获得性细菌性肺炎以及复杂腹腔感染。
T38187	6-Aminophenanthridine
	6-Aminophenanthridine is an antiprion agent. It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor agonist guanabenz . 6-Aminophenanthridine (300 μM) inhibits protein folding activity of the ribosome (PFAR) by directly competing with protein substrates for the active site and decreases the yield of refolded protein without affecting the refolding rate. It prevents progressive w...
T83714	LAP TFA Lupus Autoantigen Peptide,La Peptide
	Lupus autoantigen peptide (LAP) 是源自La的一种抗病毒肽，La是系统性红斑狼疮 (SLE) 患者中发现的一种自身抗原，对应于La的11-28氨基酸。它抑制了丙型肝炎病毒 (HCV) 5’-UTR与内部核糖体进入位点 (IRES) 跨作用因子 (ITAFs)，包括多嘧啶片段结合蛋白 (PTB) 和多聚(rC)-结合蛋白2 (PCBP2) 之间的相互作用。LAP (60 µM) 在使用Huh7细胞的报告者测定中抑制了HCV IRES介导的翻译，这一效应可以通过重组的PTB和PCBP2来逆转。
T81272	RIOK2-IN-1
	RIOK2-IN-1 (com 4) 是一种高选择性 RIOK2 抑制剂，Kd 值为 150 nM，但其细胞活性相对低下，IC50 值达 14,600 nM。RIOK2 作为一种非典型激酶，在多种人类癌症中扮演角色，涉及核糖体成熟和细胞周期的进展。基于 RIOK2-IN-1，开发出的新型小分子抑制剂 CQ211 显示出突出的体内外活性，能有效抑制 MKN-1 和 HT-29 癌细胞增殖，并在小鼠异种移植的 MKN-1 模型中抑制了肿瘤的发展。

化合物

Cat.No: T8645

Target: Others

N1-Methylpseudouridine

Cat.No: T19459

Synonym: N1-甲基-假尿苷,1-Methylpseudouridine

Target: Others

Tulathromycin A

Cat.No: T4267

Synonym: CP 472295,Draxxin,Tulathromycin,托拉菌素 A

Target: Antibacterial, Antibiotic

Spectinomycin dihydrochloride pentahydrate

Cat.No: T0788L

Synonym: 盐酸大观霉素五水合物,Trobicin,Spectogard,Spectinomycin hydrochloride hydrate

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T4222

Synonym: KKL 10

Target: ribosome, Antibacterial

Cat.No: T28506

Target: Phosphatase

Cat.No: T3265

Synonym: Desmethyl Azithromycin,阿奇霉素 A,6-Demethylazithromycin,去甲基阿奇霉素,Azaerythromycin A,Azaerythromycin

Target: Antibacterial, Antibiotic

Cat.No: T7411

Synonym: Ribozinoindole-1

Target: ATPase, Phosphatase

Cat.No: T13767

Target: Others, Antibacterial

Cat.No: T1747

Synonym: TR 700,特地唑胺,DA-7157,泰地唑利,Torezolid

Target: MAO, Antibacterial, Antibiotic

Cat.No: T5189

Synonym: PTK 0796,Amadacycline

Target: ribosome, Antibacterial, Antibiotic

Acetylspiramycin

Cat.No: T1557

Synonym: Spiramycin II,Foromacidin B,乙酰螺旋霉素,ASPM,Spiramycin B

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T3052

Synonym: Bonomycin,Norcycline,Sancyclinum,山环素,6-Demethyl-6-deoxytetracycline

Target: Antibacterial

Cat.No: T1569

Synonym: 替加环素,GAR-936

Target: ribosome, Antibacterial, Antibiotic, Autophagy

Cat.No: T2331

Synonym: 索利霉素,OP-1068,CEM-101

Target: Antibacterial, Antibiotic

Cat.No: T6638

Synonym: 瑞他莫林,SB-275833

Target: ribosome, Antibacterial, Antibiotic

Lefamulin acetate

Cat.No: T11836

Synonym: BC-3781 acetate,醋酸来法莫林

Target: ribosome, Antibacterial, Antibiotic

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]（TFA)

Cat.No: T22774L

Target: Others

Dalfopristin (mesylate) (112362-50-2 free base)

Cat.No: T22707

Synonym: Dalfopristin (mesylate)

Target: Others

Thiamphenicol palmitate

Cat.No: T71810

Cat.No: T34191

Synonym: NSC 85244

Cat.No: T70076

ELX-02 disulfate

Cat.No: T19306

Synonym: NB-124 disulfate

Target: Others

MC-Val-Cit-PAB-Retapamulin

Cat.No: T18327

Target: Others

Cat.No: T27165

Synonym: Diazaborine compound 2b18,Pkf 84.474,Pkf 84474,Pkf-84474,SA-84474

Cat.No: T9427

Target: Others

6-Amino-8-trifluoromethylphenanthridine

Cat.No: T38186

Cat.No: T19307

Synonym: NB-124 sulfate

Target: Others

Antifungal agent 74

Cat.No: T79759

eukaryotic translation initiation factor 3

Cat.No: TP2247

Target: Others

Demeclocycline calcium

Cat.No: T70250

Diethanolamine Fusidate

Cat.No: T70323

Cat.No: T40419

Synonym: IRES-C11

Target: c-Myc

Cat.No: T75318

Cat.No: T60300

Tigecycline hydrate

Cat.No: T38613

Synonym: GAR-936 hydrate

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]

Cat.No: T22774

Target: Others

Cat.No: T36706

Cat.No: T80402

Cat.No: T79015

Cat.No: T4543

Synonym: HMR3647,泰利霉素,Ketek,RU66647

Target: Antibacterial, Antibiotic

Cat.No: T78055

Target: c-Myc

Cat.No: T74144

6-Aminophenanthridine

Cat.No: T38187

Cat.No: T83714

Synonym: Lupus Autoantigen Peptide,La Peptide

Cat.No: T81272

Cat. No.	Product Name	Target	Signaling Pathways
T16674	Pseudouridine	Endogenous Metabolite	Metabolism
	Pseudouridine 是非编码 RNA 中丰富的修饰核苷，通过稳定 RNA 结构增强核糖体 RNA 和的转移 RNA 功能。
T1160	Fusidic acid Fusidine,夫西地酸	Others; CAT; Antibacterial; Antibiotic	Microbiology/Virology; Others; oxidation-reduction
	Fusidic acid (Fusidine) 是一种从 Fusidium coccineum 发酵液中分离出来的甾体类抗生素。它通过阻止核糖体释放翻译延长因子 G 来抑制细菌的生长。
T12540	Pristinamycin IA Mikamycin IA,普利霉素IA,Mikamycin B	Others; Antibiotic; P-gp	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
	Pristinamycin IA (Mikamycin B) 是 P-糖蛋白的底物，也是一种环肽类大环内酯抗生素。
T1289	Fusidic acid sodium salt Sodium fusidate,夫西地酸钠,Fusidate Sodium,Fucidin,SQ-16360	Others; CAT; Antibacterial; Antibiotic	Microbiology/Virology; Others; oxidation-reduction
	Fusidic acid sodium salt (SQ-16360) 是一种Fusidium coccineum 属甾体类抑菌抗生素。它阻止核糖体释放翻译延长因子G 来抑制细菌生长。
T0788	Spectinomycin dihydrochloride 淋必治,Spectinomycin 2HCl,盐酸奇霉素,Actinospectacin	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Spectinomycin dihydrochloride (Actinospectacin) 是一种能与细菌核糖体的30S 亚基结合，干扰蛋白质合成的抗生素。
T17143	Toyocamycin 丰加霉素,Vengicide	Apoptosis; Others; IRE1; Antibiotic; Antifungal	Apoptosis; Cell Cycle/Checkpoint; Microbiology/Virology; Others
	Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物，为 X 盒结合蛋白 1 (XBP1) 抑制剂，抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂，IC50值为 80 nM。它还诱导凋亡。
T7148	JOSAMYCIN EN-141,交沙霉素	Antibacterial; Antibiotic	Microbiology/Virology
	Josamycin (EN-141) 是一种大环内酯类抗生素，对多种病原体有抗菌活性。它对核糖体的解离常数Kd 为 5.5 nM。
T64911	Blasticidin S HCl	Antibiotic	Microbiology/Virology
	Blasticidin S HCl 是从 Streptomyces griseochromogenes 中分离的肽基核苷类抗生素 (antibiotic)，主要通过干扰核糖体中肽键的形成从而抑制原核细胞和真核细胞蛋白的合成。
T6447	Clindamycin Clinimycin,Sobelin,Chlolincocin,克林霉素	Antibacterial; Antibiotic	Microbiology/Virology
	Clindamycin (Sobelin) 从细菌核糖体中解离肽基-tRNA，破坏细菌蛋白质合成。它是一种半合成广谱抗生素，由母体化合物林可霉素化学修饰而成。
T6758	Anisomycin 茴香霉素,Flagecidin,NSC 76712,Wuningmeisu C	Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic; JNK	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; MAPK; Microbiology/Virology
	Anisomycin (NSC-76712) 是一种从各种链霉菌属中分离出来的抗生素。它通过抑制肽基转移酶或 80S 核糖体系统来干扰蛋白质和 DNA 合成。
T1214	Ribostamycin sulfate Vistamycin sulfate,硫酸核糖霉素	Antibacterial; Antibiotic	Microbiology/Virology
	Ribostamycin sulfate (Vistamycin sulfate) 是一种广谱抗菌剂, 在30S 和50S 核糖体亚基结合抑制细菌蛋白质合成, 还抑制蛋白二硫键异构酶分子伴侣活性, 用于药代动力学和肾毒性研究。
T21430	Oxytetracycline Hydrochloride Biosolvomycin,盐酸土霉素,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin	Antiviral; Endogenous Metabolite; Antibacterial; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology
	Oxytetracycline Hydrochloride (Dalimycin) 是由 Streptomyces rimosus 生产的，一种具有抗菌活性的四环素衍生物。它干扰氨酰-tRNA 与 mRNA-核糖体复合物的结合，从而阻止肽延伸并抑制蛋白质合成。
T5055	For-Met-OH fMet,N-甲酰甲硫氨酸,N-Formyl-L-methionine	Others; Endogenous Metabolite	Metabolism; Others
	For-Met-OH (N-Formyl-L-methionine) 是内源性代谢产物的一种。
T1022	Hygromycin B 潮霉素B,Hygrovetine	ribosome; Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Hygromycin B (Hygrovetine) 是一种氨基糖苷类抗生素，通过干扰易位并导致 70S 核糖体的错误翻译来抑制蛋白质合成。Hygromycin B 可用于筛选转染 hph 或 hyg 抗性基因的原核或者真核细胞。
T0912	Tetracycline hydrochloride NCI-c55561,盐酸四环素,Tetracycline HCl	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Tetracycline hydrochloride (NCI-c55561) 是一种广谱抗生素，抑制多种革兰氏阳性和革兰氏阴性细菌。
T11842	Levomecol	Others	Others
	Levomecol, a broad-spectrum antibiotic derived from Streptomyces venezuelae, comprises Chloramphenicol and Methyluracil. It exerts its bacteriostatic effect by binding to the bacterial ribosome, inhibiting protein synthesis by blocking peptidyl transferase.

天然产物

Cat.No: T16674

Target: Endogenous Metabolite

Cat.No: T1160

Synonym: Fusidine,夫西地酸

Target: Others, CAT, Antibacterial, Antibiotic

Pristinamycin IA

Cat.No: T12540

Synonym: Mikamycin IA,普利霉素IA,Mikamycin B

Target: Others, Antibiotic, P-gp

Fusidic acid sodium salt

Cat.No: T1289

Synonym: Sodium fusidate,夫西地酸钠,Fusidate Sodium,Fucidin,SQ-16360

Target: Others, CAT, Antibacterial, Antibiotic

Spectinomycin dihydrochloride

Cat.No: T0788

Synonym: 淋必治,Spectinomycin 2HCl,盐酸奇霉素,Actinospectacin

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T17143

Synonym: 丰加霉素,Vengicide

Target: Apoptosis, Others, IRE1, Antibiotic, Antifungal

Cat.No: T7148

Synonym: EN-141,交沙霉素

Target: Antibacterial, Antibiotic

Blasticidin S HCl

Cat.No: T64911

Target: Antibiotic

Cat.No: T6447

Synonym: Clinimycin,Sobelin,Chlolincocin,克林霉素

Target: Antibacterial, Antibiotic

Cat.No: T6758

Synonym: 茴香霉素,Flagecidin,NSC 76712,Wuningmeisu C

Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic, JNK

Ribostamycin sulfate

Cat.No: T1214

Synonym: Vistamycin sulfate,硫酸核糖霉素

Target: Antibacterial, Antibiotic

Oxytetracycline Hydrochloride

Cat.No: T21430

Synonym: Biosolvomycin,盐酸土霉素,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin

Target: Antiviral, Endogenous Metabolite, Antibacterial, HSV

Cat.No: T5055

Synonym: fMet,N-甲酰甲硫氨酸,N-Formyl-L-methionine

Target: Others, Endogenous Metabolite

Cat.No: T1022

Synonym: 潮霉素B,Hygrovetine

Target: ribosome, Antibacterial, Antibiotic, Antifungal

Tetracycline hydrochloride

Cat.No: T0912

Synonym: NCI-c55561,盐酸四环素,Tetracycline HCl

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T11842

Target: Others

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