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27

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5447	Anle138b	Beta Amyloid; Others	Neuroscience; Others
	Anle138b 是一种毒性低，口服生物利用度高，血脑屏障通透性好的低聚物聚集抑调节剂，可阻断朊病毒蛋白和 α-突触核蛋白病理性聚集的形成。它在体内强烈抑制低聚物积累、神经元变性和疾病进展。它阻断 Aβ 通道并挽救淀粉样变性小鼠模型的疾病表型。
T13329L	Vofopitant dihydrochloride GR 205171A,Vofopitant 2HCl	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Vofopitant dihydrochloride (GR 205171A) 是一种可口服且具有选择性的速激肽 NK1 受体拮抗剂，对 [3H]SP 与 NK1 结合有抑制作用， pKi 值分别为 9.5 和 10.6。Vofopitant dihydrochloride 是治疗病理性呕吐的潜在化合物。
T60226	CT52923	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	CT52923 is a selective, orally active antagonist of platelet-derived growth factor receptor (PDGFR), functioning as an ATP-competitive inhibitor. It has versatile applications for researching an array of pathological diseases such as atherosclerosis, glomerulonephritis, liver cirrhosis, pulmonary fibrosis, and cancer.
T9087	Creatine-d3 hydrate CREATINE-(METHYL-D3) MONOHYDRATE,肌氨酸酐-甲基-D3 一水合物	Endogenous Metabolite	Metabolism
	Creatine-d3 hydrate (CREATINE-(METHYL-D3) MONOHYDRATE) 是一种氘标记的肌酸水合物。其中肌酸水合物在肌肉和脑细胞的能量代谢中起着关键作用。
T9110	Ceapin-A7	Others	Others
	Ceapin-A7 是内质网应激 ATF6α信号的选择性阻断剂(IC50:0.59 μM)，可用于探讨 ATF6α 促细胞活化的机制及其在病理环境中的作用。
T50115	3-phenoxy-8-azabicyclo[3.2.1]octane hydrochloride	Others	Others
	3-phenoxy-8-azabicyclo[3.2.1]octane hydrochloride 是一种合成化合物，属于氮杂双环辛烷类。它是多巴胺D2受体的强效和选择性激动剂，被广泛用于研究多巴胺信号传导的机制及其在各种生理和病理过程中的作用。
T50098	TIQ-A	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	TIQ-A 是一种 PARP1 抑制剂，通过碱基切除修复途径参与 DNA 单链断裂修复。 PARP1 由 DNA 损伤触发，其过度激活已被认为是许多病理状况的致病因素，包括缺血和再灌注损伤、哮喘相关炎症和动脉粥样硬化形成。
T13763	LY88074 analog 1	Others	Others
	LY88074 analog 1, a benzothiophene compound with nitrogen-containing non-basic side chains, can be utilized either independently or alongside estrogen or progestin. This agent is effective for mitigating post-menopausal symptoms, including osteoporosis, cardiovascular-related pathological conditions, and estrogen-dependent cancer.
T25319	Diacetylsplenopentin HCl Diacetylsplenopentin hydrochloride
	Diacetylsplenopentin HCl is used as a synthetic immunomodulator that affects the proliferation and differentiation of bone marrow stem cells without stimulating pathological immune responses beyond the balance of the immune system. This effect is specific
T37268	PAF C-16 Carboxylic Acid
	PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the remodeling" and 'de novo' pathways. It is a potent mediator of neutrophil migration and the production of reactive oxygen species and IL-6. Pathological processes involving PAF include necrotizing enterocolitis
T68296	SB1578
	SB1578, also known as ONX-0805, is a novel, orally bioavailable JAK2 inhibitor with specificity for JAK2 within the JAK family and also potent activity against FLT3 and c-Fms. SB1578 blocks the activation of these kinases and their downstream signaling in pertinent cells, leading to inhibition of pathological cellular responses. The biochemical and cellular activities of SB1578 translate into its high efficacy in two rodent models of arthritis.
T38764	Amylin (8-37), human
	Amylin (8-37), human, derived from human Amylin, possesses direct vasodilator effects in isolated mesenteric resistance arteries of rats. Human Amylin is a small pancreatic β-cell hormone that forms aggregates in the absence of insulin and is a key pathological feature of type II diabetes mellitus.
T38789	BMS-984923
	BMS-984923, a highly potent silent allosteric modulator (SAM) of mGluR5, demonstrates exceptional binding affinity (K i = 0.6 nM). Additionally, this compound possesses favorable oral bioavailability and blood-brain barrier (BBB) penetration. BMS-984923 effectively inhibits the interaction between PrPC and mGluR5, preventing pathological Aβo signaling, while leaving physiological glutamate signaling unaffected.
T71093	SB-1578 citrate
	SB-1578 citrate is a novel, orally bioavailable JAK2 inhibitor with specificity for JAK2 within the JAK family and also potent activity against FLT3 and c-Fms. SB1578 blocks the activation of these kinases and their downstream signaling in pertinent cells, leading to inhibition of pathological cellular responses. The biochemical and cellular activities of SB1578 translate into its high efficacy in two rodent models of arthritis.
T69656	E197
	E197 is a DOCK5 inhibitor. E197 can inhibit both mouse and human osteoclast activity. In particular, E197 prevented pathological bone loss in mice. Most interestingly, treatment with E197 did not affect osteoclast and osteoblast numbers and hence did not impair bone formation. E197 could represent a lead molecule to develop new antiosteoporotic drugs targeting the mechanism of osteoclast adhesion onto the bone.
T60403	COX-2/NO-IN-1
	COX-2/NO-IN-1 是一种具有口服活性的一氧化氮合酶 (iNOS) 和 NO（IC 50 为 3.52 μM）抑制剂，并抑制 COX-2 的表达。 COX-2/NO-IN-1 具有抗炎作用，可减少肾脏组织的病理损伤[1]。
T78093	Cisd2 agonist 1	Others	Others
	Cisd2 agonist 1 (Compound 4q)为一种EC50值为34 nM的Cisd2激动剂，可增强Cisd2表达并改善非酒精性脂肪肝疾病（NAFLD）的病理改变，同时具备良好的代谢稳定性，适用于NAFLD研究。
T75361	BSB
	BSB，一种刚果红衍生的荧光探针，既与细胞外淀粉样β蛋白发生结合，也能与由异常tau蛋白与突触核蛋白组成的细胞内病变相结合，是作为阿尔茨海默病原型成像剂的代表。
T70180	LFS-829
	LFS-829 is a a small-molecule antagonist of exportin-1. LFS-829 showed low-range nanomolar activities. Oral administration of LFS-829 can significantly reverse the pathological features of colitis model mice. LFS-829 can attenuate dual NF-κB signaling and the Nrf2 cytoprotection pathway via targeting exportin-1 in colitis mice. Moreover, LFS-829 has a very low risk of cardiotoxicity and acute toxicity. LFS-829 holds great promise for the treatment of colitis and may warrant translation for use i...
T74923	ICy-Q	Pyroptosis	Apoptosis; Immunology/Inflammation
	ICy-Q为NQO-1激活的NIR试剂，与NQO-1反应生成还原产物ICy-OH，后者通过激活细胞焦亡(pyroptosis)路径，选择性诱导胰腺癌细胞死亡，适用于术中快速、准确诊断病理切片。
T81110	SQM-NBD
	SQM-NBD 为高效选择性AIE荧光探针，对Cys及Hcy具有卓越的敏感性，其检出限(LOD)分别为54 nM与72 nM。该探针展现出良好的细胞膜穿透能力及低毒性，适用于生理及病理状态下Cys/Hcy的识别。
T60353	Glucocerebrosidase-IN-1
	Glucocerebrosidase-IN-1 (compound 11a) 是一种有效的选择性的GCase(葡糖脑苷脂酶)抑制剂，其IC50为 29.3 μM，Ki 为 18.5 μM。由于GCase 参与酶缺乏性病理疾病，Glucocerebrosidase-IN-1 可用于戈谢病 (GD) 和帕金森病 (PD) 的研究。
T69731	Remdesivir maleate
	Remdesivir, also known as GS-5734, is a prodrug form of the antiviral nucleoside analog GS-44152. Remdesivir is a broad spectrum anti-viral drug that has shown to inhibit SARS-CoV-2, in vitro and in vivo. Efficacy of remdesivir against Ebola virus has been demonstrated. Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary les...
T79372	A3AR agonist 1	Adenosine Receptor	GPCR/G Protein; Neuroscience
	A3AR拮抗剂1（化合物12）是一种选择性的A3AR激动剂，其Ki值为25.8 nM。该化合物能有效促进β-arrestin2的募集，表现出EC50为5.17 nM的高亲和力。A3AR拮抗剂1主要用于炎症性疾病、缺血、癌症、神经性疼痛和肝脏疾病等方面的科研。
T35893	rac-1,2-bis-Palmitoyl-3-chloropropanediol
	rac-1,2-bis-Palmitoyl-3-chloropropanediol is a 3-monochloropropane-1,2-diol (3-MCPD) ester.1It has been found as a contaminant in edible olive oils, with the lowest and highest concentrations in extra virgin and olive pomace oils, respectively.rac-1,2-bis-Palmitoyl-3-chloropropanediol has also been found in cottonseed and palm oils, as well as in shortening.2It induces renal tubular necrosis and a decrease in spermatids, but no gross pathological changes, in mice.3 1.Hung, W.-C., Peng, G.-J., Ts...
T37369	Amyloid-β (1-8, A2V) Peptide Amyloid-β (1-8, A2V) Peptide
	Amyloid-β (1-8, A2V) is a truncated form of amyloid-β (Aβ) that contains a valine to alanine substitution at position 2 of the Aβ numbering convention (Aβ A2V), which corresponds to position 673 of the amyloid precursor protein (APP) numbering convention (APP A673V). An Aβ (1-40) (Aβ40) A2V peptide increases the production of Aβ and the rate and amount of amyloid fibril formation in vitro, effects that can be reduced by coincubation with wild-type Aβ40. Aβ40 and Aβ42 levels are increased in CHO ...
T64214	NXPZ-2
	NXPZ-2 是一种口服具有活力的 Keap1-Nrf2protein–protein interaction(PPI) 抑制剂 (Ki: 95 nM, EC50: 120 and 170 nM)。NXPZ-2 能够上调Nrf2含量，并促进其从细胞质向细胞核的易位，表现出对氧化应激的抑制作用。NXPZ-2 能够剂量依赖性地缓解 Aβ[1-42]诱导的认知紊乱，能够提高神经元数量和功能，增强阿尔茨海默病 (AD) 小鼠脑组织的病理改变情况。NXPZ-2 具有潜力进行 Keap1-Nrf2 PPI 抑制剂和 AD 相关的疾病的研究。

化合物

Cat.No: T5447

Target: Beta Amyloid, Others

Vofopitant dihydrochloride

Cat.No: T13329L

Synonym: GR 205171A,Vofopitant 2HCl

Target: Neurokinin receptor

Cat.No: T60226

Target: PDGFR

Creatine-d3 hydrate

Cat.No: T9087

Synonym: CREATINE-(METHYL-D3) MONOHYDRATE,肌氨酸酐-甲基-D3 一水合物

Target: Endogenous Metabolite

Cat.No: T9110

Target: Others

3-phenoxy-8-azabicyclo[3.2.1]octane hydrochloride

Cat.No: T50115

Target: Others

Cat.No: T50098

Target: PARP

LY88074 analog 1

Cat.No: T13763

Target: Others

Diacetylsplenopentin HCl

Cat.No: T25319

Synonym: Diacetylsplenopentin hydrochloride

PAF C-16 Carboxylic Acid

Cat.No: T37268

Cat.No: T68296

Amylin (8-37), human

Cat.No: T38764

Cat.No: T38789

SB-1578 citrate

Cat.No: T71093

Cat.No: T69656

Cat.No: T60403

Cisd2 agonist 1

Cat.No: T78093

Target: Others

Cat.No: T75361

Cat.No: T70180

Cat.No: T74923

Target: Pyroptosis

Cat.No: T81110

Glucocerebrosidase-IN-1

Cat.No: T60353

Remdesivir maleate

Cat.No: T69731

Cat.No: T79372

Target: Adenosine Receptor

rac-1,2-bis-Palmitoyl-3-chloropropanediol

Cat.No: T35893

Amyloid-β (1-8, A2V) Peptide

Cat.No: T37369

Synonym: Amyloid-β (1-8, A2V) Peptide

Cat.No: T64214

Cat. No.	Product Name	Target	Signaling Pathways
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
T2803	Monocrotaline 野百合碱,Crotaline	TGF-beta/Smad	Stem Cells
	Monocrotaline (Crotaline) 是一种吡咯里西啶生物碱，从猪屎豆植物的种子中提取得到，可诱导啮齿动物产生肺动脉高血压。
T3S0738	yangonin Y100550,甲氧醉椒素	Cannabinoid Receptor; NF-κB; Autophagy	Autophagy; GPCR/G Protein; NF-κB
	Yangonin (Y100550) 是一种新型 CB1 受体配体，对人重组 CB1 受体具有亲和力。它可能是干预 NF-κB 依赖性病理状况的候选药物。
T2S2172	nerolidol (±)-Nerolidol,Peruviol,橙花叔醇	Others; Endogenous Metabolite; Antibacterial; Parasite; Antifungal	Metabolism; Microbiology/Virology; Others
	Nerolidol (Peruviol) 是天然膜活性倍半萜，有抗肿瘤、抗细菌、抗真菌和抗寄生虫活性。它对动物有镇静作用，氧化过程对神经元病理后果起关键作用。
TN1849	Kuwanon H	GPR; Bombesin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Kuwanon H 是分离自桑白皮的黄酮类化合物，具有拮抗非肽类蛙皮素受体的活性。Kuwanon H 特异性抑制细胞内胃泌激素释放肽 CRP 与GRP-preferring 受体的结合，Ki 为 290 nM。
T4A2458	Resibufogenin 酯蟾毒配基,Bufogenin,Recibufogenin,酯蟾毒配基，蟾力苏	Others	Others
	Resibufogenin (Bufogenin) 是华蟾素的成分之一，表现出抑制氧化应激及肿瘤再生的活性。
TN4490	Manassantin B	ERK; BCL; p38 MAPK; TNF; NF-κB; JNK; STAT; Antifection	Apoptosis; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells
	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in pa...

天然产物

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Cat.No: T2803

Synonym: 野百合碱,Crotaline

Target: TGF-beta/Smad

Cat.No: T3S0738

Synonym: Y100550,甲氧醉椒素

Target: Cannabinoid Receptor, NF-κB, Autophagy

Cat.No: T2S2172

Synonym: (±)-Nerolidol,Peruviol,橙花叔醇

Target: Others, Endogenous Metabolite, Antibacterial, Parasite, Antifungal

Cat.No: TN1849

Target: GPR, Bombesin Receptor

Cat.No: T4A2458

Synonym: 酯蟾毒配基,Bufogenin,Recibufogenin,酯蟾毒配基，蟾力苏

Target: Others

Cat.No: TN4490

Target: ERK, BCL, p38 MAPK, TNF, NF-κB, JNK, STAT, Antifection

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