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26

抑制剂 & 化合物

10

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Cat. No.	Product Name	Target	Signaling Pathways
T11580	Heme Oxygenase-1-IN-1 HO-1-IN-1	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Heme Oxygenase-1-IN-1 (HO-1-IN-1) 是一种血红素加氧酶 1 (HO-1) 抑制剂，IC50=250 nM。
T11580L	Heme Oxygenase-1-IN-1 hydrochloride HO-1-IN-1 hydrochloride	Others	Others
	HO-1-IN-1 hydrochloride is a heme oxygenase 1 (HO-1) inhibitor (IC50: 250 nM).
T13396	Zinc Protoporphyrin Zinc Protoporphyrin-9,锌原卟啉,ZnPP,Zn(II)-protoporphyrin IX	Apoptosis; Reactive Oxygen Species; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) 是一种具有口服活性的，竞争性血红素加氧酶-1 抑制剂，显著减弱间苯三酚对 H2O2 的保护作用，具有抗癌活性。它用于评估人群铁状态与血红蛋白浓度的组合，也可用作个体孕妇和儿童缺铁的筛查标志物。
T61078	Heme Oxygenase-1-IN-2
	Heme Oxygenase-1-IN-2 is a novel inhibitor of heme oxygenase-1 (HO-1), displaying potent antiproliferative activity in vitro, with an IC50 value of 0.95 μM.
T60847	Heme Oxygenase-2-IN-1
	Heme Oxygenase-2-IN-1 (Compound 9) 是血红素加氧酶 (HO-2) 的选择性抑制剂。Heme Oxygenase-2-IN-1 对 HO-1和HO-2 的IC50值分别为 14.9 μM 和0.9 μM。
T3459	VK3-OCH3 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na	Others	Others
	VK3-OCH3 (2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na) 是一种通过血红素加氧酶(HO-1) 相关机制的选择性抗肿瘤剂；维生素 K3 类似物。
T4977	Sofalcone 索法酮,SU-88	Antibacterial; Autophagy	Autophagy; Microbiology/Virology
	Sofalcone (SU-88) 可诱导血红素加氧酶-1在胃肠上皮中的表达，是一种抗胃溃疡剂。
T75098	HIF-PHD-IN-3	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	HIF-PHD-IN-3 是一种有效的 hiPSC-CM 心脏保护支架，对 HIF-PHD 有潜在的抑制作用，可调节血红素加氧酶-1，可用于研究贫血。
T0839L	S-(+)-Ketoprofen RP-19583,Dexketoprofen,(S)-(+)-Ketoprofen,(S)-Ketoprofen,(S)-(+)-酮洛芬,右旋酮洛芬	COX	Immunology/Inflammation; Neuroscience
	S-(+)-Ketoprofen ((S)-(+)-Ketoprofen) 抑制 COX-1和 COX-2的IC50值分别为 1.9 和 27 nM。
T27064	CP-312 CP312,Cardioprotectant 312	Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	CP-312 (Cardioprotectant 312)是一种抗氧化防御反应激活剂，它通过诱导血红素加氧酶-1发挥作用，通过诱导 HMOX1 表达来靶向抗氧化反应网络，从而保护 hiPSC-CM 的活力。CP-312 保护人 iPSC 衍生的心肌细胞免受氧化应激。
T36113	Cobaltic Protoporphyrin IX chloride Protoporphyrin IX cobaltic chloride	Autophagy	Autophagy
	Cobaltic Protoporphyrin IX chloride (CoPP)是一种有效的血红素加氧酶 1(HO-1)诱导剂，具有抗病毒活性，通过诱导 I 型 IFN 反应来抑制甲型流感病毒(IAV)感染。
T1394	Ibuprofen Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil	COX	Immunology/Inflammation; Neuroscience
	Ibuprofen (Advil) 是一种丙酸衍生物和非甾体抗炎药 (NSAID)，具有抗炎、镇痛和解热作用。它是COX-1和COX-2的抑制剂，IC50值分别为 13 和 370 μM，导致前列腺素和血栓素前体的形成减少。
T0839	Ketoprofen 酮基布洛芬,RP-19583,酮洛芬	Apoptosis; COX; MRP	Apoptosis; Immunology/Inflammation; Neuroscience
	Ketoprofen (RP-19583) 是一种非甾体抗炎剂，能够有效地抑制COX 的活性，在人血单核细胞中，对 COX-1 和 COX-2 的IC50值分别为 2 nM 和 26 nM。
T68288	OB-24 free base
	OB-24 free base is a potent and selective heme oxygenase 1 (HO-1) inhibitor.
T70901	QC-308 HCl
	QC-308 HCl is a novel Heme Oxygenase-1 Inhibitor (HO-1 IC50=0.27μM; HO-2 IC50=0.46μM).
T13161	Tin-protoporphyrin IX 锡原卟啉IX,SnPPIX	Others	Others
	Tin-protoporphyrin IX is a potent inhibitor of Heme oxygenase-1 (HO-1). It sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice models.
T30681	CABP 2-CABP,2CABP,2 CABP
	CABP is a transition analog of ribulos-1, 5-diphosphate carboxylase/oxygenase (Rubisco).
T13524	9-cis-β-Carotene	Others	Others
	9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. It inhibits photoreceptor degeneration and restores retinal function in vivo.
T78623	Cobalt protoporphyrin IX	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Cobalt protoporphyrin IX 作为一种特异性的血红素加氧酶-1 (HO-1) 诱导剂，表现出对甲型流感病毒 (IAV) 的广谱抗病毒活性。
T73666	Proglumetacin
	Proglumetacin 是一种口服有效的环加氧酶 (cyclo-oxygenase) 抑制剂。Proglumetacin 可以抑制 SARS-CoVMpro(新冠病毒的主要蛋白酶)，其 AC50为 8.9 μM。Proglumetacin 具有抗炎活性，可用于炎症(如类风湿关节炎、过敏性气囊炎)的研究。
T63075	ALOX15-IN-1
	ALOX15-IN-1 (compound 8b) 是一种选择性的、有效的兔和人 ALOX15 亚油酸加氧酶 (linoleate oxygenase) 活性抑制剂，能够作用于 ALOX15 直系同源物亚油酸 (LA) (IC50: 0.04 μM) 和花生四烯酸 (AA) (IC50: 2.06 μM)。
T41175	OB 24 hydrochloride
	OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferationin vitroand PCA tumor growth and lymph node/lung metastasesin vivo. Synergizes with Taxol.
T78508	Delmitide acetate RDP-58 acetate	IFNAR	Immunology/Inflammation
	Delmitide acetate (RDP58) 是一种 d-异构体十肽，具有抗炎活性和口服活性。该化合物能够抑制 TNF-α、IFN-γ 以及白细胞介素 (IL)-12 的生成，同时提高血红素加氧酶 1 的活性，可用于针对溃疡性结肠炎的研究。
T74600	Keap1-Nrf2-IN-9
	Keap1-Nrf2-IN-9（compound 11）是一种有效Keap1-Nrf2PPI抑制剂，IC50为0.575 µM。该化合物能够提升Nrf2靶基因表达，涉及血红素加氧酶1 (Hmox1)、谷胱甘肽S转移酶P (GstP) 以及谷氨酸-半胱氨酸连接酶的催化(Gclc)与调节(Gclm)亚基。在ARPE19细胞中，Keap1-Nrf2-IN-9展现出无细胞毒活性。
T75238	YS-49 monohydrate
	YS-49 (单水合物) 作为PI3K/Akt（RhoA的下游靶点）的激活剂，有效降低3-甲基胆碱处理的细胞中RhoA/PTEN的活性。此外，YS-49通过促进血红素加氧酶（HO-1）的表达，抑制血管紧张素II（Ang II）诱导的血管平滑肌细胞（VSMC）增殖。作为一种异喹啉化合物生物碱，YS-49因激活心脏β-adrenoceptors而显示出显著的正性肌力效应。
TP2109	TAT 14	Nrf2	Immunology/Inflammation
	TAT-14 是由14 个氨基酸组成的多肽，是 Nrf2激活因子，表现出抗炎活性。它通过靶向 Nrf2 上 Keap1 的结合位点而非 Nrf2 mRNA 表达来提高 Nrf2 蛋白水平。

化合物

Heme Oxygenase-1-IN-1

Cat.No: T11580

Synonym: HO-1-IN-1

Target: Reactive Oxygen Species

Heme Oxygenase-1-IN-1 hydrochloride

Cat.No: T11580L

Synonym: HO-1-IN-1 hydrochloride

Target: Others

Zinc Protoporphyrin

Cat.No: T13396

Synonym: Zinc Protoporphyrin-9,锌原卟啉,ZnPP,Zn(II)-protoporphyrin IX

Target: Apoptosis, Reactive Oxygen Species, Endogenous Metabolite

Heme Oxygenase-1-IN-2

Cat.No: T61078

Heme Oxygenase-2-IN-1

Cat.No: T60847

Cat.No: T3459

Synonym: 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na

Target: Others

Cat.No: T4977

Synonym: 索法酮,SU-88

Target: Antibacterial, Autophagy

Cat.No: T75098

Target: Reactive Oxygen Species

S-(+)-Ketoprofen

Cat.No: T0839L

Synonym: RP-19583,Dexketoprofen,(S)-(+)-Ketoprofen,(S)-Ketoprofen,(S)-(+)-酮洛芬,右旋酮洛芬

Target: COX

Cat.No: T27064

Synonym: CP312,Cardioprotectant 312

Target: Reactive Oxygen Species, Autophagy

Cobaltic Protoporphyrin IX chloride

Cat.No: T36113

Synonym: Protoporphyrin IX cobaltic chloride

Target: Autophagy

Cat.No: T1394

Synonym: Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil

Target: COX

Cat.No: T0839

Synonym: 酮基布洛芬,RP-19583,酮洛芬

Target: Apoptosis, COX, MRP

OB-24 free base

Cat.No: T68288

Cat.No: T70901

Tin-protoporphyrin IX

Cat.No: T13161

Synonym: 锡原卟啉IX,SnPPIX

Target: Others

Cat.No: T30681

Synonym: 2-CABP,2CABP,2 CABP

9-cis-β-Carotene

Cat.No: T13524

Target: Others

Cobalt protoporphyrin IX

Cat.No: T78623

Target: Reactive Oxygen Species

Cat.No: T73666

Cat.No: T63075

OB 24 hydrochloride

Cat.No: T41175

Delmitide acetate

Cat.No: T78508

Synonym: RDP-58 acetate

Target: IFNAR

Keap1-Nrf2-IN-9

Cat.No: T74600

YS-49 monohydrate

Cat.No: T75238

Cat.No: TP2109

Target: Nrf2

Cat. No.	Product Name	Target	Signaling Pathways
TN3694	Coniferaldehyde	NOS; COX; Nrf2; PKC; Autophagy	Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience
	Coniferaldehyde 能显着抑制酒球菌菌株的生长活力。 Coniferaldehyde 通过诱导血红素加氧酶 1 (HO-1) 发挥抗炎特性。
T6S1302	Carnosol	Nrf2; Endogenous Metabolite; S6 Kinase	Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling
	Carnosol 是 Nrf2激活剂，增加 Nrf2 的水平以及能促进血红素氧合酶 1（HMOX1）表达。它是核糖体 S6激酶(RSK2)抑制剂，可用于胃癌相关研究，IC50值约为 5.5 μM。
T6S1027	Tussilagone	Others	Others
	Tussilagone 是Tussilago farfara 的主要活性成分，具有抗炎作用。它抑制盲肠结扎和穿刺导致脓毒症的小鼠的炎症反应，提高其生存率。它改善葡聚糖硫酸钠诱导的小鼠结肠炎的炎症反应。
T5515	Hemin 氯化血红素,Hemin chloride	Mitophagy; Ferroptosis; Autophagy	Apoptosis; Autophagy
	Hemin (Hemin chloride) 是一种含有氯的含铁卟啉，一种血红素加氧酶 (HO)-1 诱导剂。Hemin 对卟啉病具有治疗活性，可以减少患者的血红素缺乏，从而通过生物化学反馈抑制 δ-氨基乙酰丙酸合成酶的活性。
T6429	Caffeic Acid Phenethyl Ester Phenylethyl Caffeate,咖啡酸苯乙酯,CAPE	Apoptosis; NF-κB	Apoptosis; NF-κB
	Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) 是咖啡酸的苯乙醇酯，是蜂巢蜂胶的生物活性成分。它抑制核转录因子 NF-kappa B 的激活，具有抗肿瘤、细胞保护和免疫调节活性。它抑制 PDGF 诱导的血管平滑肌细胞增殖。
T2915	Bardoxolone RTA 401,齐墩果烷三萜化合物,CDDO	Others; Nrf2	Immunology/Inflammation; Others
	Bardoxolone (CDDO) 是新型核调节因子激活剂。
TN4420	Latifolin 檀木	IL Receptor; IκB/IKK; TNF; NOS; NF-κB; COX; Nrf2; Prostaglandin Receptor; Antifection; Autophagy	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB
	Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Latifolin displays potent anticarcinogenic phase II marker enzyme, quinone reductase (QR) inducing activity and high chemopreventive indices. Latifolin also shows antifungal activity against white- and brown-rot fungi.
TN3057	4-O-Methylbutein	Autophagy	Autophagy
	4-O-Methylbutein (2',3,4'-trihydroxy-4-methoxychalcone) may have anti-inflammation activity, it is a potent heme oxygenase-1 (HO-1) inducer, the upregulation of HO-1 has proven to be a useful tool for fighting inflammation.
T4868	gamma-Linolenic acid gamolenic acid,γ-Linolenic acid,γ-亚麻酸	Endogenous Metabolite	Metabolism
	gamma-Linolenic acid (gamolenic acid) 是一种 omega-6 (n-6)，18 碳 (18C-) 多不饱和脂肪酸 (PUFA)，可以从人乳和植物种子油中提取。
TN4064	Flavoglaucin	Phosphatase; IL Receptor; TNF; NOS; NF-κB; COX; Nrf2; Prostaglandin Receptor; Autophagy	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Flavoglaucin appears to be an antitumor promoter, it also has anti-inflammato

天然产物

Coniferaldehyde

Cat.No: TN3694

Target: NOS, COX, Nrf2, PKC, Autophagy

Cat.No: T6S1302

Target: Nrf2, Endogenous Metabolite, S6 Kinase

Cat.No: T6S1027

Target: Others

Cat.No: T5515

Synonym: 氯化血红素,Hemin chloride

Target: Mitophagy, Ferroptosis, Autophagy

Caffeic Acid Phenethyl Ester

Cat.No: T6429

Synonym: Phenylethyl Caffeate,咖啡酸苯乙酯,CAPE

Target: Apoptosis, NF-κB

Cat.No: T2915

Synonym: RTA 401,齐墩果烷三萜化合物,CDDO

Target: Others, Nrf2

Cat.No: TN4420

Synonym: 檀木

Target: IL Receptor, IκB/IKK, TNF, NOS, NF-κB, COX, Nrf2, Prostaglandin Receptor, Antifection, Autophagy

4-O-Methylbutein

Cat.No: TN3057

Target: Autophagy

gamma-Linolenic acid

Cat.No: T4868

Synonym: gamolenic acid,γ-Linolenic acid,γ-亚麻酸

Target: Endogenous Metabolite

Cat.No: TN4064

Target: Phosphatase, IL Receptor, TNF, NOS, NF-κB, COX, Nrf2, Prostaglandin Receptor, Autophagy

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