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34

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1610	Metaxalone Skelaxin,Methaxalonum,美他沙酮,Zorane,NSC170959,AHR438	Others	Others
	Metaxalone (Methaxalonum) 具有肌肉松弛作用。
T1053	Mebeverine hydrochloride 盐酸麦皮凡林,Colofac Hydrochloride,Duspatalin Hydrochloride,Duspatal Hydrochloride	Others; Sodium Channel	Membrane transporter/Ion channel; Others
	Mebeverine hydrochloride (Colofac Hydrochloride) 是 β-苯乙胺的衍生物，一种增肌剂，可有效阻止肠道蠕动。它也是电压控制的钠通道 (voltage-operated sodium channels)阻断剂，抑制细胞内钙的积累。
TP1057L	Phe-Met-Arg-Phe Like Peptide acetate Pqdpflrfamide acetate,Phe-Met-Arg-Phe Like Peptide acetate（98495-35-3 free base)	Others	Others
	Phe-Met-Arg-Phe Like Peptide acetate (Pqdpflrfamide acetate)(98495-35-3 free base) 是一种来自蜗牛 Helix aspersa 的内脏和躯体肌肉的 FMRF 样肽。 FMRF (Phe-Met-Arg-Phe) 是一种由 4 个氨基酸残基组成的神经肽肽。
T21385	Cinitapride 西尼必利,Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove	5-HT Receptor	GPCR/G Protein; Neuroscience
	Cinitapride (Blaston) 是一种促胃药。它减缓肌肉的活动，以减轻诸如胃酸反流、胃排空延迟和溃疡性消化不良等病症的症状。 Cinitapride 作为 5-HT2 受体的拮抗剂和 5-HT1 和 5-HT4 受体的激动剂。
T7218	Endomorphin 2 内吗啡肽 2	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Endomorphin 2 是一种高亲和力和选择性的 μ-阿片受体激动剂，对 kappa3 结合位点具有合理的亲和力，Ki 为 20 到 30 nM 之间。
T14021	20-HETE 20-hydroxy Arachidonic Acid	Others	Others
	20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH oxidase, ROS, and NF-κB activity, a
T1115	Doxylamine succinate 琥珀酸多西拉敏,Decapryn	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Doxylamine succinate (Decapryn) 是一种吡啶衍生物组胺 H1 拮抗剂，具有明显的镇静特性。它竞争性阻断组胺 H1 受体并限制典型的过敏和过敏反应，可防止组胺引起的皮肤和粘膜疼痛和瘙痒。
T1050	Prazosin hydrochloride Prazosin hydrochloride,哌唑嗪盐酸盐,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,盐酸哌唑嗪,Minipress	Potassium Channel; MRP; Adrenergic Receptor; ABC; Autophagy	Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Prazosin hydrochloride (Vasoflex) 是一种选择性肾上腺素能 α-1 拮抗剂，可降低外周阻力并放松血管平滑肌。它可用于研究高血压和酒精使用障碍。它是一种合成哌嗪衍生物，具有降压抗肾上腺素能特性。它抑制有机阳离子转运蛋白 OCT-1 和 OCT-3，IC50分别为 1.8 和 13 μM 。
T2196	Fipronil 氟虫腈,Fluocyanobenpyrazole,Termidor	P450; GluCls; GABA Receptor	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Fipronil (Fluocyanobenpyrazole) 是昆虫GABA 受体的选择性拮抗剂，可抑制蟑螂神经元中谷氨酸盐引起的脱敏和非脱敏。在分离的大鼠肝微粒体中，它诱导细胞色素 P450 (CYP) 亚型CYP1A1/2、CYP2B1/2和CYP3A1/2的活性。
T0210L	Tamsulosin LY253351 free base,HSDB7744,(R)-(-)-YM12617 free base,Harnal-D,Flowmax,HSDB 7744,HSDB-7744	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tamsulosin ((R)-(-)-YM12617 free base) 是一种肾上腺素能受体α 1A 拮抗剂，用于良性前列腺增生(BPH)的治疗。Tansulosin 用于治疗排尿困难，这是前列腺肥大的一种常见症状。Tansulosin 和其他被称为α受体阻滞剂的药物通过放松膀胱颈部肌肉和前列腺本身的肌肉纤维来发挥作用，使其更容易排尿。
T0782	Benzthiazide Aquatag,苄噻嗪,Lemazide,Dihydrex	Carbonic Anhydrase	Metabolism
	Benzthiazide (Lemazide) 是长效利尿剂及抗高血压剂。它也是碳酸酐酶 9 的抑制剂，他对 CA9，CA2 和 CA1 的 Ki 分别为 8.0，8.8 和 10 nM。它对肿瘤细胞增殖具有抑制作用。
T68138	Saterinone	Adrenergic Receptor; PDE	GPCR/G Protein; Metabolism; Neuroscience
	Saterinone 是一种强效且具有选择性的磷酸二酯酶III 抑制剂，是血管α - 1-肾上腺素受体的有效拮抗剂。Saterinone 具有血管舒张作用，可用于慢性心力衰竭的急性治疗。Saterinone 对豚鼠右心室匀浆中粗cAMP 磷酸二酯酶(PDE)活性具有抑制作用，ic50值为2.3 × 10(-5) mol/l。
T26757	BDF 9148 BDF-9148,BDF9148
	BDF 9148, a Na(+)-channel modulator, increases the contractile force of guinea-pig atria and papillary muscles.
T25474	GW-Amide Glycyl-tryptophanamide,GW Amide
	GW-Amide is a molluscan neuropeptide that exhibits potent modulatory effects on molluscan muscles.
T23739	Antho-riamide I
	Antho-Riamide I is an active peptide. It also inhibits the spontaneous contraction of sea anemone muscles.
T24450	Mephenoxalone Lenetran Lenetran,TAB Lenetranat
	Mephenoxalone is a muscle relaxant and mild anxiolytic. It inhibits neuron transmission and relaxing skeletal muscles by inhibiting the reflex arc.
T32097	Homoanserine Nitrate
	Homoanserine Nitrate is a dipeptide found in mammalian brains and muscles.
T61174	MT-134
	MT-134 是一种 SkMII 特异性抑制剂，在肌肉中具有良好的暴露性。
T21020	Antazoline phosphate
	Antazoline phosphate is an antihistamine with anticholinergic properties. Antazoline prevents the typical allergic symptoms on capillaries, mucous membranes, skin, and gastrointestinal and bronchial smooth muscles by antagonizing the histamine H1 receptor
T40744	Eperisone
	Eperisone is a centrally acting muscle relaxant and antispastic agent utilized in the treatment of conditions distinguished by muscle stiffness and pain. Its mechanism of action involves the relaxation of skeletal muscles and vascular smooth muscles, resulting in a range of beneficial effects including reduction of myotonia, enhancement of circulation, and suppression of the pain reflex. Additionally, Eperisone exhibits inhibitory properties on the pain reflex pathway and exerts a vasodilator ef...
TP1057	Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa Phe-Met-Arg-Phe Like Peptide
	Phe-Met-Arg-Phe-like peptide, derived from the visceral and somatic muscles of the snail Helix aspersa, is a neuropeptide known as FMRF (Phe-Met-Arg-Phe). This peptide comprises four amino acid residues[1].
T27435	GS 283 GS283,GS-283
	GS 283 is a Ca(2+) antagonist. GS 283 is also a weak histamine and muscarinic receptor blocker in rat and guinea pig tracheal smooth muscles.
T69126	Clofeverine (free base)
	Clofeverine (free base) is a highly selective relaxant for gastrointestinal smooth muscles with a beta-receptor stimulative nature. On isolated ileum, the inhibitory effect of clofeverine for spontaneous motility was comparable to that of isoproterenol and 100 times higher than that of papaverine.
T61438	Propiverine
	Propiverine is a potent antimuscarinic agent that effectively inhibits cellular calcium influx, leading to the reduction of muscle spasm. It exhibits neurotropic and musculotropic effects specifically on the smooth muscles of the urinary bladder. Propiverine proves valuable in research concerning overactive bladder (OAB) [1] [2].
T31383	D-Epinephrine L-(+)-Adrenaline,Racepinefrine, (S)-,BRN-2938799,d-Adrenaline,BRN 2938799
	D-Epinephrine can be used as a hormone, neurotransmitter, and medication. Epinephrine can be normally obtained from the adrenal glands and certain neurons. It involves in the fight-or-flight response by increasing blood flow to muscles, output of the hear
T1120L2	Dacarbazine citrate DTIC citrate
	Dacarbazine citrate is an alkylating agent used to treat cancers of the lymphatic system and malignant melanoma (a type of skin cancer) in patients with certain conditions: islet cell carcinoma (part of the pancreas) Soft tissue sarcoma (cancer of muscles
T32030	GYKI-16638 HCl GYKI 16,638,GYKI16,638,GYKI-16638,GYKI-16,638,GYKI16638,GYKI 16638
	GYKI-16638 is a novel antiarrhythmic agent that demonstrates combined class IB and class III antiarrhythmic properties in human ventricular muscles, similar to the electrophysiological findings after chronic amiodarone treatment. In addition, GYKI 16638 h
T80894	Uperolein
	Uperolein 是由褐毛乌皮草 (Uperoleia rugosa) 和泥皮乌皮草 (Uperoleia marmorata) 产生的一种类似泡蛙肽的内十肽，具有致痉挛作用，影响胃肠道和纵向肌肉。
T69324	Clofeverine hydrochloride
	Clofeverine hydrochloride is the salt form of Clofeverine (free base), a highly selective relaxant for gastrointestinal smooth muscles with a beta-receptor stimulative nature. On isolated ileum, the inhibitory effect of clofeverine for spontaneous motility was comparable to that of isoproterenol and 100 times higher than that of papaverine.
T35571	Adenosine 3’-monophosphate (sodium salt hydrate)
	Adenosine 3’-monophosphate is a nucleotide and metabolite formedviahydrolysis of 2’,3’-cAMP by metal-dependent phosphodiesterases.1It reduces proliferation of rat preglomerular vascular smooth muscles cells (PGVSMCs) and glomerular mesangial cells (GMCs) in a concentration-dependent manner, an effect that is abolished by the adenosine A2Breceptor antagonist MRS1754.2Adenosine 3’-monophosphate is also a metabolic intermediate in the biosynthesis of adenosine .
T37802	Phospho-L-Arginine (lithium salt hydrate)
	Phospho-L-arginine is a phosphorylated form of L-arginine and a highly diffusible, high-energy metabolite and phosphagen involved in energy storage in invertebrates including crustaceans, insects, and Trypanosoma species. In the locust L. migratoria, phospho-L-arginine is found in the flight muscles, where it acts as both a buffer system and shuttle mechanism for high-energy phosphate. Measurement of phospho-L-arginine by 31P-NMR spectroscopy has been used to study invertebrate energy metabolism...
T76049	Demoxytocin
	Demoxytocin为一种异源性环肽，属于催产素类似物。其通过影响细胞膜通透性，提升平滑肌细胞内钙离子含量，进而加强平滑肌细胞收缩力，具备刺激子宫平滑肌收缩的能力，发挥催产素功能。此外，Demoxytocin在研究早产破裂引发的分娩刺激中有应用。
T70097	Acefylline piperazine
	Acefylline piperazine is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. Acephylline piperazine is a theophylline derivative with a direct bronchodilator action. It has the advantages over theophylline in being far less toxic and producing minimal gastric irritation. It is indicated for the treatment of asthma, emphysema, acute and chronic bronchitis associated with bronchospasm.Acefylline relaxes smooth muscles, relieves bronchospasm & has a stimula...
T69215	Ambrein
	Ambrein is a triterpene alcohol that is the chief constituent of ambergris, a secretion from the digestive system of the sperm whale, and has been suggested as the possible active component producing the supposed aphrodisiac effects of ambergris. It serves as the biological precursor for a number of aromatic derivatives such as ambroxan and is thought to possess fixative properties for other odorants. It has been shown to act as an analgesic and it has been proven to increase sexual behavior in ...

化合物

Cat.No: T1610

Synonym: Skelaxin,Methaxalonum,美他沙酮,Zorane,NSC170959,AHR438

Target: Others

Mebeverine hydrochloride

Cat.No: T1053

Synonym: 盐酸麦皮凡林,Colofac Hydrochloride,Duspatalin Hydrochloride,Duspatal Hydrochloride

Target: Others, Sodium Channel

Phe-Met-Arg-Phe Like Peptide acetate

Cat.No: TP1057L

Synonym: Pqdpflrfamide acetate,Phe-Met-Arg-Phe Like Peptide acetate（98495-35-3 free base)

Target: Others

Cat.No: T21385

Synonym: 西尼必利,Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove

Target: 5-HT Receptor

Cat.No: T7218

Synonym: 内吗啡肽 2

Target: Opioid Receptor

Cat.No: T14021

Synonym: 20-hydroxy Arachidonic Acid

Target: Others

Doxylamine succinate

Cat.No: T1115

Synonym: 琥珀酸多西拉敏,Decapryn

Target: Histamine Receptor

Prazosin hydrochloride

Cat.No: T1050

Synonym: Prazosin hydrochloride,哌唑嗪盐酸盐,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,盐酸哌唑嗪,Minipress

Target: Potassium Channel, MRP, Adrenergic Receptor, ABC, Autophagy

Cat.No: T2196

Synonym: 氟虫腈,Fluocyanobenpyrazole,Termidor

Target: P450, GluCls, GABA Receptor

Cat.No: T0210L

Synonym: LY253351 free base,HSDB7744,(R)-(-)-YM12617 free base,Harnal-D,Flowmax,HSDB 7744,HSDB-7744

Target: Adrenergic Receptor

Cat.No: T0782

Synonym: Aquatag,苄噻嗪,Lemazide,Dihydrex

Target: Carbonic Anhydrase

Cat.No: T68138

Target: Adrenergic Receptor, PDE

Cat.No: T26757

Synonym: BDF-9148,BDF9148

Cat.No: T25474

Synonym: Glycyl-tryptophanamide,GW Amide

Antho-riamide I

Cat.No: T23739

Cat.No: T24450

Synonym: Lenetran Lenetran,TAB Lenetranat

Homoanserine Nitrate

Cat.No: T32097

Cat.No: T61174

Antazoline phosphate

Cat.No: T21020

Cat.No: T40744

Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa

Cat.No: TP1057

Synonym: Phe-Met-Arg-Phe Like Peptide

Cat.No: T27435

Synonym: GS283,GS-283

Clofeverine (free base)

Cat.No: T69126

Cat.No: T61438

Cat.No: T31383

Synonym: L-(+)-Adrenaline,Racepinefrine, (S)-,BRN-2938799,d-Adrenaline,BRN 2938799

Dacarbazine citrate

Cat.No: T1120L2

Synonym: DTIC citrate

Cat.No: T32030

Synonym: GYKI 16,638,GYKI16,638,GYKI-16638,GYKI-16,638,GYKI16638,GYKI 16638

Cat.No: T80894

Clofeverine hydrochloride

Cat.No: T69324

Adenosine 3’-monophosphate (sodium salt hydrate)

Cat.No: T35571

Phospho-L-Arginine (lithium salt hydrate)

Cat.No: T37802

Cat.No: T76049

Acefylline piperazine

Cat.No: T70097

Cat.No: T69215

Cat. No.	Product Name	Target	Signaling Pathways
T8198	Visnagin	Others	Others
	Visnagin 是一种抗氧化剂呋喃香豆素衍生物。它具有预防Cerulein 诱导的急性胰腺炎的潜力。它在血管平滑肌中具有良好的血管扩张作用。它具有抗炎作用，可用于缓解疼痛的研究。
T19493	Octadecanal 十八烷醛,stearaldehyde	Endogenous Metabolite	Metabolism
	Octadecanal (stearaldehyde) 是存在于大腿和胸部肌肉中的一种长链醛。
TN3243	7-O-Methyleriodictyol	AChR	Neuroscience
	7-O-Methyleriodictyol 是一种从单乳蒿中分离出的黄烷酮，对大鼠分离的平滑肌有生物学作用。
T4739	Sodium creatine phosphate dibasic tetrahydrate 磷酸肌酸二钠盐,Creatine phosphate disodium salt tetrahydrate	Others; Endogenous Metabolite	Metabolism; Others
	Sodium creatine phosphate dibasic tetrahydrate (Creatine phosphate disodium salt tetrahydrate) 主要存在于脊椎动物的骨骼肌中，是测定肌酸激酶的底物，能够用于骨骼肌收缩过程中 ATP 的再生。
T6805	Choline bitartrate 2,3,4-trihydroxy-4-oxobutanoate,2-hydroxyethyl(trimethyl)azanium,酒石酸氢胆碱	Others; AChR	Neuroscience; Others
	Choline bitartrate (2-hydroxyethyl(trimethyl)azanium) 是一种存在于食物中的营养胆碱，可影响肝脏疾病、动脉粥样硬化和神经系统疾病等疾病。它是神经递质乙酰胆碱的前体，作为甲基供体参与各种代谢过程和脂质代谢。
T5543	TriacetonaMine 四甲基哌啶酮,Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone	Others	Others
	TriacetonaMine (Vincubine) 是一种合成医药产品、农药和聚合物光稳定剂的中间体。它是热解油的主要组分。它是植物和真菌提取物的人工制品，使用丙酮和氢氧化铵，或在分离过程的不同步骤中天然出现铵盐。
T0266	Quinidine hydrochloride monohydrate 奎宁树,奎尼丁盐酸盐一水合物,奎尼丁盐酸盐,Quinidine hydrochloride	Potassium Channel; Sodium Channel; Parasite	Membrane transporter/Ion channel; Microbiology/Virology
	Quinidine hydrochloride monohydrate 是一种抗心律失常剂，也是 K+通道 (K+channel) 的有效阻断剂，其IC50值为 19.9 μM。它是一种有效且选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也可用作疟疾的研究。
T0892	Diphylline 二羟丙茶碱,Dyphylline,Diprophylline	PDE; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Diphylline (Diprophylline) 是一种A1/A2腺苷受体拮抗剂，也是环状核苷酸磷酸二酯酶抑制剂。它是一种黄嘌呤衍生物，具有支气管扩张和血管扩张作用，有用于治疗慢性支气管炎和肺气肿的潜力。
T19515	Phosphocreatine dipotassium Creatinephosphoric acid (dipotassium),Creatine phosphate (dipotassium)	Others	Others
	Phosphocreatine dipotassium, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives.
TN5234	Vindorosine	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles.
T2O2683	L-Proline L-(-)-Proline,proline,脯氨酸,L-脯氨酸	Endogenous Metabolite	Metabolism
	L-Proline (proline) 是人体非必需氨基酸。它是胶原蛋白的重要组成部分，对关节和肌腱的正常运作很重要。它还有助于维持和加强心脏肌肉。
T4883	Creatine Methylguanidoacetic acid,肌酸	Endogenous Metabolite	Metabolism
	Creatine (Methylguanidoacetic acid) 是一种内源性氨基酸代谢物，在细胞能量中发挥重要作用，尤其是在肌肉和大脑中。

天然产物

Cat.No: T8198

Target: Others

Cat.No: T19493

Synonym: 十八烷醛,stearaldehyde

Target: Endogenous Metabolite

7-O-Methyleriodictyol

Cat.No: TN3243

Target: AChR

Sodium creatine phosphate dibasic tetrahydrate

Cat.No: T4739

Synonym: 磷酸肌酸二钠盐,Creatine phosphate disodium salt tetrahydrate

Target: Others, Endogenous Metabolite

Choline bitartrate

Cat.No: T6805

Synonym: 2,3,4-trihydroxy-4-oxobutanoate,2-hydroxyethyl(trimethyl)azanium,酒石酸氢胆碱

Target: Others, AChR

Cat.No: T5543

Synonym: 四甲基哌啶酮,Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone

Target: Others

Quinidine hydrochloride monohydrate

Cat.No: T0266

Synonym: 奎宁树,奎尼丁盐酸盐一水合物,奎尼丁盐酸盐,Quinidine hydrochloride

Target: Potassium Channel, Sodium Channel, Parasite

Cat.No: T0892

Synonym: 二羟丙茶碱,Dyphylline,Diprophylline

Target: PDE, Adenosine Receptor

Phosphocreatine dipotassium

Cat.No: T19515

Synonym: Creatinephosphoric acid (dipotassium),Creatine phosphate (dipotassium)

Target: Others

Cat.No: TN5234

Target: Calcium Channel, Sodium Channel

Cat.No: T2O2683

Synonym: L-(-)-Proline,proline,脯氨酸,L-脯氨酸

Target: Endogenous Metabolite

Cat.No: T4883

Synonym: Methylguanidoacetic acid,肌酸

Target: Endogenous Metabolite

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