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29

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21793	CGP 35348	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	CGP 35348 是 GABAB 受体的选择性拮抗剂 (EC50 = 34 μM)。 CGP 35348 可用于研究白化新生小鼠脑损伤后的神经肌肉协调和空间学习。
T2301	SB 202190 FHPI,SB202190	Apoptosis; p38 MAPK; Autophagy	Apoptosis; Autophagy; MAPK
	SB 202190 (FHPI) 是一种 p38 MAPK 抑制剂，可以抑制 p38α 和 p38β2 (IC50=50/100 nM)，具有选择性和细胞渗透性。SB 202190 具有抗肿瘤活性，还可以诱导人胚胎干细胞向心肌细胞分化。
T21715	BRD6688	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BRD6688 为 HDAC2 的选择性抑制剂。本品可使原代小鼠神经元细胞中的 H4K12 和 H3K9 组蛋白的乙酰化作用增强。在 CK-p25 小鼠模型中，它可透过血脑屏障，并改善由p25 引起的神经退行性病变相关的记忆缺陷。
T30579	BRD4097	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BRD4097是HDAC1/2/3/8检测中的阴性对照品,是一种选择性组蛋白去乙酰化酶（HDAC3）抑制剂，可用于保护b 细胞和改善胰岛素抵抗，有助于促进认知功能和增强学习和记忆的形成。
T8448	ZSET1446 ZSET-1446,ST-101	Calcium Channel; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	ZSET1446 (ST-101) 是一种 T 型钙通道激活剂，用于治疗各类阿尔茨海默病 (AD) 模型中的学习缺陷。
T25450L	GGTI 2147 FA GGTI2147 FA,GGTI-2147 FA,GGTI 2147 FA(191102-87-1 Free base)	Others	Others
	GGTI 2147 FA 是一种选择性 GGT 抑制剂，在海马体实验中双库林诱导的树突棘密度增加被消除，可能会降低小鼠的学习和记忆能力。
T4364	Aftin-4 Aftin 4,Aftin4	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Aftin-4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。
T23821	BRD4884 BRD-4884,BRD 4884
	BRD4884 is a selective inhibitor of HDAC2 that acts by enhancing the learning and memory processes.
T37375	Uridine-3'-monophosphate (sodium salt)
	Uridine-3'-monophosphate is a nucleoside used in the biochemical synthesis of ribothymidine-3'-phosphate. It has been used as a bioavailable source of uridine in research studies designed to enhance learning and memory.
T27446	GSK-1034702 GSK-1034702 HCl,GSK 1034702
	GSK-1034702 is a selective M(1) receptor allosteric agonist, it may have therapeutic benefits in disorders of impaired learning including Alzheimer's disease.
T22734	DL-AP7	Others	Others
	DL-AP7 是一种竞争性NMDA 拮抗剂和抗惊厥剂。DL-AP7 阻断 NMDA 诱导的惊厥,并导致小鼠在被动回避任务中的学习表现受损。
T61669	BChE-IN-4
	BChE-IN-4 is a highly potent inhibitor of the enzyme butyrylcholinesterase, capable of crossing the blood-brain barrier. It effectively reduces learning and memory impairments resulting from a deficiency in cholinergic activity in a mouse model. BChE-IN-4 holds promise for further investigation in the field of Alzheimer's disease research [1].
T38192	Unifiram	Others	Others
	Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。
T70075	KDS2010 mesylate
	KDS2010 is a potent, highly selective, and reversible MAO-B inhibitor which shows 12,500-fold selectivity over MAO-A. KDS2010 overcomes the disadvantages of the irreversible MAO-B inhibitor and significantly attenuates increased astrocytic GABA levels and astrogliosis, thereby enhancing synaptic transmission, and rescuing learning and memory impairments in APP/PS1 mice.
T63708	Calpain-2-IN-1
	Calpain-2-IN-1是选择性的钙蛋白酶-2抑制剂，能够延长 ERK 激活，进而增强学习和记忆。
T36809	UoS 12258
	Positive allosteric modulator of AMPA receptors (pEC50 = 5.2 for potentiation of AMPA-mediated currents in vitro). Also potentiates AMPA-mediated synaptic responses in vivo. Improves performance of rats in various learning and memory paradigms Ward et al (2010) Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. J.Med.Chem. 53 5801 PMID:20614889 \|Ward et al (2017) Pharmacological characterization of N-[...
T71622	Duartin
	Duartin is an anti-rickettsial compound. These small molecules and the workflow, featuring a high-throughput phenotypic screen for growth inhibitors of intracellular Rickettsia spp. and machine learning models for the prediction of growth inhibition of an obligate intracellular Gram-negative bacterium, should prove useful in the search for new therapeutic strategies to treat infections from Rickettsia spp. and other obligate intracellular bacteria.
T61130	SSTR4 agonist 3
	SSTR4 agonist 3 is a potent compound that activates the SSTR4 receptor. The SSTR4 receptor is highly expressed in the hippocampus and neocortex, which are regions associated with memory, learning, and Alzheimer's disease pathology. SSTR4 agonists demonstrate strong efficacy in rodent models of pain, both acute and chronic, by reducing peripheral nociception and inflammation. Considering its potential application in pain research, SSTR4 agonist 3 is of interest[1].
T79333	LZWL02003	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	LZWL02003为抗神经炎症化合物，对MPP+引起的神经元损害展示保护效果，有效降低ROS水平。此外，LZWL02003能改善鱼藤酮诱导的帕金森病(PD)大鼠模型在认知、记忆、学习及运动能力方面的缺陷。该化合物在神经退行性疾病的研究中具有应用潜力。
T76757	Ponezumab
	Ponezumab (PF-04360365) 是一种人源化抗淀粉样蛋白 IgG2单克隆抗体。Ponezumab 可降低中枢神经系统的 Aβ水平，并改善小鼠在各种学习和记忆模型中的表现。Ponezumab 可用于阿尔茨海默症的研究。
T37367	Amyloid-β (1-42) Peptide (trifluoroacetate salt)
	Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers.1Aβ42 accumulates in the brain of many transgenic mouse models of Alzheimer's disease and, in many models, the onset of amyloid deposition positively correlates with deficits in spatial learning and memory.4 1.Wolfe, M.S.Therapeutic strategi...
T83389	2-Deoxy-D-galactose
	2-Deoxy-D-galactose，作为葡萄糖的类似物，能通过抑制糖酵解过程来抑止肿瘤生长。此外，该化合物还能干扰糖大分子的聚焦化，进而在多种学习任务中损害记忆的巩固。2-Deoxy-D-galactose 同时阻碍体内糖蛋白的集中化作用。
T76361	[DPro5] Corticotropin Releasing Factor, human, rat
	[DPro5] Corticotropin Releasing Factor, human, rat 是人类和大鼠促肾上腺皮质激素释放因子/激素 R2 的选择性激动剂。作为一种下丘脑激素，促肾上腺皮质激素释放因子 (CRF) 能够促进肾上腺皮质激素 (ACTH) 和 β-内啡肽的分泌。值得注意的是，[DPro5] Corticotropin Releasing Factor, human, rat 并不触发典型的焦虑反应，而是能调控大鼠的学习与记忆过程。
T21857	AR-R 17779 hydrochloride
	AR-R17779 hydrochloride 是一种有效和选择性的 nAChR 完全激动剂，对α7和α4β2亚型的Ki 直分别为 92 和 16000 nM。AR-R17779 hydrochloride 可以改善大鼠的学习和记忆能力。AR-R17779 hydrochloride 也具有抗焦虑活性。AR-R17779 hydrochloride 可通过激活抗炎胆碱能（迷走神经）通路减轻炎症。
T60911	SSTR4 agonist 4
	SSTR4 agonist 4 是一种有效的SSTR4激动剂，具有用于疼痛研究的潜力。SSTR4 激动剂在与急性和慢性相关的抗外周伤害感受和抗炎活性相关疼痛的啮齿动物模型中有效。SSTR4 在海马和新皮质、记忆和学习区域以及阿尔茨海默病病理学中的表达水平相对较高。
T71142	Tebuconazole-d9
	Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per...
T38100	Betamethasone 21-phosphate (sodium salt hydrate)
	Betamethasone 21-phosphate is a synthetic glucocorticoid.1It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model of parainfluenza-3 viral infection when administered at a dose of 8 mg/kg but does not prevent airway hyperresponsiveness after infection.2Betamethasone 21-phosphate inhibits cell infiltration into the aqueous humor in a rat model of endotoxin-induced uveitis when administered top...
T37800	PF-04449613
	PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50= 22 nM).1It is selective for PDE9A over PDE1C (IC50= >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 μM but does inhibit the human dopamine transporter (DAT; Ki= 293 nM). PF-04449613 (0.1-100 mg/kg, s.c.) increases cerebrospinal fluid (CSF) levels of cyclic GMP (cGMP) in rats. Subcutaneous administration of PF-0444...
T37370	Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)
	Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. It forms fibrils that react to thioflavin T and Congo red and are organized in a cross-β arrangement of β-strands similar to Aβ (1-40) and Aβ (1-42) fibrils. Aggregated Aβ (25-35) decreases the viability of rat adrenal PC12 cells. It also decreases the viability of primary rat cortical neurons at concentrations ranging from 1 nM to 30 μM....

化合物

Cat.No: T21793

Target: GABA Receptor

Cat.No: T2301

Synonym: FHPI,SB202190

Target: Apoptosis, p38 MAPK, Autophagy

Cat.No: T21715

Target: HDAC

Cat.No: T30579

Target: HDAC

Cat.No: T8448

Synonym: ZSET-1446,ST-101

Target: Calcium Channel, AChR

Cat.No: T25450L

Synonym: GGTI2147 FA,GGTI-2147 FA,GGTI 2147 FA(191102-87-1 Free base)

Target: Others

Cat.No: T4364

Synonym: Aftin 4,Aftin4

Target: Beta Amyloid, Gamma-secretase

Cat.No: T23821

Synonym: BRD-4884,BRD 4884

Uridine-3'-monophosphate (sodium salt)

Cat.No: T37375

Cat.No: T27446

Synonym: GSK-1034702 HCl,GSK 1034702

Cat.No: T22734

Target: Others

Cat.No: T61669

Cat.No: T38192

Target: Others

KDS2010 mesylate

Cat.No: T70075

Cat.No: T63708

Cat.No: T36809

Cat.No: T71622

SSTR4 agonist 3

Cat.No: T61130

Cat.No: T79333

Target: Reactive Oxygen Species

Cat.No: T76757

Amyloid-β (1-42) Peptide (trifluoroacetate salt)

Cat.No: T37367

2-Deoxy-D-galactose

Cat.No: T83389

[DPro5] Corticotropin Releasing Factor, human, rat

Cat.No: T76361

AR-R 17779 hydrochloride

Cat.No: T21857

SSTR4 agonist 4

Cat.No: T60911

Tebuconazole-d9

Cat.No: T71142

Betamethasone 21-phosphate (sodium salt hydrate)

Cat.No: T38100

Cat.No: T37800

Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)

Cat.No: T37370

Cat. No.	Product Name	Target	Signaling Pathways
T2230	Paeoniflorin 芍药苷,Peoniflorin	HSP; COX	Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience
	Paeoniflorin (Peoniflorin) 是从芍药根中提取的一种蒎烷单萜糖苷，具有抗癌作用、抗氧化应激、抗血小板聚集、血管扩张、降低血液粘度和抗炎活性等多种生物活性。它是一种热休克蛋白诱导剂，通过自噬途径保护 PC12 细胞免受 MPP+和酸性损伤。
T0469	Octopamine hydrochloride 章鱼胺盐酸盐,(±)-p-Octopamine hydrochlorid,(+,-)-Octopamine HCl,章胺盐酸盐	Dopamine Receptor; Endogenous Metabolite; Adrenergic Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Octopamine hydrochloride ((±)-p-Octopamine hydrochlorid) 是一种与去甲肾上腺素结构相关的生物单胺类物质，在无脊椎动物中起着神经调节剂、神经激素和神经递质的作用。它对转染人 alpha2-肾上腺素受体(ARs)的中国仓鼠卵巢细胞 α2-ARs 有刺激作用。它提高糖原分解、糖酵解、糖异生、摄氧量和门脉灌注压。
T2777	Ginsenoside Rg1 Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,人参皂苷Rg1,Panaxoside A,人参皂苷 Rg1,Ginsenoside A2	Apoptosis; Beta Amyloid; NF-κB	Apoptosis; Neuroscience; NF-κB
	Ginsenoside Rg1 (Panaxoside Rg1) 是人参的主要活性成分之一，可减少NF-κB 核易位。它改善认知功能受损，通过降低大脑Aβ水平来发挥作用。

天然产物

Cat.No: T2230

Synonym: 芍药苷,Peoniflorin

Target: HSP, COX

Octopamine hydrochloride

Cat.No: T0469

Synonym: 章鱼胺盐酸盐,(±)-p-Octopamine hydrochlorid,(+,-)-Octopamine HCl,章胺盐酸盐

Target: Dopamine Receptor, Endogenous Metabolite, Adrenergic Receptor

Ginsenoside Rg1

Cat.No: T2777

Synonym: Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,人参皂苷Rg1,Panaxoside A,人参皂苷 Rg1,Ginsenoside A2

Target: Apoptosis, Beta Amyloid, NF-κB

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