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37

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9625	Sandalore	Apoptosis	Apoptosis
	Sandalore 通过减少细胞凋亡和增加外根鞘中延长生长期的生长因子 IGF-1 的产生来延长人类头发的生长。 Sandalore 是嗅觉受体 OR2AT4 的选择性激动剂。
TP2364	Acetyl tetrapeptide-3 Kollaren 6,Uxi hair growth peptide,Folixyl
	Acetyl tetrapeptide-3 is a bioactive chemical.
TP2188	type I hair keratin fragment [Homo sapiens]/[Ovis aries]/[Rattus norvegicus]	Others	Others
	The human type I hair keratin subfamily comprises nine individual members, which can be subdivided into three groups. Group A (hHa1, hHa3-I, hHa3-II, hHa4) and B (hHa7, hHa8) each contains structurally related hair keratins, whereas group C members hHa2,
T1812	KX1-004 KX1 004,KX1004	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	KX1-004 是非 ATP 竞争性 Src-PTK 抑制剂，IC50=40 μM。它能够保护耳蜗，使其免受有害噪音的影响，并防止噪音引起的听力损失 (NIHL)。
T8135	Minoxidil sulfate Minoxidil sulphate,U-58838,米诺地尔硫酸盐	Potassium Channel	Membrane transporter/Ion channel
	Minoxidil sulfate (U-58838) 是米诺地尔的硫酸代谢物，是ATP 敏感的 K+通道激动剂。它被认为是血管扩张试剂，在动物实验模型中，促进头发生长。
T125323	Triptohairic acid
	Triptohairic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125323。
T15014	CTPB	Histone Acetyltransferase	Chromatin/Epigenetic
	CTPB 是一种有效的 p300 组蛋白乙酰转移酶 (HAT) 活化剂，可用于制备毛发生长促进剂和/或脱发治疗剂。
TP2496	Octapeptide-2 Acetate Octapeptide-2 Acetate(1374396-34-5 Free base)	Others	Others
	Octapeptide-2 Acetate 作为一种促进毛发生长的活性物质，是一种双层封装的仿生肽，有助于促进细胞生长和迁移。它通过激活毛囊的干细胞来促进头发生长。它比天然蛋白质更稳定且作用时间更长。
T9288	Keratin hydrolyzed	Others	Others
	Keratin hydrolyzed 是一种加工形式的角蛋白，可使其渗透到头发角质层。
T40811	Eflornithine RMI71782,α-difluoromethylornithine,DFMO,依氟乌氨酸,MDL71782
	Eflornithine is an irreversible inhibitor that specifically targets the enzyme ornithine decarboxylase. It serves as a therapeutic medication for two conditions: the treatment of African trypanosomiasis and the management of excessive facial hair growth in women.
TP2373L	Biotinoyl tripeptide-1 Acetate Biotinoyl tripeptide-1 Acetate(299157-54-3 Free base)	Others	Others
	Biotinoyl tripeptide-1 Acetate 可通过促进头皮微循环产生毛囊，减少毛囊萎缩和衰老。
T2236	RU 58841 4-[3-(4-羟基丁基)-4,4-二甲基-2,5-二氧代-1-咪唑烷基]-2-(三氟甲基)苯腈,RU58841,PSK-3841,HMR-3841	Androgen Receptor	Endocrinology/Hormones
	RU 58841 (PSK-3841) 是一种雄激素受体拮抗剂，能够促进头发再生。
T0451	Minoxidil 米诺地尔,U10858	Potassium Channel; COX	Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Minoxidil (U10858) 是一种是 ATP 敏感的钾通道 (KATP) 开放剂，可作为有效的口服降压药和外周血管舒张药，促进血管扩张并促进头发的生长。Minoxidil 还是一种大豆脂氧合酶的有效抑制剂，IC50为 20 μM。
T21249L	Myristoyl Pentapeptide-17 Acetate Myristoyl Pentapeptide-17 Acetate(959610-30-1 Free base)	Others	Others
	Myristoyl Pentapeptide-17 Acetate 是一种小肽。促进关键成分的输送，从而有效促进睫毛生长，使睫毛变长变浓密，强韧秀发，显着强化眼部表情。
T35353	Elubiol dichlorophenyl imidazoldioxolan,新康唑	Antibacterial	Microbiology/Virology
	Elubiol (dichlorophenyl imidazoldioxolan) 是咪唑类的新型广谱抗真菌产品，可抑制真菌麦角甾醇的生物合成，改变细胞膜中其他脂质化合物的组成。 Elubiol 用于油性皮肤或头皮屑患者的皮肤和头发护理。
T24897	TP0427736 TP427736,TP-0427736,TP-427736	TGF-beta/Smad	Stem Cells
	TP0427736 是一种有效的选择性 ALK5 抑制剂，IC50 为 2.72 nM，比对 ALK3 的抑制作用高 300 倍。 TP0427736 可降低人外根鞘细胞中 TGF-β 诱导的生长抑制，并延长小鼠毛囊中的生长期。
TP2497	Myristoyl Tetrapeptide-12 Acetate 醋酸肉蔻酰四胜肽-12,Myristoyl Tetrapeptide-12 Acetate(959610-24-3 Free base)	Others	Others
	Myristoyl Tetrapeptide-12 Acetate (Myristoyl Tetrapeptide-12 Acetate (959610-24-3 Free base)) 是肉豆蔻酸和 Tetrapeptide-12 的反应产物，是一种刺激头发和睫毛生长并增强睫毛和/或眉毛外观的肽。 Myristoyl tetrapeptide-12 可以增加角质形成细胞的增殖，改善外观、紧致弹性和皮肤厚度。
T2556	Nandrolone decanoate 癸酸诺龙,19-Nortestosterone decanoate	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Nandrolone decanoate (19-Nortestosterone decanoate) 是一种合成代谢雄激素，通过涉及谷氨酸诱导的 N-甲基-D-天冬氨酸受体过度兴奋的机制诱导攻击性行为表征。
T20187	Alizarin Cyanine Green F NSC41838,NSC-41838,酸性绿 25,NSC 41838	Others	Others
	Alizarin Cyanine Green F (NSC-41838) 是一种绿色染料。它用于为普通外科手术中使用的尼龙 66 和尼龙 6 不可吸收的手术缝合线着色，并用于一般药物的着色，包括用于眼部区域的药物。它也被提议用于半永久性染发剂配方中，作为化妆品成品中最大浓度为 0.3% 的直接染料。
T16668	PROTO-1	Others	Others
	PROTO-1 displays obviously protection of hair cells, with HC50(concentration that would produce 50% hair cell survival) of 1 μM-10 μM (1 μM≤HC50≤10 μM).
T20845	Kopexil Mexoryl SAG,Aminexil
	Kopexil, an N-oxide, is used to treat hair loss.
TP2373	Biotinoyl tripeptide-1 Biotin GHK,BiotinGHK,Biotin-GHK
	Biotinoyl tripeptide-1 can produce hair follicles by promoting scalp micro-circulation and reduce follicle atrophy and aging.
T32142	IM176OUT05 IM176OUT05, IM,IM176 OUT05	Others	Others
	IM176OUT05 激活干细胞代谢，具有促进头发再生的作用。
T31487	Dimethicone 350 Polysilane,Dimeticonum,Dimethicone,Ophtasiloxane,Dimeticona
	Dimethicone 350 is a silicone oil consisting of a mixture of fully methylated linear siloxane polymers end-blocking with trimethylsiloxy units. Commonly used in skin and hair products.
T40789	Eflornithine hydrochloride MDL71782hydrochloride,RMI71782hydrochloride,盐酸依氟乌氨酸,DFMO hydrochloride,α-difluoromethylornithinehydrochloride
	Eflornithine hydrochloride, a specific and irreversible inhibitor of ornithine decarboxylase enzyme, is a medication used for the treatment of African trypanosomiasis and excessive facial hair growth in women.
T34657	SL-017 ACPSL-017,S-017,ACP-SL-017,ACP-SL017
	SL-017 (ACP-SL-017, ACPSL-017, ACP-SL-017) is a Hypocrellin-B (Hb) derivative and photosensitization agent that may be used to treat abnormal hair growth. SL017 targets the mitochondria and causes the mitochondrial membrane potential to collapse, producin
T81611	Oligopeptide-74
	Oligopeptide-74为促进头发生长的生物活性肽，报道显示其作为化妆品组分。
T80628	Myristoyl tetrapeptide-12	TGF-beta/Smad	Stem Cells
	Myristoyl tetrapeptide-12 直接激活SMAD2，并促使SMAD3与DNA结合。该化合物能有效促进毛发，特别是睫毛的生长。
T10636	5α-reductase-IN-1	Others	Others
	5α-reductase-IN-1 is a potent inhibitor of the enzyme 5α-reductase. This compound is primarily employed in research studies to investigate its potential efficacy in treating patterned alopecia. It is commonly used in combination with minoxidil, a well-known treatment for hair loss.
T21249	Myristoyl Pentapeptide-17 Myr-KLAKK-NH2
	Myristoyl Pentapeptide-17 is a small peptide. It promotes the delivery of key ingredients, thus effectively promotes the growth of eyelashes, lengthens and thickens the eyelashes, fortifies the hair and noticeably intensifies eye expression.
T82681	Copper tripeptide-3 AHK-Cu
	AHK-Cu 是一种生物活性肽，具促进毛发生长功能，已作为化妆品成分使用。
T81729	Myristoyl pentapeptide-4
	Myristoyl pentapeptide-4是一款用作化妆品成分的生物活性肽，其特性包括促进毛发生长。
T74107	GP4G
	GP4G (Diguanoside tetraphosphate) 是一种对称的双二磷核苷，可以从Artemia salina 的囊肿中分离出来。GP4G 是一种上皮细胞和毛发生长调节剂。
T81404	Prezatide copper Bisprezatide copper,PC 1020,Iamin
	Prezatide Copper（亦称Iamin）具有促进伤口愈合的多重特性，且用于抑制脱发。
T38442	17,17-(Ethylenedioxy)androst-4-en-3-one
	17,17-(Ethylenedioxy)androst-4-en-3-one (4- androstene- 3, 17- dione- 17- cyclic ethylene ketal) is an effective ingredient in cosmetics, which can be used for acne and promote hair growth research. 17,17-(Ethylenedioxy)androst-4-en-3-one can inhibit the reductase activity and inhibit the bond of a receptor protein and 5α-DHT.
T80206	Oligopeptide-41	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Oligopeptide-41是一种生物活性肽，具有促进毛发生长的功能，并已作为化妆品成分使用。
T80204	Octapeptide-2	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Octapeptide-2, 已报道作为化妆品成分，是一种具促进毛发生长功能的生物活性肽。

化合物

Cat.No: T9625

Target: Apoptosis

Acetyl tetrapeptide-3

Cat.No: TP2364

Synonym: Kollaren 6,Uxi hair growth peptide,Folixyl

type I hair keratin fragment [Homo sapiens]/[Ovis aries]/[Rattus norvegicus]

Cat.No: TP2188

Target: Others

Cat.No: T1812

Synonym: KX1 004,KX1004

Target: Src

Minoxidil sulfate

Cat.No: T8135

Synonym: Minoxidil sulphate,U-58838,米诺地尔硫酸盐

Target: Potassium Channel

Triptohairic acid

Cat.No: T125323

Cat.No: T15014

Target: Histone Acetyltransferase

Octapeptide-2 Acetate

Cat.No: TP2496

Synonym: Octapeptide-2 Acetate(1374396-34-5 Free base)

Target: Others

Keratin hydrolyzed

Cat.No: T9288

Target: Others

Cat.No: T40811

Synonym: RMI71782,α-difluoromethylornithine,DFMO,依氟乌氨酸,MDL71782

Biotinoyl tripeptide-1 Acetate

Cat.No: TP2373L

Synonym: Biotinoyl tripeptide-1 Acetate(299157-54-3 Free base)

Target: Others

Cat.No: T2236

Synonym: 4-[3-(4-羟基丁基)-4,4-二甲基-2,5-二氧代-1-咪唑烷基]-2-(三氟甲基)苯腈,RU58841,PSK-3841,HMR-3841

Target: Androgen Receptor

Cat.No: T0451

Synonym: 米诺地尔,U10858

Target: Potassium Channel, COX

Myristoyl Pentapeptide-17 Acetate

Cat.No: T21249L

Synonym: Myristoyl Pentapeptide-17 Acetate(959610-30-1 Free base)

Target: Others

Cat.No: T35353

Synonym: dichlorophenyl imidazoldioxolan,新康唑

Target: Antibacterial

Cat.No: T24897

Synonym: TP427736,TP-0427736,TP-427736

Target: TGF-beta/Smad

Myristoyl Tetrapeptide-12 Acetate

Cat.No: TP2497

Synonym: 醋酸肉蔻酰四胜肽-12,Myristoyl Tetrapeptide-12 Acetate(959610-24-3 Free base)

Target: Others

Nandrolone decanoate

Cat.No: T2556

Synonym: 癸酸诺龙,19-Nortestosterone decanoate

Target: Others, HIV Protease

Alizarin Cyanine Green F

Cat.No: T20187

Synonym: NSC41838,NSC-41838,酸性绿 25,NSC 41838

Target: Others

Cat.No: T16668

Target: Others

Cat.No: T20845

Synonym: Mexoryl SAG,Aminexil

Biotinoyl tripeptide-1

Cat.No: TP2373

Synonym: Biotin GHK,BiotinGHK,Biotin-GHK

Cat.No: T32142

Synonym: IM176OUT05, IM,IM176 OUT05

Target: Others

Dimethicone 350

Cat.No: T31487

Synonym: Polysilane,Dimeticonum,Dimethicone,Ophtasiloxane,Dimeticona

Eflornithine hydrochloride

Cat.No: T40789

Synonym: MDL71782hydrochloride,RMI71782hydrochloride,盐酸依氟乌氨酸,DFMO hydrochloride,α-difluoromethylornithinehydrochloride

Cat.No: T34657

Synonym: ACPSL-017,S-017,ACP-SL-017,ACP-SL017

Oligopeptide-74

Cat.No: T81611

Myristoyl tetrapeptide-12

Cat.No: T80628

Target: TGF-beta/Smad

5α-reductase-IN-1

Cat.No: T10636

Target: Others

Myristoyl Pentapeptide-17

Cat.No: T21249

Synonym: Myr-KLAKK-NH2

Copper tripeptide-3

Cat.No: T82681

Synonym: AHK-Cu

Myristoyl pentapeptide-4

Cat.No: T81729

Cat.No: T74107

Prezatide copper

Cat.No: T81404

Synonym: Bisprezatide copper,PC 1020,Iamin

17,17-(Ethylenedioxy)androst-4-en-3-one

Cat.No: T38442

Oligopeptide-41

Cat.No: T80206

Target: EGFR

Cat.No: T80204

Target: Reactive Oxygen Species

Cat. No.	Product Name	Target	Signaling Pathways
T2902	Costunolide Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯	Apoptosis; Endogenous Metabolite; Telomerase	Apoptosis; DNA Damage/DNA Repair; Metabolism
	Costunolide (Costus lactone) 是一种天然的倍半萜内酯，具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性，可诱导乳腺癌细胞周期阻滞和凋亡。
T20476	Lauroyl lysine 月桂酰赖氨酸,N6-Lauroyl-L-lysine	Others	Others
	Lauroyl lysine (N6-Lauroyl-L-lysine) 在个人护理产品中用作皮肤和头发调理剂以及表面活性剂-清洁剂。
T2S0164	Ethyl palmitate 棕榈酸乙酯,Palmitic acid ethyl ester,Ethyl cetylate,Ethyl hexadecanoate	Others	Others
	Ethyl palmitate (Palmitic acid ethyl ester) 是一种脂肪酸乙酯 (FAEE)。在人受试者食用酒精后，它的合成量比其他 FAEE 更多。它可用作头发和皮肤调理剂。
TN6908	Polyporusterone A (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R,5S)-2,3-dihydroxy-5,6-dimethylheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one
	Polyporusterone A 是一种从 P. umbellatus 的子实体中提取出来的三萜羧酸。Polyporusterone A 抑制自由基诱导的红细胞裂解 (溶血) ，可用于研究头发再生和牛皮癣。
T0926	Azelaic acid Finacea,Azelex,壬二酸,Nonanedioic acid,Anchoic acid	Others; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	Azelaic acid (Anchoic acid) 是头发和皮肤调理剂的组分，可由油酸臭氧分解产生。Azelaic acid 通过抑制微生物细胞原蛋白合成对痤疮丙酸杆菌和表皮葡萄球菌具有抑菌活性。Azelaic acid 还具有抑制色素沉着的功能，这是由于其清除自由基作用。
T5S0896	Loureirin A 龙血素 A,龙血素A	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Loureirin A 是一种黄酮类物质，从龙血树中分离得到，能够降低Akt 的磷酸化，具有抗血小板聚集作用。
T2O2721	L-Cysteine Thioserine,L-半胱氨酸,cysteine,半胱氨酸,L-(+)-Cysteine	Endogenous Metabolite	Metabolism
	L-Cysteine (L-(+)-Cysteine) 是人体非必需的含硫氨基酸。L-Cysteine 对蛋白质合成、解毒和多种代谢功能很重要。L-Cysteine 存在于指甲、皮肤和头发的主要蛋白质-角蛋白中，对胶原蛋白的生成、皮肤弹性和质地都很重要。L-Cysteine 是抗氧化剂谷胱甘肽的一种成分，在辅酶A、肝素和生物素等基本生化物质的代谢中起着重要作用，也是氨基酸牛磺酸的制造所必需的。
TN3973	Epinodosin	Others	Others
	Epinodosin induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner.Epinodosin has a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in Lactuca sativa L. seedlings.
TN1689	Glabranine 光甘草宁,Glabranin	Antifection	Microbiology/Virology
	Glabranin has antimicrobial activity, it shows significant activities on DPPH free radical with the IC50 value of 240.20 ug/ml. Glabranin or a derivative thereof could be used to stimulate hair growth. Glabranine exerts a dose-dependent inhibitory effect
TN4604	Myricanone	BCL; HSP; NF-κB; ROS; Caspase; STAT	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Metabolism; NF-κB; Proteases/Proteasome; Stem Cells
	Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation by down-regulation of NF-ÎºB and STAT3 signalling cascades. Myricanone shows in vitro testost

天然产物

Cat.No: T2902

Synonym: Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯

Target: Apoptosis, Endogenous Metabolite, Telomerase

Cat.No: T20476

Synonym: 月桂酰赖氨酸,N6-Lauroyl-L-lysine

Target: Others

Ethyl palmitate

Cat.No: T2S0164

Synonym: 棕榈酸乙酯,Palmitic acid ethyl ester,Ethyl cetylate,Ethyl hexadecanoate

Target: Others

Polyporusterone A

Cat.No: TN6908

Synonym: (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R,5S)-2,3-dihydroxy-5,6-dimethylheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one

Cat.No: T0926

Synonym: Finacea,Azelex,壬二酸,Nonanedioic acid,Anchoic acid

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: T5S0896

Synonym: 龙血素 A,龙血素A

Target: Akt, PI3K

Cat.No: T2O2721

Synonym: Thioserine,L-半胱氨酸,cysteine,半胱氨酸,L-(+)-Cysteine

Target: Endogenous Metabolite

Cat.No: TN3973

Target: Others

Cat.No: TN1689

Synonym: 光甘草宁,Glabranin

Target: Antifection

Cat.No: TN4604

Target: BCL, HSP, NF-κB, ROS, Caspase, STAT

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