76
18
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20701 |
MCPA
NSC-2351,Krezone,NSC2351,NSC 2351,U 46 M-Fluid,Raphone |
Others | Others |
MCPA(Krezone) 是一种高效的苯氧基除草剂。使用 MCPA 会对附近的水资源和土壤资源产生影响。 | |||
T2451 |
GlyH-101
GlyH 101 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
GlyH-101 是一种可渗透入细胞的 CFTR 阻断剂,Ki 为1.4 uM。 | |||
T0142 |
Brinzolamide
布林佐胺,AL-4862 |
Carbonic Anhydrase | Metabolism |
Brinzolamide (AL-4862) 是一种碳酸酐酶(carbonic anhydrase)II 抑制剂(IC50:3.19 nM)。 | |||
T8593 |
RU 24969
5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole |
5-HT Receptor | GPCR/G Protein; Neuroscience |
RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole) 是 5-HT1A 和 5-HT1B 受体的选择性激动剂,Ki 值分别为 0.38 和 2.5 nM。它可减少液体消耗并增加向前运动。 | |||
T20971 |
Mefluidide
VEL3973,VEL-3973,VEL 3973,MBR 12325 |
||
Mefluidide is a biochemical. | |||
T33930 |
Perfluidone
SB1528,SB 1528,Destun,SB-1528,WL 43423 |
||
Perfluidone is a a fluorinated arylalkylsulphonamide plant growth regulator and herbicide. | |||
T19507 |
Perfluamine
FTPA,Tris(perfluoropropyl)amine,Perfluorotripropylamine |
Others | Others |
Perfluamine (FTPA) 是一种疏水性载液,可用作血液替代品。 | |||
TP1745L |
Ceratotoxin A acetate
Ceratotoxin A acetate(150671-04-8 Free base) |
Antibacterial | Microbiology/Virology |
Ceratotoxin A acetate 是从副腺分泌液中分离出来的,具有抗菌作用。 | |||
T68118 |
Nufenoxole
|
Others | Others |
Nufenoxole 是一种具有口服活性和止泻作用的化合物,可抑制人空肠中的液体分泌。 | |||
T12478L |
Pinacidil
吡那地尔,S 1230,P 1134,S-1230,P-1134,P1134 |
Potassium Channel | Membrane transporter/Ion channel |
Pinacidil (P 1134) 是钾通道的有效激活剂。Pinacidil 通过打开 K+-通道使血管平滑肌超极化,显示出抗高血压活性。它显著改善再灌注功能和心脏顺应性。它具有直接的心脏保护作用。 | |||
T6581 |
Methyclothiazide
Duretic,Enduron,甲氯噻嗪,Aquatensen |
Others; Carbonic Anhydrase | Metabolism; Others |
Methyclothiazide (Aquatensen) 是一种具有口服活性的利尿剂,也是一种降压剂。它能够拮抗体外的电压依赖性钙通道的 (VDCC) 活性,也可以抑制内源性血管收缩刺激导致的血管反应。 | |||
T7295 |
Miridesap
Ro63-8695,CPHPC,GSK2315698 |
Others | Others |
Miridesap (GSK2315698) 是一种血清淀粉样蛋白 P 组分 (SAP) 的配体,能够利用肝脏清除导致循环 SAP 的快速消耗。 它也可以明显减少脑脊液和内脏淀粉样蛋白沉积物中的 SAP。 | |||
T63540 |
Astrophloxine
|
Beta Amyloid | Neuroscience |
Astrophloxine 是一种荧光成像探针,靶向反平行二聚体。Astrophloxine 能够用于检测阿尔茨海默症 (AD) 小鼠脑组织和脑脊液样本中聚集的 Aβ。 | |||
T4103 |
(L)-Sodium lactate
L-乳酸钠,Sodium L-Lactate |
Others | Others |
(L)-Sodium lactate (Sodium L-Lactate) 是由乳酸脱氢酶从丙酮酸中产生的。它在无氧糖酵解过程中或增殖活跃的细胞中产生。 它在人和动物的血液和肌肉液中少量存在。剧烈运动后,肌肉和血液中的乳酸浓度会增加。 它也存在于肝脏、肾脏、胸腺、人羊水以及其他器官和体液中。 | |||
TQ0291 |
Firategrast
SB 683699 |
Integrin | Cytoskeletal Signaling |
Firategrast (SB 683699) 是一种具有口服活性和特异性的α4β1/α4β7整合素拮抗剂。Firategrast 减少淋巴细胞进入中枢神经系统 (CNS) 的运输,降低多发性硬化症 (MS) 的活性。Firategrast 用于复发缓解性多发性硬化症。Firategrast 治疗与中位脑脊液与 CD4,CD8和CD19淋巴细胞计数的适度降低有关。 | |||
T31751 |
Fce 21258
Ddh-carbo pgl2 |
||
Fce 21258 is used to stimulate the adenylate cyclase of synovial fluid macrophages. | |||
T22551 | ACSF | Others | Others |
ACSF is often used as a replacement of CSF for perfusion of brain slices to preserve interneurons. ACSF is invented to reduce the incidence of cerebral edema and further suppress brain cell disorders. And ACSF is often used as an irrigation fluid or perfu | |||
T32098 |
Homocarnosine
NSC-92522,NSC92522,高肌肽,L-Homocarnosine,NSC 92522 |
||
Homocarnosine is an endogenous dipeptide in cerebral regions and cerebrospinal fluid. | |||
T71738 |
DRAinh-A250
|
||
DRAinh-A250 is a SLC26A3 inhibitor which blocks colonic fluid absorption and reduces constipation. | |||
T27243 |
Efipladib
PLA-902,PLA 902,PLA902 |
||
Efipladib is a phospholipase inhibitor. Efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid. | |||
T35849 |
17(S)-HETE
|
||
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney.17(S)-HETE inhibits proximal tubule ATPase activity by as much as 70% at a concentration of 2 μM. | |||
TP1745 |
Ceratotoxin A
|
||
Ceratotoxin A is a 29-residue peptide extracted from the accessory gland secretion fluid, known for its potent antibacterial properties. | |||
T69287 |
NAA-004
|
||
NAA-004, also known as APAZA, has been shown to significantly inhibit toxin A-induced myeloperoxidase activity, luminal fluid accumulation, and structural damage to the colon in instances of toxin A-induced colitis. | |||
T37708 |
17(R)-HETE
|
||
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. 17(R)-HETE is an inactive isomer of 17-HETE, whereas the (S) enantiomer can inhibit proximal tubule ATPase activity at a concentration of 2 μM. | |||
T37863 |
9(S),10(S),13(S)-TriHOME
|
||
9(S),10(S),13(S)-TriHOME is an oxylipin derived from linoleic acid. It has been detected in beer and in bronchoalveolar lavage fluid (BALF) from female smokers. | |||
T34107 |
Polythiazide
P2525,NSC-108161,NSC 108161,P-2525,NSC108161 |
||
Polythiazide (NSC-108161, P-2525) is used to treat fluid retention (edema) caused by a variety of causes, including congestive heart failure, severe liver disease (cirrhosis), kidney disease, or steroid or hormonal medication. | |||
T38227 |
Quin C1
|
||
Potent and selective FPR2 agonist (EC50 = 15 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory. Zhou et al (2007) Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol.Pharmacol. 72 976 PMID:17652444 |Corminboeuf et al (2014) FPR2/ALXR agonist... | |||
T37373 |
4-hydroxy-3-Methoxyphenylglycol (piperazine salt)
|
||
4-hydroxy-3-Methoxyphenylglycol (piperazine salt) is a metabolite of norepinephrine derived in part by deamination of normetanephrine or by O-methylation of dihydroxyphenylglycol after cellular uptake of either intermediate. It is released into the blood and cerebrospinal fluid and has been used as a biochemical index of recent sympathetic nervous system activity. | |||
T68344 |
AGG-523
|
||
AGG-523 is an aggrecanase specific inhibitor that has been shown to attenuate increases in synovial fluid ARG-aggrecan levels following surgically-induced joint instability in the rat MT model. Pharmacologic inhibition of aggrecanase activity in humans using AGG-523 may be an effective treatment for slowing cartilage degradation following joint injury. | |||
T73795 | Normetanephrine | ||
Normetanephrine 是存在于脑脊液中的内源代谢物,可用于研究高血压。 | |||
T70807 |
Lanabecestat HCl
|
||
Lanabecestat, also known as AZD3293 and LY3314814, is a potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, BACE1 inhibitor with unique slow off-rate kinetics. AZD3293 displayed significant dose- and time-dependent reductions in plasma, cerebrospinal fluid, and brain concentrations of Aβ40, Aβ42, and sAβPPβ. | |||
T39244 |
Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled
|
||
Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, is one of three mammalian natriuretic peptides (NPs) that exerts endocrine effects on fluid homeostasis and blood pressure. Atrial Natriuretic Peptide holds promise for cardiovascular diseases research. | |||
TP1866 |
β-Amyloid (1-11)
β-amyloid 1-11 |
||
Anionic interaction of Beta-amyloid (1-11) with Factor XII is suspected to cause massive activation of the C4 (complement 4) system in the cerebrospinal fluid of Alzheimer’s disease patients. | |||
T35847 |
16(R)-HETE
|
||
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that... | |||
TP2094 |
Apelin-36(rat, mouse)
Apelin-36 (rat, mouse) |
||
Endogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4 nM) and potently inhibits cAMP production in vitro (EC50 = 0.52 nM). Involved in regulation of cardiovascular function, fluid homeostasis | |||
T22575 | Angiotensin Fragment 1-7 (acetate) | Others | Others |
Angiotensin Fragment 1-7 is a type 1 angiotensin II receptor agonist. In the renin-angiotensin system, angiotensin I is cleaved by the angiotensin-converting enzyme to form angiotensin II, which has effects on fluid and electrolyte, as well as homeostasis | |||
TP1048 |
Secretin, porcine
Porcine secretin acetate |
||
Secretin, porcine (Porcine secretin acetate) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid. Secretin porcine stimulates pancreatic and gastric secretions to a | |||
T39823 |
Apelin-12
|
||
Apelin-12 is a highly potent C-terminal fragment of a polypeptide that exhibits a strong affinity towards the orphan receptor APJ. It plays a role in maintaining body fluid balance and regulating feeding control in the central nervous system. Additionally, Apelin-12 functions as an inhibitor of HIV-1 entry through the APJ receptor and demonstrates neuroprotective properties. | |||
T35848 |
16(S)-HETE
|
||
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. 16(S)-HETE inhibits proximal tubule ATPase activity by as much as 60% at a concentration of 2 μM. | |||
T75973 |
Secretin, porcine TFA
|
||
Porcine secretin TFA (Porcine secretin TFA) 是一种含有27个氨基酸的多肽,能够影响胰腺腺泡细胞和导管上皮细胞,促进碳酸氢盐丰富的流体生成。 | |||
T81539 | PAT1inh-B01 | ||
PAT1inh-B01为选择性SLC26A6抑制剂,抑制PAT1(Cl-/HCO3-交换器)介导的阴离子交换(IC50: 350 nM),并阻断小肠液体吸收,适用于小肠分泌不足相关疾病研究。 | |||
T73783 | D-Ribofuranose | ||
D-Ribofuranose (D-Ribose) 是一种在脑脊液中发现的内源性代谢物,用于磷酸 5 核糖异构酶缺乏症和中链酰基 CoA 脱氢酶缺乏症的研究。 | |||
T80438 |
Atrial natriuretic peptide (3-28) (human)
ANP (3-28) (human) |
Endothelin Receptor | GPCR/G Protein |
Atrial natriuretic peptide (3-28) (human) 是由心房心肌细胞合成并分泌的肽类激素,主要在调节血压、体液平衡及电解质稳态方面发挥作用。 | |||
T69664 | Umibecestat HCl | ||
Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP-transgenic mice. CNP520 reduces Aβ load and neuroinflammation in APP‐transgenic mice | |||
T70800 | Elenbecestat free base | ||
Elenbecestat,also known as E2609 is a BACE1 inhibitor. By inhibiting BACE, a key enzyme in the production of Aβ peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and protofibrils and eventually form amyloid plaques in the brain. Elenbecestat has been shown to reduce Aβ levels in cerebrospinal fluid, was investigated in two global phase 3 studies in early AD. | |||
TP2093 |
Apelin-36(human)
Apelin-36 (human) |
||
Endogenous APJ receptor agonist (EC50 = 20 nM) that is secreted by adipocytes. Binds with high affinity to human APJ receptors expressed in HEK 293 cells (pIC50= 8.61). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Bloc | |||
T77109 | Omfiloctocog alfa | ||
Omfiloctocog alfa (SCT-800) 是一种重组的 factor VIII(FVIII)。FVIII 是一种必需的凝血蛋白,是液相凝血系统的关键组成部分。Omfiloctocog alfa 可用于血友病 A 的研究。 | |||
T35523 |
(±)17-HETE
|
||
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. At a concentration of 2 μM the (S)-enantiomer of 17-HETE inhibits proximal tubule ATPase activity by as much as 70%, whereas the (R)-isomer is inactive. | |||
T76178 |
Aspartate aminotransferase
|
||
Aspartate aminotransferase (AST) 是一种转氨酶,常用于生化研究。Aspartate aminotransferase 催化天冬氨酸和 α-酮戊二酸转化为草酰乙酸和谷氨酸。Aspartate aminotransferase 可存在于在脑脊液、渗出液和渗出物。 | |||
T80059 |
Complement factor I
|
Endogenous Metabolite | Metabolism |
Complement factor I,一丝氨酸蛋白酶,可与辅助因子H (FH)、补体受体1 (CR1/CD35)、C4结合蛋白 (C4BP) 或膜辅助因子蛋白 (MCP/CD46) 结合,调控液相及/或细胞表面补体系统的活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5224 |
2-Hydroxyhexanoic acid
DL-2-羟己酸,2-Hydroxycaproic acid |
Others; Endogenous Metabolite | Metabolism; Others |
2-Hydroxyhexanoic acid (2-Hydroxycaproic acid) 是内源性代谢产物的一种。 | |||
T4884 |
alpha-D-glucose
α-D-Glucose,α-葡萄糖,alpha-Glucose,α-Dextrose |
Others; Endogenous Metabolite | Metabolism; Others |
alpha-D-glucose (α-Dextrose) 是内源性代谢产物的一种。 | |||
T5590 |
2-(4-Methoxyphenyl)acetic acid
4-Methoxyphenylacetic acid,对甲氧基苯乙酸 |
Others; Endogenous Metabolite | Metabolism; Others |
2-(4-Methoxyphenyl)acetic acid (4-Methoxyphenylacetic acid) 是血浆代谢物,具有高度敏感性和特异性,能够作为区分非小细胞癌患者和健康对照组之间的生物指标。 | |||
TN7246 |
3-Sulfopropanoic acid
3-SPA |
Drug Metabolite | Metabolism |
3-Sulfopropanoic acid 是曲吡罗酯及其前药ALZ-801的主要代谢产物,是存在于AD患者的脑脊液(CSF)中的内源性分子,可抑制 Aβ42 寡聚体的形成。 | |||
T13516 |
5-Methyltetrahydrofolic acid
甲基叶酸盐,5-Methyl THF |
Endogenous Metabolite | Metabolism |
5-Methyltetrahydrofolic acid (5-Methyl THF) 是四氢叶酸的甲基化衍生物,具有生物活性。5-Methyltetrahydrofolic acid 是主要的天然膳食叶酸,是血浆和脑脊液中叶酸的主要形式。 | |||
T3762 |
Hyaluronic acid
透明质酸,Hyaluronate,玻尿酸,hyaluronan |
Others; Endogenous Metabolite | Metabolism; Others |
Hyaluronic acid (hyaluronan) 由玉米发酵得到,是由二糖的重复单元组成的生物聚合物,应用领域广泛。 | |||
T0887 |
D-Glucose
Dextrose,D-无水葡萄糖,Glucopyranose,Grape sugar,葡萄糖,D(+)-Glucose |
Endogenous Metabolite | Metabolism |
D-Glucose (Glucopyranose) 是一种单糖。D-Glucose 是甜味剂,是一般代谢的关键组成部分,并作为与细胞代谢状态以及生物和非生物应激反应有关的关键信号分子。 | |||
T4710 |
3-Methoxytyramine hydrochloride
3-O-methyl Dopamine hydrochloride,3-O-methyl Dopamine hydrochloride),3-O-甲基多巴胺盐酸盐 |
Others; Endogenous Metabolite; Drug Metabolite | Metabolism; Others |
3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride) 是多巴胺的无活性代谢物,能够活化痕量胺相关受体1 。 | |||
T5279 |
Ethylmalonic acid
alpha-Carboxybutyrate,2-Ethylmalonic acid,乙基丙二酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Ethylmalonic acid (alpha-Carboxybutyrate) 是潜在有毒物质,非致癌性,与神经性厌食和甲氧基脱羧酶缺乏症有关。 | |||
T5287 |
N-Acetyl-L-aspartic acid
AC-ASP-OH,N-Acetylaspartic acid,N-乙酰-L-天门冬氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-L-aspartic acid (AC-ASP-OH) 是天冬氨酸的衍生物, 是由氨基酸天冬氨酸和乙酰辅酶 A 在神经元中合成的。 | |||
T5S0106 |
Peimisine
贝母辛,Ebeiensine |
RAAS; AChR | Endocrinology/Hormones; Neuroscience |
Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体,抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放,促进一氧化氮释放,可舒张气管平滑肌,有平喘作用。 | |||
T8053 |
N-Acetyl-L-arginine
N-Α-乙酰-L-精氨酸,Ac-Arg-OH |
Endogenous Metabolite | Metabolism |
N-Acetyl-L-arginine (Ac-Arg-OH) 是一种胍基诺化合物,被发现存在于血液渗析性肾不足儿童患者血清中的。 | |||
T37499 | Estriol 3-glucuronide | ||
Estriol-3-glucuronide, a natural compound found in urine, is also present in amniotic fluid during normal pregnancy [1][2]. | |||
TN6685 |
Homovanillic Acid Sulfate
|
||
Homovanillic acid sulfate is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain.In psychiatry and neuroscience, brain and cerebrospinal fluid levels of homovanillic acid are measured as a marker of metabolic | |||
TN3114 |
5-Hydroxy-1-(4-hydroxyphenyl)-7-phenyl-3-heptanone (AO 2210)
|
Others | Others |
(±)-5-hydroxyl-1-(4'-hydroxyphenyl)-7-phenyl-3-heptanone have digestibility inhibition in vitro in cow rumen fluid. | |||
T21893 |
Luffariellolide
|
||
Luffariellolide 是人滑膜蛋白磷脂酶A2 (HSF-PLA2) 抑制剂 (IC50=5 μM)。Luffariellolide (ED50=50 μg/耳)可有效抑制佛波酯 (PMA) 引起的耳水肿。 | |||
TN4505 | Masticadienolic acid | Others | Others |
Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid, and bee venom. Masticadienolic ac | |||
TN5147 |
Tilifodiolide
|
IL Receptor; TNF; GABA Receptor | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreasing the intestinal fluid accumulation and vasorelaxant effects mediated by nitric oxide and cyclic guanosine monophosphate, it also showed anxiolytic and antidepressant effects by the partial involvement of gamma-Aminobutyric acid (GABA) receptors and the possible participation of α2-adrenoreceptors, respectively. |