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Angiotensin Fragment 1-7 (acetate)

产品编号 T22575 CAS T22575

Angiotensin Fragment 1-7 is a type 1 angiotensin II receptor agonist. In the renin-angiotensin system, angiotensin I is cleaved by the angiotensin-converting enzyme to form angiotensin II, which has effects on fluid and electrolyte, as well as homeostasis blood pressure.

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Angiotensin Fragment 1-7 (acetate) Chemical Structure

Angiotensin Fragment 1-7 (acetate), CAS T22575

规格	价格/CNY		货期	数量
5 mg	￥ 2,956		待询
10 mg	￥ 4,909		待询

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生物活性

化学信息

存储 & 溶解度

产品描述	Angiotensin Fragment 1-7 is a type 1 angiotensin II receptor agonist. In the renin-angiotensin system, angiotensin I is cleaved by the angiotensin-converting enzyme to form angiotensin II, which has effects on fluid and electrolyte, as well as homeostasis blood pressure.
体外活性	In a previous study, peripheral atherectomy plaques collected from diabetic (DM) and 12 non-DM patients were immunostained. Results showed that the tissue contents of ACE2, angiotensin fragment 1-7, and AT1R were increased in DM when compared to non-DM. IL-6 and TNF-α were also increased in DM when compared to non-DM, as well as macrophage infiltration score and neovessel counting [1].
体内活性	The effects of chronic angiotensin fragment 1-7 treatment was studied in an experimental model of the metabolic syndrome, rats given high-fructose/low-magnesium diet (HFrD). After 6 months, angiotensin fragment 1-7-treated animals had lower body weight, total fat mass, and serum triglycerides, improved glucose tolerance, and better insulin sensitivity. Similar metabolic effects were also evident, albeit in the absence of weight loss, in rats first exposed to HFrD for 5 months and then subjected to short-term treatment with angiotensin fragment 1-7 [2].

分子量	899
分子式	C41H62N12O11·XC2H4O2
CAS No.	T22575

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

PBS: ≤10mg/ml

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对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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