Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ACSF is often used as a replacement of CSF for perfusion of brain slices to preserve interneurons. ACSF is invented to reduce the incidence of cerebral edema and further suppress brain cell disorders. And ACSF is often used as an irrigation fluid or perfusion fluid in the field of neurosurgery, such as intracranial surgery, or when used as a replenishing fluid for lost cerebrospinal fluid. ACSF is also used to maintain pH balance and tissue oxygen delivery for research.
产品描述 | ACSF is often used as a replacement of CSF for perfusion of brain slices to preserve interneurons. ACSF is invented to reduce the incidence of cerebral edema and further suppress brain cell disorders. And ACSF is often used as an irrigation fluid or perfusion fluid in the field of neurosurgery, such as intracranial surgery, or when used as a replenishing fluid for lost cerebrospinal fluid. ACSF is also used to maintain pH balance and tissue oxygen delivery for research. |
体外活性 | ACSF is often used to maintain oxygen supply in the study of basic characteristics of a neuronal function were acute in vitro brain slice models are required. When tested with neocortical mouse slices, carbonated ACSF treatment could keep pH balance and tissue oxygen delivery; otherwise, seizure-like events occurred in the slices with no-magnesium ACSF treatment [1]. |
体内活性 | In the study of targeted drugs to protect neurons, ACSF is often to treat the mice and worked as a control to calculate drug efficiency. It is also reported in the rat brain slice model, treated with ACSF, a replacement of human CSF, could powerfully boost spontaneous firing of CA1, CA3, and layer 5 pyramidal neurons [3][4]. |
分子量 | 320.38 |
分子式 | C20H20N2O2 |
CAS No. | T22551 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ACSF T22551 Others Inhibitor inhibitor inhibit