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Search Results for " farnesyl "

47

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T78081	Farnesyl Pyrophosphate ammonium Farnesyl diphosphate ammonium
	Farnesyl pyrophosphate ammonium salt为15碳类异戊二烯代谢中间体，源自MVA途径，兼具TRPM2激动剂功能，能够触发TRPM2通道开放并促进离子流入细胞。它亦是胆固醇合成、泛醌合成、蛋白质法尼基化修饰以及GGPP合成的关键底物。
T10363	Arazine N-Acetyl-S-farnesyl-L-cysteine	Others	Others
	Arazine (N-Acetyl-S-farnesyl-L-cysteine) 可以成为异戊二烯基半胱氨酸甲基转移酶的底物通过与异戊二烯化 G 蛋白或其受体位点竞争。 Arazine 是 G 蛋白和 GPCR 信号传导的细胞渗透性调节剂。
T35433	α-hydroxy Farnesyl Phosphonic Acid
	α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.
T35764	S-Farnesyl Thioacetic Acid
	S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine which behaves as a competitive inhibitor of isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). It can also inhibit methylation of both farnesylated and geranylgeranylated substrates.
T37775	Farnesyl Pyrophosphate (ammonium salt)
	Farnesyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway and used in the biosynthesis of terpenes, terpenoids, and sterols. It also serves as a donor in post-translational isoprenylation of proteins. FPP has been identified as an antagonist of P2Y12 receptors (IC50 = 45 μM), attenuating platelet aggregation. It has also been shown to regulate adipocyte function as an endogenous PPARγ agonist. Additionally, because of a flexible hydrocarbon chain that enables different conformat...
T6163	Salirasib 沙利雷塞,法尼基硫代水杨酸,Farnesyl Thiosalicylic Acid,S-Farnesylthiosalicylic acid,FTS	Autophagy; Ras	Autophagy; GPCR/G Protein; MAPK
	Salirasib (Farnesyl Thiosalicylic Acid) 是一种有效的竞争性异戊二烯化蛋白甲基转移酶抑制剂，抑制 Ras 甲基化并具有潜在的抗肿瘤活性。
T73755	Farnesyl pyrophosphate
	Farnesyl pyrophosphate (Farnesyl diphosphate) 是一种由15个碳原子组成的异戊二烯类化合物，作为甲羟戊酸 (MVA) 途径的关键代谢中间体。它充当TRPM2 (TRP Channel) 的激动剂，通过激活并打开TRPM2通道，促使离子流入细胞。此外，Farnesyl pyrophosphate 在胆固醇合成、泛醌合成、蛋白质法尼基化修饰以及香叶基-香叶基焦磷酸 (GGPP) 合成过程中扮演着至关重要的底物角色。
T11282	FGTI-2734	Transferase	Metabolism
	FGTI-2734 是有效的RAS C-末端法尼基转移酶 (FT) 和香叶烯基转移酶-1 (GGT-1) 抑制剂，IC50s 分别为 250 nM 和 520 nM。它可以阻断 KRAS 的膜定位，从而解决 KRAS 耐药性问题，并抑制突变的 KRAS 胰腺肿瘤。
T6302	Lonafarnib Sarasar,氯那法尼,Sch66336	Raf; Transferase; Autophagy; Ras	Autophagy; GPCR/G Protein; MAPK; Metabolism
	Lonafarnib (Sch66336) 是一种可口服的 FPTase 抑制剂，作用于 H-ras、K-ras 和 N-ras，IC50分别为 1.9 nM、5.2 nM 和 2.8 nM。它具有抗肝炎三角洲病毒的活性。
T2678	LB42708	Transferase	Metabolism
	LB42708 是一种口服有活力的特异性法尼基转移酶抑制剂。它对H-Ras、N-Ras 和K-Ras4B 的法尼基化均有抑制作用，其IC50分别为 0.8 nM、1.2 nM 和 2.0 nM。
T3182	L-778123 hydrochloride L 778123	Telomerase; Transferase	DNA Damage/DNA Repair; Metabolism
	L-778123 hydrochloride 是一种FPTase 和GGPTase-I 双重抑制剂，IC50分别为2 nM 和 98 nM。
T38050	CP-609754	Transferase	Metabolism
	CP-609754 是高效的、可逆的法尼基转移酶抑制剂，对重组人 H-Ras 和重组 K-Ras 法尼基化的 IC50分别为 0.57 ng/mL 和 46 ng/mL。CP-609754有潜在的抗癌作用。
T2700	FTI-277 hydrochloride FTI 277 HCl	Apoptosis; Transferase; Ras	Apoptosis; GPCR/G Protein; MAPK; Metabolism
	FTI-277 hydrochloride (FTI 277 HCl) 是一种法尼基转移酶FTase 抑制剂，高效 Ras CAAX 肽模拟物，可抑制H-Ras 和K-Ras 信号转导，还可抑制hepatitis delta virus 感染。
T6271	Tipifarnib 替吡法尼,R115777,Zarnestra,IND 58359	Transferase	Metabolism
	Tipifarnib (IND 58359) 能够抑制法尼基转移酶 (FTase)，IC50=0.86 nM，具有潜在抗肿瘤特性。
T17102	Tipifarnib (S enantiomer) Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer	Transferase	Metabolism
	Tipifarnib S enantiomer ((S)-(-)-R-115777) 是Tipifarnib 的 S 型对映体，它比 Tipifarnib 特性低。其中 Tipifarnib 是farnesyltransferase 高效特异性抑制剂，IC50=0.6 nM。
T25403	Farnesylthiotriazole
	Farnesylthiotriazole is a persistent PKC activator agent.
T123900	p-O-Farnesylcoumaric acid
	p-O-Farnesylcoumaric acid 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T123900。
T12507	Prednisolone farnesylate 泼尼松龙法尼酯,PNF21	Others	Others
	Prednisolone farnesylate is a novel transdermal corticosteroid with anti-inflammatory activity.
T10586L	BPH-1358 NSC50460	Others; Antibacterial	Microbiology/Virology; Others
	BPH-1358 (NSC-50460) 是一种人 FPPS 和 UPPS 抑制剂，IC50值分别为 1.8 μM 和 110 nM，对金黄色葡萄球菌的 MIC 值大约为 250 ng/mL。
T30677L	C15AlkOPP Tetrabutylamine salt(946615-44-7 Free base) C15AlkOPP Tetrabutylamine salt(946615-44-7 Free base)	Others	Others
	C15AlkOPP Tetrabutylamine salt 是一种"可点击"的farnesyl diphosphate (FPP)的炔烃修饰类似物。
T8489	Minodronic acid monohydrate	Transferase	Metabolism
	Minodronic acid monohydrate 是一种法尼基二磷酸合成酶抑制剂，可作为骨吸收抑制剂。
T8659	K-Ras-PDEδ-IN-1	PDE	Metabolism
	K-Ras-PDEδ-IN-1 是新型的 K-Ras-PDEδ 抑制剂，它能够以低纳摩尔Kd8 nM 与 PDEδ 的法尼基结合袋竞争性结合。
T6373	Alendronate sodium hydrate G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,阿仑膦酸钠,G-704650 Adronat,Fosamax	Transferase	Metabolism
	Alendronate sodium hydrate (MK 217) 是 farnesyl diphosphate synthase 抑制剂(IC50:460 nM)。
T10586	BPH-1358 free base NSC50460 free base	Others	Others
	BPH-1358 (NSC50460) free base is a potent human undecaprenyl diphosphate synthase (UPPS) and farnesyl diphosphate synthase (FPPS) inhibitor (IC50s: 110 nM and 1.8 μM) and is active against S. aureus in vitro (MIC ~250 ng/mL).
T28151	NE21650 NE-21650,NE 21650
	NE21650, a bisphosphonate, inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase.
T34932	Trichodermol Roridin C
	Trichodermol is a fungal sesquiterpene derived from the farnesyl diphosphate pathway.
T24356	L 739749 L 739,749,L739749,L-739749,L-739,749,L739,749
	L 739749 is a CAAX peptidomimetic. It is also an inhibitor of farnesyl-protein transferase.
T26012	R 115777 R115777,R-115777
	R 115777 is an inhibitor of farnesyl transferase.
T26348	Zaragozic acid D(2)
	Zaragozic acid D(2) inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger.
T26347	Zaragozic acid D
	Zaragozic acid D inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger.
T10223	ABT-100	Others	Others
	ABT-100 is a potent, highly selective, and orally active farnesyl transferase inhibitor with broad-spectrum antitumor activity.
T82123	ICMT-IN-21
	ICMT-IN-21（化合物6ag）是一种具有8.8 μM IC50值的ICMT抑制剂，属于磺胺修饰法尼基半胱氨酸（SMFC）。该化合物以其特有的法尼基和羧酸基序列对ICMT活性起抑制作用。
T70157	GGTI-297
	GGTI-297 is a potent, cell-permeable, and selective peptidomimetic inhibitor of GGTase I compared to Farnesyl Transferase (FTase).
T22559	Alendronate sodium	Others	Others
	The compound binds and blocks farnesyl diphosphate synthase in the HMG-CoA pathway (IC50 = 460 nM for recombinant human FPPS). It causes macrophage apoptosis and inhibits prenylation and sterol biosynthesis in purified osteoclasts.
T26469	A-176120
	A-176120 is a potent farnesyl pyrophosphate (FPP) analogues, it selectively inhibits farnesyltransferase. It has anti-angiogenic potential and may reduce H-ras NIH3T3 tumour growth.
T11330L	FTI-2148	Others	Others
	FTI-2148 is an inhibitor of RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) (IC50s: 1.4 nM and 1.7 μM, respectively).
T35589	Geranyl pyrophosphate triammonium
	Geranyl pyrophosphate is an intermediate in the mevalonate pathway. It is formed from dimethylallyl pyrophosphate and isopentenyl pyrophosphate by geranyl pyrophosphate synthase. Geranyl pyrophosphate is used in the biosynthesis of farnesyl pyrophosphate , geranylgeranyl pyrophosphate , cholesterol, terpenes, and terpenoids.
T15709	Lapaquistat acetate TAK-475	Others	Others
	Lapaquistat acetate is a squalene synthase inhibitor. It also blocks the conversion of farnesyl diphosphate (FPP) to squalene. Lapaquistat acetate is used to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholester
T11330	FTI-2148 diTFA	Others	Others
	FTI-2148 diTFA is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 1.4 nM and 1.7 μM, respectively.
T62135	Tubulin polymerization-IN-25
	Tubulin polymerization-IN-25 是一种选择性的、双重 tubulin polymerization (IC50: 1.11 μM) 和 farnesyl transferase (FTase) (IC50: 0.39 μM) 抑制剂。Tubulin polymerization-IN-25 对癌细胞表现出细胞毒性，能够阻断细胞增殖。
T11282L	FGTI-2734 mesylate (1247018-19-4 free base) FGTI-2734 mesylate	Others	Others
	FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates KRAS resistance by preventing its membrane localization, effectively impeding mutant KRAS patient-derived pancreatic tumors.
T10567	BMS-214662	Raf	MAPK
	BMS-214662是一种有效的、有选择性的 farnesyl transferase 抑制剂，可诱导原始CD34+慢性髓性白血病(CML)干细胞/祖细胞的线粒体凋亡，具有选择性靶向CML 干细胞/祖细胞的能力，具有抗肿瘤活性。
T36863	Geranylgeranyl Pyrophosphate (ammonium salt) Geranylgeranyl Pyrophosphate (ammonium salt),GGPP
	Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.[2] This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug disco...
T82088	ICMT-IN-54
	ICMT-IN-54 (compound 7c) 为一adamantyl类似物，具有ICMT抑制活性（IC50=12.4 μM），能够有效抑制ICMT的甲基转移作用。此化合物可在表达ICMT的酿酒酵母样本中阻断BFC甲基化，展现出间接抑制ICMT甲基化的能力。
T72587	BPH-1358 mesylate NSC50460 mesylate
	BPH-1358 mesylate (NSC50460 mesylate) 是一种有效的人FPPS 和UPPS 抑制剂，IC50值分别为 1.8 μM 和 110 nM，在体外对金黄色葡萄球菌的 MIC 值大约为 250 ng/mL。
T72707	(Rac)-Lonafarnib Sch66336 racemate
	(Rac)-Lonafarnib (Sch66336外消旋体) 作为Lonafarnib的外消旋体，属于一种口服有效的法尼基蛋白转移酶 (FPTase) 抑制剂，针对H-ras、K-ras及N-ras展现出杰出的抑制效能，其IC50值分别为1.9 nM、5.2 nM和2.8 nM。此外，Lonafarnib还显示出对抗肝炎三角洲病毒 (HDV) 的潜在活性。
T69618	XR3054
	XR3054 is a novel inhibitor of farnesyl protein transferase (FPTase). XR3054 inhibited the proliferation of the prostatic cancer cell lines LnCAP and PC3 and the colon carcinoma SW480 and HT1080 (IC50 values of 12.4, 12.2, 21.4 and 8.8 microM, respectively) but was relatively inactive when tested against a panel of breast carcinoma cell lines. The activity did not relate to the presence of mutant or wild-type ras in the cell lines tested. In conclusion XR3054 inhibits ras farnesylation, MAP kina...

化合物

Farnesyl Pyrophosphate ammonium

Cat.No: T78081

Synonym: Farnesyl diphosphate ammonium

Cat.No: T10363

Synonym: N-Acetyl-S-farnesyl-L-cysteine

Target: Others

α-hydroxy Farnesyl Phosphonic Acid

Cat.No: T35433

S-Farnesyl Thioacetic Acid

Cat.No: T35764

Farnesyl Pyrophosphate (ammonium salt)

Cat.No: T37775

Cat.No: T6163

Synonym: 沙利雷塞,法尼基硫代水杨酸,Farnesyl Thiosalicylic Acid,S-Farnesylthiosalicylic acid,FTS

Target: Autophagy, Ras

Farnesyl pyrophosphate

Cat.No: T73755

Cat.No: T11282

Target: Transferase

Cat.No: T6302

Synonym: Sarasar,氯那法尼,Sch66336

Target: Raf, Transferase, Autophagy, Ras

Cat.No: T2678

Target: Transferase

L-778123 hydrochloride

Cat.No: T3182

Synonym: L 778123

Target: Telomerase, Transferase

Cat.No: T38050

Target: Transferase

FTI-277 hydrochloride

Cat.No: T2700

Synonym: FTI 277 HCl

Target: Apoptosis, Transferase, Ras

Cat.No: T6271

Synonym: 替吡法尼,R115777,Zarnestra,IND 58359

Target: Transferase

Tipifarnib (S enantiomer)

Cat.No: T17102

Synonym: Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer

Target: Transferase

Farnesylthiotriazole

Cat.No: T25403

p-O-Farnesylcoumaric acid

Cat.No: T123900

Prednisolone farnesylate

Cat.No: T12507

Synonym: 泼尼松龙法尼酯,PNF21

Target: Others

Cat.No: T10586L

Synonym: NSC50460

Target: Others, Antibacterial

C15AlkOPP Tetrabutylamine salt(946615-44-7 Free base)

Cat.No: T30677L

Synonym: C15AlkOPP Tetrabutylamine salt(946615-44-7 Free base)

Target: Others

Minodronic acid monohydrate

Cat.No: T8489

Target: Transferase

K-Ras-PDEδ-IN-1

Cat.No: T8659

Target: PDE

Alendronate sodium hydrate

Cat.No: T6373

Synonym: G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,阿仑膦酸钠,G-704650 Adronat,Fosamax

Target: Transferase

BPH-1358 free base

Cat.No: T10586

Synonym: NSC50460 free base

Target: Others

Cat.No: T28151

Synonym: NE-21650,NE 21650

Cat.No: T34932

Synonym: Roridin C

Cat.No: T24356

Synonym: L 739,749,L739749,L-739749,L-739,749,L739,749

Cat.No: T26012

Synonym: R115777,R-115777

Zaragozic acid D(2)

Cat.No: T26348

Zaragozic acid D

Cat.No: T26347

Cat.No: T10223

Target: Others

Cat.No: T82123

Cat.No: T70157

Alendronate sodium

Cat.No: T22559

Target: Others

Cat.No: T26469

Cat.No: T11330L

Target: Others

Geranyl pyrophosphate triammonium

Cat.No: T35589

Lapaquistat acetate

Cat.No: T15709

Synonym: TAK-475

Target: Others

Cat.No: T11330

Target: Others

Tubulin polymerization-IN-25

Cat.No: T62135

FGTI-2734 mesylate (1247018-19-4 free base)

Cat.No: T11282L

Synonym: FGTI-2734 mesylate

Target: Others

Cat.No: T10567

Target: Raf

Geranylgeranyl Pyrophosphate (ammonium salt)

Cat.No: T36863

Synonym: Geranylgeranyl Pyrophosphate (ammonium salt),GGPP

Cat.No: T82088

BPH-1358 mesylate

Cat.No: T72587

Synonym: NSC50460 mesylate

(Rac)-Lonafarnib

Cat.No: T72707

Synonym: Sch66336 racemate

Cat.No: T69618

Cat. No.	Product Name	Target	Signaling Pathways
T8028	Farnesyl acetate Farnesyl Acetate (mixture of isomers),3,7,11-三甲基-2,6,10-十二烷三烯-1-醇乙酸酯,乙酸法呢醇酯	Others	Others
	Farnesyl acetate (Farnesyl Acetate(mixture of isomers)) 是一种倍半萜，分离自 Amomum gagnepainii 中。它对红棕榈象虫幼虫有显著的毒性(LD50:7867 ppm)。
TN7168	Farnesylacetone (5E,9E)-6,10,14-Trimethylpentadeca-5,9,13-trien-2-one,法尼基丙酮,Farnesyl acetone,E,E-farnesylacetone	Others	Others
	Farnesylacetone ((5E,9E)-6,10,14-Trimethylpentadeca-5,9,13-trien-2-one) 是一种海洋来源的天然产物，存在于Sargassum micracanthum。
TN6512	Tectol	Transferase; Parasite	Metabolism; Microbiology/Virology
	Tectol 是从Lippia sidoides 中分离的，对人白血病细胞株 HL60 和 CEM 具有显著的抑制作用。它是法尼基转移酶抑制剂，在人和布氏锥虫的IC50分别为 2.09 和 1.73 μM。它具有抗疟原虫活性，是一种中等活性的生长抑制剂，IC50 为 3.44±0.20μM。
TQ0165	Arglabin 阿格拉宾,(+)-Arglabin	NOD-like Receptor (NLR); Transferase; NOD; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Arglabin ((+)-Arglabin) 是从青蒿中分离出的一种天然产物，是一种 NLRP3 炎性体抑制剂，具有抗动脉粥样硬化和抗癌作用。
T8249	Hexahydrofarnesyl acetone 植酮,Phytone	Others; Antibacterial	Microbiology/Virology; Others
	Hexahydrofarnesyl acetone (Phytone) 是从Launaea mucronata 中分离得到的倍半萜，具有抗菌和抗炎活性，可研究缓解疼痛。
TN5828	(2Z,6Z,10E,14E,18E)-Farnesylfarnesol
	(2Z,6Z,10E,14E,18E)-Farnesylfarnesol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5828，CAS号为 90695-03-7。
T75441	(8′α,9′β-Dihydroxy)-3-farnesylindole
	(8'α,9'β-Dihydroxy)-3-farnesylindole 对枯草芽孢杆菌具有较强的抑制活性（EC509.8μM）。
T3314	Perillyl alcohol Isocarveol,Perilla alcohol,紫苏醇	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Perillyl alcohol (Isocarveol) 是一种单萜，可在不影响正常细胞的情况下诱导肿瘤细胞凋亡。
TN4443	Lipiferolide	Telomerase; Antifection	DNA Damage/DNA Repair; Microbiology/Virology
	Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells, it possesses cytotoxic activity against KB cells. Liriodenine also has antiplasmodial activity.

天然产物

Farnesyl acetate

Cat.No: T8028

Synonym: Farnesyl Acetate (mixture of isomers),3,7,11-三甲基-2,6,10-十二烷三烯-1-醇乙酸酯,乙酸法呢醇酯

Target: Others

Farnesylacetone

Cat.No: TN7168

Synonym: (5E,9E)-6,10,14-Trimethylpentadeca-5,9,13-trien-2-one,法尼基丙酮,Farnesyl acetone,E,E-farnesylacetone

Target: Others

Cat.No: TN6512

Target: Transferase, Parasite

Cat.No: TQ0165

Synonym: 阿格拉宾,(+)-Arglabin

Target: NOD-like Receptor (NLR), Transferase, NOD, Autophagy

Hexahydrofarnesyl acetone

Cat.No: T8249

Synonym: 植酮,Phytone

Target: Others, Antibacterial

(2Z,6Z,10E,14E,18E)-Farnesylfarnesol

Cat.No: TN5828

(8′α,9′β-Dihydroxy)-3-farnesylindole

Cat.No: T75441

Perillyl alcohol

Cat.No: T3314

Synonym: Isocarveol,Perilla alcohol,紫苏醇

Target: Apoptosis, Endogenous Metabolite

Cat.No: TN4443

Target: Telomerase, Antifection

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