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13
Cat. No. | Product Name | Target | Signaling Pathways |
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TP1328 |
TB500
|
Others | Others |
TB500 是一种胸腺素β4活性区域的合成分子。它可促进内皮细胞分化,角质形成细胞迁移,真皮组织中的血管生成,胶原沉积和减少炎症。 | |||
T38369 |
CAY10678
|
Prostaglandin Receptor; PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; GPCR/G Protein; Immunology/Inflammation |
CAY10678 是一种 mPGES-1抑制剂,抑制 PD-1。CAY10678 可减少胶原沉积和T细胞耗竭,可用于研究黑色素瘤。 | |||
TP2308 |
TB500 acetate(885340-08-9 free base)
Frag17-23 Acetate,TB500 Acetate |
Others | Others |
TB500 acetate(885340-08-9 free base) (Frag17-23 Acetate) 是胸腺素 β4 活性区域的合成版本。它促进内皮细胞分化、真皮组织中的血管生成、角质形成细胞迁移、胶原沉积和减少炎症。 | |||
T2753 |
Avasimibe
PD-148515,阿伐麦布,CI-1011 |
P450; Acyltransferase | Metabolism |
Avasimibe (PD-148515) 是一种口服有效的酰基辅酶 A: 胆固醇酰基转移酶 (ACAT) 抑制剂,对 ACAT1和 ACAT2的 IC50分别为 24 和 9.2 µM。Avasimibe 在前列腺癌中有研究的价值。 | |||
T15300 |
Fluorofenidone
AKF-PD |
Others | Others |
Fluorofenidone (AKF-PD) 是 AMR69 的类似物,抗纤维化活性与 AMR69相同,但 Fluorofenidone 的毒性更低,半衰期长。它部分通过 PI3K/Akt 信号通路抑制 NADPH 氧化酶和细胞外基质 (ECM) 的沉积,能够减少肾间质纤维化的发生。 | |||
T28248 |
Ono-3307 mesylate
Ono-3307,Ono3307,Ono 3307 |
Protease | Proteases/Proteasome |
Ono-3307 mesylate 是一种蛋白酶抑制剂,对多种蛋白酶均具有抑制作用。Ono-3307 mesylate 对大鼠的肝损伤具有显着的保护作用,抑制放射性纤维蛋白在肾脏和肺部的沉积 ,可用于研究胰腺炎。 | |||
T24270 |
KS370G
KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide |
||
KS370G (Caffeic Acid Phenethyl Amide) 抑制 UUO 诱导的肾纤维化标志物表达。KS370G 是一种具有口服活性的降糖和心血管保护剂,可减少梗阻肾脏中胶原蛋白的沉积,并显著降低肾脏炎症趋化因子/粘附分子和单核细胞标志物的表达,改善压力过载小鼠心脏左室肥厚和功能。KS370G 可用于研究肾阻塞性肾病。 | |||
T67961 |
Safironil
|
Others | Others |
safironil 是一种新型抗纤维化化合物,是胶原蛋白合成的竞争性抑制剂。safironil 在体外实验中对由胶原蛋白I mRNA 或平滑肌α-actin 水平监测的成纤维细胞的激活,以及由I 型和III 型胶原蛋白和层粘连蛋白生产判断的纤维生成有抑制作用。safironil 在不改变总羟脯氨酸的情况下对肝脏肉芽肿的大小没有影响,但通过增加III 型和减少I 型胶原的沉积改变了纤维化的模式。 | |||
T1641 |
Strontium ranelate
Distrontium renelate,S12911,雷尼酸锶 |
Calcium Channel; CaSR | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
Strontium ranelate (S12911) 是抗骨质疏松的药物,能够抑制骨吸收,促进骨形成,进而促使正骨平衡。它还能够激活非骨骼细胞中的钙敏感受体 (CaSR),进而促进肌醇 1,4,5-三磷酸的生成及丝裂原活化的蛋白激酶信号转导。 | |||
T124358 |
Deferoxamine
Deferoxamine B,Desferrioxamine B |
Apoptosis; Antioxidant; HIF; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; oxidation-reduction |
Deferoxamine(Desferrioxamine B) 是一种铁螯合剂 (结合 Fe(III) 和许多其他金属阳离子),可抑制神经元病变,可用于改减少铁在组织中的积累和沉积,可通过抑制创伤性脑损伤后的铁死亡和神经炎症来改善神经功能障碍。Desferrioxamin-B 具有抗氧化、抗增殖、抗肿瘤活性,可诱导 HIF-1α 产生,诱导癌细胞凋亡和自噬。Desferrioxamin-B 可用于治疗急性铁中毒和与 COVID-19 相关疾病。 | |||
T26879 |
BNC-1
BNC 1 |
||
BNC-1 is a modulator of amyloid pathology. BNC-1 significantly decreases amyloid burden and improves markers of synaptic integrity in well-established mouse models of amyloid deposition by promoting phosphorylation and activation of Elk-1. | |||
T38902 |
Cyanine 5 Tyramide
Tyramide-Cy5 |
||
Cyanine 5 Tyramide (Tyramide-Cy5), a red fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition, a signal amplification method employed in immunoassays and in situ hybridization of nucleic acids. | |||
T26611 |
AM7499
AM 7499,AM-7499 |
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AM7499 is a non-selective cannabinoid receptor agonist with remarkably high in vitro and in vivo potency. It is readily hydrolysed by plasma esterases and to be less prone to deposition in bodily fat than existing classical cannabinoid agonists. | |||
T69436 | Endosidin7 | ||
Endosidin7 is a specific inhibitor for plant callose deposition during cytokinesis without affectting endomembrane trafficking during interphase or cytoskeletal organization. | |||
T26705 |
AZ-4217
AZ4217,AZ 4217 |
||
AZ-4217 is a high potency BACE inhibitor. It displays acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. AZ-4217 has IC50 160 pM in human SH-SY5Y cells with an excellent in vivo efficacy. | |||
T33595 |
Naproxcinod
AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582 |
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Naproxcinod, a nitric oxide-releasing NSAID derivative, significantly improved skeletal muscle strength and fatigue resistance in sedentary and exercise mice, reducing inflammatory infiltration and fibrotic deposition in the myocardium and diaphragm. In a | |||
T11359 | gamma-secretase modulator 2 | Others | Others |
gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease .γ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain. γ-secretase modulator is usful in particular Alzheimer's disease. | |||
T39181 |
Cyanine 3 Tyramide
Cyanine 3 Tyramide,Tyramide-Cy3 |
||
Cyanine 3 Tyramide (Tyramide-Cy3), an orange fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition for signal amplification in immunoassays and in situ nucleic acid hybridization. | |||
T71904 |
Chlormadinone (free base)
|
||
Chlormadinone (free base) is a synthetic steroid hormone and antagonist at androgen and estrogen receptors used to treat BPH and polycystic ovary syndrome. It also promotes osteoblast differentiation and Ca deposition in bone marrow stem cells. | |||
T23874 |
CESTRIN
|
||
CESTRIN is a cellulose synthase trafficking probe that acts by inhibiting cellulose deposition and interferes with the trafficking of cellulose synthase complexes and their associated proteins KORRIGAN1 and POM2/CSI1. | |||
T16898 |
Complement factor D-IN-1
|
Others | Others |
Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively). | |||
T69664 | Umibecestat HCl | ||
Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP-transgenic mice. CNP520 reduces Aβ load and neuroinflammation in APP‐transgenic mice | |||
T68302 |
KD3010 tosylate
|
||
KD-3010 is a peroxisome proliferator-activated receptor delta agonist potentially for the treatment of diabetes and obesity. KD-3010 dramatically ameliorates liver injury induced by carbon tetrachloride (CCl(4)) injections. Deposition of extracellular matrix proteins was lower in the KD3010-treated group than in the vehicle- or GW501516-treated group. Interestingly, profibrogenic connective tissue growth factor was induced significantly by GW501516, but not by KD-3010, following CCl(4) treatmen... | |||
TP1233 |
Amylin (8-37), rat
Amylin (8-37) (mouse, rat) |
||
Amylin (8-37), rat is a truncated analog of native Amylin that selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. Amylin is also known as islet amyloid precursor peptide (IAPP) and is co-secreted with insulin fro | |||
T74073 | Cyanine 5 Tyramide methyl indole | ||
Cyanine 5 Tyramide (Tyramide-Cy5) methyl indole 为红色荧光染料,用于HRP催化沉积报告中作为荧光底物,应用于免疫测定及核酸原位杂交信号放大。储存须避光。 | |||
T25977 |
Ppack trifluoroacetate
Ppack trifluoroacetate salt |
||
Ppack trifluoroacetate is a peptide derivative that irreversibly and specifically suppresses thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki: 0.24 nM). It has been utilized as an anticoagulant (100 μM | |||
T39638 |
Eprodisate
|
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Eprodisate is a novel compound specifically developed to disrupt the interactions between amyloidogenic proteins and glycosaminoglycans, effectively impeding the polymerization of amyloid fibrils and their deposition in tissues. This compound shows potential for delaying the advancement of AA amyloidosis-related renal disease and could apply to various forms of amyloidosis. | |||
T63691 |
Chrysamine G
|
||
Chrysamine G 是一种刚果红的羧酸类似物,对 Aβ 诱导的 PC12 细胞毒性具有抑制作用。Chrysamine G 能够用作阿尔茨海默病中淀粉样蛋白沉积的探针。 | |||
T74402 |
FAP-PI3KI1
|
||
FAP-PI3KI1 是一种成纤维细胞活化蛋白 (FAP) 靶向 PI3K 抑制剂,可选择性靶向表达 FAP 的人特发性肺纤维化 (IPF)细胞并有效抑制胶原蛋白合成,减少胶原蛋白沉积。 | |||
T36357 |
Dimethyldioctadecylammonium (bromide)
|
||
Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid. DDA liposomes containing an Ag85B-ESAT-6 antigen induce antigen deposition at an intramuscular or subcutaneous injection site in mice, increasing immune cell exposure to the antigen. In a guinea pig model of M. tuberculosis infection, spleen bacterial load is reduced and lung and spleen lesion numbers are decreased when the mycobacterial lipid antigens Ac2SGL and PIM2 are administered in liposomes comprised of DDA and a synthetic... | |||
T69571 | SEW84 | ||
SEW84 是 Aha1 刺激的 Hsp90(ASH) ATP 酶活性的抑制剂。SEW84 抑制 Aha1 刺激的 Hsp90(ASH) 活性,IC50值为 0.3 μM。SEW84 可用于蛋白质沉积疾病的研究。 | |||
T25976 |
Ppack HCl
Ppack dihydrochloride,Fprmecl, dihydrochloride |
||
Ppack HCl is a peptide derivative that irreversibly and specifically suppresses thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki: 0.24 nM). It has been utilized as an anticoagulant (100 μM) and to stud | |||
T62301 |
J-1063
|
||
J-1063 是一种选择性、口服具有活力的、有效的 ALK5 抑制剂 (IC50: 0.039 μM)。 J-1063 能够抑制炎症浸润,胶原沉积,肝细胞坏死,表现出抗肝纤维化作用。J-1063 具有潜力进行肝纤维化的研究。 | |||
T38048 |
Globotetraosylceramides (porcine RBC)
|
||
Globotetraosylceramides are bioactive neutral glycosphingolipids. They are the major glycolipids in human erythrocytes. They act as receptors for the Shiga toxins Stx1, Stx2, and Stx2e, the cytotoxic protein pierisin-1, and parvovirus B19. Globotetraosylceramides increase the expression of proteins responsible for enamel deposition, including ameloblastin, amelogenin, and enamelin, in dental epithelial cells and activate the ERK and p38 MAPK signaling pathways. Levels of globotetraosylceramides ... | |||
T78406 |
Cyanine 3 Tyramide methyl indole
|
||
Cyanine 3 Tyramidemethyl indole为Cyanine 3 Tyramide(Tyramide-Cy3)的衍生物,后者作为一种橙色荧光染料,在免疫测定和核酸原位杂交技术中,用作辣根过氧化物酶(HRP)催化沉积的报告荧光底物,用于信号放大。 | |||
T64141 |
ATX inhibitor 11
|
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ATX inhibitor 11 是 ATX (autotaxin) 的有效抑制剂 (IC50: 2.7 nM)。ATX inhibitor 11 能够缓解小鼠纤维化模型中纤维化组织的严重程度,有效减少纤维化生物标志物 α-SMA 的沉积。ATX inhibitor 11 能够用于研究肺纤维化。 | |||
T37367 |
Amyloid-β (1-42) Peptide (trifluoroacetate salt)
|
||
Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers.1Aβ42 accumulates in the brain of many transgenic mouse models of Alzheimer's disease and, in many models, the onset of amyloid deposition positively correlates with deficits in spatial learning and memory.4 1.Wolfe, M.S.Therapeutic strategi... | |||
T60438 |
PXS-6302
|
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PXS-6302 是不可逆的赖氨酸氧化酶 (LOX) 抑制剂,对Bovine LOX、rh LOXL1、rh LOXL2、rh LOXL3、rh LOXL4的IC50分别为 3.7 μM,3.4 μM,0.4 μM,1.5 μM 和0.3 μM。PXS-6302 可以轻松渗透皮肤,减少胶原蛋白沉积和交联,显着改善疤痕外观而不降低组织强度。 PXS-6302 在其他纤维化疾病中也可能有更广泛的应用。 | |||
T72506 |
Antioxidant agent-8
|
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Antioxidant agent-8是一种口服活性的Aβ1-42沉积抑制剂。其抑制原纤维聚集的IC50值为11.15 µM,促进原纤维分解的IC50值为6.87 µM。此外,Antioxidant agent-8对Cu2+诱导的Aβ1-42原纤维聚集有抑制作用(IC50=3.69 µM),并能促进Cu2+诱导的Aβ1-42原纤维分解(IC50=3.35 µM)。该化合物具备抗氧化活性、抗炎活性、生物安全性、血脑屏障通透性和神经保护作用。 | |||
T65440 | Sodium Thiosulfate Pentahydrate | ||
Sodium thiosulfate (Pentahydrate) is an antioxidant and antifungal. Sodium thiosulfate protects against cisplatin-induced hearing loss in children and is not associated with serious adverse events attributed to its use[3]. The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among children with standard-risk hepatoblastoma, without jeopardizing overall or event-free survival[4]. Calciphylaxis is a p... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0928 |
L-Ascorbic acid
维生素C,Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,抗坏血酸,L-Ascorbate |
Apoptosis; Calcium Channel; Reactive Oxygen Species; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB |
L-Ascorbic acid (Vitamin C) 属于天然产物,是一种强效的还原剂和抗氧化剂。L-Ascorbic acid 具有抗细菌感染、解毒反应和胶原蛋白形成的作用。L-Ascorbic acid 被用于治疗坏血病。 | |||
T37512 |
cis-4-Hydroxy-L-proline
|
Endogenous Metabolite | Metabolism |
cis-4-Hydroxy-L-proline 是脯氨酸的一种类似物,抑制胶原蛋白的产生。它通过阻止三层螺旋胶原在细胞层上的沉积从而抑制成纤维细胞的生长。它还可抑制原发性N-亚硝基甲基脲诱导的大鼠乳腺肿瘤的生长。 | |||
T5788 |
XYLOBIOSE
|
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
Xylobiose 是一种木糖单体的二糖,单体之间具有 β-1, 4 键。 | |||
T10822 |
Cirsimarin
Cirsitakaoside |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Cirsimarin (Cirsitakaoside) 是一种从 Microtea debilis 中分离出来的黄酮类化合物。它具有很强的抗脂肪生成作用,能减少小鼠脂肪组织的沉积。Cirsimarin 对腺苷 A1 受体有拮抗作用,对磷酸二酯酶有抑制作用 | |||
T40646 |
Lipoteichoic acid
|
Complement System | Immunology/Inflammation |
Lipoteichoic acid 是 Staphylococcus aureus 细胞壁的聚合物,通过诱导 C3 和抑制 CD55 来激活补体系统,通过 IGF-1 途径减少脂肪沉积。 | |||
T3869 |
Skimmin
茵芋苷,Skimmine |
Others | Others |
Skimmin (Skimmine) 是一种香豆素类物质。存在于圆锥绣球中,能够抑制免疫复合物的沉积,具有抗炎作用。 | |||
TL0001 |
dencichine
L-Dencichin,ODAP,Dencichin,三七素 |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Dencichine (ODAP) 是抑制从三七中分到的非蛋白氨基酸,可抑制 HIF-prolyl hydroxylase-2 的活性。 | |||
T6S1966 |
Curculigoside
Curculigoside A,仙茅苷 |
Antioxidant; NF-κB; JAK; STAT | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; oxidation-reduction; Stem Cells |
Curculigoside (Curculigoside A) 是仙茅中的主要皂苷,具有显著的抗氧化、抗骨质疏松、抗抑郁和神经保护作用。它通过调节JAK/STAT/NF-κB 信号传导途径,具有抗关节炎作用。 | |||
T5074 |
Cholesteryl palmitate
|
Others; Endogenous Metabolite | Metabolism; Others |
Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。 | |||
TMS1461 |
Qingyangshengenin B
青阳参甙元B,青阳参苷元B,Otophylloside B |
Beta Amyloid | Neuroscience |
Qingyangshengenin B (Otophylloside B) 是一种分离自 Qingyangshen 的 C-21 甾体苷。它能够在 mRNA 水平上抑制 Aβ 的表达来减少 Aβ 的沉积,对 Aβ 的毒性有保护作用。它具有抗癫痫作用。 | |||
T40641 |
Crocin-4
|
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Crocin-4, a carotenoid compound found in saffron, possesses potent antioxidant properties and can penetrate the brain. It effectively inhibits the aggregation and deposition of Aβ fibrils, making it useful for Alzheimer's Disease research. Additionally, Crocin-4 demonstrates antitumor and anti-inflammatory activities. | |||
T29607 |
Acid Red 88
11391 Red,Eniacid Fast Red A,Peony,Red No. 506 |
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Acid red 88 is an anionic dye with potentially useful photocatalytic research applications. Acid red 88 has been used to determine the effect of Au deposition on ZnO photocatalytic activity under visible light. Additionally, the photocatalyst Au-TiO2 was | |||
T35624 | Ajoene | ||
Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 µM), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 µM).2It reduces... |