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64

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5447	Anle138b	Beta Amyloid; Others	Neuroscience; Others
	Anle138b 是一种毒性低，口服生物利用度高，血脑屏障通透性好的低聚物聚集抑调节剂，可阻断朊病毒蛋白和 α-突触核蛋白病理性聚集的形成。它在体内强烈抑制低聚物积累、神经元变性和疾病进展。它阻断 Aβ 通道并挽救淀粉样变性小鼠模型的疾病表型。
T9928	Ranibizumab	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Ranibizumab 是一种人源化单克隆抗体片段，旨在靶向和抑制血管内皮生长因子 (VEGF)，包括 VEGF110、VEGF121 和 VEGF165。 Ranibizumab 选择性靶向和中和 VEGF-A 同工型的能力使其成为湿性年龄相关性黄斑变性 (AMD) 研究和治疗策略的重要组成部分。
T10122	Anti-neurodegeneration agent 1	Others	Others
	Anti-neurodegeneration agent 1 a neurodegeneration-targeting agent.
T27084	Crisdesalazine AAD2004,AAD 2004,AAD-2004	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Crisdesalazine (AAD 2004) 是微粒体前列腺素 E2 合酶 1 (mPGES-1) 的抑制剂。 Crisdesalazine 可减少自噬体形成、轴索病变和运动神经元变性，改善运动功能并延长寿命。
T28273L	OT-551 HCl OT-551 HCl（627085-11-4 Free base）	NF-κB	NF-κB
	OT-551 HCl 是一种 NF-Κb 抑制剂，是一种具有抗氧化特性的二取代羟胺可用于治疗白内障和老年性黄斑变性和地域性萎缩 (GA)。
T13048	SynuClean-D SC-D	Others	Others
	SynuClean-D (SC-D) 是一种 α-突触核蛋白聚集的抑制剂，能够破坏成熟的淀粉样蛋白原纤维，抑制原纤维繁殖，防止帕金森氏病动物模型中多巴胺能神经元的变性。
T5359	RCGD423	Interleukin	Immunology/Inflammation
	RCGD423 是一种gp130调节剂，能阻断关节软骨的退化，并诱导其修复。
T13157	TG 100801 TG100801,TG 100572	VEGFR; Src	Angiogenesis; Tyrosine Kinase/Adaptors
	TG 100801 是 VEGFr2 和 Src 家族（Src 和 YES）激酶的双重抑制剂，是治疗年龄相关性黄斑变性（AMD）的候选化合物。
T77600	Methyl-4-oxoretinoate	Apoptosis	Apoptosis
	Methyl-4-oxoretinoate 是一种合成的类视黄醇化合物，具有抗癌化合物，可可以诱导癌细胞分化和凋亡。Methyl-4-oxoretinoate 可用于治疗痤疮、牛皮癣和其他皮肤病。Methyl-4-oxoretinoate 具有治疗各种眼部疾病（如年龄相关性黄斑变性）的潜力。
T2706	Palomid 529 P529,SG 00529	Apoptosis; mTOR	Apoptosis; PI3K/Akt/mTOR signaling
	Palomid 529 (SG 00529) 是一种mTORC1和mTORC2复合体抑制剂，已用于研究治疗年龄相关性黄斑变性的试验。
T7493	AG-13958 AG-013958,N-[2-氟-5-[[3-[(1E)-2-(2-吡啶基)乙烯基]-1H-吲唑-6-基]氨基]苯基]-1,3-二甲基-1H-吡唑-5-甲酰胺	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	AG-13958 (AG-013958) 是 VEGFR 酪氨酸激酶抑制剂，可用于年龄相关性黄斑变性 (AMD) 的脉络膜新生血管形成的研究。
T19739	Simazine Tafazine,Aquazine,Radocon,Herbex,西玛津	Others	Others
	Simazine (Tafazine) 是三嗪类除草剂，普遍用于农业、盆栽植物和树木的生产。它具有植物毒性，但对土壤微生物和藻类毒性较低。
T34399	Rovatirelin KPS-0373,S0373,S-0373,S 0373	AChE	Neuroscience
	Rovatirelin (S-0373) 是一种新合成的促甲状腺激素释放激素（TRH）类似物，通过乙酰胆碱和多巴胺神经传递改善胞嘧啶阿拉伯糖苷诱导的脊髓小脑变性大鼠模型的运动功能障碍。
T10531	BGB-102 JNJ-26483327	EGFR; VEGFR; FLT; Src	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BGB-102 (JNJ-26483327) 是一种针对FLT3 和 YES1 的激酶抑制剂和针对 EGFR 和 VEGFR3 的拮抗剂，可用于研究黄斑变性和与遗传病与畸形相关的疾病。
T8860	DSRM-3716	Androgen Receptor	Endocrinology/Hormones
	DSRM-3716 是选择性的SARM1 NADase 抑制剂，IC50为 75 nM，相较于其他 NAD+加工酶、受体和转运蛋白具有选择性。DSRM-3716显示出强大的轴突保护作用。
T35182	Xinidamine BRN 0891979,Xinidaminum,Xinidamino
	Xinidamine (BRN 0891979) 具有抗肿瘤活性，可用于研究良性前列腺增生、黄斑变性和前列腺上皮内瘤。Xinidamine 对PWR-1E 细胞的增殖具有抑制作用，IC50为4μM。
T21300	Trientine-2HCl Triethylenetetramine,Trientine HCl,Trientine,盐酸三乙烯四胺,Triethylene tetramine,TETA,Trien	Others	Others
	Trientine-2HCl (Trien) 是一种螯合剂，通过结合和去除体内的铜来治疗威尔逊氏病。曲恩汀还可用作肝豆状核变性中铜的螯合剂，环氧树脂的稳定剂，等电聚焦的两性电解质。
T35689	MTP 131 acetate	Others	Others
	MTP 131 acetate 是一种小的线粒体靶向四肽。
T37081	HIOC
	Selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant.
T27443	GSK 894281 GSK894281,GSK-894281
	GSK 894281 is a ghrelin receptor agonist. It may produces myocardial degeneration/necrosis in rats.
T40037	Timtraxanib AVI-3207
	Timtraxanib (AVI-3207) is a potent and specific inhibitor of VEGF-2, offering great potential for investigating senile macular degeneration.
T28273	OT-551 CPC 551,OT 551,CPC551,CPC-551
	OT-551, a NF-κB inhibitor, is used potentially for the treatment of cataracts and age-related macular degeneration.
T34551	SC 32855 SC-32855,SC32855
	SC 32855 is a 1,4-benzodiazepine that has been shown to arrest of spermatogenesis and degeneration of the germinal epithelium.
T71715	CU239
	CU239 is a selective non-retinoid inhibitor of RPE65 which suppresses visual cycle and prevents retinal degeneration.
T34750	Sut 8701 Sut8701,Sut-8701
	Sut 8701 is a cholecystokinin analog that prevents cholinergic degeneration in the rat cerebral cortex following basal forebrain lesioning and can slow down the degenerative processes in Alzheimer's disease.
T28409	Photoregulin1
	Photoregulin1 is a modulator of Nr2e3. Photoregulin1 slows the progression of photoreceptor degeneration in two common mouse models of autosomal dominant RP, the RhoP23H and the Pde6brd1 mutations.
T27670	JNJ-26076713 JNJ26076713
	JNJ-26076713, an orally active alpha V integrin antagonist, represents a potential therapeutic candidate for the treatment of macular edema, age-related macular degeneration, and proliferative diabetic retinopathy.
T26665	AS604872 AS-604872,AS 604872
	AS604872 is a selective antagonist of the FP receptor.. AS604872 significantly accelerated degeneration of the media in both cerebral artery and aorta as evidenced by thinning of the media and disruption of the elastic lamina and promoted IA and aortic di
T39706	Pegaptanib sodium
	Pegaptanib sodium, an RNA aptamer specifically targeting vascular endothelial growth factor (VEGF)-165, holds great promise for investigating neovascular age-related macular degeneration (AMD).
T28488	Quinuronium Sulfate Pirevan,Zothelone,Acaprin
	Quinuronium sulfate is a drug used to treat Babesia divergens infections in calves. It did not prevent treated animals from being disease carriers. It may also cause hepatic centrilobular fatty degeneration, but no depletion of hepatic glutathione (GSH).
TP1390	CEP dipeptide 1
	CEP dipeptide 1, a potent angiogenic compound, exhibits robust activity in promoting angiogenesis. This compound is specifically implicated in the pathogenesis of age-related macular degeneration (AMD).
T13524	9-cis-β-Carotene	Others	Others
	9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. It inhibits photoreceptor degeneration and restores retinal function in vivo.
T73476	YC-001
	YC-001 是一种针对杆状视蛋白的反向激动剂和拮抗剂。它能与视杆视蛋白可逆地结合，从而稳定其结构，保护小鼠免受强光诱导的视网膜变性，显示出研究视网膜变性疾病潜力。
T71988	Moxaverine hydrochloride
	Moxaverine hydrochloride is a derivative of papaverine, a phosphodiesterase inhibitor. Moxaverine has been studied in phase III of a clinical trial for the treatment of ocular blood flow in patients with age- related macular degeneration and primary open angle glaucoma.
T36092	Fenobucarb
	Fenobucarb, a widely employed carbamate insecticide, poses potential risks to the cardiovascular and cerebrovascular systems in animals[1][2]. It triggers developmental neurotoxicity in zebrafish by engaging pathways related to inflammation, oxidative stress, degeneration, and apoptosis.
T71552	ASC-JM-17
	ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts on Nrf1, Nrf2 and Hsf1 to increase the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. ASC-JM17 ameliorates toxicity of the mutant androgen receptor (AR) responsible for SBMA in cell, fly and mouse models. Knockdown of the Drosophila Nrf1 and Nrf2 ortholog cap ‘n’ collar isoform-C, but not Hsf1, blocks the protective effect of ASC-JM17 on mutant AR-induced eye degeneration in flies.
T36620	ALK4290 ALK4290
	ALK4290 (AKST4290) is a potent and orally actively CCR3 inhibitor, compound Example 2, with a Ki of 3.2 nM for hCCR3[1]. ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism[2][3].
T9695L	POT-4 acetate POT-4 acetate (934461-40-2 free base)	Complement System	Immunology/Inflammation
	POT-4 acetate 抑制 Complement C3 的活化。 POT-4 acetate 可用于年龄相关性黄斑变性的研究。
TP1464	Risuteganib hydrochloride
	Risuteganib hydrochloride is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order to restore homeostasis in the retin
T13157L	TG 100801 Hydrochloride	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	TG 100801 Hydrochloride is a prodrug to treat age-related macular degeneration. TG 100572 is a inhibitor of multi-targeted kinase(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src,
T77016	Galegenimab
	Galegenimab (FHTR 2163; RG 6147; RO 7171009)，一种抗 HTRA1抗体片段。Galegenimab 可用于年龄相关性黄斑变性 (AMD) 研究。
T75156L	Bevasiranib sodium
	Bevasiranib sodium 是一种siRNA，可沉默产生血管内皮生长因子(VEGF)的基因。VEGF 在脉络膜新生血管形成(choroidal neo-vascularization, CNV)的发病机制中起着关键作用，而CNV 是湿性年龄相关性黄斑变性(wet age-related macular degeneration, wet AMD)的前兆。
T76887	Rinucumab
	Rinucumab (REGN 2176) 是一种单克隆抗体，是PDGF 的抑制剂。Rinucumab (REGN 2176) 可用于新生血管性年龄相关性黄斑变性的研究。
T76210	POT-4 TFA
	POT-4 TFA (AL-78898A TFA)，Compstatin 衍生物，有效抑制补体因子 C3 激活，适应于年龄相关黄斑变性研究。
T35670	Miro1 Reducer
	Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.
T75156	Bevasiranib
	Bevasiranib 是一种siRNA，可沉默产生血管内皮生长因子(VEGF)的基因。VEGF 在脉络膜新生血管形成(choroidal neo-vascularization, CNV)的发病机制中起着关键作用，而CNV 是湿性年龄相关性黄斑变性(wet age-related macular degeneration, wet AMD)的前兆。
T76987	Tarcocimab
	Tarcocimab (OG1953) 是一种人源化抗VEGFA 单克隆抗体 (IgG1 型)。Tarcocimab 可用于视网膜静脉阻塞 (RVO) 和湿性老年性黄斑变性 (AMD) 的研究。
T69452	AG-13958 monohydrochloride
	AG-13958 monohydrochloride is the HCl salt of AG-13958 --- a VEGFA inhibitor potentially for the treatment of age-related macular degeneration. Neovascular AMD, a subtype characterized by the growth of new, pathologic blood vessels, results in most of the cases of severe and rapid vision loss associated with AMD. A critical activator of angiogenesis in neovascular AMD is VEGF.
T74551	Avacincaptad pegol sodium
	Avacincaptad pegol (ARC1905) 是一种靶向补体因子5 (C5)的核酸适配体，抑制C5剪切为C5a 和C5b。Avacincaptad pegol 被用于研究与年龄相关的黄斑变性(AMD)。
T79010	Lp-PLA2-IN-12	Phospholipase	Metabolism
	Lp-PLA2-IN-12（compound 19）为一种Lp-PLA2抑制剂，主要应用于神经退行性疾病（如AD、青光眼、AMD）及心血管疾病（诸如动脉粥样硬化）的研究。

化合物

Cat.No: T5447

Target: Beta Amyloid, Others

Cat.No: T9928

Target: VEGFR

Anti-neurodegeneration agent 1

Cat.No: T10122

Target: Others

Cat.No: T27084

Synonym: AAD2004,AAD 2004,AAD-2004

Target: Prostaglandin Receptor

Cat.No: T28273L

Synonym: OT-551 HCl（627085-11-4 Free base）

Target: NF-κB

Cat.No: T13048

Synonym: SC-D

Target: Others

Cat.No: T5359

Target: Interleukin

Cat.No: T13157

Synonym: TG100801,TG 100572

Target: VEGFR, Src

Methyl-4-oxoretinoate

Cat.No: T77600

Target: Apoptosis

Cat.No: T2706

Synonym: P529,SG 00529

Target: Apoptosis, mTOR

Cat.No: T7493

Synonym: AG-013958,N-[2-氟-5-[[3-[(1E)-2-(2-吡啶基)乙烯基]-1H-吲唑-6-基]氨基]苯基]-1,3-二甲基-1H-吡唑-5-甲酰胺

Target: VEGFR

Cat.No: T19739

Synonym: Tafazine,Aquazine,Radocon,Herbex,西玛津

Target: Others

Cat.No: T34399

Synonym: KPS-0373,S0373,S-0373,S 0373

Target: AChE

Cat.No: T10531

Synonym: JNJ-26483327

Target: EGFR, VEGFR, FLT, Src

Cat.No: T8860

Target: Androgen Receptor

Cat.No: T35182

Synonym: BRN 0891979,Xinidaminum,Xinidamino

Cat.No: T21300

Synonym: Triethylenetetramine,Trientine HCl,Trientine,盐酸三乙烯四胺,Triethylene tetramine,TETA,Trien

Target: Others

MTP 131 acetate

Cat.No: T35689

Target: Others

Cat.No: T37081

Cat.No: T27443

Synonym: GSK894281,GSK-894281

Cat.No: T40037

Synonym: AVI-3207

Cat.No: T28273

Synonym: CPC 551,OT 551,CPC551,CPC-551

Cat.No: T34551

Synonym: SC-32855,SC32855

Cat.No: T71715

Cat.No: T34750

Synonym: Sut8701,Sut-8701

Cat.No: T28409

Cat.No: T27670

Synonym: JNJ26076713

Cat.No: T26665

Synonym: AS-604872,AS 604872

Pegaptanib sodium

Cat.No: T39706

Quinuronium Sulfate

Cat.No: T28488

Synonym: Pirevan,Zothelone,Acaprin

CEP dipeptide 1

Cat.No: TP1390

9-cis-β-Carotene

Cat.No: T13524

Target: Others

Cat.No: T73476

Moxaverine hydrochloride

Cat.No: T71988

Cat.No: T36092

Cat.No: T71552

Cat.No: T36620

Synonym: ALK4290

Cat.No: T9695L

Synonym: POT-4 acetate (934461-40-2 free base)

Target: Complement System

Risuteganib hydrochloride

Cat.No: TP1464

TG 100801 Hydrochloride

Cat.No: T13157L

Target: VEGFR

Cat.No: T77016

Bevasiranib sodium

Cat.No: T75156L

Cat.No: T76887

Cat.No: T76210

Cat.No: T35670

Cat.No: T75156

Cat.No: T76987

AG-13958 monohydrochloride

Cat.No: T69452

Avacincaptad pegol sodium

Cat.No: T74551

Cat.No: T79010

Target: Phospholipase

Cat. No.	Product Name	Target	Signaling Pathways
T3849	Kinsenoside 金线莲苷,(+)-Kinsenoside	Apoptosis; Nrf2	Apoptosis; Immunology/Inflammation
	Kinsenoside ((+)-Kinsenoside) 是从金盏花属植物中分离得到的主要活性成分，以 Nrf2 依赖的方式保护髓核细胞在氧化应激下的生存能力，防止细胞凋亡、衰老和线粒体功能障碍。它显示出显着的抗肝毒性和抗炎活性。
TN1833	Karacoline	NF-κB	NF-κB
	Karacoline 是发现于植物Aconitum kusnezoffii 中的一种二萜生物碱，通过 NF-κB 信号通路，抑制椎间盘退变中细胞外基质的降解。
T3S1858	Lutein Vegetable Lutein,叶黄素,Xanthophyll,Bo-Xan,Xantofyl	Antibacterial	Microbiology/Virology
	Lutein (Xantofyl) 具有抗肿瘤作用。它具有抗诱变作用。它具有广泛的抗菌作用。它可能对治疗黄斑变性有用。
TMS0418	Dihydroergotoxine mesylate 甲磺酸二氢麦角碱,Ergoloid mesylates,甲磺酸双氢麦角毒碱	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Dihydroergotoxine mesylate (Ergoloid mesylates) 是系列生物碱盐混合物，对GABAA 受体高结合活性。它主要用于改善与衰老相关的精神退化的症状和身体症状。
T2795	Amygdalin 苦杏仁苷,Laetrile	Others	Others
	Amygdalin (Laetrile) 是一种植物葡萄糖苷，分离自蔷薇果实的果核中，如杏，桃，杏仁，樱桃和李子。
T5S2357	Acetylcorynoline (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵	Antifungal	Microbiology/Virology
	Acetylcorynoline (O-Acetylcorynoline) 是提取自 Corydalis bungeana 中的一种主要生物碱成分，具有抗炎活性。
T10348	Apigenin-7-diglucuronide	Others	Others
	Apigenin-7-diglucuronide is a flavonoid glycoside that exists in an assortment of medicinal plants with anti-inflammatory or ant-oxidant activities. It protects retinas against bright light-induced photoreceptor degeneration through the inhibition of reti
TN3351	Aflatrem	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamma-aminobutyric acid (GABA)-induced
T83915	Norbixin hydrate
	Norbixin是一种在B. orellana中发现的类胡萝卜素，具有多样的生物活性。在无细胞测试中，它与过氧化物酶体增殖物激活受体γ (PPARγ)结合（Ki = 1.15 µM）。在心脑血管代谢综合征大鼠模型中，Norbixin (47.7 mg/kg) 能够减轻高血糖、高胰岛素血症和胰岛素抗性，降低血清脂质水平及心脏中硫代巴比妥酸反应性物质（TBARS）和谷胱甘肽（GSH）的水平。在胆固醇诱导的动脉粥样硬化兔模型中，它降低氧化型LDL和主动脉蛋白氧化水平，并减少动脉粥样硬化面积。Norbixin（每天0.1和1 mg/kg）减少汞诱导的大鼠肝细胞和白细胞DNA损伤。此外，它还能预防与年龄相关的黄斑变性（AMD）Abca4-/- Rdh8-/-小鼠模型中的光感受器退化。
T75608	Myricetin 3-O-α-L-arabinopyranoside
	Myricetin 3-O-α-L-arabinopyranoside 抑制 A2E 光氧化诱导的RPE 细胞死亡。Myricetin 3-O-α-L-arabinopyranoside 对视网膜变性具有保护作用，可保护蓝光 (BL) 诱导对 RPE 细胞和小鼠模型的损伤。

天然产物

Cat.No: T3849

Synonym: 金线莲苷,(+)-Kinsenoside

Target: Apoptosis, Nrf2

Cat.No: TN1833

Target: NF-κB

Cat.No: T3S1858

Synonym: Vegetable Lutein,叶黄素,Xanthophyll,Bo-Xan,Xantofyl

Target: Antibacterial

Dihydroergotoxine mesylate

Cat.No: TMS0418

Synonym: 甲磺酸二氢麦角碱,Ergoloid mesylates,甲磺酸双氢麦角毒碱

Target: GABA Receptor

Cat.No: T2795

Synonym: 苦杏仁苷,Laetrile

Target: Others

Acetylcorynoline

Cat.No: T5S2357

Synonym: (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵

Target: Antifungal

Apigenin-7-diglucuronide

Cat.No: T10348

Target: Others

Cat.No: TN3351

Target: GABA Receptor

Norbixin hydrate

Cat.No: T83915

Myricetin 3-O-α-L-arabinopyranoside

Cat.No: T75608

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