Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SynuClean-D (SC-D) 是一种 α-突触核蛋白聚集的抑制剂,能够破坏成熟的淀粉样蛋白原纤维,抑制原纤维繁殖,防止帕金森氏病动物模型中多巴胺能神经元的变性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,397 | 现货 | ||
5 mg | ¥ 3,713 | 现货 | ||
10 mg | ¥ 5,190 | 现货 | ||
25 mg | ¥ 8,090 | 现货 | ||
50 mg | ¥ 10,900 | 现货 | ||
100 mg | ¥ 14,700 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,610 | 现货 |
产品描述 | SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease. |
体外活性 | SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. SynuClean-D significantly reduces the aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D can bind to cavities in mature α-synuclein fibrils[1]. |
体内活性 | SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. SynuClean-D is able to rescue dopaminergic neurons from α-synuclein-induced degeneration[1]. In two parkinson’s disease (PD) Caenorhabditis elegans models, SynuClean-D expresses α-synuclein either in muscle or in dopaminergic neurons and significantly reduces the toxicity exerted by α-synuclein[1]. |
别名 | SC-D |
分子量 | 354.2 |
分子式 | C13H5F3N4O5 |
CAS No. | 685121-45-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 77 mg/mL (217.39 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8233 mL | 14.1163 mL | 28.2326 mL | 70.5816 mL |
5 mM | 0.5647 mL | 2.8233 mL | 5.6465 mL | 14.1163 mL | |
10 mM | 0.2823 mL | 1.4116 mL | 2.8233 mL | 7.0582 mL | |
20 mM | 0.1412 mL | 0.7058 mL | 1.4116 mL | 3.5291 mL | |
50 mM | 0.0565 mL | 0.2823 mL | 0.5647 mL | 1.4116 mL | |
100 mM | 0.0282 mL | 0.1412 mL | 0.2823 mL | 0.7058 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SynuClean-D 685121-45-3 Others inhibit Inhibitor SynuClean D SC-D SynuCleanD inhibitor