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Search Results for " cognitive disorders "

32

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T28368	PF-04859989 HCl PF 04859989,PF04859989,PF-04859989HCl,PF-04859989	Others	Others
	PF-04859989 HCl 是不可逆的犬尿氨酸转氨酶 KAT II 抑制剂，可透过血脑屏障，抑制 hKATⅡ 和 rKATⅡ 的 IC50分别为 23 和 263 nM。它对 KATⅡ 的选择性高于人 KATⅠ、KATⅢ 和 KATⅣ (IC50分别为22、11和 >50 μM)。
T2150	Guanfacine hydrochloride 盐酸胍法辛,Tenex,Intuniv,Guanfacine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Guanfacine hydrochloride (Intuniv) 是一种 α2A 肾上腺素受体激动剂，Kd=31 nM，具有抗高血压作用。
T7165	Basmisanil RG1662,RO5186582,巴米沙尼	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Basmisanil (RG1662) 是高度选择性GABAAα5负调节剂，用于治疗与唐氏综合症相关的认知障碍。
T27462	GSK-239512 GSK239512,GSK 239512	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	GSK-239512 是 H3 受体拮抗剂，可用于治疗神经退行性疾病认知功能障碍的研究。
T10499	H3 receptor-MO-1	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	H3 receptor-MO-1 是一种有效的组胺 H3 受体 (histamine H3 receptor) 调节剂，可用于研究神经分裂和认知障碍。
T28856	SSR180711 hydrochloride SSR-180711A HCl,SSR-180711C HCl,SR-180711 HCl	AChR	Neuroscience
	SSR180711 hydrochloride (SSR-180711A HCl) 是一种具有选择性的 Alpha7 尼古丁乙酰胆碱部分激动剂，可用于研究神经分裂和认知障碍。
T0183	Pramiracetam CI-879,普拉西坦	Others	Others
	Pramiracetam (CI-879) 来源于piracetam，能改善脑外伤引起的认知障碍。它是更有效的促智药物。
T31079	CP-810123 CP 810123,UNII-E6G4550EC4,CP810123	AChR	Neuroscience
	CP-810123 是一种新的α 7 nAChR 激动剂，可用于治疗与精神分裂症和阿尔茨海默病等精神或神经疾病相关的认知障碍。
T0426	Piracetam UCB-6215,吡拉西坦	GluR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Piracetam (UCB-6215) 是神经递质 γ-氨基丁酸 (GABA) 的环状衍生物，用于治疗广泛的认知障碍。
T23066	NGD 94-1	Dopamine Receptor	GPCR/G Protein; Neuroscience
	NGD 94-1 是一种选择性的 D4 受体拮抗剂，对D4受体的亲和力为3 nM，而对D1、D2、D3和D5受体的亲和力大于2 pM。NGD 94-1 可用研究认知障碍等精神性疾病。
T14507	Bay 60-7550 BAY 607550	PDE	Metabolism
	Bay 60-7550 是一种具有选择性和高效性的 PDE2 抑制剂（Ki：3.8 nM），通过增加 PKA 介导的磷酸化来发挥大鼠心脏的正性肌力作用，可用于改善认知障碍和记忆障碍。
T28655	Sabeluzole R 58735,R58735,R-58735	Microtubule Associated	Cytoskeletal Signaling
	Sabeluzole (R-58735) 具有抗癫痫和增强认知的作用，抑制神经毒素诱导的tau表达和细胞死亡。Sabeluzole 对氯氮卓诱导的习惯障碍有保护作用，可用于研究阿尔茨海默症。
T8451	Tropanserin MDL 72422	5-HT Receptor	GPCR/G Protein; Neuroscience
	Tropanserin (MDL 72422) 是一种 5-羟色胺受体拮抗剂，抑制5-HT3受体活性。Tropanserin 具有抗焦虑活性，可用于治疗抑郁症和认知障碍。
T61278	Aminopeptidase-IN-1	Aminopeptidase	Metabolism
	Aminopeptidase-IN-1 是一种有效的胰岛素调节氨肽酶 (IRAP) 抑制剂（Ki： 7.7 μM）。Aminopeptidase-IN-1 可用于认知和记忆障碍的研究。
T12054L	MK-0249 FA MK-0249 FA(862309-06-6 Free base)	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	MK-0249 FA 是一种具有口服活性、选择性和高效性的组胺 H3 反向激动剂，可用于研究成人注意力缺陷、多动症神经分裂和认知障碍。
T68064	Elziverine	CaMK	Neuroscience
	Elziverine是一种可口服的小分子钙调蛋白拮抗剂。Elziverine体外处理以浓度依赖性方式抑制了SHRSP，WKY和Wistar大鼠中Ca负载诱导的棘皮细胞形成。Elziverine可用于治疗神经疾病，可用于研究认知障碍。
T30798	Cerlapirdine PF05212365,P -05212365,SAM-531,SAM531,PF-05212365,SAM 531,WAY-262,531	5-HT Receptor	GPCR/G Protein; Neuroscience
	Cerlapirdine (PF-05212365) 是一种选择性 5-羟色胺 6 (5-HT6) 受体的完全拮抗剂，用于治疗与阿尔茨海默病和精神分裂症相关的认知障碍。
T26646	AQW051 AQ W051,VQW-765,AQW-051	AChR	Neuroscience
	AQW051 (VQW-765)是一种口服活性alpha -7烟碱乙酰胆碱受体(α7-nAChR)特异性激活剂，与重组人alpha7-nAChR 表达相互作用(pKD 值7.56)。alpha7-nAChR 被认为是治疗与神经障碍相关的认知障碍的一个有吸引力的靶点，因此VQW-051经常用于焦虑障碍和急性焦虑的研究
T16481	PF-04995274	5-HT Receptor	GPCR/G Protein; Neuroscience
	PF-04995274 是强效，高亲和力，口服活性血清素 4 受体的部分激动剂。它是可脑渗透的，可用于与阿尔茨海默症相关的认知障碍的研究。
T29043	UCL-1972 UCL 1972
	UCL-1972, a Histamine H3 Receptor Antagonist, used to treat cognitive disorders.
T10510	CB1 antagonist 1	Cannabinoid Receptor	GPCR/G Protein
	CB1 antagonist 1 is a CB1 receptor antagonist, used in the research of obesity and metabolic syndrome, neuroinflammatory disorders, cognitive disorders, and gastrointestinal disorders, psychosis, and cardiovascular.
T26798	Bibn 140 Bibn140,Bibn-140
	Bibn 140 is a highly selective M2 antagonist, it is used to treat Alzheimer's disease and other cognitive disorders.
T34752	Samelisant dihydrochloride SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl
	Samelisant dihydrochloride (SUVN-G3031) is a antagonist of histamine H3 receptor with potential for the treatment of cognitive impairment, dementia, attention deficit hyperactivity disorder, epilepsy, sleep disorders, obesity, schizophrenia, eating disorders, and pain.
T61684	S 17092
	S 17092 (S 17092-1) is a highly effective inhibitor of cerebral prolyl-endopeptidase (PEP), displaying an IC50 value of 1.2 nM. It is utilized in research focused on understanding memory impairment and cognitive disorders associated with cerebral aging [1].
T70787	AZD1446 tosylate
	AZD1446 tosylate, also known as TC-6683, is a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. AZD1446 tosylate showed favorable pharmaceutical properties and in vivo efficacy in animal models has been identified as a potential treatment for cognitive deficits associated with psychiatric or neurological conditions and had been evaluated in phase 2 clinical trials as a treatment for Alzheimer's disease.
T70196	AZD1446 HCl
	AZD1446 HCl, also known as TC-6683, is a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. AZD1446 HCl showed favorable pharmaceutical properties and in vivo efficacy in animal models has been identified as a potential treatment for cognitive deficits associated with psychiatric or neurological conditions and had been evaluated in phase 2 clinical trials as a treatment for Alzheimer's disease.
T61348	Bradanicline
	Bradanicline is a potent and highly selective agonist of the α7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 17 nM and a Ki of 1.4 nM for the human α7 nAChR. It is primarily employed in research pertaining to cognitive disorders [1] [2].
T74673	Z-Thioprolyl-Thioproline
	Z-Thioprolyl-Thioproline 作为一种脯氨酰内肽酶 (PEP) 抑制剂（IC50=16 µM；Ki=37 µM），在牛脑中发现。该化合物主要用于神经性疾病（例如记忆障碍和认知障碍）的研究。
T73055	(S)-VQW-765 (S)-AQW-051
	(S)-VQW-765 ((S)-AQW-051)是一种α7 烟碱Ach受体(nAChR)部分激动剂，具有口服活性、选择性和有效性，能在阿尔茨海默病或精神分裂症等神经疾病相关认知障碍中展现潜在应用。
T68330	Cerlapirdine hydrochloride
	Cerlapirdine, also known as SAM-531, WAY-262,531 and PF-05212365, is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine has been in clinical development for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia. As of 2011, it is in phase II clinical trials, and has demonstrated a trend toward efficacy along with a good side effect profile and no incidence of serious adverse events. It exerts its effects by acti...
T64214	NXPZ-2
	NXPZ-2 是一种口服具有活力的 Keap1-Nrf2protein–protein interaction(PPI) 抑制剂 (Ki: 95 nM, EC50: 120 and 170 nM)。NXPZ-2 能够上调Nrf2含量，并促进其从细胞质向细胞核的易位，表现出对氧化应激的抑制作用。NXPZ-2 能够剂量依赖性地缓解 Aβ[1-42]诱导的认知紊乱，能够提高神经元数量和功能，增强阿尔茨海默病 (AD) 小鼠脑组织的病理改变情况。NXPZ-2 具有潜力进行 Keap1-Nrf2 PPI 抑制剂和 AD 相关的疾病的研究。
T35892	Q134R Q134R
	Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer’s disease (AD) and aging-related disorders research[1]. Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo...

化合物

PF-04859989 HCl

Cat.No: T28368

Synonym: PF 04859989,PF04859989,PF-04859989HCl,PF-04859989

Target: Others

Guanfacine hydrochloride

Cat.No: T2150

Synonym: 盐酸胍法辛,Tenex,Intuniv,Guanfacine

Target: Adrenergic Receptor

Cat.No: T7165

Synonym: RG1662,RO5186582,巴米沙尼

Target: GABA Receptor

Cat.No: T27462

Synonym: GSK239512,GSK 239512

Target: Histamine Receptor

H3 receptor-MO-1

Cat.No: T10499

Target: Histamine Receptor

SSR180711 hydrochloride

Cat.No: T28856

Synonym: SSR-180711A HCl,SSR-180711C HCl,SR-180711 HCl

Target: AChR

Cat.No: T0183

Synonym: CI-879,普拉西坦

Target: Others

Cat.No: T31079

Synonym: CP 810123,UNII-E6G4550EC4,CP810123

Target: AChR

Cat.No: T0426

Synonym: UCB-6215,吡拉西坦

Target: GluR, iGluR

Cat.No: T23066

Target: Dopamine Receptor

Cat.No: T14507

Synonym: BAY 607550

Target: PDE

Cat.No: T28655

Synonym: R 58735,R58735,R-58735

Target: Microtubule Associated

Cat.No: T8451

Synonym: MDL 72422

Target: 5-HT Receptor

Aminopeptidase-IN-1

Cat.No: T61278

Target: Aminopeptidase

Cat.No: T12054L

Synonym: MK-0249 FA(862309-06-6 Free base)

Target: Histamine Receptor

Cat.No: T68064

Target: CaMK

Cat.No: T30798

Synonym: PF05212365,P -05212365,SAM-531,SAM531,PF-05212365,SAM 531,WAY-262,531

Target: 5-HT Receptor

Cat.No: T26646

Synonym: AQ W051,VQW-765,AQW-051

Target: AChR

Cat.No: T16481

Target: 5-HT Receptor

Cat.No: T29043

Synonym: UCL 1972

CB1 antagonist 1

Cat.No: T10510

Target: Cannabinoid Receptor

Cat.No: T26798

Synonym: Bibn140,Bibn-140

Samelisant dihydrochloride

Cat.No: T34752

Synonym: SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl

Cat.No: T61684

AZD1446 tosylate

Cat.No: T70787

Cat.No: T70196

Cat.No: T61348

Z-Thioprolyl-Thioproline

Cat.No: T74673

Cat.No: T73055

Synonym: (S)-AQW-051

Cerlapirdine hydrochloride

Cat.No: T68330

Cat.No: T64214

Cat.No: T35892

Synonym: Q134R

Cat. No.	Product Name	Target	Signaling Pathways
T32614	L-Clausenamide (-)-Clausenamide	Microtubule Associated	Cytoskeletal Signaling
	L-Clausenamide 是从黄皮 (Clausena lansium (Lour) skeels) 的树叶中提取出来的生物碱，可用于提高认知功能。L-Clausenamide 对β-淀粉样蛋白 (Aβ) 毒性有抑制作用，通过抑制 tau 蛋白磷酸化阻止神经纤维缠结的形成。L-Clausenamide 具有神经保护活性，可用于调节 Aβ25-35 引发的刺激。L-Clausenamide 可用于研究阿尔兹海默症类的神经系统疾病。
T4439	sn-Glycero-3-phosphocholine Choline Alfoscerate,甘磷酸胆碱,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC	Endogenous Metabolite; AChE	Metabolism; Neuroscience
	sn-Glycero-3-phosphocholine (Choline glycerophosphate) 是脑磷脂生物合成的前体，能够提高胆碱在神经组织中的生物利用度。它对认知功能有显著影响，同时具有良好的耐受性和安全性，因此能够用于阿尔茨海默病和痴呆症的研究。
TN1798	Isorosmanol 异迷迭香酚	Beta Amyloid; AChR	Neuroscience
	Isorosmanol 具有抗氧化、神经保护和神经营养作用，可能用于老年性疾病，如认知功能下降和色素沉着。
T79963	Feralolide
	Feralolide是从芦荟树脂的甲醇提取物中分离出的一种二氢异香豆素。其作为AChE和BuChE的双抑制剂，具有IC50s分别为55 μg/mL和52 μg/mL。该化合物还表现出抗氧化活性，能够抑制2,2-diphenyl-1-picrylhydrazyl (DPPH) 和 2, 2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS)。在认知障碍如阿尔茨海默病的研究中，Feralolide可能应用于恢复和增强记忆功能。

天然产物

Cat.No: T32614

Synonym: (-)-Clausenamide

Target: Microtubule Associated

sn-Glycero-3-phosphocholine

Cat.No: T4439

Synonym: Choline Alfoscerate,甘磷酸胆碱,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC

Target: Endogenous Metabolite, AChE

Cat.No: TN1798

Synonym: 异迷迭香酚

Target: Beta Amyloid, AChR

Cat.No: T79963

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