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Search Results for " chemokines "

15

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13114	CCR2 antagonist 4 Teijin compound 1	CCR	Immunology/Inflammation; Microbiology/Virology
	CCR2 antagonist 4 (Teijin compound 1) 是高效的、特异性的CCR2拮抗剂，对 CCR2b 的IC50为 180 nM，抑制 MCP-1 诱导的趋化作用的 IC50为 24 nM。
T24270	KS370G KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide
	KS370G (Caffeic Acid Phenethyl Amide) 抑制 UUO 诱导的肾纤维化标志物表达。KS370G 是一种具有口服活性的降糖和心血管保护剂，可减少梗阻肾脏中胶原蛋白的沉积，并显著降低肾脏炎症趋化因子/粘附分子和单核细胞标志物的表达，改善压力过载小鼠心脏左室肥厚和功能。KS370G 可用于研究肾阻塞性肾病。
T32353	K 76 Carboxylic acid K76 Carboxylic acid,K-76 Carboxylic acid
	K 76 Carboxylic acid effectively blocks human complement from forming tumor cell chemokines.
T41086	IDR-1
	IDR-1 is an antimicrobial peptide with activity against both Gram-positive and Gram-negative bacteria. This compound modulates innate immunity to counter infections while avoiding evident toxicities. Additionally, IDR-1 exhibits anti-inflammatory and anti-infective properties, increases the levels of monocyte chemokines, and reduces the release of pro-inflammatory cytokines.
T22477	(±)-AMG 487	Others	Others
	AMG 487 is an effective and selective antagonist of chemokine receptor 3. AMG 487 inhibited CXCR3-mediated cell migration induced by three CXCR3 chemokines, IP-10, ITAC and MIG (IC50: 8, 15 and 36 nM, respectively).
T73424	GA-O-06
	GA-O-06是一种18β-Glycyrrhetinic acid衍生物，有效的抗菌及抗炎剂。它通过抑制NO、促炎细胞因子以及趋化因子来发挥抗炎效果，并对革兰氏阳性菌展现出高度的抗菌活性。
T78552	PB118
	PB118是一种新型组蛋白去乙酰化酶 6（HDAC6）抑制剂，具备穿越血脑屏障的能力，可用于AD治疗。PB118 对 HDAC6 的 IC50 为 5.6 nM。
T61621	IMMH001
	IMMH001, also known as SYL930, is an orally active compound that exhibits potent selectivity as an agonist for the S1P1 receptor, which is the sphingosine-1-phosphate receptor 1. This compound effectively reduces the levels of various chemokines and proinflammatory cytokines, such as IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 finds utility in research focused on rheumatoid arthritis (RA) [1] [2].
T73423	GA-O-02
	GA-O-02，一种18β-Glycyrrhetinic acid衍生物，具有显著的抗菌和抗炎效果。该化合物通过抑制NO、促炎细胞因子及趋化因子来发挥其抗炎作用，并对革兰氏阳性菌显示出高度的抗菌活性。
T4411	DAMGO TFA (78123-71-4(Free base))	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	DAMGO TFA (78123-71-4(Free base)) 是Mu-opioid 受体的强效选择性激动剂。它也是镇痛药。它刺激钙激活的腺苷酸环化酶相关 cAMP 的产生。通过 TGF-beta1 表达趋化因子和趋化因子受体。增加老鼠的食物摄入量。
T36623	Antileukinate
	Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutrophils (Ki = 2.7-13 μM), prevents neutrophil chemotaxis and β-glucuronidase release, and blocks IL-8-induced skin edema in rabbits. At 53 mg/kg, antileukinate has been shown to protect mice against acute pancreatitis and associated lung injury.
T81738	Murabutide
	Murabutide是一种合成的安全免疫调节剂，能够降低CD4和CCR5受体的表达，并促使β-趋化因子的高水平分泌，从而增强机体对病毒感染的非特异性防御能力。此外，Murabutide不会干扰病毒的进入过程、逆转录酶的活性或是在感染细胞的细胞质中早期前病毒DNA的形成。
T79256	DPP-4-IN-8
	DPP-4-IN-8 (compound 27) 是一种高效的选择性DPP4抑制剂，具有 0.96 μM 的 Ki。该化合物能够抑制 Caco-2 和 HepG-2 细胞中的 DPP4 二肽酶活性，并剂量依赖性地降低 TNF-α、IL-6 和 IL-1β 的表达水平[1]。
T68182	3-Hydroxykynurenamine
	3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis ...
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9,...

化合物

CCR2 antagonist 4

Cat.No: T13114

Synonym: Teijin compound 1

Target: CCR

Cat.No: T24270

Synonym: KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide

K 76 Carboxylic acid

Cat.No: T32353

Synonym: K76 Carboxylic acid,K-76 Carboxylic acid

Cat.No: T41086

Cat.No: T22477

Target: Others

Cat.No: T73424

Cat.No: T78552

Cat.No: T61621

Cat.No: T73423

DAMGO TFA (78123-71-4(Free base))

Cat.No: T4411

Target: Opioid Receptor

Cat.No: T36623

Cat.No: T81738

Cat.No: T79256

3-Hydroxykynurenamine

Cat.No: T68182

Cat.No: T37861

Cat. No.	Product Name	Target	Signaling Pathways
T17214	Valencene NSC 148969,NSC-148969,NSC148969	Others; Antioxidant; NF-κB	NF-κB; Others; oxidation-reduction
	Valencene (NSC-148969) 是一种从 Cyperus rotundus 中分离出来的倍半萜类化合物，是柑橘类水果和柑橘类衍生气味的香气成分。ValenceneValencene 具有抗过敏、抗炎、抗黑色素生成、和抗氧化活性。通过阻断 NF-κB 通路，Valencene 通过阻断 NF-κB 通路抑制 Th2 趋化因子和促炎性趋化因子的过度表达。
T9113	Myristicin Myristicine,肉豆蔻醚	IL Receptor; Anti-infection; BCL; P450; PARP; 5-HT Receptor; Caspase; GABA Receptor; NO Synthase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Myristicin (Myristicine) 是一种在香料和伞形植物中发现的天然产物。肉豆蔻素具有抗胆碱能、抗菌和肝保护作用，还具有抗炎作用，其通过钙途径抑制dsrna 刺激的巨噬细胞中的NO、细胞因子、趋化因子和生长因子。Myristicin 可以诱导细胞凋亡，其特征是改变线粒体膜电位、细胞色素c 释放、Caspase-3激活、parp 切割和DNA 断裂。
T6677	Sophocarpine	ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT	Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长，具有抗肿瘤活性。
TN5149	Tirotundin	NF-κB; COX; PPAR	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activation of NF-kappa B, thereby, the synthesis of inflammatory mediators such as cytokines and chemo
TN3983	Ergosta-7,22-dien-3-one	NO Synthase; LTR	Immunology/Inflammation
	Ergosta-7,22-dien-3-one 是一种羊毛甾烷，能够从台湾灵芝的子实体中分离得到。Ergosta-7,22-dien-3-one 具有促炎特性，它能刺激一氧化氮的产生，诱导基因的表达，并诱导 J774A.1 细胞产生 TLRs、细胞因子、趋化因子和细胞粘附分子。

天然产物

Cat.No: T17214

Synonym: NSC 148969,NSC-148969,NSC148969

Target: Others, Antioxidant, NF-κB

Cat.No: T9113

Synonym: Myristicine,肉豆蔻醚

Target: IL Receptor, Anti-infection, BCL, P450, PARP, 5-HT Receptor, Caspase, GABA Receptor, NO Synthase

Cat.No: T6677

Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT

Cat.No: TN5149

Target: NF-κB, COX, PPAR

Ergosta-7,22-dien-3-one

Cat.No: TN3983

Target: NO Synthase, LTR

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