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Search Results for " butyrylcholinesterase "

53

抑制剂 & 化合物

27

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0229	Rivastigmine SDZ-ENA 713,卡巴拉汀,S-Rivastigmine,Exelon,利凡斯的明	AChE	Neuroscience
	Rivastigmine (Exelon) 是具有口服活性的、有效的、可透过血脑屏障的胆碱酯酶抑制剂，可抑制丁酰胆碱酯酶和乙酰胆碱酯酶，IC50分别为 0.037 μM 和 4.15 μM。它是一种拟副交感神经剂或胆碱能剂，用于研究轻度至中度阿尔茨海默氏型痴呆和帕金森氏病引起的痴呆。
T1628	Rivastigmine tartrate SDZ-ENA 713,ENA 713,酒石酸卡巴拉汀	AChR; AChE	Neuroscience
	Rivastigmine tartrate (SDZ-ENA 713) 是一种具有口服活性的、可透过血脑屏障的胆碱酯酶抑制剂，能够抑制丁酰胆碱酯酶和乙酰胆碱酯酶。它是一种拟副交感神经剂或胆碱能剂，用于研究轻度至中度阿尔茨海默氏型痴呆和帕金森氏病引起的痴呆。
T23131	PE 154	AChE	Neuroscience
	PE 154是一种强效的 acetylcholinesterase (AChE) 和 butyrylcholinesterase (BChE) 荧光抑制剂，IC50 分别为 280 pM 和 16 nM。PE 154 在组织化学分析中常用来标记 β 淀粉样蛋白斑块。
T10630	BuChE-IN-TM-10 TM-10	AChR	Neuroscience
	BuChE-IN-TM-10 (TM-10) 是一种有效的丁基胆碱酯酶 (BuChE) 抑制剂，其IC50 值为8.9 nM。BuChE inhibitor 1能够抑制和分解自诱导的Aβ聚合, 表现出强大的抗氧化活性和良好的血脑屏障 (BBB) 渗透性。可用于阿尔兹海默症的研究。
T21393	Ethopropazine Hydrochloride Lysivane,Parphezein,Dibutil,Parfezin,Profenamine HCl,Pardisol
	Ethoproprazine hydrochloride is an butyrylcholinesterase inhibitor. It reduces extrapyramidal motor effects and used as an antidyskinetic, characteristic of Parkinson′s disease. It also alleviates thermal hyperalgesia in rats.
T70607	Cymserine
	Cymserine is a drug related to physostigmine, which acts as a reversible cholinesterase inhibitor, with moderate selectivity for the plasma cholinesterase enzyme butyrylcholinesterase, and relatively weaker inhibition of the better-known acetylcholinesterase enzyme.
T73187	BuChE-IN-7
	BuChE-IN-7 是一种 hBuChe 和 eqBuChE 的高选择性抑制剂，IC50分别为 40 nM、80 nM。BuChE-IN-7 能透过血脑屏障促进认知，改善了情境性与恐惧性记忆，表现出对新事物的偏好。
T38740	Rivastigmine carbamate impurity 利凡斯的明氨基甲酸酯杂质；利瓦斯的明氨基甲酸酯杂质；卡巴拉汀氨基甲酸酯杂质；利斯的明氨基甲酸酯杂质,3-Nitrophenyl ethyl(methyl)carbamate
	Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is a byproduct found in Rivastigmine, which is recognized as a powerful and orally active inhibitor of cholinesterase (ChE). Specifically, Rivastigmine effectively inhibits both butyrylcholinesterase (BChE) and acetylcholinesterase (AChE), with IC50 values of 0.037 μM and 4.15 μM, respectively.
T75145	TRV-7019
	TRV-7019，一种能穿透血脑屏障的放射性配体，用于丁酰胆碱酯酶的脑成像，适用于淀粉样蛋白病、多发性硬化症、脑肿瘤或丁酰胆碱酯酶活性的诊断。
T16814	RX 67668	Others	Others
	RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue. RX 67668 is an effective cholinesterase inhibitor (IC50: 5 μM for both acetylcholinesterase and butyrylcholinesterase). RX 67668 can reverse the neuromuscular blockade induced by D-tub
T40904	ACG548B
	ACG548B (compound 24) is a highly effective inhibitor of acetyl- and butyrylcholinesterase (AChE and BChE) with IC50 values of 1.78 and 0.496 μM, respectively. It exhibits a greater affinity for AChE and demonstrates selectivity over BChE and ChoK (choline kinase).
T30876	CHF 2819 Ganstigmine HCl,CHF-2819,Ganstigmine hydrochloride,CHF2819
	CHF 2819 is a novel orally active acetylcholinesterase inhibitor (AChE) developed for the treatment of Alzheimer's disease (AD). CHF 2819 is a selective inhibitor of AChE, it is 115 times more potent against this enzyme than against butyrylcholinesterase (BuChE).
T69495	Affinisine
	Affinisine is a monoterpenoid indole alkaloid which can be isolated from plants of the genus Tabernaemontana. It may be an effective inhibitor of both acetylcholinesterase and butyrylcholinesterase based on previous research.
T26827	Bisnorcymserine N1 N8 Bisnorcymserine,N1N8Bisnorcymserine,N1-N8-Bisnorcymserine
	Bisnorcymserine is a reversible inhibitor of butyrylcholinesterase. The leaving group, bisnoreseroline, interacts in a non-covalent way with Ser(200) and His(440), disrupting the existing interactions within the catalytic triad, and it stacks with Trp(84)
T73184	BChE-IN-15
	BChE-IN-15 是一种伪不可逆、共价BChE 抑制剂，对 hBChE 的IC50为 1.76 nM。
T61418	BuChE-IN-6
	BuChE-IN-6 (compound 1b) is a highly effective and specific inhibitor of BuChE (butyrylcholinesterase), demonstrating an IC50 value of 0.46 μM for eqBuChE and 0.51 μM for hBuChE. Furthermore, BuChE-IN-6 has the additional capability of inhibiting the self-aggregation of Aβ 42 [1].
T61342	BChE-IN-13
	BChE-IN-13 (Compound 17c) is an orally active, potent, and selective inhibitor of Butyrylcholinesterase (BChE). It exhibits IC50 values of 0.22 μM and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 demonstrates the capability to enhance memory and cognitive impairments, making it valuable for Alzheimer's disease (AD) research [1].
T61669	BChE-IN-4
	BChE-IN-4 is a highly potent inhibitor of the enzyme butyrylcholinesterase, capable of crossing the blood-brain barrier. It effectively reduces learning and memory impairments resulting from a deficiency in cholinergic activity in a mouse model. BChE-IN-4 holds promise for further investigation in the field of Alzheimer's disease research [1].
T61638	Dihydro Donepezil
	Dihydro Donepezil, also known as Dihydro E2020, is a metabolite derived from Donepezil. Donepezil is a highly specific and potent inhibitor of acetylcholinesterase (AChE) with IC50 values of 8.12 nM and 11.6 nM for butyrylcholinesterase (bAChE) and human acetylcholinesterase (hAChE), respectively [1].
T82915	BChE-IN-21
	BChE-IN-21，作为一种BChE抑制剂，表现出强效的活性，其IC50值为0.14±0.02 μM。该化合物因具备阿尔茨海默病研究潜力而备受关注。
T64156	AChE/BChE-IN-1
	AChE/BChE-IN-1 是一种有效的、具有血脑屏障通透性的乙酰胆碱酯酶 (Acetylcholinesterase) 和丁酰胆碱酯酶 (Butyrylcholinesterase) 的双重抑制剂，对hAChE 和hBChE 的IC50值分别为 1.06 和 7.3 nM，表现出抗氧化效果。AChE/BChE-IN-1 能够用于阿尔茨海默症的研究。
T61399	Z164597606
	Z164597606 is a compound that acts as a selective inhibitor of the enzyme Butyrylcholinesterase (BChE), with IC50 values of 1.3 μM and 1.7 μM for equine BChE and human BChE, respectively. Through a π-π stacking interaction, Z164597606 specifically interacts with the amino acid Trp82 of human BChE. This compound has potential applications in Alzheimer's disease research [1] [2].
T79422	BuChE-IN-8
	BuChE-IN-8 (compound 19c) 为有效抑制 BuChE 的化合物，IC50 值为 559 nM；展现对 BACE1 及 Aβ40 聚集的抑制活性，亦具有显著的抗遗忘特性。
T62336	BChE-IN-3
	BChE-IN-3 是一种选择性的、选择性的、时间依赖性的、假不可逆的 BChE 丁酰胆碱酯酶抑制剂 (IC50: 56.9 nM)。BChE-IN-3 对 AChE 乙酰胆碱酯酶表现出边缘可逆 (不依赖于时间) 的抑制作用。
T81998	K1833
	K1833是一种同时具备抑制和重激活特性的hrAChE抑制剂，其IC50值为58μM。对hrBChE亦有高度抑制活性（IC50=0.57μM），但再激活能力较弱。
T79966	AChE/BChE-IN-14
	AChE/BChE-IN-14（compound 13）是一种从多花菜根分离提取的苯基异喹啉生物碱。该化合物对乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）展现了抑制效应，并具备抗氧化性能，可作为阿尔茨海默病研究的实验材料。
T62538	AChE-IN-15
	AChE-IN-15 (Compound 3d) 是一种可逆的人乙酰胆碱酯酶 (huAChE) 和人丁酰胆碱酯酶 (huBChE) 抑制剂，对 huAChE 和 huBChE 的 IC50 值分别为 6.8 μM、16.1 μM，具有明显的抗氧化活性。AChE-IN-15 能够用于研究阿尔茨海默症。
T79548	AChE/BChE-IN-13
	AChE/BChE-IN-13 (compound 5j) 为针对AChE和BChE的双重抑制剂，其IC50分别为20.89 μM和17.37 μM，适用于阿尔茨海默病(AD)的研究。
T61603	H3R antagonist 2
	H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor antagonist. It exhibits inhibitory effects on acetylcholinesterase, butyrylcholinesterase, and human monoamine oxidase B (hMAO B) with IC50 values of 180 nM, 880 nM, and 775 nM, respectively. With a Ki of 170 nM for hH3R, H3R antagonist 2 demonstrates favorable anti-neuropathic pain and memory-enhancing effects. Additionally, it can cross the blood-brain barrier (BBB) [1].
T78905	AChE-IN-29
	AChE-IN-29，是一款3-OH 吡咯烷衍生的胆碱酯酶 (ChE) 抑制剂。针对hAChE、eeAChE及eqBChE的抑制活性表现出的IC50值分别为0.25 μM、0.23 μM和0.72 μM，可作为阿尔茨海默病研究中的实验化合物。
T74812	hBChE-IN-1
	hBChE-IN-1 (compound 4) 是一种喹啉基衍生物，是一种有效的 hBChE 抑制剂 (IC50=7 nM) 并且具有高选择性超过 hAChE。 hBChE-IN-1 对tau 和Aβ40蛋白聚集具有抑制活性，IC50值分别为 20 和 4.3 μM。 hBChE-IN-1 可用于阿尔茨海默病的研究。
T79502	PD24
	PD24是AChE和BuChE的抑制剂，表现出一定的抑制效力（hAChE IC50: 1.72 μM；eeAChE IC50: 1.76 μM；eqBuChE IC50: 2.64 μM）。该化合物还具备抗氧化性能，能有效抑制DPPH自由基（IC50: 28.72 μM）。因此，PD24适用于阿尔茨海默病相关的研究。
T39678	Multitarget AD inhibitor-1
	Multitarget AD inhibitor-1 is a reversible and selective inhibitor of butyrylcholinesterase (BuChE) with IC50 values of 7.22 μM and 1.55 μM for human BuChE (hBuChE) and equine serum BuChE (eqBuChE), respectively. Additionally, it exhibits inhibitory activity towards β-secretase (IC50 value of 41.60 μM), amyloid β aggregation (IC50 value of 3.09 μM), and tau aggregation. As a diphenylpropylamine derivative, Multitarget AD inhibitor-1 holds promise for research pertaining to the multifunctional, d...
T62578	BuChE-IN-1
	BuChE-IN-1 (Compound 23) 是一种丁酰胆碱酯酶 (BuChE) 的有效抑制剂。其中丁酰胆碱酯酶 (BuChE) 被认为是进展性阿尔茨海默病 (AD) 的生物标志物。BuChE-IN-1 具有低细胞毒性和高血脑屏障 (BBB) 渗透性。BuChE-IN-1 是一种具有潜力能够用于研究 AD 的 BuChE 抑制剂。
T79423	BuChE-IN-9
	BuChE-IN-9 (compound 22a) 作为eqBuChE的抑制剂，表现出相当的效力，具有173 nM的IC50值。除此之外，BuChE-IN-9对人BACE1、Aβ聚集及小鼠mGAT1和mGAT4也具有抑制作用，并且显示出显著的抗遗忘特性。
T78695	BChE-IN-16
	BChE-IN-16 (compound 87) 作为一种高效BChE抑制剂，展现出对hBChE的强效作用，IC50值仅为3.8 nM。该化合物具备低细胞毒性和潜在的CNS渗透能力，且因其独特适应性，适合用于阿尔茨海默病（AD）的研究。
T79501	PD10
	PD10为同时针对AChE与BuChE的抑制剂，在人脑AChE (hAChE IC50: 0.56 μM)、电鳗AChE (eeAChE IC50: 0.59 μM)、马血清BuChE (eqBuChE IC50: 1.06 μM) 均有显著抑制效果，适用于阿尔茨海默病相关研究。
T61206	AChE/BChE/BACE-1-IN-1
	AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor that targets acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1). It displays IC50 values of 0.058 μM, 0.082 μM, and 0.115 μM against hAChE, hBChE, and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 exhibits significant binding affinity with PAS-AChE, excellent ability to cross the blood-brain barrier, potential disassembly of amyloid-beta (Aβ) aggregates, and ne...
T72876	sEH/AChE-IN-4
	sEH/AChE-IN-4 -15) 是一种高效穿透血脑屏障的双重抑制剂，针对sEH(可溶性环氧水解酶)和AChE(乙酰胆碱酯酶)，IC50值分别为hsEH 3.1 nM、hAChE 1660 nM、hBChE(丁酰胆碱酯酶) 179 nM、msEH 14.5 nM 以及mAChE 102 nM。
T78828	AChE/BChE-IN-15
	AChE/BChE-IN-15 (Compound 6d) 是一种抑制剂，针对AChE/BChE的IC50值为20 nM和220 nM。该化合物能够与AChE和BChE的活性位点中的催化阴离子位点(CAS)及外周阴离子位点(PAS)相结合，适用于阿尔茨海默病的研究。
T72804	Isograndifoliol
	Isograndifoliol 是一种选择性丁酰胆碱酯酶 (BChE) 抑制剂，IC50值为 0.9 μM。Isograndifoliol 对乙酰胆碱酯酶 (AChE) 有一定的抑制作用，IC50值为 342.9 μM。Isograndifoliol 还具有血管松弛作用和抗肿瘤作用。Isograndifoliol 可用于研究神经退行性疾病引起的痴呆。
T79342	BChE-IN-17
	BChE-IN-17（compound 6n）是一种高效的BChE选择性抑制剂，对eqBChE和hBChE的IC50值为10.5 nM和32.5 nM。与AChE相比，其对BChE的选择性提高了1000倍，且表现出较低的神经毒性和中等程度的神经保护效果。
T64238	Aβ1–42 aggregation inhibitor 1
	Aβ1-42 aggregation inhibitor 1 抑制乙酰胆碱酯酶 AChE 和丁酰胆碱酯酶 BuChE 的 IC50值分别为 2.64 μM 和 1.29 μM。Aβ1-42 aggregation inhibitor 1 是一种可以自身介导的Aβ1-42聚集抑制剂，在浓度为 25 μM 抑制 51.29%。Aβ1-42 aggregation inhibitor 1 可用于抗阿尔兹海默症的研究。
T72875	sEH/AChE-IN-3
	sEH/AChE-IN-3 -15) 是一种有效的、可透过血脑屏障的 sEH(可溶性环氧水解酶)和 AChE(乙酰胆碱酯酶)的双重抑制剂，其 IC50分别为 0.4 nM (hsEH)、1.94 nM (hAChE)、615 (hBChE，丁酰胆碱酯酶)、4.3 nM (msEH) 和 2.61 nM (mAChE)。
T60983	BChE-IN-14
	BChE-IN-14 (compound 19c) 可以在体内恢复认知障碍，可用于研究阿尔茨海默症。BChE-IN-14 具有原代细胞安全性和良好的血脑屏障通透性。BChE-IN-14 是丁酰胆碱酯酶(BChE) 的选择性抑制剂，其对人BChE 和马血清BChE 的IC50值分别为 0.011 μM 和0.23μM。
T72453	AChE/BChE/MAO-B-IN-3
	AChE/BChE/MAO-B-IN-3 是一种 1-茚满酮衍生物，是一种有效的MAO-B 抑制剂，对人MAO-B 的IC50为 0.0359 μM。AChE/BChE/MAO-B-IN-3 是一种有效的AChE 和BChE 酶抑制剂，对人AChE 和BChE 酶的IC50值分别为 0.0473 μM 和 0.0782 μM。AChE/BChE/MAO-B-IN-3 显示出显着的抗氧化活性，并具有用于阿尔茨海默病 (AD) 研究的潜力。
T82242	hAChE-IN-6
	hAChE-IN-6（化合物51）是一种能够穿透血脑屏障的AChE抑制剂，具有0.16 μM的IC50。该化合物同时对hBuChE与GSK3β显示出抑制活性，其IC50分别为0.69 μM和0.26 μM。hAChE-IN-6亦能抑制tau蛋白与Aβ1-42的自聚集，适用于阿尔茨海默病（AD）的相关研究。
T62441	AChE-IN-14
	AChE-IN-14 是一种有效的胆碱酯酶抑制剂，能够作用于电鳗乙酰胆碱酯酶 (eeAChE) (IC50: 0.46 μM)、人重组乙酰胆碱酯酶 (hAChE) (IC50: 0.48 μM) 和马血清丁酰胆碱酯酶 (eqBuChE) (IC50: 0.44 μM)。AChE-IN-14 对人 H3 受体 (H3R) 的亲和力高 (Ki: 159.8 nM)。AChE-IN-14 能够用于研究阿尔茨海默病。
T62504	BChE-IN-8
	BChE-IN-8 (compound 20) 是一种能透过血脑屏障的、口服具有活力的 BChE (丁酰胆碱酯酶) 抑制剂，能够作用于 eqBChE (IC50: 0.15 nM)、hBChE (IC50: 45.2 nM)。BChE-IN-8 具有高度稳定性，有助于显著改善血液浓度和组织暴露。BChE-IN-8 能够利用胆碱能系统、Aβ 聚集、神经肽水平等多种调控机制，发挥神经保护和认知改善作用。BChE-IN-8 能够用于研究阿尔茨海默病 (AD)。
T36639	Donecopride (fumarate hydrate)
	Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E(Ki= 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50= 16 nM).1It is selective for AChE over butyrylcholinesterase (BChE; IC50= 3,530 nM) but does bind to 5-HT2Band sigma-2 (σ2) receptors (Ki= 1.6 nM for both) in a panel of 42 neurotransmitter receptors and transporters. Donecopride induces release of soluble amyloid precursor protein-α (sAPP-α) in COS-7 cells transiently expressing 5-HT4with an EC50value...

化合物

Cat.No: T0229

Synonym: SDZ-ENA 713,卡巴拉汀,S-Rivastigmine,Exelon,利凡斯的明

Target: AChE

Rivastigmine tartrate

Cat.No: T1628

Synonym: SDZ-ENA 713,ENA 713,酒石酸卡巴拉汀

Target: AChR, AChE

Cat.No: T23131

Target: AChE

Cat.No: T10630

Synonym: TM-10

Target: AChR

Ethopropazine Hydrochloride

Cat.No: T21393

Synonym: Lysivane,Parphezein,Dibutil,Parfezin,Profenamine HCl,Pardisol

Cat.No: T70607

Cat.No: T73187

Rivastigmine carbamate impurity

Cat.No: T38740

Synonym: 利凡斯的明氨基甲酸酯杂质；利瓦斯的明氨基甲酸酯杂质；卡巴拉汀氨基甲酸酯杂质；利斯的明氨基甲酸酯杂质,3-Nitrophenyl ethyl(methyl)carbamate

Cat.No: T75145

Cat.No: T16814

Target: Others

Cat.No: T40904

Cat.No: T30876

Synonym: Ganstigmine HCl,CHF-2819,Ganstigmine hydrochloride,CHF2819

Cat.No: T69495

Bisnorcymserine

Cat.No: T26827

Synonym: N1 N8 Bisnorcymserine,N1N8Bisnorcymserine,N1-N8-Bisnorcymserine

Cat.No: T73184

Cat.No: T61418

Cat.No: T61342

Cat.No: T61669

Dihydro Donepezil

Cat.No: T61638

Cat.No: T82915

Cat.No: T64156

Cat.No: T61399

Cat.No: T79422

Cat.No: T62336

Cat.No: T81998

AChE/BChE-IN-14

Cat.No: T79966

Cat.No: T62538

AChE/BChE-IN-13

Cat.No: T79548

H3R antagonist 2

Cat.No: T61603

Cat.No: T78905

Cat.No: T74812

Cat.No: T79502

Multitarget AD inhibitor-1

Cat.No: T39678

Cat.No: T62578

Cat.No: T79423

Cat.No: T78695

Cat.No: T79501

AChE/BChE/BACE-1-IN-1

Cat.No: T61206

Cat.No: T72876

AChE/BChE-IN-15

Cat.No: T78828

Isograndifoliol

Cat.No: T72804

Cat.No: T79342

Aβ1–42 aggregation inhibitor 1

Cat.No: T64238

Cat.No: T72875

Cat.No: T60983

AChE/BChE/MAO-B-IN-3

Cat.No: T72453

Cat.No: T82242

Cat.No: T62441

Cat.No: T62504

Donecopride (fumarate hydrate)

Cat.No: T36639

Cat. No.	Product Name	Target	Signaling Pathways
T3819	Ursolic acid acetate 熊果酸乙酸酯,Acetylursolic acid,3-Acetylursolic Acid	AChE	Neuroscience
	Ursolic acid acetate (Acetylursolic acid) 分离于 Ficus microcarpa 的气根中，对 KB 细胞显示细胞毒性(IC50:8.4 μM)。
TN1305	Ethoxysanguinarine 乙氧基血根碱,6-Ethoxydihydrosanguinarine	Apoptosis; AChR	Apoptosis; Neuroscience
	Ethoxysanguinarine (6-Ethoxydihydrosanguinarine) 是存在于龙葵中的一种苯并菲啶生物碱天然产物，通过抑制蛋白磷酸酶 2A，可抑制结直肠癌细胞活力，诱导细胞凋亡。
TN3466	Atherosperminine	cAMP; Calcium Channel; AChR; Parasite	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Atherosperminine 是一种天然生物碱，在体外表现出抗疟原虫活性，IC50为 5.80 μM。它具有DPPH 自由基清除活性，其IC50值为 29.56 µg/mL。它对气管有非特异性的弛缓作用。它是一种良好的还原剂，具有螯合金属的能力。
TN1341	8-Deoxygartanin 8-脱氧藤黄苷	Beta Amyloid; NF-κB; Parasite	Microbiology/Virology; Neuroscience; NF-κB
	8-Deoxygartanin 是山竹果中的异戊烯化呫吨酮。它是丁基胆碱酯酶选择性抑制剂，对阿尔茨海默病 (AD) 具有多功能活性，可能是有希望治疗 AD 的化合物。
T7052	Gnetol	Tyrosinase; COX; HDAC; AChR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience; Proteases/Proteasome
	Gnetol 是从买麻藤的根中分离出来的一种酚类。它是酪氨酸酶抑制剂，对鼠酪氨酸酶的 IC50为 4.5 μM，可抑制黑色素的生物合成。它有效抑制 COX-1和 HDAC，具有抗氧化、抗增殖、抗癌和保肝活性，还具有浓度依赖性的 α-淀粉酶、α-葡萄糖苷酶和脂肪形成活性。
T11366	Garcinol	Apoptosis; Endogenous Metabolite; Histone Acetyltransferase; AChR; AChE	Apoptosis; Chromatin/Epigenetic; Metabolism; Neuroscience
	Garcinol 是一种从印度藤黄提取的聚异戊二烯基二苯甲酮，对乙酰胆碱酯酶和丁酰胆碱酯酶具有抗胆碱酯酶的特性，IC50分别为 0.66 µM 和 7.39 µM。它还抑制组蛋白乙酰转移酶和 p300/CPB 相关因子，具有抗炎和抗癌活性。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
TN6050	Macusine B
	Macusine B is a dual inhibitor, has almost equal inhibitory activity on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).
TN4456	Lucidadiol	AChR; HSV	Microbiology/Virology; Neuroscience
	Lucidadiol exhibits butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM, it also possesses inhibitory activity against acetylcholinesterase (AChE) with the percentage inhibition at 100 uM. Lucidadiol shows antiviral activity against i
TN4613	(-)-N-methylcoclaurine N-Methylcoclaurine	Others	Others
	N-Methylcoclaurine shows binding affinities for the ĸ opioid receptor with the equilibrium dissociation constant (Ki) value of 0.9 ± 0.1 uM. N-methylcoclaurine also shows promising butyrylcholinesterase inhibition activities, with the IC50 value of 1
TN3696	Conodurine	AChR	Neuroscience
	Conodurine shows leishmanicidal and antibacterial activities, it shows inhibition activity for acetyl (AChE) and butyrylcholinesterase (BuChE).
TN3287	8-Lavandulylkaempferol	Reductase; AChR	Endocrinology/Hormones; Metabolism; Neuroscience
	8-Lavandulylkaempferol exhibits significant inhibitory effects with IC(50) values of 7.10 and 8.11 microM for butyrylcholinesterase and acetylcholinesterase, respectively. It shows inhibitory activities against aldose reductase, with the the IC50 of 0.79 microM.
T75511	BChE-IN-10
	BChE-IN-10 (compound 6)，一种从白芨 (Bletilla striata) 分离提取的丁酰胆碱酯酶 (BChE) 混合型抑制剂，具有 6.4 μM 的IC50，适用于阿尔兹海默症 (AD) 研究。
TN4570	Minumicrolin	Others	Others
	Minumicrolin is a plant growth inhibitor against the 2nd leaf sheath elongation of rice seedlings. Murrangatin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100, it might be valuable anti-tumor-promoting agents. Minumicrolin shows mild butyrylcholinesterase inhibition activity.
TN2504	1,5-Dihydroxyxanthone	EGFR; AChR	Angiogenesis; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors
	1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have anticholinesterase activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzym
T75514	Blestrin D
	Blestrin D，作为一种丁酰胆碱酯酶(BChE)的有效混合型抑制剂，具有8.1 μM的IC50值，可从白芨(Bletilla striata)中分离提取，适用于阿尔兹海默症(AD)研究。
T73202	BChE-IN-11
	BChE-IN-11 是一种有效的、选择性的、非竞争性BChE(丁基胆碱酯酶)抑制剂，其IC50为 2.1 μM。BChE-IN-11 可用于阿尔茨海默病 (AD) 的研究。
T75512	Bleformin A
	Bleformin A 是一种有效的BChE 抑制剂，其IC50值为 5.2 μM。Bleformin A 是可以从Bletilla striata 中分离得到的天然产物。Bleformin A 可用于研究阿尔茨海默病 (AD)。
T4700	1,3,5-Trihydroxy-4-prenylxanthone
	1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 valu
T79973	Dehydrodiscretamine chloride
	Dehydrodiscretamine chloride作为AChE和BChE的双重抑制剂，展现了其抑制效力，其中对AChE的IC50为17.8 μM，对BChE的IC50为118.8 μM。此外，该化合物具备抗氧化活性，并可被应用于阿尔茨海默病相关研究。
TN1848	Kuwanon E 桑黄酮 E,桑皮酮 E,5'-[(E)-3,7-二甲基-2,6-辛二烯基]-2',4',5,7-四羟基黄烷酮	AChR	Neuroscience
	Kuwanon E inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, respectively. Kuwanon E also inh
T75513	BChE-IN-12
	BChE-IN-12 (compound 12) 为一种高效BChE非竞争性抑制剂，其IC50值为2.3 μM。该化合物可从白芨(Bletilla striata)中分离提取，适用于阿尔兹海默症(AD)的研究。
TN3744	Cyclomorusin	NOS; AChR	Immunology/Inflammation; Neuroscience
	Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion generation in fMLP-stimulated rat neutrophils. Cyclomorusin , neocyclomorusin
T75544	AChE/BChE-IN-11
	AChE/BChE-IN-11 (compound 1) 是一种有效的 AChE 和 BChE 双重抑制剂，AChE 和BChE 的IC50值为分别为 70 和 71 μM。AChE/BChE-IN-11 是一种天然产物，可以从朝鲜蓟叶中分离得到。AChE/BChE-IN-11 可用于阿尔茨海默病 (AD) 研究。
TC0022	Desoxypeganine Deoxypeganine	AChE	Neuroscience
	Desoxypeganine (Deoxypeganine) 是胆碱酯酶的抑制剂。它优先作用于丁酰胆碱酯酶，作为单胺氧化酶 A 而不是单胺氧化酶 B 的选择性抑制剂。它在酒精滥用的药理学治疗中的潜在用途，以减少酒精滥用者的渴望和抑郁，并且也可能有用作为戒烟辅助。
T79963	Feralolide
	Feralolide是从芦荟树脂的甲醇提取物中分离出的一种二氢异香豆素。其作为AChE和BuChE的双抑制剂，具有IC50s分别为55 μg/mL和52 μg/mL。该化合物还表现出抗氧化活性，能够抑制2,2-diphenyl-1-picrylhydrazyl (DPPH) 和 2, 2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS)。在认知障碍如阿尔茨海默病的研究中，Feralolide可能应用于恢复和增强记忆功能。
T75436	Jatrorrhizine hydroxide
	Jatrorrhizine hydroxide, 一种从黄连中提取的生物碱，展现了神经保护、抗菌、抗疟原虫及抗氧化的活性。作为一种高效的乙酰胆碱酯酶(AChE)抑制剂(IC50=872 nM)，其对BuChE的选择性高达115倍。此外，Jatrorrhizine hydroxide还能通过抑制uptake-2 transporter活性来减少血清素(5-HT)和去甲肾上腺素(NE)的摄取，表现出口服活性。

天然产物

Ursolic acid acetate

Cat.No: T3819

Synonym: 熊果酸乙酸酯,Acetylursolic acid,3-Acetylursolic Acid

Target: AChE

Ethoxysanguinarine

Cat.No: TN1305

Synonym: 乙氧基血根碱,6-Ethoxydihydrosanguinarine

Target: Apoptosis, AChR

Atherosperminine

Cat.No: TN3466

Target: cAMP, Calcium Channel, AChR, Parasite

8-Deoxygartanin

Cat.No: TN1341

Synonym: 8-脱氧藤黄苷

Target: Beta Amyloid, NF-κB, Parasite

Cat.No: T7052

Target: Tyrosinase, COX, HDAC, AChR

Cat.No: T11366

Target: Apoptosis, Endogenous Metabolite, Histone Acetyltransferase, AChR, AChE

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Cat.No: TN6050

Cat.No: TN4456

Target: AChR, HSV

(-)-N-methylcoclaurine

Cat.No: TN4613

Synonym: N-Methylcoclaurine

Target: Others

Cat.No: TN3696

Target: AChR

8-Lavandulylkaempferol

Cat.No: TN3287

Target: Reductase, AChR

Cat.No: T75511

Cat.No: TN4570

Target: Others

1,5-Dihydroxyxanthone

Cat.No: TN2504

Target: EGFR, AChR

Cat.No: T75514

Cat.No: T73202

Cat.No: T75512

1,3,5-Trihydroxy-4-prenylxanthone

Cat.No: T4700

Dehydrodiscretamine chloride

Cat.No: T79973

Cat.No: TN1848

Synonym: 桑黄酮 E,桑皮酮 E,5'-[(E)-3,7-二甲基-2,6-辛二烯基]-2',4',5,7-四羟基黄烷酮

Target: AChR

Cat.No: T75513

Cat.No: TN3744

Target: NOS, AChR

AChE/BChE-IN-11

Cat.No: T75544

Cat.No: TC0022

Synonym: Deoxypeganine

Target: AChE

Cat.No: T79963

Jatrorrhizine hydroxide

Cat.No: T75436

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