45
10
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4985 |
Neticonazole Hydrochloride
|
Antifungal | Microbiology/Virology |
Neticonazole hydrochloride 是一种咪唑衍生物,具有抗感染和抗癌作用。它也是一种长效抗真菌剂。 | |||
T35427 |
β-Lactamase-IN-2
|
Antibacterial | Microbiology/Virology |
β-Lactamase-IN-2 是 β-内酰胺酶的有效抑制剂。β-Lactamase-IN-2显示出抗菌活性。 | |||
T1647 |
Ronidazole
洛硝哒唑,Ronidazol,罗硝唑,Ridzol |
Antibacterial; Antibiotic; Parasite | Microbiology/Virology |
Ronidazole (Ronidazol) 是一种口服有效的抗原虫和抗菌试剂。它在猫模型中对胎儿三毛滴虫有效,还可研究组织口癣和猪痢疾。 | |||
T31482 |
Diloxanide
Diloxanid,RD 3803,RD3803,RD-3803,Diloxanida,二氯尼特 |
Parasite | Microbiology/Virology |
Diloxanide (RD3803) 是一种抗原虫制剂,可研究组织学内阿米巴原虫或者其他原虫感染引起的无症状肠道阿米巴病。它是一种活性的鲁米那抗阿米巴试剂,是由其前药二氯尼特糠酸酯在胃肠道中水解得来的。 | |||
T24178 |
Isatoribine
Isatoribine free base,ANA 245,Immusine,ANA-245,Isatoribine,Isatoribine monohydrate,ANA245 |
HCV Protease; TLR | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Isatoribine(ANA245) free base 是一种有效的 TLR7 受体激动剂,具有抗丙型肝炎病毒感染活性,可用于研究HCV感染。 | |||
T16914 |
SP187
UV4,MON-DNJ |
Others; Virus Protease; Influenza Virus | Microbiology/Virology; Others |
SP187 (MON-DNJ) 是一种靶向作用于宿主的亚氨基糖。它具有抗丝状病毒感染活性。SP187可用于治疗抗流感和登革热病毒。 | |||
T15210 |
Elsulfavirine
Elpida,VM-1500 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Elsulfavirine (VM-1500) 是一种 HIV-1 感染的逆转录酶抑制剂,也是抗 HIV 的新药。 | |||
T8238 |
Fosamprenavir Calcium Salt
福沙那伟钙,Diallyl Trisulfide,GW433908G |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Fosamprenavir Calcium Salt (GW433908G) 是抗逆转录病毒蛋白酶抑制剂 Amprenavir 的磷酸酯前药,具有改善的溶解性和抗HIV 感染作用。 | |||
T2239L |
Raltegravir
雷特格韦,MK-0518 |
HIV Protease; Integrase | Microbiology/Virology; Proteases/Proteasome |
Raltegravir (MK-0518) 是一种HIV 整合酶抑制剂。 | |||
T26987 |
CF-1743
CF1743 |
HSV | Microbiology/Virology |
CF-1743 是一种抗水痘带状疱疹病毒核苷,可抑制 VZV 复制。 CF-1743可用于水痘和带状疱疹感染的研究。 | |||
T41249 |
Tenofovir alafenamide fumarate
GS-7340 fumarate |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Tenofovir alafenamide fumarate (GS-7340 fumarate) 是一种可口服的 Tenofovir 前体化合物。Tenofovir alafenamide fumarate 具有抗 HIV 活性,可用于预防 HIV 感染。 | |||
T79906 |
ADS032
BT-032 |
NOD | Immunology/Inflammation; NF-κB |
ADS032 (BT-032)是一种 NLRP1和 NLRP3 抑制剂,具有抗炎活性,抑制 NLRP1和NLRP3 的激活,抑制 Nigericin 引起的IL-1β产生,可用于研究呼吸道炎症或感染。 | |||
T8736 |
Cidofovir dihydrate
HPMPC,(S)-HPMPC,GS 0504,西多福韦二水合物 |
Others | Others |
Cidofovir dihydrate (HPMPC) 是注射型巨细胞病毒 DNA 聚合酶抑制剂,通过选择性抑制病毒 DNA 聚合酶来抑制 CMV 复制,从而阻止病毒复制和转录。 | |||
T60440 |
Antiviral agent 17
|
||
Antiviral agent 17 (Compound 4) 是一种抗感染剂,在人类复制子试验中显著保留其抗病毒作用,EC50值为0.015 μM。Antiviral agent 17 对小鼠诺如病毒(MNV)表现出良好的抗病毒活性。Antiviral agent 17 在研究传染性和恶性疾病方面具有潜力。 | |||
T60540 |
Netivudine
|
||
Netivudine 是一种有效的核苷类逆转录酶抑制剂(NRTIs),是一种核苷类似物,具有抗水痘带状疱疹病毒活性,可用于治疗人类免疫缺陷病毒(HIV)感染。Netivudine 通过抑制逆转录酶起作用,通过抑制作用减少体内的病毒载量,减缓疾病的进展。 | |||
T0920 |
Ambroxol
氨溴索,氨溴索碱,Ambroxolum,NA-872 |
P450; Autophagy | Autophagy; Metabolism |
Ambroxol (NA-872) 是前药溴己辛的活性代谢产物,是一种分泌溶解剂,具有强效祛痰作用,用于治疗与粘液或过多粘液相关的呼吸道疾病。它可诱导肺组织细胞自噬,有用于帕金森氏病和神经性戈谢病的研究潜力。它是一种葡糖脑苷脂酶伴侣,可增加葡糖脑苷脂酶的活性。 | |||
T25136 |
Aztreonam lysine
Corus 1020,Corus1020,Corus-1020,Aztreonam lysinate |
||
Aztreonam lysine is an inhaled anti-pseudomonal treatment for people who have pulmonary Pseudomonas aeruginosa infection with cystic fibrosis (CF). | |||
T15110 | DHQZ 36 | Others | Others |
DHQZ 36 is a potent retrograde trafficking inhibitor. It has potent anti-parasite activity. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages (EC50: 13.63 μM). | |||
T14488 |
Azt-pmap
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
AZT-PMPA, an aryl phosphate derivative of AZT and a nucleoside analogue, demonstrates anti-HIV activity[1]. As a nucleoside reverse transcriptase inhibitor (NRTI), AZT-PMPA targets HIV infection effectively[2]. | |||
T13281 |
Valopicitabine
NM283 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic HCV infection. | |||
T61824 |
NIOCH 14
|
||
NIOCH 14 is an antiviral agent and pro-drug with demonstrated potency against orthopoxviruses. It exhibits significant efficacy in reducing infection rates and lung viral load in mice. NIOCH 14 is particularly useful for anti-smallpox research [1] [2], as it displays marked anti-orthopoxvirus activity. | |||
T33282 |
Memotine HCl
UK-237101,UK-2371,UK 237101,UK 2371,UK2371 |
||
Memotine HCl has antiviral activity against respiratory tract infection and is used as a therapeutic agent for acute respiratory diseases. It is also a memo fracture in the form of hydrochloride, an isoquinoline, with anti-myxovirus and paramyxovirus acti | |||
T36653 | Anti-SARS-80R mAb | ||
Anti-SARS-80R mAb (SARS-80R) is a human IgG1 monoclonal antibody that is derived from CHO cells. Its main function is to selectively bind to the Spike (S1) protein, effectively preventing the infection of susceptible cells by the SARS virus[1]. | |||
T39816 |
Ceftaroline fosamil inner salt
TAK-599 free acid,PPI0903freeacid |
||
Ceftaroline fosamil (TAK-599) inner salt, a cephalosporin derivative, is an N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) T-91825. Ceftaroline fosamil inner salt can be used for the research of MRSA infection. | |||
T61158 | Anti-infective agent 5 | ||
Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi exhibiting an IC50 value of 0.10 μM. In addition to its potent inhibitory effect, anti-infective agent 5 demonstrates efficacy in reducing parasite burden in vivo. Consequently, this compound holds promising potential for research pertaining to infection. [1] | |||
T69250 |
JMX0312
|
||
JMX0312 is a salicylamide derivative used as a potent inhibitor of HAdV infection. JMX0312 showed significantly improved anti-HAdV activities with nanomolar to submicromolar IC50 values and high selectivity indexes (SI > 100), indicating better safety windows, compared to those of the lead compound niclosamide. | |||
T61606 |
Indomethacin sodium
|
||
Indomethacin sodium, a powerful and orally active inhibitor of COX1/2, exhibits IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Apart from its potent anti-inflammatory effects, this compound possesses notable anticancer and anti-infective activities. Since it has such versatile attributes, it finds useful applicability in cancer, inflammation, and viral infection research [1] [2] [3]. | |||
T4555 |
Fosamprenavir
GW 433908,福沙那韦,Amprenavir phosphate |
||
Fosamprenavir (Amprenavir phosphate; GW 433908) 是抗逆转录病毒蛋白酶抑制剂 Amprenavir 的磷酸酯前药,与母体分子相比具有更高的溶解度。具有抗HIV 感染作用。 | |||
T75300 | Cefazolin sodium pentahydrate | ||
Cefazolin sodium pentahydrate 是一代头孢菌素类抗生素,可用于多种细菌感染的研究。Cefazolin sodium pentahydrate 具有抗炎作用,可以减轻术后认知功能障碍 (POCD)。 | |||
T60876 | HOE961 | ||
HOE961 是 S2242 的二乙酸酯前药,具有抗正痘病毒活性。HOE961 在感染模型中具有口服活性。HOE961 对呼吸道牛痘病毒感染具有活性。 | |||
T60673 |
Antiviral agent 18
|
||
Antiviral agent 18 (Compound 5) 对鼠诺如病毒显示出良好的抗病毒活性。Antiviral agent 18 是一种抗感染剂,具有用于传染性和恶性疾病的研究潜力。 | |||
T70859 |
ent-Abacavir
|
||
ent-Abacavir is an enatiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuroni... | |||
T79238 |
SDH-IN-3
|
Antibiotic | Microbiology/Virology |
SDH-IN-3,作为一种琥珀酸脱氢酶(SDH)抑制剂,其IC50为7.6 μg/mL。该化合物对Nigrospora oryzae显示出高效的抗真菌活性,具有EC50值1.9 μg/mL,适用于抗感染研究领域。 | |||
T78113 |
Tylvalosin
Acetylisovaleryltylosin |
Antibiotic | Microbiology/Virology |
Tylvalosin (Acetylisovaleryltylosin) 是一种具有抗菌和抗病毒特性的广谱大环内酯抗生素。它能够诱导细胞凋亡(apoptosis)、展现抗炎效果、缓解氧化应激,并通过抑制NF-κB的激活减轻急性肺损伤。此外,Tylvalosin 在研究PRRSV感染方面作为抗病毒试剂亦被应用。 | |||
T36655 | Anti-Spike-RBD mAb | ||
Anti-Spike-RBD mAb is a CHO cell derived human monoclonal IgG1 antibody. Blocking the interaction of spike protein and ACE2 is a potential therapeutic approach for SARS-CoV-2 treatment[1]. [1]. Chunyan Wang, et al. A Human Monoclonal Antibody Blocking SARS-CoV-2 Infection. Nat Commun. 2020 May 4;11(1):2251. | |||
T60292 | Ibuprofen sodium | ||
Ibuprofen ((±)-Ibuprofen) sodium 是一种口服活性的选择性COX-1抑制剂,IC50值为 13 μM。Ibuprofen sodium 抑制细胞增殖、血管生成,并诱导细胞凋亡 (apoptosis)。Ibuprofen sodium 是一种非甾体抗炎剂和一氧化氮 (NO) 供体。Ibuprofen sodium 可用于疼痛、肿胀、炎症、感染、免疫学、癌症的研究。 | |||
T69081 | KRH-1636 | ||
KRH-1636 is an orally active, selective and extremely potent CXC chemokine receptor 4 antagonist. KRH-1636 exhibits a potent and selective anti-HIV-1 activity. KRH-1636 efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXC chemokine receptor (CXCR)4 coreceptor but not via CC chemokine receptor 5. KRH-1636 also inhibits binding of the CXC chem... | |||
T79567 |
Antiviral agent 35
|
Influenza Virus | Microbiology/Virology |
Antiviralagent 35 (compound 4d) 作为一种口服抗流感病毒药物,针对流感病毒复制的早期阶段有效。该化合物能够阻断流感病毒引发的ROS积聚、自噬及细胞凋亡,同时在肺部感染的小鼠模型中,抑制RIG-1通路所介导的炎症响应。Antiviralagent 35展现出低细胞毒性(CC50>800 μM,MDCK细胞)且对H1N1(A/Weiss/43)展现出显著的抗病毒活性,EC50为2.28 μM。 | |||
T14493 |
Balapiravir
R1626,Ro 4588161 |
Others | Others |
Balapiravir (R1626, Ro 4588161) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479). IC50 Value: Target: HCV Balapiravir was discontinued for safety reasons in 28-36% of patients (m | |||
T37295 |
Ganglioside GM1 Asialo Mixture
|
||
Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive na... | |||
T79735 |
DHFR-IN-9
|
||
DHFR-IN-9(化合物8A)是一种二氢叶酸还原酶(DHFR)抑制剂,通过干扰细胞内嘌呤和胸苷酸的生物合成而影响细胞生长和增殖。该化合物对抗耐甲氧西林金黄色葡萄球菌(MRSA)ATCC 43300展现出显著的抑制效果(IC50=0.25 μg/mL),并在全身及大腿感染的小鼠模型中显示出抗感染能力(剂量:2.5 mg/kg,5 mg/kg;ip)。此外,DHFR-IN-9在乳腺癌小鼠模型中展示了超过紫杉醇(Y-B0015)的抗癌活性(剂量:2.5 mg/kg;ip;每3天1次)。 | |||
T35802 |
ML-345
|
||
Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer's disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. [2] It de... | |||
T64692 |
AMY-101 acetate
|
||
Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exerting direct effector functions, and helping to coordinate downstream immune responses[3]. In C3-/- mice alcohol-induced liver steatosis is absent or strongly reduced after chronic or acute alcohol exposure. This suggests that the complement system and its component C3 contribute... | |||
T38009 |
Kocurin
|
||
Kocurin is a thiazolyl peptide originally isolated fromK. palustrisand has antibiotic activity.1It is active against methicillin-resistantS. aureus(MRSA; MIC = 0.25 μg/ml), as well asB. subtilisandE. faeciumin a solid agar test when used at a concentration of 8 μg/ml. Kocurin is also active againstE. faecium,E. faecalis,S. epidermidis, and clinical isolates of vancomycin-resistant enterococci (MICs = 0.004-1.025 μg/ml).2In vivo, kocurin (2.5, 5, and 10 mg/ml) increases survival in a mouse model ... | |||
T38174 | Mpro inhibitor N3 hemihydrate | ||
Mpro inhibitor N3 hemihydrate is a potent inhibitor of SARS-CoV-2 Mpro with an EC50 of 16.77 μM for SARS-CoV-2. Mpro inhibitor N3 hemihydrate specifically inhibits Mpro from multiple coronaviruses, including SARS-CoV and MERS-CoV. Mpro inhibitor N3 hemihydrate displays inhibition against HCoV-229E, FIPV, and MHV-A59 with individual IC50 of 4.0 μM, 8.8 μM, and 2.7 μM, respectively[1][2]. Mpro inhibitor N3 hemihydrate (0-0.64 μM) is able to penetrate cells to inhibit the replication of IBV viruses... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0974 |
Novobiocin Sodium
Albamycinsodium,新生霉素钠,Cathomycin,Albamycin |
Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy | Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology |
Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。 它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。 | |||
TN2111 |
Prunin
Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷 |
Phosphatase; Anti-infection; Virus Protease | Metabolism; Microbiology/Virology |
Prunin (Naringenin 7-0-glucoside) 是一种人肠道病毒 A71 抑制剂。它抑制蛋白酪氨酸磷酸酶 1B,IC50值为 5.5 μM。 | |||
T0956 |
Avermectin B1
Avermectin B1a-Avermectin B1b mixt.,Abamectin,阿维菌素 |
Antibiotic; Parasite; Autophagy | Autophagy; Microbiology/Virology |
Avermectin B1 是驱虫杀虫剂。 | |||
TN3500 |
beta-Amyrone
β-Amyron,β-香树脂酮 |
COX; AChR; PPAR; Antifection | DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience |
beta-Amyrone (β-Amyron) 对基孔肯雅病毒复制具有抗真菌活性,EC50 为 86 uM。 beta-Amyrone 通过抑制 COX-2 的表达而具有抗炎活性。 beta-Amyrone 表现出抗α-葡萄糖苷酶抑制活性和中等 AChE 活性。 β-Amyrone 可用于炎症、感染和肥胖等疾病的研究。 | |||
TN1877 |
Lonicerin
忍冬苦苷,金银花 |
Apoptosis; Antibacterial | Apoptosis; Microbiology/Virology |
Lonicerin 是一种抗藻酸盐分泌蛋白的黄酮类化合物,对铜绿假单胞菌有抑制作用。它可预防脂多糖诱导的急性肺损伤的炎症和细胞凋亡。 | |||
T3667 |
Kalii Dehydrographolidi Succinas
Ddhads,穿琥宁,Dehydroandrographolide Succinate Potasium Salt |
Others | Others |
Kalii Dehydrographolidi Succinas (Dehydroandrographolide Succinate Potasium Salt) 从中药穿心莲中提取得到,具有免疫刺激、抗感染和抗炎作用,对病毒性肺炎和病毒性上呼吸道感染具有潜在的研究价值。 | |||
T8716 |
physalin F
酸浆苦味素F,酸浆苦素 F |
Apoptosis | Apoptosis |
Physalin F 是一种分泌型甾体,诱导人外周血单个核细胞凋亡,降低人 T 淋巴细胞 1 型病毒感染后的自发增殖和细胞因子的产生,具有强烈抗炎和免疫调节作用。 | |||
T37876 | Fengycin | ||
Fengycin is a cyclic lipopeptide used as an agricultural fungicide. Fengmycin has an anti-fungal infection effect by damaging the target’s cell membrane[1]. [1]. Sreyoshi Sur, et al. Selectivity and Mechanism of Fengycin, an Antimicrobial Lipopeptide, from Molecular Dynamics. J Phys Chem B. 2018 Mar 1;122(8):2219-2226. | |||
T11895 |
Luteolin-7-rutinoside
|
Others | Others |
Luteolin-7-rutinoside has both antifungal activities and anti-arthritic, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection. | |||
T75555 | (6E,12E)-Tetradecadiene-8,10-diyne-1,3-diol | ||
'(6E,12E)-Tetradecadiene-8,10-diyne-1,3-diol' 是从白术根中分离出的一种具有抗菌活性的化合物,对 MRSA 显示出 4 - 32 μg/mL 的最小抑菌浓度(MIC),表现出对抗性细菌感染研究的潜力。 |