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Cat. No. | Product Name | Target | Signaling Pathways |
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T23550 |
YM-750
YM 750 |
Acyltransferase | Metabolism |
YM-750 是一种有效的酰基:胆固醇酰基转移酶(ACAT)抑制剂,IC50为0.18 μM。 | |||
T1781 |
GW9508
GW 9508 |
GPR; Potassium Channel | Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel |
GW 9508 是一种选择性 G 蛋白偶联受体FFA1(GPR40) 和GPR120激动剂。它是一种葡萄糖敏感性胰岛素促分泌剂和 ATP 敏感性钾通道开放剂,具有抗炎和抗动脉粥样硬化活性。 | |||
T0686 |
Orlistat
Ro-18-0647,奥利司他,Tetrahydrolipstatin |
Apoptosis; Others; Fatty Acid Synthase | Apoptosis; Metabolism; Others |
Orlistat (Tetrahydrolipstatin) 是一种不可逆的胰腺和胃脂肪酶抑制剂,也是一种脂肪酸合成酶抑制剂,可研究肥胖症,具有抗动脉粥样硬化作用。 | |||
T10063 |
LDL-IN-3
|
Antioxidant | oxidation-reduction |
LDL-IN-3 具有抗动脉粥样硬化和抗氧化活性。 | |||
T12981 |
SP-8356
|
Autophagy | Autophagy |
SP-8356 是一种有效的、口服活性的分化簇 147 (CD147) 抑制剂,具有抗动脉粥样硬化作用。 | |||
T12848 |
SB-657510
|
Others; Neurotensin Receptor | GPCR/G Protein; Others |
SB-657510 是 urotensin II (UII) receptor (UT) 拮抗剂。 对于人,猴,猫,大鼠和小鼠的UT 的 Ki 值分别为 61、17、30、65 和 56 nM。SB-657510 通过抑制 UII 诱导的人类血管内皮细胞中炎性介质,如粘附分子,使细胞因子和组织因子上调从而发挥抗炎作用。SB 657510对糖尿病小鼠模型中糖尿病相关动脉粥样硬化疾病具有治疗作用。 | |||
T24592 |
Pamaqueside
CP-148,623,CP 148623,L 165313,L165313,L-165313 |
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Pamaqueside is an anti-atherosclerotic agent. | |||
T28290 |
Pactimibe
CS 505,CS-505,CS505,Pactimibe free base,帕替麦布 |
||
Pactimibe is a ACAT inhibitor. It has anti-atherosclerotic activity. | |||
T32028 |
GYKI-14451 sulfate
GYKI14451,GYKI14,451,GYKI-14451,GYKI 14451,GYKI 14,451,GYKI-14,451 |
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GYKI-14451 (LY-178207) is a synthetic thrombin tripeptide inhibitor with anti-atherosclerotic activity. | |||
T30917 |
CI 924
EINECS 279-174-7,CI-924,CI924 |
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CI 924 is a lipid-lowering drug. CI 924 increased anti-atherosclerotic HDL and decreased VLDL at 600 mg/day. | |||
T7072 |
Pitavastatin
|
||
Pitavastatin (NK-104) 是有效的羟甲基戊二酰-CoA(HMG-CoA)还原酶抑制剂。Pitavastatin 抑制乙酸合成胆固醇,在 HepG2 细胞中的IC50为 5.8 nM。Pitavastatin 是一种高效的肝细胞低密度脂蛋白胆固醇 (LDL-C) 受体诱导剂。Pitavastatin 具有抗动脉粥样硬化、抗哮喘、抗骨关节炎、抗肿瘤、神经保护、肝保护和肾保护等作用。 | |||
T35578 |
Phosphatidylserines (sodium salt)
Phosphatidylserines (sodium salt),L-α-Phosphatidylserine |
||
Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum (ER) and can be reversibly converted back by the same enzymes. It can also be irre... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2901 |
Daidzin
NPI-031D,大豆苷,Daidzein 7-O-glucoside,Daidzoside,黄豆苷,Daidzein 7-glucoside |
Dehydrogenase; Reverse Transcriptase; Mitochondrial Metabolism | Metabolism; Microbiology/Virology |
Daidzin (Daidzoside) 是从大豆中分离出来的一种异黄酮,具有抗氧化、抗癌和抗动脉粥样硬化的活性。 | |||
T10584 |
Bovinic acid
(9Z,11E)-Octadecadienoic acid,Rumenic acid |
Endogenous Metabolite | Metabolism |
Bovinic acid ((9Z,11E)-Octadecadienoic acid) 是一种具有抗癌和抗动脉硬化的活性的共轭亚油酸,可用于研究老年冠心病和肥胖。 | |||
T1082 |
Benzyl isothiocyanate
Benzoylthiocarbimide,苄基异硫氰酸酯,异硫氰酸苯甲酯,Isothiocyanic Acid Benzoyl Ester |
Apoptosis; Antibacterial; Antibiotic | Apoptosis; Microbiology/Virology |
Benzyl isothiocyanate (Benzoylthiocarbimide) 是一种具有杀菌活性的天然异硫氰酸酯,最初存在于十字花科蔬菜中。 它显示出免疫调节、抗寄生虫、抗生素、抗氧化、抗动脉粥样硬化、抗血管生成、抗转移、抗癌化疗和化学预防活性。 | |||
T8189 |
Dihydroberberine
|
Potassium Channel; HSP; HER | Angiogenesis; Cytoskeletal Signaling; JAK/STAT signaling; Membrane transporter/Ion channel; Metabolism; Tyrosine Kinase/Adaptors |
Dihydroberberine 可抑制人类 ether-a-go-go 相关基因 (hERG) 通道并显着降低 Hsp90 表达及其与 hERG 的相互作用,具有抗动脉粥样硬化、抗炎、降血脂和抗肿瘤活性。 | |||
T3S0364 |
L-Arginine
L-精氨酸,L-Arg,(S)-(+)-Arginine |
IL Receptor; Endogenous Metabolite; NO Synthase | Immunology/Inflammation; Metabolism |
L-Arginine (L-Arg) 是内皮型一氧化氮合酶(eNOS) 的底物。L-Arginine 通过阳离子氨基酸转运体家族转运到血管平滑肌细胞,并被代谢成一氧化氮、多胺或 L-脯氨酸。 | |||
TN1711 |
Gossypetin
|
Antioxidant; p38 MAPK; MAPK; Antibacterial | MAPK; Microbiology/Virology; oxidation-reduction |
Gossypetin 是一种可从Rhodiola rosea Linn.中提取的六羟基化的类黄酮,是一种有效的 MKK3 和 MKK6 抑制剂,可强烈减弱 MKK3/6-p38 信号传导途径。Gossypetin 具有抗突变、抗动脉粥样硬化、抗氧化以及细胞保护和抗菌作用,它通过下调溶酶体酪蛋白酶 K 的活性和诱导肌动蛋白环破骨细胞中的自噬相关蛋白来抑制骨吸收。 | |||
TN2075 |
Pimaric acid
|
MMP; p38 MAPK; NF-κB | MAPK; NF-κB; Proteases/Proteasome |
Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced human aortic smooth muscle cells. | |||
T35577 |
Phosphatidylserines (bovine)
|
||
Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversi... |