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35

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4505	Ferrous Bisglycinate Bisglycine iron(II) salt,Iron(II) bisglycinate,甘氨酸亚铁	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Ferrous Bisglycinate (Bisglycine iron(II) salt) 是口服具有活力的铁强化剂剂补充剂。它可用于研究缺铁性贫血。
T8132	Iron sucrose Iron saccharate,蔗糖铁,Sucroferric oxyhydroxide	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Iron sucrose (Sucroferric oxyhydroxide) 是一种静脉注射铁制剂，也是一种促氧化剂，可用于研究缺铁性贫血。
T13692	Ferric maltol Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate,麦芽酚铁	Others	Others
	Ferric maltol (Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate) 是一种具有口服活性的单一铁离子 (Fe3+) 复合物，可用于研究炎症性肠病缺铁性贫血。
T7606	Guanosine 5'-diphosphate disodium salt 5'-二磷酸鸟苷二钠,5'-GDP-Na2,鸟苷-5'-二磷酸二钠盐	Endogenous Metabolite	Metabolism
	Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) 是一种核苷二磷酸。它是一种潜在的铁动员剂，能够阻断铁调素-铁转运蛋白相互作用，也可以调节白 IL-6/stat-3 途径。
T25702	Levovirin ICN 17261,L-Ribavirin,ICN-17261,ICN17261
	Levovirin is a monocyclic L-nucleosides with type 1 cytokine-inducing activity. Levovirin is the L-enantiomer of Ribavirin. Levovirin has similar immunomodulatory activity but does not have direct antiviral activity or hemolytic anemia.
T77595	H3B-8800	Others	Others
	H3B-8800是一种SF3B1调节剂，可用于研究输血依赖性贫血。
T61144	Hepcidin antagonist-1	Others	Others
	Hepcidin antagonist-1 是一种铁调素拮抗剂。Hepcidin antagonist-1 可用于研究像缺铁疾病和贫血类的代谢紊乱。
T77726	INCB-000928	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	Zilurgisertib (INCB-000928）是一种具有选择性和有效性的 ALK 2 抑制剂，用于研究癌症和 MF 贫血。
T15219	Enarodustat JTZ-951	Others; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Others
	Enarodustat (JTZ-951) 是口服具有活力的 hypoxia-inducible factor prolyl hydroxylase 抑制剂，EC50=0.22 μM，有用于肾性贫血症的研究潜力。
T40823	NCGC00029283	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom syndrome protein helicase (BLM) and Fanconi anemia group J protein helicase (FANCJ) with IC 50 values of 12.5 μM and 3.4 μM, respectively.
T15422	GSK-626616	DYRK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	GSK-626616 是一种口服具有活力的 DYRK3抑制剂 (IC50:0.7 nM)。它以相似的效力抑制 DYRK 家族的其他成员，可用于研究贫血。
T13730	Hydroxocobalamin acetate	Others	Others
	Hydroxocobalamin acetate 是可注射的天然维生素 B12，其不良反应特征良好，可用于研究维生素 B12 缺乏症 (包括恶性贫血) 。
T39520	Vamifeport VIT-2763	Ferroptosis	Apoptosis
	Vamifeport (VIT-2763) 是一种新型具有口服活性且靶向铁转运蛋白的抑制剂，可降低 SCD Townes 模型中的溶血标志物。VIT-2763 可改善贫血和红细胞生成，可改善血管炎症，可研究 β-地中海贫血。
T1386	Phenazopyridine hydrochloride Urodine,Pyridium,Phenazopyridine HCl,盐酸非那吡啶	Sodium Channel	Membrane transporter/Ion channel
	Phenazopyridine hydrochloride (Pyridium) 是一种具有局部止痛作用的化学物质，常被用于缓解手术、损伤尿道及尿路感染引起的疼痛、刺激、不适和尿急。
T16478	PF-04447943 PF 04447943,Edelinontrine,PF04447943	PDE	Metabolism
	PF-04447943 (Edelinontrine) 是一种有效且具有选择性的的磷酸二酯酶 9A 抑制剂，IC50 为 12 nM，比作用于其他PDE家族成员选择性高 78 倍 (IC50>1000 nM)。PF-04447943 具有抗炎活性，通过抑制氧化应激、炎症和调节T细胞极化来减轻炎症反应，且可用于研究镰刀型贫血症。
T3528	Senicapoc 塞尼卡泊,ICA-17043	Potassium Channel	Membrane transporter/Ion channel
	Senicapoc (ICA-17043) 是有效的，选择性的Gardos 通道 (Ca2+激活的 K+通道;KCa3.1) 阻断剂，IC50为 11 nM。Senicapoc 阻断人红细胞的 Ca2+诱导的铷通量，IC50为 11 nM，抑制红细胞脱水的IC50为 30 nM。
T19846	Butafenacil
	Butafenacil is an effective anemia inducer.
T70823	Momelotinib HCl
	Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.
T32193	Iron sorbitex Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572
	Iron Sorbitex is used for the treatment of Iron Sorbitex deficiency anemia in patients with chronic kidney disease. Iron Sorbitex can be used as an Iron Sorbitex replacement product used for the treatment of Iron Sorbitex deficiency anemia in patients wit
T31851	Formiminoglutamic acid NSC-334078,NSC334078,NSC 334078
	Formiminoglutamic acid is used to indicate folic acid deficiency and megaloblastic anemia of pregnancy with the measurement in the urine after oral administration of histidine.
T82454	Epoetin zeta
	Epoetin zeta，内源性促红细胞生成素(Erythropoietin)的衍生物，作为促红细胞生成剂使用。它主要应用于肾源性贫血及其相关研究领域。
T72184	Ac-Tyr-Val-Lys-Asp-aldehyde
	Ac-Tyr-Val-Lys-Asp-aldehyde，一种caspase-1抑制剂，适用于慢性疾病相关贫血、化疗诱导贫血及钻石黑扇贫血的研究。
T72817	Colibactin 742
	Colibactin 742 是一种稳定的大肠杆菌素衍生物，可诱导DNA 链间交联、激活 Fanconi Anemia DNA 修复途径和 G2/M 期阻滞。
T39040	HIF-PHD-IN-1
	HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising.
T82455	Epoetin beta Genetical recombination,rhEPO,EPOCH
	Epoetin beta (rhEPO)为促红细胞生成素的重组形式，起着维持红细胞生成的作用，常用于贫血研究。
T25496	Hexaglutamate folate Pteglu6
	Hexaglutamate folate is a naturally occurring form of folic acid. The bioavailability of dietary folate may be limited by the need for the glutamate moieties to be deconjugated before absorption. Folate deficiency in humans results in anemia, neural tube
T16993	Taribavirin	Others	Others
	Taribavirin is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of he
T79241	PHD2-IN-1	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	PHD2-IN-1 为一种口服活性强效 HIF-脯氨酰羟化酶2 (PHD2) 抑制剂，具有 22.53 nM 的 IC50 值，适用于贫血病研究。
T16992	Taribavirin hydrochloride	Others	Others
	Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin hydrochloride is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells and
T18667	(S,R,S)-AHPC-C5-COOH VH032-C5-COOH	Others	Others
	(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases[1].
T75328	Hydroxocobalamin hydrochloride
	Hydroxocobalamin hydrochloride 是天然维生素B12的可注射形式，因其优良的安全性质，被用于研究维生素B12缺乏症（包括恶性贫血）相关治疗。
T74544	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine 是一种能同时靶向Smad3的泛素化和降解并提高HIF-α蛋白水平的双靶点PROTAC，展现出对肾性贫血的多途径抗纤维化和肾脏保护作用。
T72120	Guanosine 5'-diphosphate sodium GDP sodium
	Guanosine 5'-diphosphate (GDP) sodium 是一种核苷二磷酸，可激活 5'-三磷酸腺苷敏感的 K+通道。Guanosine 5'-diphosphate sodium 是一种潜在的铁动员剂，可阻断铁调素-铁转运蛋白 (hepcidin-ferroportin) 相互作用并调节 IL-6/stat-3通路。Guanosine 5'-diphosphate sodium 可用于炎症研究，如炎症性贫血 (AI)。
T82474	Empasiprubart ARGX-117
	Empasiprubart (ARGX-117) 是一种针对补体 C2 的人源化抑制性单克隆抗体。该抗体通过结合 C2 的 Sushi-2 结构域来阻止 C3 原转化酶的形成，进而抑制 C3 的激活，并阻断经典途径与凝集素途径的上游激活。Empasiprubart 展现出 pH 和钙依赖性的靶标结合能力，并在自身免疫性溶血性贫血以及抗体介导的器官移植排斥模型中，预防了补体介导的细胞毒性作用。
T69966	Roxadustat-d5
	Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and ...

化合物

Ferrous Bisglycinate

Cat.No: T4505

Synonym: Bisglycine iron(II) salt,Iron(II) bisglycinate,甘氨酸亚铁

Target: Estrogen/progestogen Receptor

Cat.No: T8132

Synonym: Iron saccharate,蔗糖铁,Sucroferric oxyhydroxide

Target: Reactive Oxygen Species

Cat.No: T13692

Synonym: Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate,麦芽酚铁

Target: Others

Guanosine 5'-diphosphate disodium salt

Cat.No: T7606

Synonym: 5'-二磷酸鸟苷二钠,5'-GDP-Na2,鸟苷-5'-二磷酸二钠盐

Target: Endogenous Metabolite

Cat.No: T25702

Synonym: ICN 17261,L-Ribavirin,ICN-17261,ICN17261

Cat.No: T77595

Target: Others

Hepcidin antagonist-1

Cat.No: T61144

Target: Others

Cat.No: T77726

Target: ALK

Cat.No: T15219

Synonym: JTZ-951

Target: Others, HIF/HIF Prolyl-Hydroxylase

Cat.No: T40823

Target: DNA/RNA Synthesis

Cat.No: T15422

Target: DYRK

Hydroxocobalamin acetate

Cat.No: T13730

Target: Others

Cat.No: T39520

Synonym: VIT-2763

Target: Ferroptosis

Phenazopyridine hydrochloride

Cat.No: T1386

Synonym: Urodine,Pyridium,Phenazopyridine HCl,盐酸非那吡啶

Target: Sodium Channel

Cat.No: T16478

Synonym: PF 04447943,Edelinontrine,PF04447943

Target: PDE

Cat.No: T3528

Synonym: 塞尼卡泊,ICA-17043

Target: Potassium Channel

Cat.No: T19846

Momelotinib HCl

Cat.No: T70823

Cat.No: T32193

Synonym: Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572

Formiminoglutamic acid

Cat.No: T31851

Synonym: NSC-334078,NSC334078,NSC 334078

Cat.No: T82454

Ac-Tyr-Val-Lys-Asp-aldehyde

Cat.No: T72184

Cat.No: T72817

Cat.No: T39040

Cat.No: T82455

Synonym: Genetical recombination,rhEPO,EPOCH

Hexaglutamate folate

Cat.No: T25496

Synonym: Pteglu6

Cat.No: T16993

Target: Others

Cat.No: T79241

Target: HIF/HIF Prolyl-Hydroxylase

Taribavirin hydrochloride

Cat.No: T16992

Target: Others

(S,R,S)-AHPC-C5-COOH

Cat.No: T18667

Synonym: VH032-C5-COOH

Target: Others

Hydroxocobalamin hydrochloride

Cat.No: T75328

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

Cat.No: T74544

Guanosine 5'-diphosphate sodium

Cat.No: T72120

Synonym: GDP sodium

Cat.No: T82474

Synonym: ARGX-117

Cat.No: T69966

Cat. No.	Product Name	Target	Signaling Pathways
T7210	Guanosine 5'-diphosphate GDP,鸟苷-5ˊ-二磷酸	Endogenous Metabolite	Metabolism
	Guanosine 5'-diphosphate (GDP) 是核苷二磷酸，是潜在的铁动员剂，能够阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6 (IL-6)/stat-3 途径。
T1040	Vitamin B12 Cyanocobalamin,Cobalamin,维生素B12	Endogenous Metabolite	Metabolism
	Vitamin B12 (Cobalamin) 是一种维生素，在维持血流形成和脑、神经系统正常功能等方面发挥关键作用。
T9171	Methenolone enanthate	Others	Others
	Methenolone enanthate 是一种雄激素和合成代谢类固醇 (AAS) 药物，主要用于治疗由于骨髓衰竭引起的贫血。
T8117	Metenolone acetate Methenolone acetate,美替诺龙醋酸酯	Others; Androgen Receptor	Endocrinology/Hormones; Others
	Metenolone acetate (Methenolone acetate) 是一种合成代谢类固醇(AAS) 药物，是一种雄激素，主要用于治疗由于骨髓衰竭引起的贫血。
T8074	Esafosfan trisodium Fosfructose trisodium,D-果糖-1,6-二磷酸三钠盐,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium	Others; Endogenous Metabolite	Metabolism; Others
	Esafosfan trisodium (FDP trisodium) 是一种细胞保护性的天然糖磷酸盐，用于镰状细胞性贫血，心血管缺血和哮喘的研究。Fosfructose trisodium 通过刺激无氧糖酵解起作用，其在缺血条件下产生三磷酸腺苷。
T5543	TriacetonaMine 四甲基哌啶酮,Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone	Others	Others
	TriacetonaMine (Vincubine) 是一种合成医药产品、农药和聚合物光稳定剂的中间体。它是热解油的主要组分。它是植物和真菌提取物的人工制品，使用丙酮和氢氧化铵，或在分离过程的不同步骤中天然出现铵盐。
T3228	Fosfructose D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,二磷酸果糖,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan	Others; Endogenous Metabolite	Metabolism; Others
	D-fructose-1,6-diphosphate 是一种细胞保护性的天然糖磷酸盐，Fosfructose 通过刺激无氧糖酵解起作用，其在缺血条件下产生三磷酸腺苷,有潜力用于心血管缺血，镰状细胞性贫血和哮喘的研究。
T4723	D-Tagatose 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos	Others; Endogenous Metabolite	Metabolism; Others
	D-Tagatose (D-(-)-Tagatose) 是自然界中发现的一种罕见的单糖，具有益生元特性。它是研究II 型糖尿病的潜在抗糖尿病药物，也是帮助提升结肠有益细菌、预防结肠癌和抑制胆固醇的益生元。它是蔗糖的替代品，也是口香糖、果汁和饮料等食品中的低热量甜味剂。
T31836	Folate sodium Folic acid, monosodium salt,Folvite sodium
	Folate sodium, as a member of the vitamin B family, can stimulate the hematopoietic system. Folic acid can be used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
T13731	Hydroxocobalamin monohydrochloride Vitamin B12a monohydrochloride,盐酸羟钴胺	Others	Others
	Hydroxocobalamin monohydrochloride is an injectable naturally occurring form of vitamin B12. It is used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia.
T78476	Hydroxocobalamin Vitamin B12a	Endogenous Metabolite	Metabolism
	Hydroxocobalamin（Vitamin B12a）为可注射型天然维生素B12，不良反应特性良好，适用于治疗维生素B12缺乏症（包括恶性贫血）的膳食补充。

天然产物

Guanosine 5'-diphosphate

Cat.No: T7210

Synonym: GDP,鸟苷-5ˊ-二磷酸

Target: Endogenous Metabolite

Cat.No: T1040

Synonym: Cyanocobalamin,Cobalamin,维生素B12

Target: Endogenous Metabolite

Methenolone enanthate

Cat.No: T9171

Target: Others

Metenolone acetate

Cat.No: T8117

Synonym: Methenolone acetate,美替诺龙醋酸酯

Target: Others, Androgen Receptor

Esafosfan trisodium

Cat.No: T8074

Synonym: Fosfructose trisodium,D-果糖-1,6-二磷酸三钠盐,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium

Target: Others, Endogenous Metabolite

Cat.No: T5543

Synonym: 四甲基哌啶酮,Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone

Target: Others

Cat.No: T3228

Synonym: D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,二磷酸果糖,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan

Target: Others, Endogenous Metabolite

Cat.No: T4723

Synonym: 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos

Target: Others, Endogenous Metabolite

Cat.No: T31836

Synonym: Folic acid, monosodium salt,Folvite sodium

Hydroxocobalamin monohydrochloride

Cat.No: T13731

Synonym: Vitamin B12a monohydrochloride,盐酸羟钴胺

Target: Others

Hydroxocobalamin

Cat.No: T78476

Synonym: Vitamin B12a

Target: Endogenous Metabolite

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