Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hydroxocobalamin monohydrochloride is an injectable naturally occurring form of vitamin B12. It is used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 2,730 | 待询 |
Hydroxocobalamin monohydrochloride 的其他形式现货产品:
产品描述 | Hydroxocobalamin monohydrochloride is an injectable naturally occurring form of vitamin B12. It is used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia. |
体外活性 | Hydroxocobalamin monohydrochloride ?is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile.Hydroxocobalamin monohydrochloride ?used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia. |
体内活性 | More than 60% of the mice administered 35 mg/kg (0.63 mmol/kg) of NaSH (LD90) survive (at 24 h) when hydroxocobalamin (0.25 mmol/kg) is given after NaSH administration whereas less than 15% of the mice survive without hydroxocobalamin. Hydroxocobalamin (50–100 μM) or cobalt (50–100 μM) also preventes hepatocyte cytotoxicity induced by NaSH (500 μM). Furthermore, adding hydroxocobalamin 60 min later than NaSH still shows some protective activity.Treatment with hydroxocobalamin before or after giving LPS attenuates LPS-induced hypotension and increases in plasma RNI and enhances LPS-induced urinary excretion of RNI.?Hydroxocobalamin (20 mg/kg i.p.) given to Swiss-Webster mice 30 min before giving LPS (16 mg/kg i.p.) decreases the 24-hr mortality of LPS from 80 to 50% and the 36- and 96-hr mortality from 100 to 60% (hydroxocobalamin). |
别名 | Vitamin B12a monohydrochloride, 盐酸羟钴胺 |
分子量 | 1382.82 |
分子式 | C62H90ClCoN13O15P |
CAS No. | 59461-30-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (72.32 mM), Sonication is recommended.
H2O: 25 mg/mL (18.08 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 0.7232 mL | 3.6158 mL | 7.2316 mL | 18.079 mL |
5 mM | 0.1446 mL | 0.7232 mL | 1.4463 mL | 3.6158 mL | |
10 mM | 0.0723 mL | 0.3616 mL | 0.7232 mL | 1.8079 mL | |
DMSO | 20 mM | 0.0362 mL | 0.1808 mL | 0.3616 mL | 0.9039 mL |
50 mM | 0.0145 mL | 0.0723 mL | 0.1446 mL | 0.3616 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Hydroxocobalamin monohydrochloride 59461-30-2 Others Vitamin B12a Vitamin B12a monohydrochloride Vitamin B12a Monohydrochloride 盐酸羟钴胺 Hydroxocobalamin Hydroxocobalamin Monohydrochloride Inhibitor inhibitor inhibit